High‐ and Low‐Dose Mazindol for Cocaine Dependence in Methadone‐Maintained Patients: A Preliminary Evaluation
Abstract
We conducted a preliminary investigation comparing high‐dose mazindol (8 mg/day), low dose mazindol (1 mg/day), and placebo for cocaine abstinence initiation in a 12‐week, double‐blind, randomized clinical trial enrolling 17 cocaine‐dependent, methadone‐maintained patients. Outcome data did not support a difference between the two dose levels on percentage positive urine screens positive for cocaine (1 mg mazindol=68%, 8 mg mazindol=75%, placebo=91%). Doses of mazindol greater than 8 mg may be needed for a cocaine blocking effect, although potential pressor effects may be a limiting factor.
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A review of 300 Australian cases from 2009 to 2015 found that suicide comprised 18.2% of all methamphetamine-related deaths.
“A review of 300 cases from Australian data (2009-2015) found that suicide comprised 18.2% of all methamphetamine-related deaths.248”
From The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder (2024) · cites this paper as [248]
Cites
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
[3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites.
Javitch, J. A., Blaustein, R. O., & Snyder, S. H. (1984) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14974-2 · Cited by 283 · see citing works
Cocaine use by clients in methadone programs: Significance, scope, and behavioral interventions
Condelli, W. S., Fairbank, J. A., Dennis, M. L., & Rachal, J. V. (1991) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(91)90040-h · Cited by 155 · see citing works
Rothman, R. B. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90466-5 · Cited by 126 · see citing works
Reinforcing and subjective effects of several anorectics in normal human volunteers.
Chait, L. D., UHLENHUTH, E. H., & Johanson, C. E. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39173-1 · Cited by 101 · see citing works
Effects of cocaine alone and in combination with mazindol in human cocaine abusers.
Preston, K. L., Sullivan, J. T., Berger, P. A., & Bigelow, G. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39434-6 · Cited by 75 · see citing works
TREATMENT OF COCAINE ABUSE WITH MAZINDOL
Berger, P. A., Gawin, F. H., & Kosten, T. R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91299-3 · Cited by 70 · see citing works
Self-citationIncreased dopamine receptor binding in rat brain by repeated cocaine injections.
Dl, T., Bt, H., & Jd, F. (1979) · PubMed · Cited by 65 · see citing works
Mazindol treatment for cocaine dependence
Stine, S. M., Krystal, J. H., Kosten, T. R., & Charney, D. S. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01174-4 · Cited by 58 · see citing works
Self-citationMazindol for Relapse Prevention to Cocaine Abuse in Methadone-Maintained Patients
Margolin, A., Avants, S. K., & Kosten, T. R. (1995) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999509002711 · Cited by 54 · see citing works
Self-citationEffects of mazindol on behavior maintained or occasioned by cocaine
Mansbach, R. S., & Balster, R. L. (1993) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(93)90071-w · Cited by 38 · see citing works
Crossover Trial of Mazindol for Cocaine Dependence
Kosten, T. R., Steinberg, M., & Diakogiannis, I. A. (1993) · American Journal on Addictions · doi:10.1111/j.1521-0391.1993.tb00216.x · Cited by 15 · see citing works
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Bentzley, B. S., Han, S. S., Neuner, S., Humphreys, K., Kampman, K. M., & Halpern, C. H. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.8049 · Cited by 161 · see citing works
Efficacy of Psychostimulant Drugs for Cocaine Dependence
Cervelló, X. C., Casas, M., Pérez‐Mañá, C., Roncero, C., Vidal, X., & Capellà, D. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub3 · Cited by 130 · see citing works
The ASAM/AAAP Clinical Practice Guideline on the Management of Stimulant Use Disorder
(2024) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001299 · Cited by 78 · see citing works
Chan, B., Freeman, M., Ayers, C., Korthuis, P. T., Paynter, R., Kondo, K., & Kansagara, D. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108193 · Cited by 56 · see citing works
Cervelló, X. C., Kosten, T. R., Capellà, D., Vidal, X., Colom, J., & Casas, M. (2009) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990903108215 · Cited by 58 · see citing works
Self-citationChoosing a behavioral therapy platform for pharmacotherapy of substance users
Carroll, K. M., Kosten, T. R., & Rounsaville, B. J. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.02.007 · Cited by 55 · see citing works
Self-citationPérez-Mañá, C., Castells, X., Vidal, X., Casas, M., & Capellà, D. (2011) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2010.08.012 · Cited by 33 · see citing works
Psychostimulant drugs for cocaine dependence
Castells, X., Cunill, R., Pérez-Mañá, C., Vidal, X., & Capellà, D. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub4 · Cited by 110 · see citing works
Perry, E. B., Gil, R. B., Miles, D., Brenner, L. M., Macdougall, L., Johnson, R., Degen, K. C., Gueorguieva, R. V., Petrakis, I. L., Krystal, J. H., et al. (2005) · Journal of Dual Diagnosis · doi:10.1300/j374v01n01_04 · Cited by 7 · see citing works
Houlihan, W. J., & Kelly, L. A. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02791-7 · Cited by 4 · see citing works
Paterson, C., Parkhouse, T., Burke, C., Halicka, M., Palmer, J. C., Gabr, H., Wilson, R. J., Webster, K. E., Spiga, F., Dawson, S., et al. (2025) · medRxiv · doi:10.64898/2025.12.10.25341965
Paterson, C. A., Parkhouse, T., Burke, C., Halicka, M., Palmer, J. C., Gabr, H., Wilson, R. J., Webster, K. E., Spiga, F., Dawson, S., et al. (2026) · Addiction · doi:10.1111/add.70486
- Authors
- Margolin, A., Avants, S. K., Malison, R. T., & Kosten, T. R.
- Affiliations
- Yale University (US)
- Venue
- Substance Abuse
- Publisher
- SAGE Publications
- Published
- 1997-09
- Volume
- 18
- Issue
- 3
- Pages
- 125-131
- ISSN
- 0889-7077 (ISSN-L)
- 1547-0164
- OpenAlex
- W2056260816
- Cited by
- 11
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 1 · 2020: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Substance Abuse (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mazindol, cocaine dependence, methadone maintenance treatment, cocaine abstinence, dose comparison, pressor response, opioid substitution therapy
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