Cited by 288HER2/EGFR in Cancer ResearchLung Cancer Treatments and MutationsMetabolism, Diabetes, and Cancer

EGFR family: Structure physiology signalling and therapeutic targets †

Burgess, Antony W.·2008·Growth Factors

Abstract

There are four members of the EGFR family: EGFR, erbB2, erbB3 and erbB4. These receptors form ligand-activated oligomers which regulate intracellular processes via an oligomeric tyrosine kinase scaffold. The receptors are activated when the extracellular domain undergoes a conformational change which facilitates either homo- or hetero-oligomerization with other family members. The absence of one EGFR family member leads to embryonic or early post-natal death due to implantation, central nervous system or cardiac defects. Many mouse models of defective or deficient EGFR family members are available for studying physiology and/or pathology of EGFR family members. Sophisticated antibody and kinase inhibitors which target different family members have been designed, produced. EGFR and erbB2 are frequently activated, over expressed or mutated in many common cancers and the antagonists and/or inhibitors of EGFR and/or erbB2 signalling have already been shown to have therapeutic benefits for cancer patients.

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Crossref · 10.1080/08977190802312844

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152 of 152 references verified0 citation errors · 0 not checkable

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Authors
Burgess, A. W.
Affiliations
Ludwig Cancer Research (AU)
Corresponding author
Burgess, Antony W.
Venue
Growth Factors
Published
2008-01
Volume
26
Issue
5
Pages
263-274
ISSN
  • 0897-7194 (ISSN-L)
  • 1029-2292
OpenAlex
W2161879730
Cited by
288
References
152
Citations by year
2026: 14 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 6 · 2018: 13 · 2017: 15 · 2016: 13 · 2015: 17 · 2014: 16 · 2013: 24 · 2012: 18
FWCI
10.56
Type
journal article
Language
en
Open access
closed
Locations
  • Growth Factors (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
ErbB receptors, epidermal growth factor receptor, ERBB2, HER3, ErbB4, receptor oligomerization, tyrosine kinase signaling, receptor conformational change, hetero-oligomerization, embryonic lethality, mouse model, kinase inhibitors, cancer therapy
MeSH terms
Animals, Humans, Models, Genetic, Models, Molecular, Protein Conformation, Structure-Activity Relationship, Signal Transduction, Protein Structure, Tertiary, Erb-b2 Receptor Tyrosine Kinases, Genes, erbB, Dimerization, Receptor, ErbB-3, Mice, ErbB Receptors

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