Cited by 335Neutropenia and Cancer InfectionsCytokine Signaling Pathways and InteractionsBlood disorders and treatments

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

G-CSF: A key regulator of neutrophil production, but that's not all!

Roberts, Andrew W.·2005·Growth Factors

DOI 10.1080/08977190500055836

Open this paper in CoChat — free account

Abstract

G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…

Integrity signals

Registry

Crossref · 10.1080/08977190500055836

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
Background
2000 Update of Recommendations for the Use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines
Ozer, H., Armitage, J. O., Bennett, C. L., Crawford, J., Demetri, G. D., Pizzo, P. A., Schiffer, C. A., Smith, T. J., Somlo, G., Wade, J. C., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.20.3558 · Cited by 1,044
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956
Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy
Sheridan, W. P., Fox, R. M., Begley, C. G., Maher, D., McGrath, K. M., Begley, C. G., Juttner, C. A., To, L. B., Szer, J., & Mostyn, G. (1992) · The Lancet · doi:10.1016/0140-6736(92)90795-5 · Cited by 856
Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
Wood, A. J. J., Lieschke, G. J., & Burgess, A. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207023270106 · Cited by 811
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
Lévesque, J.-P., Hendy, J., Takamatsu, Y., Simmons, P. J., & Bendall, L. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15994 · Cited by 760
Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
Bussolino, F., Wang, J., Defilippi, P., Turrini, F., Sanavio, F., Edgell, C. J., Aglietta, M., Arese, P., & Mantovani, A. (1989) · Nature · doi:10.1038/337471a0 · Cited by 631
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients
Dührsen, U., Villeval, J., Boyd, J., Kannourakis, G., Morstyn, G., & Metcalf, D. (1988) · Blood · doi:10.1182/blood.v72.6.2074.2074 · Cited by 583
Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
Arpinati, M., Green, C. L., Heimfeld, S., Heuser, J. E., & Anasetti, C. (2000) · Blood · doi:10.1182/blood.v95.8.2484.008k01_2484_2490 · Cited by 570
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor.
Nicola, N. A., Metcalf, D., Matsumoto, M., & Johnson, G. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32158-6 · Cited by 555

