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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

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Rationale and design of the avoiding cardiovascular events through combination therapy in patients living with systolic hypertension (ACCOMPLISH) trialThe first randomized controlled trial to compare the clinical outcome effects of first-line combination therapies in hypertension

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Baseline characteristics in the Avoiding Cardiovascular events through Combination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: A hypertensive population at high cardiovascular risk

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The ALLHAT Report: A Case of Information and Misinformation

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Cardiovascular Protection by Initial and Subsequent Combination of Antihypertensive Drugs in Daily Life Practice

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State of Hypertension Management in the United States: Confluence of Risk Factors and the Prevalence of Resistant Hypertension

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Improving Outcomes in Hypertensive Patients: Focus on Adherence and Persistence With Antihypertensive Therapy

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Optimizing Blood Pressure Control in Patients with Chronic Kidney Disease

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External adjustment for unmeasured confounders improved drug–outcome association estimates based on health care utilization data

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Single-pill combination of amlodipine and valsartan in the management of hypertension

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Valsartan/Amlodipine Compared to Nifedipine GITS in Patients with Hypertension Inadequately Controlled by Monotherapy

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How early should blood pressure control be achieved for optimal cardiovascular outcomes?

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Initial combination therapy for rapid and effective control of moderate and severe hypertension

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Prompt, Aggressive BP Lowering in High‐Risk Patients

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The Diabetes Subgroup Baseline Characteristics of the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) Trial

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Cost Implications of Improving Blood Pressure Management among U.S. Adults

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Impact of Statin Therapy on the Blood Pressure-Lowering Efficacy of a Single-Pill Perindopril/Amlodipine Combination in Hypertensive Patients with Hypercholesterolemia

On behalf of the PERSPECTIVA Study Group, Sirenko, Y., & Radchenko, G. (2017) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-017-0184-5 · Cited by 12 · see citing works

Overcoming Therapeutic Inertia in Patients with Hypertension

Nesbitt, S. D. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.01.2105 · Cited by 12 · see citing works

Combinations of inhibitors of the renin–angiotensin system with calcium channel blockers for the treatment of hypertension: focus on perindopril/amlodipine

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Effects of valsartan versus olmesartan addition to amlodipine/hydrochlorothiazide combination in treating stage 2 hypertensive patients

Fogari, R., Zoppi, A., Mugellini, A., Preti, P. S., Perrone, T., Maffioli, P., & Derosa, G. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.667077 · Cited by 11 · see citing works

Difficult-to-Treat or Resistant Hypertension: Etiology, Pathophysiology, and Innovative Therapies

Papademetriou, V., Tsioufis, C. P., Gradman, A. H., & Punzi, H. A. (2011) · International Journal of Hypertension · doi:10.4061/2011/438198 · Cited by 11 · see citing works

Comparison of ambulatory blood pressure measurement with home, office and pharmacy measurements: is arterial blood pressure measured at pharmacy reliable?

Mutlu, S., Sarı, O., Arslan, E., Aydoğan, Ü., Doğaner, Y. Ç., & Koç, B. (2015) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12424 · Cited by 10 · see citing works

A rapid method for the simultaneous determination of 25 anti-hypertensive compounds in dietary supplements using ultra-high-pressure liquid chromatography

Heo, S., Yoo, G. J., Choi, J. Y., Park, H. J., Park, S.-K., & Baek, S. Y. (2016) · Food Additives & Contaminants Part A · doi:10.1080/19440049.2016.1235799 · Cited by 10 · see citing works

The Clock Is Ticking: The Case for Achieving More Rapid Control of Hypertension

Berlowitz, D. R., & Franklin, S. S. (2010) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2010.00274.x · Cited by 10 · see citing works

Antihypertensive Therapy With CCB/ARB Combination in Older Individuals: Focus on Amlodipine/Valsartan Combination

Kostis, J. B. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181a2ba2d · Cited by 10 · see citing works

Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide: An Open-Label, Randomized, 4-Period Crossover Study in Healthy Egyptian Male Volunteers

Hedaya, M. A., & Helmy, S. A. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.04.014 · Cited by 9 · see citing works

The Importance of Prompt Blood Pressure Control

Basile, J. (2008) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.08027.x · Cited by 9 · see citing works

Long-term tolerability and efficacy of the combination of amlodipine/valsartan in hypertensive patients: a 54-week, open-label extension study

Philipp, T., Glazer, R. D., Zhao, Y., & Pospiech, R. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802628046 · Cited by 9 · see citing works

Clinical Inertia and Blood Pressure Goal Attainment

Basile, J. (2009) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2009.00210.x · Cited by 8 · see citing works

