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The relationship between religion and cardiovascular outcomes and all-cause mortality in the women's health initiative observational study
Abstract
Some studies suggest that religiosity may be related to health outcomes. The current investigation, involving 92,395 Women's Health Initiative Observational Study participants, examined the prospective association of religious affiliation, religious service attendance, and strength and comfort from religion with subsequent cardiovascular outcomes and death. Baseline characteristics and responses to religiosity questions were collected at enrollment. Women were followed for an average of 7.7 years and outcomes were judged by physician adjudicators. Cox proportional regression models were run to obtain hazard ratios (HR) of religiosity variables and coronary heart disease (CHD) and death. After controlling for demographic, socioeconomic, and prior health variables, self-report of religious affiliation, frequent religious service attendance, and religious strength and comfort were associated with reduced risk of all-cause mortality [HR for religious affiliation = 0.84; 95% confidence interval (CI): 0.75-0.93] [HR for service attendance = 0.80; CI: 0.73-0.87] [HR for strength and comfort = 0.89; CI: 0.82-0.98]. However, these religion-related variables were not associated with reduced risk of CHD morbidity and mortality. In fact, self-report of religiosity was associated with increased risk of this outcome in some models. In conclusion, although self-report measures of religiosity were not associated with reduced risk of CHD morbidity and mortality, these measures were associated with reduced risk of all-cause mortality.
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“Of the 13 studies with the most rigorous methodology, nine (69%) found inverse relationships with CHD [357–365] and one found a positive one [366].”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [360]
In the citing paper
“Of the 20 methodologically most rigorous studies, 12 (60%) found an association between R/S and lower risk or better outcomes [469–480], and none reported worse risk or outcomes.”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [471]
In the citing paper
“Considering the 63 methodologically most rigorous studies (quality ratings of 8 or higher), 47 (75%) found R/S predicting greater longevity (two at trend level) [548–566], whereas three (5%) reported shorter longevity [567–569].”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [556]
In the citing paper
“In both the WHI and MESA cohorts, point estimates actually showed a higher risk of CVD among the more religiously involved.”
From Advancing our understanding of religion and spirituality in the context of behavioral medicine (2017) · cites this paper as Schnall et al., 2010
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“eScholarship@UMMS Cardiovascular Medicine Publications and Presentations Cardiovascular Medicine 2013-5”
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“Analyses of major epidemiologic cohorts, with sample sizes in the tens-of-thousands, have examined these relationships and suggested service attendance is associated with reduced all-cause mortality rates (6,8,13-18).”
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“Schnall and colleagues ( 2008 ) recently studied data on the religious practices of nearly 100,000 postmenopausal women participating in the Women's Health Initiative (WHI) Study.”
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“, McCullough, Hoyt, Larson, Koenig, & Thoresen, 2000), as well as the leading causes of death in the United States, cancer and cardiovascular disease (e.g., Gillum & Ingram, 2006; Schnall et al., 2010), and also one of the most prevalent mental illnesses in the United States, that is, depression (Smith, McCullough, &…”
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“Besides, religious activitieswere found tobe a protective factor, which improved mental health and quality of life in patients with cancer, and cardiovascular, respiratory, and neurological problems (Banerjee et al. 2014; Schnall et al. 2010; Unterrainer et al. 2011).”
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InfluentialPsychometric Testing of a Religious Belief Scale
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“For example, Schnall et al. (2010) investigated 92,395 subjects and found that self-reported religious affiliations, frequent religious service attendance, and perceived comfort from religion were each significantly associated with reduced risks of all-cause mortality.”
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“Religious involvement, with regular prayer, seems to represent a general protective factor that promotes psychological health and improves QOL in patients with chronic diseases, including patients with cancer and coronary, pulmonary, or neurological diseases [4, 16, 26].”
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“While some longitudinal studies that have been conducted in a large cohort of healthy people didn’t acknowledged the protective association between religious affiliation and practice [69, 70], the other study findings indicated that restful religiousness was longitudinally associated with higher odds of heart attack […”
ResultLitman, L., Robinson, J., Weinberger-Litman, S. L., & Finkelstein, R. (2017) · Journal of Religion and Health · doi:10.1007/s10943-017-0460-7 · Cited by 10
“At the broadest level of health, numerous studies have shown that religious people live longer (Kark et al. 1996; Hummer et al. 1999; Schnall et al. 2010; Bartkowski et al. 2010; McCullough and Willoughby 2009; McCullough et al. 2005a, b), and that religiosity impacts general health as well as…”
BackgroundVanderWeele and Chen Respond to “Religion as a Social Determinant of Health”
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“Regular involvement in organized religious activities such as prayer has been positively correlated with numerous positive outcomes, including physical health (Idler & Stanislav, 1997; Selway & Ashman, 1998), life expectancy (Schnall, 2010), and happiness (Lewis, 2002; Lewis, Maltby, & Day, 2005; Siegel & Anderman, 20…”
BackgroundTran, T. V., Chan, K., & Nguyen, T. (2011) · Psychological Reports · doi:10.2466/07.17.pr0.108.3.756-762 · Cited by 9
Divine Placebo: Health and the Evolution of Religion
Lindenfors, P. (2019) · Human Ecology · doi:10.1007/s10745-019-0066-7 · Cited by 8
“ysis controlled for age, ethnicity, income level, and current health (Schnall et al. 2010).”
