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Cited by 191Gut microbiota and healthAlzheimer's disease research and treatmentsGastrointestinal motility and disorders

Crosstalk between Gut and Brain in Alzheimer’s Disease: The Role of Gut Microbiota Modulation Strategies

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Shabbir, Umair, Arshad, Muhammad Sajid, Sameen, Aysha, Oh, Deog-Hwan·2021·Nutrients
DOI 10.3390/nu13020690PMC PMC7924846
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Abstract

The gut microbiota (GM) represents a diverse and dynamic population of microorganisms and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies suggest that the GM can influence the health of the host, and several factors can modify the GM composition, such as diet, drug intake, lifestyle, and geographical locations. Gut dysbiosis can affect brain immune homeostasis through the microbiota–gut–brain axis and can play a key role in the pathogenesis of neurodegenerative diseases, including dementia and Alzheimer’s disease (AD). The relationship between gut dysbiosis and AD is still elusive, but emerging evidence suggests that it can enhance the secretion of lipopolysaccharides and amyloids that may disturb intestinal permeability and the blood–brain barrier. In addition, it can promote the hallmarks of AD, such as oxidative stress, neuroinflammation, amyloid-beta formation, insulin resistance, and ultimately the causation of neural death. Poor dietary habits and aging, along with inflammatory responses due to dysbiosis, may contribute to the pathogenesis of AD. Thus, GM modulation through diet, probiotics, or fecal microbiota transplantation could represent potential therapeutics in AD. In this review, we discuss the role of GM dysbiosis in AD and potential therapeutic strategies to modulate GM in AD.

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Cited by

Sorted by citations

Authors
Shabbir, U., Arshad, M. S., Sameen, A., & Oh, D.-H.
Affiliations
  • Kangwon National University (KR)
  • Government College University, Faisalabad (PK)
  • University of Agriculture Faisalabad (PK)
Corresponding author
Oh, Deog-Hwan
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2021-02-21
Volume
13
Issue
2
Pages
690
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu13020690
PMC
PMC7924846
OpenAlex
W3129754660
Cited by
191
References
14
Citations by year
2026: 29 · 2025: 31 · 2024: 50 · 2023: 37 · 2022: 29 · 2021: 15
FWCI
3.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Ulster University Research Portal (Ulster University) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Brain Korea (BK) 21 Plus Project (Grant No. 22A20153713433)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Alzheimer's disease, gut microbiota, microbiota-gut-brain axis, gut dysbiosis, neuroinflammation, oxidative stress, amyloid-beta, lipopolysaccharide, intestinal permeability, blood-brain barrier, insulin resistance, probiotics, fecal microbiota transplantation, diet, neurodegeneration
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Diet Therapy, Humans, Intestinal Mucosa, Permeability, Probiotics, Dysbiosis

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