Ambulatory blood pressure response to triple therapy with an angiotensin-receptor blocker (ARB), calcium-channel blocker (CCB), and HCTZ versus dual therapy with an ARB and HCTZ

Duprez, D. A., Ferdinand, & Wright (2011) · Vascular Health and Risk Management · doi:10.2147/vhrm.s25743 · Cited by 8 · see citing works

Effectiveness of initiating treatment with valsartan/hydrochlorothiazide in patients with stage-1 or stage-2 hypertension

Zappe, D. H., Palmer, B. F., Calhoun, D. A., Purkayastha, D. S., Samuel, R., & Jamerson, K. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.90 · Cited by 8 · see citing works

Predictors of systolic BP <140 mmHg and systolic BP level by randomly assigned treatment group (benazepril plus amlodipine or hydrochlorothiazide) in the ACCOMPLISH Study

Kjeldsen, S. E., Jamerson, K., Bakris, G. L., Pitt, B., Dahlöf, B., Velazquez, E. J., Hua, T. A., Kelly, R. Y., Zappe, D., Hester, A., et al. (2011) · Blood Pressure · doi:10.3109/08037051.2011.598699 · Cited by 8 · see citing works

Recent Clinical Trials

Kaplan, N. M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.117473 · Cited by 8 · see citing works

Combining RAAS and calcium channel blockade: ACCOMPLISH in perspective

Kjeldsen, S. E., Weber, M. A., Oparil, S., & Jamerson, K. (2008) · Blood Pressure · doi:10.1080/08037050802565171 · Cited by 7 · see citing works

Antihypertensive and organ-protective effects of benazepril

Barrios, V., & Escobar, C. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.159 · Cited by 7 · see citing works

Simultaneous determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma using UPLC-MS/MS method

Zheng, X., Gao, H., Cui, X., Zhang, Y., Chen, R., Wang, Y., Lauruol, P., & Wang, H. (2021) · Journal of Chromatography B · doi:10.1016/j.jchromb.2021.122585 · Cited by 6 · see citing works

Renoprotective effects of benazepril: current perspective

Stompór, T. P., Napora, M., & Olszewski, A. (2011) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.11.55 · Cited by 6 · see citing works

The Importance of Integrated Risk Management When Treating Patients with Hypertension: Benefits of Angiotensin II Receptor Antagonist Therapy

Ruilope, L. M., & Segura, J. (2008) · Clinical and Experimental Hypertension · doi:10.1080/10641960802279066 · Cited by 6 · see citing works

Optimizing Management of Hypertension With Combination Therapy

Roberts, M. E., & Epstein, B. J. (2009) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0b013e3181aed18e · Cited by 6 · see citing works

Stagnant Cardiovascular Prevention: Alarming Trends and Persistent Socioeconomic Hurdles

Romero, T. E., & Romero, C. X. (2010) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(10)70258-9 · Cited by 6 · see citing works

Trials That Matter: The Effect of a Fixed-Dose Combination of an Angiotensin-Converting Enzyme Inhibitor and a Diuretic on the Complications of Type 2 Diabetes

Bakris, G. L., & Berkwits, M. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-148-5-200803040-00012 · Cited by 6 · see citing works

An Overview of the PRESYON 4 Trial and Its Impact on Practice

Sison, J. (2023) · Journal of Asian Pacific Society of Cardiology · doi:10.15420/japsc.2022.16 · Cited by 5 · see citing works

Uncontrolled arterial hypertension: main causes, features of pathogenesis and approaches to treatment

Denisova, A. R., Solntseva, T. D., Анатольевна, С. О., & Chazova, I. E. (2021) · Systemic Hypertension · doi:10.26442/2075082x.2021.1.200724 · Cited by 5 · see citing works

Factores modificables de riesgo cardiovascular: ¿Cuáles estamos realmente modificando?

Romero, T. E. (2009) · Revista médica de Chile · doi:10.4067/s0034-98872009001100014 · Cited by 4 · see citing works

Characterizing Workers Participating in a Worksite Wellness Health Screening Program Using Blood Pressure Control, Self-Monitoring, Medication Adherence, Depression, and Exercise

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Hypertension in Ireland: public awareness and doctors choice of therapy

Zaharan, N. L., Mahmud, A., Bennett, K., & Feely, J. (2009) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-009-0367-8 · Cited by 4 · see citing works

Time to Initiation of Antihypertensive Therapy After Onset of Elevated Blood Pressure in Patients With Primary Proteinuric Kidney Disease

