Cited by 335Neutropenia and Cancer InfectionsCytokine Signaling Pathways and InteractionsBlood disorders and treatments

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G-CSF: A key regulator of neutrophil production, but that's not all!

Roberts, Andrew W.·2005·Growth Factors

DOI 10.1080/08977190500055836

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Abstract

G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system. Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro in semi-solid cultures (Burgess and Metcalf 1980, Nicola et al. 1983), G-CSF influences the survival, proliferation and differentiation of all cells in the neutrophil lineage, from haemopoietic stem cell through to mature neutrophil. Further, G-CSF influences the function of mature neutrophils. These actions underpin its rapid uptake into clinical medicine as a drug that increases the production of neutrophils in patients with chemotherapy-induced neutropenia. Ongoing research has uncovered initially unsuspected polyfunctionality for G-CSF. G-CSF is well recognised as a potent mobiliser of haemopoietic stem cells from the bone marrow into the blood, and now is being increasingly accepted as a regulator of immune responses. These two "new" actions of G-CSF first came to light through observations made during clinical trials of G-CSF. Subsequent investigations into the cellular and molecular basis for this polyfunctionality have generated exciting new knowledge about the biology of G-CSF. This review emphasises recent advances in knowledge about G-CSF signalling, mechanisms of G-CSF-induced stem cell mobilisation, and how G-CSF influences T-cell function and dendritic cell activation. An attempt is made to link the current issues about the biology of G-CSF with its clinical uses, both present a…

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T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“More recently, IL-17 has been implicated as a major upstream extracellular regulator of G-CSF production by tissues, particularly the bone marrow stroma (Fossiez et al. 1996).”
Background
2000 Update of Recommendations for the Use of Hematopoietic Colony-Stimulating Factors: Evidence-Based, Clinical Practice Guidelines
Ozer, H., Armitage, J. O., Bennett, C. L., Crawford, J., Demetri, G. D., Pizzo, P. A., Schiffer, C. A., Smith, T. J., Somlo, G., Wade, J. C., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.20.3558 · Cited by 1,044
Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization
Lieschke, G. J., Grail, D., HODGSON, G. S., Metcalf, D., Stanley, E. G., Cheers, C., Fowler, K., Basu, S., Zhan, Y., & Dunn, A. (1994) · Blood · doi:10.1182/blood.v84.6.1737.1737 · Cited by 956
Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy
Sheridan, W. P., Fox, R. M., Begley, C. G., Maher, D., McGrath, K. M., Begley, C. G., Juttner, C. A., To, L. B., Szer, J., & Mostyn, G. (1992) · The Lancet · doi:10.1016/0140-6736(92)90795-5 · Cited by 856
Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor
Wood, A. J. J., Lieschke, G. J., & Burgess, A. W. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207023270106 · Cited by 811
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
Lévesque, J.-P., Hendy, J., Takamatsu, Y., Simmons, P. J., & Bendall, L. J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15994 · Cited by 760
Granulocyte- and granulocyte– macrophage-colony stimulating factors induce human endothelial cells to migrate and proliferate
Bussolino, F., Wang, J., Defilippi, P., Turrini, F., Sanavio, F., Edgell, C. J., Aglietta, M., Arese, P., & Mantovani, A. (1989) · Nature · doi:10.1038/337471a0 · Cited by 631
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients
Dührsen, U., Villeval, J., Boyd, J., Kannourakis, G., Morstyn, G., & Metcalf, D. (1988) · Blood · doi:10.1182/blood.v72.6.2074.2074 · Cited by 583
Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells
Arpinati, M., Green, C. L., Heimfeld, S., Heuser, J. E., & Anasetti, C. (2000) · Blood · doi:10.1182/blood.v95.8.2484.008k01_2484_2490 · Cited by 570
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor.
Nicola, N. A., Metcalf, D., Matsumoto, M., & Johnson, G. R. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32158-6 · Cited by 555

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Chin, J. L., Tan, Z. C., Chan, L. C., Ruffin, F., Parmar, R., Ahn, R. S., Taylor, S. D., Bayer, A. S., Hoffmann, A., Fowler, V. G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.28.521386 · Cited by 4
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Growth factors as indicators of prognosis in liver failure
Shackel, N. A. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05005.x
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Anticytokine Autoantibody-Associated
Browne, S. (2014)
( The Chiba Medical Society Award (2015)) Granulocyte colony-stimulating factor-mediated neuroprotective therapy for acute spinal cord injury: From bench to bedside
Koda, M., Furuya, T., Inada, T., Kamiya, K., Ota, M., Maki, S., Ijima, Y., Saito, J., Takahashi, K., & Yamazaki, M. (2015) · Institutional Repositories DataBase (IRDB) · doi:10.20776/s03035476-91e-6-p33

Authors: Roberts, A. W.
Affiliations: Walter and Eliza Hall Institute of Medical Research (AU)
Corresponding author: Roberts, Andrew W.
ORCID: Roberts, Andrew W.
Venue: Growth Factors
Publisher: Informa UK Limited
Published: 2005-03
Volume: 23
Issue: 1
Pages: 33-41
ISSN: 0897-7194 (ISSN-L)
1029-2292
DOI: 10.1080/08977190500055836
OpenAlex: W1981127449
Cited by: 335
References: 87
Citations by year: 2026: 3 · 2025: 10 · 2024: 14 · 2023: 25 · 2022: 35 · 2021: 27 · 2020: 21 · 2019: 17 · 2018: 16 · 2017: 22 · 2016: 17 · 2015: 17 · 2014: 20 · 2013: 20 · 2012: 18
FWCI: 4.20
Type: journal article
Language: en
Open access: closed
Locations: Growth Factors (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
Cancer Council Victoria
National Medical Research Council
National Cancer Institute (CA22556)
Topics: Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Health Sciences › Medicine › Hematology › Blood disorders and treatments
Keywords: granulocyte colony-stimulating factor, neutrophil production, hematopoiesis, T cell function, dendritic cell activation, innate immunity, chemotherapy-induced neutropenia, G-CSF therapy
MeSH terms: Animals, Dendritic Cells, Forecasting, Humans, Models, Biological, Neutropenia, Neutrophils, T-Lymphocytes, Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Mobilization

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