The DOI matches its Crossref record; 282 of the 282 references it cites were found in a registry or an index.
Inflammation and cortisol response in coronary artery disease
Open accessAbstract
Atherosclerosis is characterized by chronic inflammation involving autoimmune components. The degree of inflammatory activity, as detectable both within the atherosclerotic plaque and in the circulation, is associated with plaque destabilization and atherothrombotic complications. Endogenous glucocorticoids are modulators of innate and acquired immune responses, and as such play a key role in the reciprocal interaction between neuroendocrine and immune systems. Abnormalities in hypothalamic-pituitary-adrenal axis (HPA) function have been described in several chronic inflammatory disorders, and evidence has emerged lately that HPA dysfunction may be implicated also in the pathogenesis of coronary artery disease. This review is an outline of knowledge gained so far by previous studies of glucocorticoids in coronary atherosclerosis and myocardial infarction. The results consistently point towards a dysregulated cortisol secretion that may involve a failure to contain inflammatory activity. A dysfunctional HPA axis and its possible implications for coronary artery disease progress, including the hypothetical link between stress and inflammation, are discussed.
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“chronic conditions such as coronary artery disease, fibromyalgia, rheumatoid arthritis, and mood disorders such as Major Depressive Disorder (MDD) and Post Traumatic Stress Disorder (PTSD) have also been associated with abnormally high CORT levels and metabolic disruptions ( 5-13 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [5]
In the citing paper
“in hypercortisolism, it is not only that CORT levels are higher than normal, but in some cases, they also display abnormal rhythmicity. This varies depending on whether the underlying condition is associated with Cushing's syndrome, depression, PTSD, acute inflammation following major surgery, or chronic inflammatory diseases (e.g., rheumatoid arthritis) ( 2, 5-13, 57-60 ).”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [5]
In the citing paper
“many of these conditions are accompanied by a disruption of normal glucose metabolism while preserving some degree of CORT rhythmicity.”
From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [5]
In the citing paper
“Dysregulation of the HPA axis contributes to inflammatory processes that play a role in hypertension, atherosclerosis, and coronary heart disease [67–69].”
From Loneliness matters: a theoretical and empirical review of consequences and mechanisms (2010) · cites this paper as [68]
Citations
Cites
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Cited by
Sorted by citations
Loneliness matters: a theoretical and empirical review of consequences and mechanisms
Hawkley, L. C., & Cacioppo, J. T. (2010) · Annals of Behavioral Medicine · doi:10.1007/s12160-010-9210-8 · Cited by 4,782
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Caregiving Burden, Stress, and Health Effects Among Family Caregivers of Adult Cancer Patients
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Michopoulos, V., Norrholm, S. D., & Jovanovic, T. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.005 · Cited by 206
Metadata
- Authors
- Nijm, J., & Jonasson, L.
- Affiliations
- Ryhov Hospital Jönköping (SE)
- Linköping University (SE)
- ORCID
- Jonasson, Lena
- Venue
- Annals of Medicine
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 41
- Issue
- 3
- Pages
- 224-233
- ISSN
- 0785-3890 (ISSN-L)
- 1365-2060
- OpenAlex
- W2027066260
- Cited by
- 128
- References
- 282
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 10 · 2014: 4 · 2013: 6 · 2012: 8
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Medicine (publishedVersion)
- PubMed (publishedVersion)
- DiVA (Linkoping University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- coronary artery disease, atherosclerosis, inflammation, cortisol, hypothalamic-pituitary-adrenal axis, glucocorticoids, myocardial infarction, stress, neuroendocrine-immune interaction, plaque destabilization, atherothrombosis
- MeSH terms
- Coronary Artery Disease, Glucocorticoids, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Inflammation, Myocardial Infarction, Pituitary-Adrenal System, Stress, Physiological, Neuroimmunomodulation, Biomarkers, Autoimmunity
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