Show all 87 references

Sorted by citations

Items 101–200 of 335

Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft‐tissue infection
Hedetoft, M., Garred, P., Madsen, M. B., & Hyldegaard, O. (2021) · Physiological Reports · doi:10.14814/phy2.14757 · Cited by 31
Soluble Prokaryotic Overexpression and Purification of Bioactive Human Granulocyte Colony-Stimulating Factor by Maltose Binding Protein and Protein Disulfide Isomerase
Do, B. H., Ryu, H.-B., Hoang, P., Koo, B., & Choe, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089906 · Cited by 30
The immune-enhancing activity of Cervus nippon mantchuricus extract (NGE) in RAW264.7 macrophage cells and immunosuppressed mice
Hong, S. H., Ku, J. M., Kim, H. I., Ahn, C.-W., Park, S.-H., Seo, H. S., Shin, Y. C., & Ko, S. (2017) · Food Research International · doi:10.1016/j.foodres.2017.06.053 · Cited by 30
A neutralizing anti–G-CSFR antibody blocks G-CSF–induced neutrophilia without inducing neutropenia in nonhuman primates
Scalzo‐Inguanti, K., Monaghan, K., Edwards, K. M., Herzog, E., Mirosa, D., Hardy, M., Sorto, V., Huynh, H., Rakar, S., Kurtov, D., et al. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5a1116-489r · Cited by 29
Shuxuening injection facilitates neurofunctional recovery via down-regulation of G-CSF-mediated granulocyte adhesion and diapedesis pathway in a subacute stroke mouse model
Li, Z., Xiao, G., Lyu, M., Wang, Y., He, S., Du, H., Wang, X., Feng, Y., & Zhu, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110213 · Cited by 29
The negative regulatory roles of suppressor of cytokine signaling proteins in myeloid signaling pathways
Wormald, S., & Hilton, D. J. (2007) · Current Opinion in Hematology · doi:10.1097/00062752-200701000-00004 · Cited by 29
A Brief Overview of Neutrophils in Neurological Diseases
Chakraborty, S., Tabrizi, Z., Bhatt, N. N., Franciosa, S. A., & Bracko, O. (2023) · Biomolecules · doi:10.3390/biom13050743 · Cited by 29
A Combination of Podophyllotoxin and Rutin Attenuates Radiation Induced Gastrointestinal Injury by Negatively Regulating NF-κB/p53 Signaling in Lethally Irradiated Mice
Kalita, B., Ranjan, R., Singh, A., Yashavarddhan, M. H., Bajaj, S., & Gupta, M. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168525 · Cited by 28
Granulocyte colony‐stimulating factor (G‐CSF) plays an important role in immune complex‐mediated arthritis
Christensen, A. D., Haase, C., Cook, A. D., & Hamilton, J. A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546185 · Cited by 28
RETRACTED: Anti-neutrophil antibody enhances the neuroprotective effects of G-CSF by decreasing number of neutrophils in hypoxic ischemic neonatal rat model
Doycheva, D. M., Hadley, T., Li, L., Applegate, R. L., Zhang, J. H., & Tang, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.024 · Cited by 27
Retracted
Neuroprotective therapy using granulocyte colony-stimulating factor for patients with worsening symptoms of compression myelopathy, part 1: a phase I and IIa clinical trial
Sakuma, T., Yamazaki, M., Okawa, A., Takahashi, H., Kato, K., Hashimoto, M., Hayashi, K., Furuya, T., Fujiyoshi, T., Kawabe, J., et al. (2011) · European Spine Journal · doi:10.1007/s00586-011-2020-2 · Cited by 27
The Tuberculosis Vaccine Candidate Bacillus Calmette-Guérin ΔureC::hly Coexpressing Human Interleukin-7 or -18 Enhances Antigen-Specific T Cell Responses in Mice
Rao, M., Vogelzang, A., Kaiser, P., Schuerer, S., Kaufmann, S. H. E., & Gengenbacher, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078966 · Cited by 28
Gcsf-Chr19 Promotes Neutrophil Migration to Damaged Tissue through Blood Vessels in Zebrafish
Galdames, J. A., Zúñiga-Traslaviña, C., Reyes, A. E., & Feijóo, C. G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303220 · Cited by 27
Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease
Kash, J. C., Walters, K., Kindrachuk, J., Baxter, D. H., Scherler, K., Janosko, K. B., Adams, R. D., Herbert, A. S., James, R. M., Stonier, S. W., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai9321 · Cited by 26
Alphavirus replicon-based enhancement of mucosal and systemic immunity is linked to the innate response generated by primary immunization