BackgroundAssociation of religiosity and spirituality with survival among older adults: a systematic review
Buja, A., Grotto, G., & Vo, D. (2024) · Journal of Public Health · doi:10.1007/s10389-024-02303-1 · Cited by 8
“(Oman and Reed 1998; Hart 2001; Hill et al. 2005; Bagiella et al. 2005; Teinonen et al. 2005; Dupre et al. 2006; Zhang 2008; Schnall et al. 2010; Zeng et al. 2011; McDougle et al. 2016; Park et al. 2016), one asked whether they were part of a religious community (Fraser et al. 2020), two assessed…”
Ai, A. L., Fincham, F. D., & Carretta, H. J. (2021) · Journal of Religion and Health · doi:10.1007/s10943-020-01146-w · Cited by 7
“Certain character strengths, such as hope and spirituality, have been associated with better health outcomes and survival in older adults and in cardiac patients (Anthony et al. 2016; Bouchard et al. 2018; Chida et al. 2009; Galatzer-Levy and Bonanno 2014; Gillum et al. 2008; Li et al. 2016; Rasmussen et al. 2009; Sch…”
BackgroundBhavsar, N. A., Davenport, C. A., Yang, Z., Peskoe, S. B., Scialla, J. J., Hall, R. K., Tyson, C. C., Strigo, T. S., Sims, M., Pendergast, J., et al. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02594-6 · Cited by 6
“A smaller number of studies have reported that religiosity and spirituality are not protective for health outcomes [10, 11] or that there is a salutary association of religiosity and health outcomes [50, 51].”
BackgroundReligion and survival among European older adults
Christopoulos, K. (2023) · European Journal of Ageing · doi:10.1007/s10433-023-00789-4 · Cited by 6
“…et al. 2000; Hill et al. 2005; Idler et al. 2017; Hummer et al. 1999; Kim et al. 2015; Li et al. 2016; McCullough et al. 2009; Musick et al. 2004; Schnall et al. 2010; Sullivan 2010; VanderWeele et al. 2017), but studies from other countries such as Denmark (Ahrenfeldt et al. 2023; La Cour et…”
BackgroundShields, A. E., Zhang, Y., Argentieri, M. A., Warner, E. T., Cozier, Y. C., Liu, C., Dye, C. K., Kent, B. V., Baccarelli, A., & Palmer, J. R. (2021) · Epigenomics · doi:10.2217/epi-2021-0275 · Cited by 9
Eilat-Adar, S., Hellerstein, D., & Goldbourt, U. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912607 · Cited by 6
Tindle, H. A., Chang, Y., Kuller, L. H., Siegle, G. J., Matthews, K. A., Manson, J. E., Robinson, J. G., & Rosal, M. C. (2010) · Circulation · doi:10.1161/circulationaha.109.929166 · Cited by 6
Understanding the Socioeconomic Determinants of Religiosity and Religious Participation in Asia
Zhou, J. (2023) · Journal of Asian and African Studies · doi:10.1177/00219096231200598 · Cited by 5
“Schnall et al. (2010) found that regular religious service attendance was associated with a significantly reduced risk of mortality for women over 50 years.”