Weaver, D. J., Waldo, A., Oh, G. J., Kamil, E. S., Elliott, M., Adler, S. G., Pesenson, A., Modes, M., Gipson, P. E., Lafayette, R. A., et al. (2020) · Kidney Medicine · doi:10.1016/j.xkme.2019.10.012 · Cited by 4 · see citing works

Pharmacokinetics and Pharmacodynamics of Aliskiren/Hydrochlorothiazide Single‐Pill Combination Tablets and Free Combination of Aliskiren and Hydrochlorothiazide

Yan, J., Jarugula, V. R., Sabo, R., Papst, C. C., Zhang, J. Y., & Dole, W. P. (2011) · The Journal of Clinical Pharmacology · doi:10.1177/0091270011405499 · Cited by 3 · see citing works

Resistant hypertension: Diagnostic strategies and management

Bravo, E. L. (2013) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.80gr.12005 · Cited by 3 · see citing works

Rationale for Fixed-Dose Combination Therapy to Reach Lower Blood Pressure Goals

Basile, J. (2008) · Southern Medical Journal · doi:10.1097/smj.0b013e3181812907 · Cited by 3 · see citing works

Resistant Hypertension: Questions and Contemporary Answers

Podzolkov, V. I., Bragina, A. E., & Osadchiy, K. K. (2019) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2019-15-4-568-577 · Cited by 3 · see citing works

Polypharmacology in Clinical Applications: Renal Polypharmacology

Wang, Z., & Yang, B. (2022) · Springer eBooks · doi:10.1007/978-3-031-04998-9_9 · Cited by 2 · see citing works

Blood Pressure Control in the Patient With Difficult‐to‐Control Hypertension: Which Agent for Which Patient?

Bakris, G. L., Sowers, J. R., & Ferdinand, K. C. (2008) · Preventive Cardiology · doi:10.1111/j.1520-037x.2007.08148.x · Cited by 3 · see citing works

The Evolution of Combination Therapy in Treating Hypertension

Weber, M. A. (2007) · Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2007.07806.x · Cited by 3 · see citing works

ASH Position Article Combination therapy in hypertension

Gradman, A. H., BASILE, J. N., Carter, B. L., & Bakris, G. L. (2010) · Cited by 3 · see citing works

Achieving blood pressure control with monotherapy: real-world evidence from office and home blood pressure measurements

Bezerra, R., Feitosa, A. D. M., Neto, V. D. S. G., Barbosa, R. H. D. A., Moura, F. F., Gomes, M. A. M., de Paiva, A. M. G., Barroso, W. K. S., Miranda, R. D., Barbosa, E. C. D., et al. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004165 · Cited by 2 · see citing works

Importance and efficiency of blood pressure control not only in type 2 diabetes patients

Vejtasová, V., Urbanová, J., Brunerová, L., Lustigová, M., Jenšovský, M., Prýmková, B., Pálová, S., & Brož, J. (2021) · Vnitřní lékařství · doi:10.36290/vnl.2021.056 · Cited by 2 · see citing works

Not only the effective, but a rapid blood pressure reduction as a novel aim in hypertension treatment. The role of combination therapy

Конради, А. О. (2008) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2008-14-2-137-142 · Cited by 2 · see citing works

Cardiac lipotoxic effects of obesity

Асташкин, Е. И., & Глезер, М. Г. (2009) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2009-15-3-335-341 · Cited by 2 · see citing works

The Role of Combination Therapy for Hypertension After ACCOMPLISH

Lackland, D. T. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0101-0

The Avoiding Cardiovascular events through COMbination therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial: a comparison of first-line combination therapies

Weder, A. B. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.2.275 · Cited by 18 · see citing works

Predictors of blood pressure response to intensified and fixed combination treatment of hypertension: The ACCOMPLISH Study

Kjeldsen, S. E., Jamerson, K., Bakris, G. L., Pitt, B., Dahlöf, B., Velazquez, E. J., Gupte, J., Staikos-Byrne, L., Hua, T. A., Shi, V. C., et al. (2008) · Blood Pressure · doi:10.1080/08037050801972857 · Cited by 52 · see citing works

Review of blood pressure control rates and outcomes

Bakris, G. L., Sarafidis, P. A., Agarwal, R., & Ruilope, L. M. (2013) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2013.07.009 · Cited by 65 · see citing works

Design of the accomplish (avoiding cardiovascular events through combination therapy in patients living with systolic hypertension) trial

Jamerson, K. (2003) · American Journal of Hypertension · doi:10.1016/s0895-7061(03)00603-4 · Cited by 5 · see citing works