Tonkin, D. R., Jorquera, P. A., Todd, T., Beard, C. W., Johnston, R. E., & Barro, M. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.010 · Cited by 26
Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors
Lu, J., Sun, K., Yang, H., Fan, D., Huang, H., Hong, Y., Wu, S., Zhou, H., Fang, F., Li, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.732612 · Cited by 26
Assessment of Neutrophil Chemotaxis Upon G-CSF Treatment of Healthy Stem Cell Donors and in Allogeneic Transplant Recipients
Salzer, A. T., Niemiec, M. J., Hosseinzadeh, A., Stylianou, M., Åström, F., Röhm, M., Ahlm, C., Wåhlin, A., Ermert, D., & Urban, C. F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01968 · Cited by 25
Neutrophils in Tumorigenesis: Missing Targets for Successful Next Generation Cancer Therapies?
Tolle, F., Umansky, V., Utikal, J. S., Kreis, S., & Bréchard, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136744 · Cited by 27
Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro
Blom, C., Deller, B., Fraser, D. D., Patterson, E. K., Martin, C. M., Young, G. B., Liaw, P. C., Yazdan-Ashoori, P., Ortiz, A., Webb, B., et al. (2015) · Critical Care · doi:10.1186/s13054-015-0883-z · Cited by 24
Therapeutic Mechanism of Macrophage Inflammatory Protein 1 α Neutralizing Antibody (CCL3) in Clostridium difficile Infection in Mice
Wang, J., ORTIZ, C. W., Fontenot, L., Mukhopadhyay, R., Xie, Y., Chen, X., Feng, H., Pothoulakis, C., & Koon, H. W. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz640 · Cited by 23
Receptor Tyrosine Kinase Inhibitor Sunitinib as Novel Immunotherapy to Inhibit Myeloid-Derived Suppressor Cells for Treatment of Endometriosis
He, Y., Hung, S. W., Liang, B., Zhang, R., Gao, Y., Chu, C. Y., Zhang, T., Xu, H., Chung, J. P. W., & Wang, C. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641206 · Cited by 24
The effect of polyphenols on cytokine and granulocyte response to resistance exercise
Jajtner, A., Hoffman, J., Townsend, J., Beyer, K., Varanoske, A. N., Church, D. D., Oliveira, L. P., Herrlinger, K. A., Radom-Aizik, S., Fukuda, D., et al. (2016) · Physiological Reports · doi:10.14814/phy2.13058 · Cited by 23
Prophylactic Administration of Vector-Encoded Porcine Granulocyte-Colony Stimulating Factor Reduces Salmonella Shedding, Tonsil Colonization, and Microbiota Alterations of the Gastrointestinal Tract in Salmonella-Challenged Swine
Bearson, S. M. D., Bearson, B. L., Loving, C. L., Allen, H. K., Lee, I., Madson, D., & Kehrli, M. E. (2016) · Frontiers in Veterinary Science · doi:10.3389/fvets.2016.00066 · Cited by 23
Preferential production of G-CSF by a protein-like Lactobacillus rhamnosus GR-1 secretory factor through activating TLR2-dependent signaling events without activation of JNKs
Meshkibaf, S., Fritz, J., Gottschalk, M. G., & Kim, S. O. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0578-2 · Cited by 22
Improvement of the breaking strength of wound by combined treatment with recombinant human G‐CSF, recombinant human M‐CSF, and a TGF‐β1 receptor kinase inhibitor in rat skin
Sugiyama, K., Ishii, G., Ochiai, A., & Esumi, H. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00761.x · Cited by 22
Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease
Martins, A. J., Colquhoun, P. H. D., Reid, G., & Kim, S. O. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20808 · Cited by 22
Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis
Rogers, J. A., Mishra, M. K., Hahn, J. N., Greene, C. J., Yates, R. M., Metz, L. M., & Yong, V. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620774114 · Cited by 22
Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells
Verna, G., Liso, M., Cavalcanti, E., Bianco, G., Sarno, V. D., Santino, A., Campiglia, P., & Chieppa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158349 · Cited by 22
Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice
Cho, Y., Joshi, R., Lowe, P., Copeland, C., Ribeiro, M. D. C., Morel, C., Catalano, D. E., & Szabó, G. (2022) · Hepatology Communications · doi:10.1002/hep4.1925 · Cited by 20
Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish
García-López, J. P., Grimaldi, A., Chen, Z., Meneses, C., Bravo-Tello, K., Bresciani, E., Banderas, A., Burgess, S. M., Hernández, P. P., & Feijóo, C. G. (2023) · Nature Communications · doi:10.1038/s41467-023-40662-7 · Cited by 21
Role of Semen in Altering the Balance Between Inflammation and Tolerance in the Female Genital Tract: Does it Contribute to HIV Risk?
Rametse, C. L., Olivier, A. J., Masson, L., Barnabas, S. L., McKinnon, L. R., Ngcapu, S., Liebenberg, L. J. P., Jaumdally, S. Z., Gray, C. M., Jaspan, H. B., et al. (2014) · Viral Immunology · doi:10.1089/vim.2013.0136 · Cited by 22
Expression of cytokines and chemokines in mouse skin treated with sulfur mustard
Chang, Y.-C., Soriano, M., Hahn, R. A., Casillas, R. P., Gordon, M. K., Laskin, J. D., & Gerecke, D. R. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.06.008 · Cited by 21
Chronic Neutrophilic Leukemia: A Comprehensive Review of Clinical Characteristics, Genetic Landscape and Management
Thomopoulos, T. P., Symeonidis, A. S., Kourakli, A., Papageorgiou, S. G., & Pappa, V. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891961 · Cited by 21
Antifungal activity of posaconazole and granulocyte colony‐stimulating factor in the treatment of disseminated zygomycosis (mucormycosis) in a neutropaenic murine model
Saoulidis, S., Simitsopoulou, M., Dalakiouridou, M., Walsh, T. J., Wheat, L. J., Papaioannidou, P., & Roilides, E. (2010) · Mycoses · doi:10.1111/j.1439-0507.2010.01958.x · Cited by 21
Granulocyte and granulocyte macrophage colony-stimulating factors as therapy in human and veterinary medicine
Fernández-Varón, E., & Villamayor, L. (2006) · The Veterinary Journal · doi:10.1016/j.tvjl.2006.08.001 · Cited by 21
Proinflammatory chemokines are major mediators of exuberant immune response associated with Influenza A (H1N1) pdm09 virus infection
Thomas, M., Mani, R. S., Philip, M., Adhikary, R., Joshi, S., Revadi, S. S., Buggi, S., Desai, A. S., & Ravi, V. (2017) · Journal of Medical Virology · doi:10.1002/jmv.24781 · Cited by 22
Study protocol for the G-SPIRIT trial: a randomised, placebo-controlled, double-blinded phase III trial of granulocyte colony-stimulating factor-mediated neuroprotection for acute spinal cord injury
Koda, M., Hanaoka, H., Sato, T., Fujii, Y., Hanawa, M., Takahashi, S., Furuya, T., Ijima, Y., Saito, J., Kitamura, M., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019083 · Cited by 20
Characterizing Chemotherapy-Induced Neutropenia and Monocytopenia Through Mathematical Modelling
Cassidy, T., Humphries, A. R., Craig, M., & Mackey, M. C. (2020) · Bulletin of Mathematical Biology · doi:10.1007/s11538-020-00777-0 · Cited by 21
The change in peripheral blood monocyte count: A predictor to make the management of chemotherapy-induced neutropenia
Xie, C., Ouyang, W., Liu, Y., Deng, D., & Zhou, F. (2018) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.177502 · Cited by 20
Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice
Zhang, Y., Sheng, Z., Chen, Q., Zhou, A., Cao, J., Xue, F., Ye, Y., Wu, N. Q., Gao, N., Fan, D., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104739 · Cited by 19
Neuroinflammation after SCI: Current Insights and Therapeutic Potential of Intravenous Immunoglobulin
Gillespie, E. R., & Ruitenberg, M. J. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6952 · Cited by 20
G-CSF Administration Accelerates Cutaneous Wound Healing Accompanied With Increased Pro-Hyp Production In db/db Mice
Jimi, S. (2017) · Journal of Clinical Research in Dermatology · doi:10.15226/2378-1726/4/2/00155 · Cited by 19
A Multicenter Analysis of the Outcome of Cancer Patients with Neutropenia and COVID-19 Optionally Treated with Granulocyte-Colony Stimulating Factor (G-CSF): A Comparative Analysis
Sereno, M., Jimenez-Gordo, A. M., Baena, J., Aguado, C., Mielgo-Rubio, X., Pertejo, A., Álvarez-Álvarez, R., Sánchez, A., López, J. L., Molina, R., et al. (2021) · Cancers · doi:10.3390/cancers13164205 · Cited by 18
G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle
Wright, C. R., Brown, E. L., Gatta, P. A. D., Ward, A. C., Lynch, G. S., & Russell, A. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00170 · Cited by 19
Binding of proteins to PEGylated liposomes and improvement of G-CSF efficacy in mobilization of hematopoietic stem cells
Yatuv, R., Carmel-Goren, L., Dayan, I., Robinson, M., & Baru, M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.12.004 · Cited by 18
The risk of febrile neutropenia in breast cancer patients following adjuvant chemotherapy is predicted by the time course of interleukin‐6 and C‐reactive protein by modelling
Netterberg, I., Karlsson, M. O., Nielsen, E. I., Quartino, A. L., Lindman, H., & Friberg, L. E. (2017) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13477 · Cited by 18
Perspectives on the Current State of the Biosimilar Regulatory Pathway in the United States
Dougherty, M. K., Zineh, I., & Christl, L. A. (2017) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.909 · Cited by 18
Granulocyte colony-stimulating factor attenuates spinal cord injury-induced mechanical allodynia in adult rats
Kato, K., Koda, M., Takahashi, H., Sakuma, T., Inada, T., Kamiya, K., Ota, M., Maki, S., Okawa, A., Takahashi, K., et al. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.05.024 · Cited by 18
Intravenous administration of granulocyte colony-stimulating factor for treating neuropathic pain associated with compression myelopathy: a phase I and IIa clinical trial
Kato, K., Yamazaki, M., Okawa, A., Furuya, T., Sakuma, T., Takahashi, H., Kamiya, K., Inada, T., Takahashi, K., & Koda, M. (2012) · European Spine Journal · doi:10.1007/s00586-012-2556-9 · Cited by 18
The Effects of p38 MAPK Inhibition Combined with G-CSF Administration on the Hematoimmune System in Mice with Irradiation Injury
Li, D., Wang, Y., Wu, H., Lu, L., Wang, X., Zhang, J., Zhang, H., Fan, S., Fan, F., Zhou, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062921 · Cited by 18
Activation of mitogen-activated protein kinase pathways by the granulocyte colony-stimulating factor receptor: mechanisms and functional consequences
Tulene, S. K. (2006) · Frontiers in bioscience · doi:10.2741/2085 · Cited by 18
Regulation of Granulocyte Colony-Stimulating Factor and Its Receptor in Skeletal Muscle Is Dependent Upon the Type of Inflammatory Stimulus
Wright, C. R., Brown, E. L., Gatta, P. A. D., Fatouros, I. G., Karagounis, L. G., Terzis, G. D., Mastorakos, G., Michailidis, Y., Mandalidis, D. G., Spengos, K., et al. (2015) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0159 · Cited by 17
Neuroprotective Therapy Using Granulocyte Colony–Stimulating Factor for Patients With Worsening Symptoms of Thoracic Myelopathy
Sakuma, T., Yamazaki, M., Okawa, A., Takahashi, H., Kato, K., Hashimoto, M., Hayashi, K., Furuya, T., Fujiyoshi, T., Kawabe, J., et al. (2012) · Spine · doi:10.1097/brs.0b013e318260cc71 · Cited by 17
Mastitis Pathogens with High Virulence in a Mouse Model Produce a Distinct Cytokine Profile In Vivo
Johnzon, C., Artursson, K., Söderlund, R., Guss, B., Rönnberg, E., & Pejler, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00368 · Cited by 17
Identification and bioactivity of a granulocyte colony-stimulating factor b homologue from large yellow croaker (Larimichthys crocea)
Li, Q., Xu, L., Ao, J., Ai, C., & Chen, X. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.04.048 · Cited by 17
G-CSF Inhibits Growths of Osteoblasts and Osteocytes by Upregulating Nitric Oxide Production in Neutrophils
Zhao, J., Zhao, Q., Ning, P., Shang, K., Liu, C., Ni, M., Li, C., Zhang, K., & Gao, C. (2019) · Journal of Craniofacial Surgery · doi:10.1097/scs.0000000000005769 · Cited by 17
Protein Multifunctionality: Principles and Mechanisms
Zaretsky, J. Z., & Wreschner, D. H. (2008) · Translational Oncogenomics · doi:10.4137/tog.s657 · Cited by 18
Steroid-induced fibroblast growth factors drive an epithelial-mesenchymal inflammatory axis in severe asthma
Guidi, R., Xu, D., Choy, D. F., Ramalingam, T. R., Lee, W. P., Modrusan, Z. D., Liang, Y., Marsters, S. A., Ashkenazi, A., Huynh, A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl8146 · Cited by 16
