The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
G-CSF: A key regulator of neutrophil production, but that's not all!
Abstract
G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, we observed lower levels of GCSF, which not only is a key regulator of neutrophil production [60] but also plays an essential role in neutrophil trafficking [61].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [60]
Citations
Cites
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
BackgroundOzer, H., Armitage, J. O., Bennett, C. L., Crawford, J., Demetri, G. D., Pizzo, P. A., Schiffer, C. A., Smith, T. J., Somlo, G., Wade, J. C., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.20.3558 · Cited by 1,044
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956
Sheridan, W. P., Fox, R. M., Begley, C. G., Maher, D., McGrath, K. M., Begley, C. G., Juttner, C. A., To, L. B., Szer, J., & Mostyn, G. (1992) · The Lancet · doi:10.1016/0140-6736(92)90795-5 · Cited by 856
Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
Wood, A. J. J., Lieschke, G. J., & Burgess, A. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207023270106 · Cited by 811
Lévesque, J.-P., Hendy, J., Takamatsu, Y., Simmons, P. J., & Bendall, L. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15994 · Cited by 760
Bussolino, F., Wang, J., Defilippi, P., Turrini, F., Sanavio, F., Edgell, C. J., Aglietta, M., Arese, P., & Mantovani, A. (1989) · Nature · doi:10.1038/337471a0 · Cited by 631
Dührsen, U., Villeval, J., Boyd, J., Kannourakis, G., Morstyn, G., & Metcalf, D. (1988) · Blood · doi:10.1182/blood.v72.6.2074.2074 · Cited by 583
Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
Arpinati, M., Green, C. L., Heimfeld, S., Heuser, J. E., & Anasetti, C. (2000) · Blood · doi:10.1182/blood.v95.8.2484.008k01_2484_2490 · Cited by 570
Nicola, N. A., Metcalf, D., Matsumoto, M., & Johnson, G. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32158-6 · Cited by 555
Cited by
Sorted by citations
Items 301–335 of 335
Granulocyte Colony-Stimulating Factor-Mediated Neuroprotective Therapy for Spinal Cord Injury
Koda, M., Furuya, T., Ianada, T., Kamiya, K., Ota, M., Maki, S., Okawa, A., Takahashi, K., & Yamazaki, M. (2014) · Springer eBooks · doi:10.1007/978-4-431-54502-6_13
Paludisme en zone d'hyperendémie : apport de la réponse cytokinique et transcriptomique
Marseille, F. D. M. D. (2013)
Dey, A. (2016) · UCL Discovery (University College London)
Modeling of hematopoiesis using ES and patients-derived iPS cells
Zahabi, A. (2017) · Universitätsbibliothek Tübingen · doi:10.15496/publikation-15460
Kocherlokata, P., Crow, M. K., Vakkalanka, R., & Gamma, E. F. L. (2017) · Journal of Pediatric Infectious Diseases · doi:10.1055/s-0037-1603206
Role of Immune Changes in Neonatal Infections
Omar, S. A. (2017) · Journal of Pediatric Infectious Diseases · doi:10.1055/s-0037-1602827
Dewi, K. S., Wahyuni, F. D., Salsabila, S., Aminah, Yanthi, N. D., & Fuad, A. M. (2021) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/948/1/012081
Tsai, A. C., Lin, H.-T. C., Chou, M., Bolen, J., Zimmerman, C., DeMarzo, D., & Enchautegui-Colon, Y. (2022) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2022.100859
Mecsas, J. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725495566.793562342
Training-Associated Alterations In Equine Respiratory Immunity – A Multi-Omics Comparative Approach.Preprint
Karagianni, A. E., Kurian, D., Cillán‐García, E., Eaton, S. L., Wishart, T. M., & Pirie, R. S. (2021) · Research Square · doi:10.21203/rs.3.rs-770868/v1
Yu, F., Zheng, L., Wang, L., Yang, X., Ma, Z., Tang, Y., Li, N., Wang, Y., Gu, W., & Shi, Y. (2020) · doi:10.21203/rs.3.rs-35955/v1
