Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation

Shaw, Leslee J.; Bairey Merz, C. Noel; Azziz, Ricardo; Stanczyk, Frank Z.; Sopko, George; Braunstein, Glenn D.; Kelsey, Sheryl F.; Kip, Kevin E.; Cooper-DeHoff, Rhonda M.; Johnson, B. Delia; Vaccarino, Viola; Reis, Steven E.; Bittner, Vera; Hodgson, T. Keta; Rogers, William; Pepine, Carl J.

doi:10.1210/jc.2007-0425

Cited by 427Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsMenopause: Health Impacts and Treatments

Withdrawn: Postmenopausal Women with a History of Irregular Menses and Elevated Androgen Measurements at High Risk for Worsening Cardiovascular Event-Free Survival: Results from the National Institutes of Health—National Heart, Lung, and Blood Institute Sponsored Women’s Ischemia Syndrome Evaluation

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Shaw, Leslee J., Bairey Merz, C. Noel, Azziz, Ricardo, Stanczyk, Frank Z., Sopko, George, Braunstein, Glenn D., Kelsey, Sheryl F., Kip, Kevin E. +8 more·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-0425PMC PMC2291491

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Abstract

BACKGROUND: Women with polycystic ovary syndrome (PCOS) have a greater clustering of cardiac risk factors. However, the link between PCOS and cardiovascular (CV) disease is incompletely described. OBJECTIVE: The aim of this analysis was to evaluate the risk of CV events in 390 postmenopausal women enrolled in the National Institutes of Health-National Heart, Lung, and Blood Institute (NIH-NHLBI) sponsored Women's Ischemia Syndrome Evaluation (WISE) study according to clinical features of PCOS. METHODS: A total of 104 women had clinical features of PCOS defined by a premenopausal history of irregular menses and current biochemical evidence of hyperandrogenemia. Hyperandrogenemia was defined as the top quartile of androstenedione (> or = 701 pg/ml), testosterone (> or = 30.9 ng/dl), or free testosterone (> or = 4.5 pg/ml). Cox proportional hazard model was fit to estimate CV death or myocardial infarction (n = 55). RESULTS: Women with clinical features of PCOS were more often diabetic (P < 0.0001), obese (P = 0.005), had the metabolic syndrome (P < 0.0001), and had more angiographic coronary artery disease (CAD) (P = 0.04) compared to women without clinical features of PCOS. Cumulative 5-yr CV event-free survival was 78.9% for women with clinical features of PCOS (n = 104) vs. 88.7% for women without clinical features of PCOS (n = 286) (P = 0.006). PCOS remained a significant predictor (P < 0.01) in prognostic models including diabetes, waist circumference, hypertension, and angiographic CAD as covariates. CONCLUSION: Among postmenopausal women evaluated for suspected ischemia, clinical features of PCOS are associated with more angiographic CAD and worsening CV event-free survival. Identification of postmenopausal women with clinical features of PCOS may provide an opportunity for risk factor intervention for the prevention of CAD and CV events.

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Obesity exacerbates the PCOS-related increased risk factors for impaired glucose tolerance, DM2 and CVD.
“obesity exacerbates the PCOS-related increased risk factors for impaired glucose tolerance, DM2 and CVD, 22”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [22]
Cardiovascular risk factors are increased and CVD appears more prevalent among women with PCOS, despite inadequate long-term studies to appropriately address this question.
“Cardiovascular risk factors are increased and CVD appears more prevalent among women with PCOS despite inadequate long-term studies to appropriately address this question. 22”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [22]
Shaw and colleagues examined a subset of postmenopausal women from the Women's Ischemia Syndrome Evaluation study who had displayed clinical features consistent with PCOS and confirmed increased cardiovascular events and deaths.
“In contrast, Shaw and colleagues examined a subset of postmen-pausal women from the Women's Ischemia Syndrome Evaluation study who had displayed clinical features consistent with PCOS and confirmed increased cardiovascular events and deaths. 22”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [22]

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Authors: Shaw, L. J., Bairey Merz, C. N., Azziz, R., Stanczyk, F. Z., Sopko, G., Braunstein, G. D., Kelsey, S. F., Kip, K. E., Cooper-DeHoff, R. M., Johnson, B. D., Vaccarino, V., Reis, S. E., Bittner, V., Hodgson, T. K., Rogers, W., & Pepine, C. J.
Affiliations: Cedars-Sinai Medical Center (US)
University of Southern California (US)
National Institutes of Health (US)
University of Pittsburgh (US)
Emory University (US)
University of Alabama at Birmingham (US)
University of Florida Health (US)
Corresponding author: Shaw, Leslee J.
ORCID: Shaw, Leslee J.
Azziz, Ricardo
Stanczyk, Frank Z.
Sopko, George
Braunstein, Glenn D.
Kip, Kevin E.
Vaccarino, Viola
Bittner, Vera
Hodgson, T. Keta
Pepine, Carl J.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-04
Volume: 93
Issue: 4
Pages: 1276-1284
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-0425
PMC: PMC2291491
OpenAlex: W2144997397
Cited by: 427
References: 42
Citations by year: 2026: 3 · 2024: 2 · 2023: 6 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 11 · 2018: 13 · 2017: 19 · 2016: 25 · 2015: 47 · 2014: 41 · 2013: 34 · 2012: 39
Type: retraction
Language: en
Status: Retracted
Update notices: retraction (2015-03-01)
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Alabama at Birmingham
National Institutes of Health (n01hv068164-006, n01hv068162-009, n01hv068161-005, n01hv068163-006)
U.S. Public Health Service (U0164829)
National Heart, Lung, and Blood Institute (U01HL064829, N01-HV68162, N01 HV068162, N01HV68163, N01 HV068164, N01- HV-068161, N01 HV068163, U01HL064914, U01HL064924)
National Center for Research Resources (M01RR000425)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: polycystic ovary syndrome, postmenopausal women, cardiovascular event-free survival, hyperandrogenemia, coronary artery disease, myocardial infarction, cardiovascular mortality, Women's Ischemia Syndrome Evaluation, metabolic syndrome, diabetes mellitus, obesity, cardiovascular risk
MeSH terms: Aged, Cardiovascular Diseases, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Risk Factors, Proportional Hazards Models, Postmenopause

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