Administration of granulocyte colony-stimulating factor with radiotherapy promotes tumor growth by stimulating vascularization in tumor-bearing mice
Kim, J., Son, Y., Bae, M. J., Lee, M. Y., Lee, C. G., Jo, W. S., Kim, S., & Yang, K. (2015) · Oncology Reports · doi:10.3892/or.2015.3977 · Cited by 16
Non-invasive Imaging of Sendai Virus Infection in Pharmacologically Immunocompromised Mice: NK and T Cells, but not Neutrophils, Promote Viral Clearance after Therapy with Cyclophosphamide and Dexamethasone
Mostafa, H. H., Vogel, P., Srinivasan, A., & Russell, C. J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005875 · Cited by 16
1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation
Jeong, J., Kim, Y., Lee, D. Y., Moon, B.-G., Sohn, K., Yoon, S. Y., & Kim, J. W. (2019) · Cell & Bioscience · doi:10.1186/s13578-018-0266-7 · Cited by 16
Training associated alterations in equine respiratory immunity using a multiomics comparative approach
Karagianni, A. E., Kurian, D., Cillán‐García, E., Eaton, S. L., Wishart, T. M., & Pirie, R. S. (2022) · Scientific Reports · doi:10.1038/s41598-021-04137-3 · Cited by 16
Dietary fish oil increases the proportion of a specific neutrophil subpopulation in blood and total neutrophils in peritoneum of mice following endotoxin-induced inflammation
Arnardottir, H. H., Freysdóttir, J., & Harðardóttir, I. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.05.012 · Cited by 16
Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes; a case of FVIII, FVIIa and G-CSF
Yatuv, R., Robinson, M., Dayan, I., & Baru, M. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903463846 · Cited by 16
Identification and bioactivity of a granulocyte colony-stimulating factor a homologue from large yellow croaker (Larimichthys crocea)
Li, Q., Chen, Y., Xu, L., Yang, Y., Wen, Q., Gu, L., Ao, J., & Chen, X. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.01.003 · Cited by 15
Transcriptomic Regulation of Macrophages by Matrix-Bound Nanovesicle-Associated Interleukin-33
Cramer, M. C., Molina, C. P., Hussey, G. S., Turnquist, H. R., & Badylak, S. F. (2022) · Tissue Engineering Part A · doi:10.1089/ten.tea.2022.0006 · Cited by 15
Neutrophil generation from hematopoietic progenitor cells and induced pluripotent stem cells (iPSCs): potential applications
Jafarzadeh, A., Motaghi, M., Patra, S. K., Jafarzadeh, Z., Nemati, M., & Saha, B. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.03.483 · Cited by 15
Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection
Hulsebus, H. J., Najarro, K. M., McMahan, R. H., Boe, D. M., Orlicky, D. J., & Kovacs, E. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884719 · Cited by 15
Consecutive pseudogout attacks after repetitive granulocyte colony-stimulating factor administration for neutropenia
Ames, P. R. J., & Rainey, M. G. (2007) · Modern Rheumatology · doi:10.1007/s10165-007-0601-z · Cited by 15
Granulocyte Colony-Stimulating Factor Improves Motor Function in Rats Developing Compression Myelopathy
Yoshizumi, T., Murata, H., Yamamoto, S., Kurokawa, R., Kim, P., & Kawahara, N. (2016) · Spine · doi:10.1097/brs.0000000000001659 · Cited by 15
Very Small Embryonic-Like Stem Cells, Endothelial Progenitor Cells, and Different Monocyte Subsets Are Effectively Mobilized in Acute Lymphoblastic Leukemia Patients after G-CSF Treatment
Eljaszewicz, A., Bołkuń, Ł., Grubczak, K., Rusak, M., Wasiluk, T., Dąbrowska, M., Radziwon, P., Marlicz, W. M., Kamiński, K. A., Kloczko, J. S., et al. (2018) · Stem Cells International · doi:10.1155/2018/1943980 · Cited by 15
Biomarker Supervised G-CSF (Filgrastim) Response in ALS Patients
Johannesen, S. W., Budeus, B., Peters, S., Iberl, S., Meyer, A.-L., Kammermaier, T., Wirkert, E., Bruun, T., Samara, V. C., Schulte‐Mattler, W., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00971 · Cited by 15
Granulocyte Colony-Stimulating Factors
Molineux, G. (2010) · Cancer treatment and research · doi:10.1007/978-1-4419-7073-2_3 · Cited by 15
Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation
Snyder, B. L., Huang, R., Burkholder, A., Donahue, D., Mahler, B. W., Bortner, C. D., Lai, W. S., & Blackshear, P. J. (2023) · Life Science Alliance · doi:10.26508/lsa.202302222 · Cited by 14
Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor
El-Haggar, R. S., Kamikawa, K., Machi, K., Ye, Z., Ishino, Y., Tsumuraya, T., & Fujii, I. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.12.010 · Cited by 14
Role for Granulocyte Colony‐Stimulating Factor in Neutrophilic Extramedullary Myelopoiesis in a Murine Model of Systemic Juvenile Idiopathic Arthritis
Malengier‐Devlies, B., Bernaerts, E., Ahmadzadeh, K., Filtjens, J., Vandenhaute, J., Boeckx, B., Burton, O. T., Visscher, A. D., Mitera, T., Berghmans, N., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42104 · Cited by 14
Immune dysregulation in new-onset refractory status epilepticus (NORSE): current insights and therapeutic perspectives
Hanin, A., & Hirsch, L. J. (2025) · Brain and Development · doi:10.1016/j.braindev.2025.104406 · Cited by 15
Cord blood cytokine profiles in children later diagnosed with autism spectrum disorder: Results from the prospective MARBLES study
Moreno, R. J., Rose, D. R., Tancredi, D. J., Schmidt, R. J., Ozonoff, S. J., & Ashwood, P. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.036 · Cited by 13
The anti-inflammatory role of granulocyte colony-stimulating factor in macrophage–dendritic cell crosstalk afterLactobacillus rhamnosusGR-1 exposure
Martins, A. J., Spanton, S., Sheikh, H. I., & Kim, S. O. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810445 · Cited by 13
Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
Monserrat, J., Asúnsolo, Á., Gomez-Lahoz, A. M., Ortega, M. A., Gasalla-Herraiz, J., Gasulla, Ó., Fortuny-Profitós, J., Mazaira‐Font, F. A., Román, M. T., Arranz, A., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111675 · Cited by 13
Pegfilgrastim Enhances the Antitumor Effect of Therapeutic Monoclonal Antibodies
Cornet, S., Mathé, D., Chettab, K., Evesque, A., Matera, E., Trédan, O., & Dumontet, C. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0759 · Cited by 13
Granulocyte Colony-Stimulating Factor Combined with Methylprednisolone Improves Functional Outcomes in Rats with Experimental Acute Spinal Cord Injury
Teixeira, W. G. J., Cristante, A. F., Marcon, R. M., Bispo, G., Ferreira, R. J. R., & Filho, T. E. P. D. B. (2018) · Clinics · doi:10.6061/clinics/2018/e235 · Cited by 13
Serotonin receptor 5-HT7 modulates inflammatory-associated functions of macrophages
Bahr, F. S., Müller, F. E., Kasten, M., Benen, N., Sieve, I., Scherr, M., Falk, C. S., Hilfiker‐Kleiner, D., Ricke‐Hoch, M., & Ponimaskin, E. G. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05570-z · Cited by 12
Early use of granulocyte colony stimulating factor improves survival in a rabbit model of chronic myocardial ischemia
Zhao, Q., Sun, C., Xu, X. P., Zhou, J., Wu, Y., Tian, Y., Ma, A., & Liu, Z. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.09.003 · Cited by 12
Multiple cycles of granulocyte colony-stimulating factor in decompensated cirrhosis: a double-blind RCT
Venkitaraman, A., De, A., Verma, N., Kumari, S., Leishangthem, B., Sharma, R. R., Kalra, N., Grover, S., & Singh, V. (2022) · Hepatology International · doi:10.1007/s12072-022-10314-x · Cited by 12
Protective effects of dietary grape against atopic dermatitis-like skin lesions in NC/NgaTndCrlj mice
Singh, C. K., Mintie, C. A., Ndiaye, M. A., Chhabra, G., Roy, S., Sullivan, R., Longley, B. J., Schieke, S. M., & Ahmad, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051472 · Cited by 12
Thymic stromal lymphopoietin contributes to ozone-induced exacerbations of eosinophilic airway inflammation via granulocyte colony-stimulating factor in mice
Kurihara, Y., Tashiro, H., Konomi, Y., Sadamatsu, H., Ihara, S., Takamori, A., Kimura, S. H., Sueoka‐Aragane, N., & Takahashi, K. (2023) · Allergology International · doi:10.1016/j.alit.2023.12.002 · Cited by 12
Nanoparticles modify dendritic cell homeostasis and induce non-specific effects on immunity to malaria
Xiang, S. D., Kong, Y., Hanley, J. C., Fuchsberger, M., Crimeen‐Irwin, B., & Plebanski, M. (2015) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/tru182 · Cited by 12
