Cited by 126Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Gut microbes in neurocognitive and mental health disorders

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Halverson, Tyler, Alagiakrishnan, Kannayiram·2020·Annals of Medicine

DOI 10.1080/07853890.2020.1808239PMC PMC7877977

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Abstract

Introduction As individuals age, the prevalence of neurocognitive and mental health disorders increases. Current biomedical treatments do not completely address the management of these conditions. Despite new pharmacological therapy the challenges of managing these diseases remain.There is increasing evidence that the Gut Microbiome (GM) and microbial dysbiosis contribute to some of the more prevalent mental health and neurocognitive disorders, such as depression, anxiety, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), schizophrenia, bipolar disorder (BP), and dementia as well as the behavioural and psychological symptoms of dementia (BPSD) through the microbiota-gut-brain axis.Methodology: Scoping review about the effect of gut microbiota on neurocognitive and mental health disorders.Results This scoping review found there is an evolving evidence of the involvement of the gut microbiota in the pathophysiology of neurocognitive and mental health disorders. This manuscript also discusses how the psychotropics used to treat these conditions may have an antimicrobial effect on GM, and the potential for new strategies of management with probiotics and faecal transplantation.Conclusions This understanding can open up the need for a gut related approach in these disorders as well as unlock the door for the role of gut related microbiota management.KEY MESSAGESChallenges of managing mental health conditions remain in spite of new pharmacological therapy.Gut dysbiosis is seen in various mental health conditions.Various psychotropic medications can have an influence on the gut microbiota by their antimicrobial effect.

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Authors: Halverson, T., & Alagiakrishnan, K.
Affiliations: University of Alberta (CA)
Corresponding author: Alagiakrishnan, Kannayiram
ORCID: Halverson, Tyler
Alagiakrishnan, Kannayiram
Venue: Annals of Medicine
Publisher: Informa UK Limited
Published: 2020-08-31
Volume: 52
Issue: 8
Pages: 423-443
ISSN: 0785-3890 (ISSN-L)
1365-2060
DOI: 10.1080/07853890.2020.1808239
PMC: PMC7877977
OpenAlex: W3047682179
Cited by: 125
References: 195
Citations by year: 2026: 14 · 2025: 24 · 2024: 28 · 2023: 26 · 2022: 24 · 2021: 9
FWCI: 1.44
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annals of Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, dysbiosis, microbiota-gut-brain axis, neurocognitive disorders, mental illness, depression, anxiety, obsessive-compulsive disorder, post-traumatic stress disorder, schizophrenia, bipolar disorder, dementia, behavioral and psychological symptoms of dementia, psychotropic drugs, probiotics, fecal microbiota transplantation
MeSH terms: Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Mental Disorders, Cognition, Combined Modality Therapy, Humans, Mental Health, Psychotropic Drugs, Treatment Outcome, Probiotics, Dysbiosis

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