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Gut microbes in neurocognitive and mental health disorders
Open accessAbstract
Introduction As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the Gut Microbiome (GM) and microbial dysbiosis contribute to some of the more prevalent mental health and neurocognitive disorders, such as depression, anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), schizophrenia, bipolar disorder (BP), and dementia as well as the behavioural and psychological symptoms of dementia (BPSD) through the microbiota-gut-brain axis.Methodology: Scoping review about the effect of gut microbiota on neurocognitive and mental health disorders.Results This scoping review found there is an evolving evidence of the involvement of the gut microbiota in the pathophysiology of neurocognitive and mental health disorders. This manuscript also discusses how the psychotropics used to treat these conditions may have an antimicrobial effect on GM, and the potential for new strategies of management with probiotics and faecal transplantation.Conclusions This understanding can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management.KEY MESSAGESChallenges of managing mental health conditions remain in spite of new pharmacological therapy.Gut dysbiosis is seen in various mental health conditions.Various psychotropic medications can have an influence on the gut microbiota by their antimicrobial effect.
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“Certainly, the MGB axis has multiple sites for off-target activity, which may lead to positive or negative neurocognitive effects downstream, emphasizing the importance of antibiotic stewardship (404–407).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [404]
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
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“[71] Meanwhile, antibiotics and poor diet can cause dysfunction of the gut microbiome leading to disparities in neurotransmitters that are involved in depressive disorders through the microbiome-gut-brain axis, possibly caused by either an increase in neuroinflammation or a decrease in…”
Background
Metadata
- Authors
- Halverson, T., & Alagiakrishnan, K.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Alagiakrishnan, Kannayiram
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2020-08-31
- Volume
- 52
- Issue
- 8
- Pages
- 423-443
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- PMC
- PMC7877977
- OpenAlex
- W3047682179
- Cited by
- 125
- References
- 195
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 28 · 2023: 26 · 2022: 24 · 2021: 9
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, dysbiosis, microbiota-gut-brain axis, neurocognitive disorders, mental illness, depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, bipolar disorder, dementia, behavioral and psychological symptoms of dementia, psychotropic drugs, probiotics, fecal microbiota transplantation
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Mental Disorders, Cognition, Combined Modality Therapy, Humans, Mental Health, Psychotropic Drugs, Treatment Outcome, Probiotics, Dysbiosis
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