Efficacy of combined administration of chemoimmunotherapy with bone marrow cells or granulocyte-colony stimulating factor-mobilized stem cells on expansion of myeloid and stem cells
Salam, S. G. R. A., Salem, M., Nassef, M., Abdu, S. H., & ELAdl, R. I. (2017) · Clinical Cancer Investigation Journal · doi:10.4103/ccij.ccij_4_17 · Cited by 12
Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia–Reperfusion Injury
McRae, J. L., Vikstrom, I. B., Bongoni, A. K., Salvaris, E. J., Fisicaro, N., Ng, M., Alhamdoosh, M., Morelli, A. B., Cowan, P. J., & Pearse, M. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000390 · Cited by 12
Heterogeneity in Neutrophil Extracellular Traps from Healthy Human Subjects
Collins, M. S., Imbrogno, M., Kopras, E. J., Howard, J. A., Zhang, N., Kramer, E. L., & Hudock, K. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010525 · Cited by 12
Old drug, new use: Recent advances for G-CSF
Yan, L., Li, J., Yang, Y., Zhang, X., & Zhang, C. (2024) · Cytokine · doi:10.1016/j.cyto.2024.156759 · Cited by 11
Investigating neutropenic enterocolitis: a systematic review of case reports and clinical insights
Nematolahi, S., Amanati, A., Vardanjani, H. M., Pourali, M., Hosseini‐Bensenjan, M., Nozari, F., Vali, M., Mehrian, S. R. A., Nabavizadeh, S. A., & Safari, F. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-03601-y · Cited by 11
A Novel microRNA of Japanese Flounder Regulates Antimicrobial Immunity Involving a Bacteria-Binding CSF3
Li, W., Guan, X., Sun, B., & Sun, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.723401 · Cited by 11
Granulocyte colony-stimulating factor in bronchoalveolar lavage fluid is a potential biomarker for prognostic prediction of idiopathic pulmonary fibrosis
Lee, J.-U., Choi, J. S., Kim, M. K., Min, S. A., Park, J., & Park, C. (2022) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2021.442 · Cited by 11
Altered sialidase expression in human myeloid cells undergoing apoptosis and differentiation
Hyun, S. W., Feng, C., Liu, A., Lillehoj, E. P., Trotta, R., Kingsbury, T. J., Passaniti, A., Lugkey, K. N., Chauhan, S., Cipollo, J. F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18448-6 · Cited by 11
G-CSF preferentially supports the generation of gut-homing Gr-1high macrophages in M-CSF-treated bone marrow cells
Meshkibaf, S., Gower, M., Dekaban, G. A., & Kim, S. O. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0314-172r · Cited by 11
Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils
Loving, C. L., Kehrli, M. E., Brockmeier, S. L., Bayles, D. O., Michael, D. D., Schlink, S. N., & Lager, K. M. (2013) · Biologicals · doi:10.1016/j.biologicals.2013.07.001 · Cited by 11
G-CSF Enhances Resolution of Staphylococcus aureus Wound Infection in an Age-Dependent Manner
Brubaker, A. L., & Kovacs, E. J. (2013) · Shock · doi:10.1097/shk.0b013e3182a43651 · Cited by 11
The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability
Xie, T., Fang, H., Ouyang, W., Angart, P. A., Chiang, M., Bhirde, A. A., Sheikh, F. G., Lynch, P. M., Shah, A. B., Patil, S. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59346-z · Cited by 11

Authors: Roberts, A. W.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
Corresponding author: Roberts, Andrew W.
ORCID: Roberts, Andrew W.
Venue: Growth Factors
Publisher: Informa UK Limited
Published: 2005-03
Volume: 23
Issue: 1
Pages: 33-41
ISSN: 0897-7194 (ISSN-L)
1029-2292
DOI: 10.1080/08977190500055836
OpenAlex: W1981127449
Cited by: 335
References: 87
Citations by year: 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
FWCI: 4.20
Type: journal article
Language: en
Open access: closed
Locations: Growth Factors (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
Cancer Council Victoria
National Medical Research Council
National Cancer Institute (CA22556)
Topics: Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords: granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
MeSH terms: Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

G-CSF: A key regulator of neutrophil production, but that's not all!

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks