An hour in the morning is worth two in the evening: association of morning component of morningness—eveningness with single nucleotide polymorphisms in circadian clock genes
Abstract
Sub-constructs of morning–evening preference might be differentially related to polymorphisms in circadian clock genes. We previously reported significant association between a single nucleotide polymorphism in PER3 (rs2640909) and Morning but not Evening Lateness scale of the Sleep–Wake Pattern Assessment Questionnaire. To further explore such a scale-specific relationship, seven single nucleotide polymorphisms in five circadian clock genes were studied using exploratory and confirmatory samples (in total, n = 698). The association of rs2640909 with Morning Lateness scale was not replicated in the confirmatory sample but remained significant in the merged sample. Moreover, we found and confirmed an association of this scale with rs1159814 in RORα. The results provided further evidence for differential relationship of polymorphisms in circadian clock genes with morning and evening components of morning–evening preference. We also suggested possibility to take into account the pattern of geographic variation in allele frequency for prioritization of circadian clock polymorphisms in candidate gene studies.
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Previous studies found a latitudinal cline in some circadian allele frequencies in humans.
“and a latitudinal cline in some circadian allele frequencies (Dorokhov et al. 2018; Putilov et al. 2018, 2019)”
From Archaic Introgression Shaped Human Circadian Traits (2023) · cites this paper as Dorokhov et al. 2018
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Archaic Introgression Shaped Human Circadian Traits
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- Authors
- Dorokhov, V. B., Puchkova, A. N., Taranov, A. O., Slominsky, P. A., Tupitsina, T. V., Ivanov, I. D., Vavilin, V. A., Nechunaev, V. V., Kolomeichuk, S. N., Morozov, A. V., Budkevich, E. V., Budkevich, R. O., Dementienko, V. V., Sveshnikov, D. S., Donskaya, O. G., & Putilov, A. A.
- Affiliations
- Laboratory of Sleep/Wake Neurobiology, The Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russia
- Russian Academy of Sciences (RU)
- Institute of Molecular Biology and Biophysics (RU)
- Laboratory of Drug Metabolism and Pharmacokinetics, The Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russia
- Novosibirsk State University (RU)
- Laboratory of Nanobiotechnology and Biophysics, North-Caucasus Federal University, Stavropol, Russia
- North-Caucasus Federal University (RU)
- Peoples' Friendship University of Russia (RU)
- Corresponding author
- Putilov, Arcady A.
- ORCID
- Venue
- Biological Rhythm Research
- Publisher
- Informa UK Limited
- Published
- 2017-10-23
- Volume
- 49
- Issue
- 4
- Pages
- 622-642
- ISSN
- 0929-1016 (ISSN-L)
- 1744-4179
- OpenAlex
- W2767049130
- Cited by
- 11
- References
- 79
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2021: 1 · 2018: 1 · 2017: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Rhythm Research (publishedVersion)
- Funders
- Federal Research Program (0221-2014-0034)
- Russian Foundation for Basic Research (16-06-00235-a, 13-06-00042-a, 10-06-00114-a, 07-06-00263-a)
- Russian Humanitarian Foundation (15-06-10909a, 15-06-10874a, 15-06-10403-a, 12-06-18001-e, 06-06-00375-a, 14-06-00963a)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- chronotype, clock genes, single nucleotide polymorphisms, Per3, RORα, eveningness, genetic association, allele frequency variation, candidate gene association
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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