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Cited by 133Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersHormonal Regulation and Hypertension

Adrenal incidentalomas: a manifestation of the metabolic syndrome?

Reincke, M., Faßnacht, M., Väth, S., Mora, P., Allolio, B.·1996·Endocrine Research
DOI 10.1080/07435809609043773
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Abstract

Recent evidence suggests that insulin is mitogenic on the adrenal cortex and stimulates adrenocortical tumor formation. We, investigated whether hyperinsulinemia is present in 13 patients with incidentally detected adrenal tumors. Patients with adrenal incidentalomas were obese (mean BMI 29.7 +/- 1.2 kg/m2, normal < 25; % body fat 35 +/- 1.5%, normal < 30%) with increased abdominal fat deposition (waist to hip ratio 0.92 +/- 0.02, normal < 0.85). All 13 patients were insulin resistant. Five had NIDDM, of the remaining patients 5 had fasting insulin concentrations above 15 microE/ml, and all 8 patients had elevated insulin concentrations after 75 g of glucose orally. To further investigate the potential role of insulin we examined its effects on the NCI-h295 cell line. Insulin (1-100 micrograms/ml) stimulated cell proliferation in a time and dose-dependent matter without affecting cortisol synthesis. At this concentrations insulin was equally potent to IGF I (10-80 ng/ml) or IGF II (10-100 ng/ml). We conclude that the majority of patients with adrenal incidentalomas are insulin-resistant/hyperinsulinemic. Insulin stimulates adrenal cancer cell lines in vitro. We propose that adrenal incidentalomas are a newly recognized manifestation of the metabolic syndrome comparable to insulin-mediated stimulation of the ovary in the polycystic ovary syndrome.

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Crossref · 10.1080/07435809609043773

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8 of 8 references verified0 citation errors · 0 not checkable

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  • Autonomous cortisol secretion in patients with adrenal incidentaloma has been associated with hypertension, insulin resistance, type 2 diabetes mellitus, obesity, metabolic syndrome, and increased mortality.

    “Despite the absence of florid signs and symptoms, ACS in patients AI has been associated with hypertension (215), insulin resistance (216), type 2 diabetes mellitus (217), obesity (218), metabolic syndrome (219), and increased mortality (75).”

    From Adrenal incidentaloma (2020) · cites this paper as [216]

  • Insulin is mitogenic, capable of stimulating adrenal cortex cell proliferation and tumor formation in a time- and dose-dependent manner without affecting cortisol synthesis.

    “In fact, it has been demonstrated that insulin is mitogenic, capable of stimulating adrenal cortex cell proliferation and tumor formation in a time-and dose-dependent manner, without affecting cortisol synthesis (, ).”

    From Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management (2017) · cites this paper as [218]

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Authors
Reincke, M., Faßnacht, M., Väth, S., Mora, P., & Allolio, B.
Affiliations
University of Würzburg (DE)
ORCID
Venue
Endocrine Research
Publisher
Informa UK Limited
Published
1996-11
Volume
22
Issue
4
Pages
757-761
ISSN
  • 0743-5800 (ISSN-L)
  • 1532-4206
DOI
10.1080/07435809609043773
OpenAlex
W1904058160
Cited by
133
References
8
Citations by year
2025: 3 · 2024: 4 · 2023: 13 · 2022: 6 · 2021: 1 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 5 · 2013: 2 · 2012: 7
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
adrenal incidentaloma, metabolic syndrome, hyperinsulinemia, insulin resistance, obesity, abdominal fat deposition, type 2 diabetes, insulin-like growth factor I, insulin-like growth factor II
MeSH terms
Adrenal Cortex Neoplasms, Body Constitution, Cell Division, Diabetes Mellitus, Type 2, Humans, Hyperinsulinism, Hypertension, Insulin, Insulin Resistance, Obesity, Body Mass Index

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