Cant, A. J., Gennery, A. R., Russell, A. B., & Isaacs, D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-7020-3479-4.00040-4
G-CSF Promotes the Viability and Angiogenesis of Injured Liver via Direct Effects on the Liver CellsPreprint
Liu, Z., Zhang, G., Chen, J., Tong, J., Wang, H., Chen, J., Yang, D., & Hu, J. (2022) · Research Square · doi:10.21203/rs.3.rs-1626770/v1
AB0646 G- CSF treatment for refractory digital ulcers in systemic sclerosis
Keret, S., Slobodin, G., Awisat, A., Kaly, L., Rosner, I., Rosenbaum, M., Boulman, N., Shouval, A., & Rimar, D. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2022-eular.250
Santos, C. S., Moriano, C., Fernández, I. G., Rojas, X. E. L., Castro, C. Á., & Álvarez, E. D. (2022) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2022-eular.345
Kumar, A., Chawla, V., Chawla, P. A., Bhatia, N., Singh, G., & Singh, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99988-5.00014-0
Maloisel, F., Leprêtre, S., Kamioner, D., Berthou, C., & Cals, L. (2024) · Hematological Diseases and Therapies · doi:10.29011/2577-1418.000133
Rajabpour, M., Vakili, P., & Abolhasani, S. (2023) · Biomedical Research Bulletin · doi:10.34172/biomedrb.2023.12
Hematologic profile in a Persian cat with osteosarcoma
Prasaja, A. G., Mutiara, C. K., Wijaya, S. A., Lestari, N. A. A., Santoso, F. T., & Windria, S. (2025) · ARSHI Veterinary Letters · doi:10.29244/avl.8.4.87-88
Emerging path promoting neovascularization in chronic ischemia
Eton, D. (2025) · JVS-Vascular Insights · doi:10.1016/j.jvsvi.2025.100190
Songur, M., Kaplan, Ö., İmamoğlu, R., & Gökçe, İ. (2025) · Karadeniz Fen Bilimleri Dergisi · doi:10.31466/kfbd.1465411
Quartino, A. L., Karlsson, M. O., Lindman, H., & Friberg, L. E. (2011)
Rôle du système immunitaire dans la relation Arterio Veineuse normale et pathologique
Champin, T. (2019) · theses.fr (ABES) · doi:10.70675/0b690bbez4593z4355z8fd5zf237e0bb0eee
Etude et origine des neutrophiles régulateurs dans l'infection pulmonaire
Creusat, F. (2019) · theses.fr (ABES) · doi:10.70675/7ea1f65czced3z48c9z9de0za4071fbb41a8
Modifications du microenvironnement cytokinique dans les leucémies aigües myéloïdes
Guermouche, H. (2021) · theses.fr (ABES) · doi:10.70675/e0e649a1z9428z4e58z93b3z0b5d7ec2fea8
Pereira-Abrantes, M. (2023) · theses.fr (ABES) · doi:10.70675/9966b97fz01d9z430dzb93dzb43bababd470
Solute Carrier Transporter Family Modulates Neutrophil Metabolism During Health and DiseasePreprint
Malla, S., & Saha, R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.20.726273
Serum meprin α levels for the detection of systemic inflammatory response syndrome
Beckinger, S., Mengel, M., Lindner, M., Köhling, V., Peters, F., Götting, I., Stoske, J., Rusch, J., Radke, D. I., Schädler, D., et al. (2026) · Molecular Medicine · doi:10.1186/s10020-026-01570-w
Metadata
- Authors
- Roberts, A. W.
- Affiliations
- Walter and Eliza Hall Institute of Medical Research (AU)
- Corresponding author
- Roberts, Andrew W.
- ORCID
- Roberts, Andrew W.
- Venue
- Growth Factors
- Publisher
- Informa UK Limited
- Published
- 2005-03
- Volume
- 23
- Issue
- 1
- Pages
- 33-41
- ISSN
- 0897-7194 (ISSN-L)
- 1029-2292
- OpenAlex
- W1981127449
- Cited by
- 335
- References
- 87
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Growth Factors (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Cancer Council Victoria
- National Medical Research Council
- National Cancer Institute (CA22556)
- Topics
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
- MeSH terms
- Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