Religious Communities, Health, and Well-Being – Address to the US Air Force Chaplain
VanderWeele, T. J. (2018) · Military Medicine · doi:10.1093/milmed/usx206 · Cited by 5
Religious/Spiritual Effects on Physical Morbidity and Mortality
Oman, D. (2018) · Religion, spirituality and health: a social scientific approach · doi:10.1007/978-3-319-73966-3_4 · Cited by 5
Sanctification of Work: A Potential Moderator of the Relationship between Work Stress and Health
Backus, L. N. (2013) · ScholarWorks@BGSU (Bowling Green State University) · Cited by 5
Ai, A. L., Peterson, C., Koenig, H. G., Paloutzian, R. F., & Harris, K. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-52140-0_10 · Cited by 4
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0002 · Cited by 5
Understanding the Religion, Mental, and Social Health Relationship
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0016 · Cited by 7
Schachter, A. B., Argentieri, M. A., Seddighzadeh, B., Isehunwa, O. O., Kent, B. V., Trevvett, P., McDuffie, M. T., Mandel, L., Pargäment, K. I., Underwood, L. G., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043830 · Cited by 3
Positive Psychology and Judaism
SCHIFFMAN, M. H., Cherniak, A. D., Schnall, E., Brooks, S., Pirutinsky, S., & Shabtai, D. (2022) · Springer eBooks · doi:10.1007/978-3-031-10274-5_11 · Cited by 3
Self-citationMasters, K. S., Wilson, C. L., & Boylan, J. M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319002 · Cited by 4
Adelufosi, A. O., Abayomi, O., Oyewole, A. O., & Ayankola, A. K. (2013) · Journal of Behavioral Health · doi:10.5455/jbh.20130325033852 · Cited by 3
“Despite a troubled history between psychiatry and religion [9], a growing body of research have reported the positive impact of religiosity on treatment outcomes among those with mental and even physical health problems [10-14].”
BackgroundKusumawardani, D. N., & Asih, S. R. (2019) · International Conference on Intervention and Applied Psychology (ICIAP) · doi:10.2991/iciap-18.2019.22 · Cited by 2
“In addition, patients’ self-esteem and optimism tend to increase when they have high spiritual well-being (Petrie & Weinman, 2006; Schnall et al., 2010).”
Hiernaux, C., & Varescon, I. (2022) · Alcoholism Treatment Quarterly · doi:10.1080/07347324.2022.2047130 · Cited by 2
“Studies on the relationship between spirituality and health find a significant influence of gender, age (Feinstein, Liu, Ning, Fitchett, & Lloyd-Jones, 2010; Hummer, Rogers, Nam, & Ellison, 1999; Musick, House, & Williams, 2004; Powell, Shahabi, & Thoresen, 2003), marital status (Helm, Hays, Flint, Koenig, & Blazer, 2…”
Szałachowski, R. R., & Tuszyńska-Bogucka, W. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031942 · Cited by 2
Psychological Well-Being and Positive Emotions
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0012 · Cited by 2
Religion, Spirituality, and Cardiovascular Disease
Masters, K. S. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_27 · Cited by 2
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0025 · Cited by 1
Substance Use and Substance Use Disorders
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0010 · Cited by 2
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0014 · Cited by 4
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0015 · Cited by 1
Brown, M. T., Zhang, W., Hwang, W., & Silverstein, M. D. (2025) · Journal of Religion and Health · doi:10.1007/s10943-025-02297-4 · Cited by 1
“…in the U.S. (Dupre et al., 2006; Gillum et al., 2008; Hart, 2001; Hill et al., 2005; Hummer et al., 1999; Li et al., 2016; Oman & Reed, 1998; Schnall et al., 2010; VanderWeele et al., 2017), in Europe (Christopoulos, 2023; Darviri, et al., 2016), and in East Asia (Hidajat et al., 2013; Zeng…”
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0027 · Cited by 1
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0008 · Cited by 2
Public Health and Human Flourishing
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0032 · Cited by 1
Understanding the Religion–Physical Health Relationship
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0031 · Cited by 1
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0017 · Cited by 1
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780190088859.003.0006 · Cited by 1
Hochstetler, E., & Hill, K. K. (2024) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2024.03.005 · Cited by 1
Metadata
- Authors
- Schnall, E., Wassertheil-Smoller, S., Swencionis, C., Zemon, V., Tinker, L., O'Sullivan, M. J., Van Horn, L., & Goodwin, M.
- Affiliations
- Yeshiva University (US)
- Albert Einstein College of Medicine (US)
- Fred Hutch Cancer Center (US)
- Corresponding author
- Schnall, Eliezer
- Venue
- Psychology & Health
- Publisher
- Informa UK Limited
- Published
- 2010-02
- Volume
- 25
- Issue
- 2
- Pages
- 249-263
- ISSN
- 0887-0446 (ISSN-L)
- 1476-8321
- OpenAlex
- W2162283541
- Cited by
- 139
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 45 · 2022: 4 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 5
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychology and Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Sociology and Political Science › Religion and Society Interactions
- Keywords
- religiosity, religious affiliation, religious service attendance, cardiovascular outcomes, coronary artery disease, all-cause mortality, women's health, Women's Health Initiative Observational Study
- MeSH terms
- Aged, Cardiovascular Diseases, Cause of Death, Female, Humans, Middle Aged, Religion and Medicine, United States, Health Behavior, Proportional Hazards Models, Women's Health, Outcome Assessment, Health Care, Observation
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