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The Health Relevance of Ambient Particulate Matter Characteristics: Coherence of Toxicological and Epidemiological Inferences

Schlesinger, R. B., Kunzli, N., Hidy, G. M., Gotschi, T., Jerrett, M.·2006·Inhalation Toxicology
DOI 10.1080/08958370500306016
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Abstract

The aim of this article is to review progress toward integration of toxicological and epidemiological research results concerning the role of specific physicochemical properties, and associated sources, in the adverse impact of ambient particulate matter (PM) on public health. Contemporary knowledge about atmospheric aerosols indicates their complex and variable nature. This knowledge has influenced toxicological assessments, pointing to several possible properties of concern, including particle size and specific inorganic and organic chemical constituents. However, results from controlled exposure laboratory studies are difficult to relate to actual community health results because of ambiguities in simulated PM mixtures, inconsistent concentration measurements, and the wide range of different biological endpoints. The use of concentrated ambient particulates (CAPs) coupled with factor analysis has provided an improved understanding of biological effects from more realistic laboratory-based exposure studies. Epidemiological studies have provided information concerning sources of potentially toxic particles or components, adding insight into the significance of exposure to secondary particles, such as sulfate, compared with primary emissions, such as elemental and organic carbon from transportation sources. Recent epidemiological approaches incorporate experimental designs that take advantage of broadened speciation monitoring, multiple monitoring stations, source proximity d…

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Metadata

Authors
Schlesinger, R. B., Kunzli, N., Hidy, G. M., Gotschi, T., & Jerrett, M.
Venue
Inhalation Toxicology
Publisher
Informa UK Limited
Published
2006-01
Volume
18
Issue
2
Pages
95-125
ISSN
  • 0895-8378
  • 1091-7691
DOI
10.1080/08958370500306016
Cited by
245
References
8
Language
en

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CoChat. (2026). Citation check: The Health Relevance of Ambient Particulate Matter Characteristics: Coherence of Toxicological and Epidemiological Inferences. https://app.cochat.ai/papers/10.1080/08958370500306016
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Schlesinger, R. B., Kunzli, N., Hidy, G. M., Gotschi, T., & Jerrett, M. (2006). The Health Relevance of Ambient Particulate Matter Characteristics: Coherence of Toxicological and Epidemiological Inferences. Inhalation Toxicology. https://doi.org/10.1080/08958370500306016