Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: Who is really at risk?
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Objective To study the cardiometabolic profile characteristics and compare the prevalence of cardiovascular (CV) risk factors between women with different polycystic ovary syndrome (PCOS) phenotypes.Design A cross-sectional multicenter study analyzing 2,288 well phenotyped women with PCOS.Setting Specialized reproductive outpatient clinic.Patient(s) Women of reproductive age (18-45 years) diagnosed with PCOS.Intervention(s) Women suspected of oligo- or anovulation underwent a standardized screening consisting of a systematic medical and reproductive history taking, anthropometric measurements, and transvaginal ultrasonography followed by an extensive endocrinologic/metabolic evaluation.Main outcome measure(s) Differences in cardiometabolic profile characteristics and CV risk factor prevalence between women with different PCOS phenotypes, i.e., obesity/overweight, hypertension, insulin resistance, dyslipidemia, and metabolic syndrome.Result(s) Women with hyperandrogenic PCOS (n=1,219; 53.3% of total) presented with a worse cardiometabolic profile and a higher prevalence of CV risk factors, such as obesity and overweight, insulin resistance, and metabolic syndrome, compared with women with nonhyperandrogenic PCOS. In women with nonhyperandrogenic PCOS overweight/obesity (28.5%) and dyslipidemia (low-density lipoprotein cholesterol≥3.0 mmol/L; 52.2%) were highly prevalent.Conclusion(s) Women with hyperandrogenic PCOS have a worse cardiometabolic profile and higher prevalence of CV risk factors compared with women with nonhyperandrogenic PCOS. However, all women with PCOS should be screened for the presence of CV risk factors, since the frequently found derangements at a young age imply an elevated risk for the development of CV disease later in life.
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For the analyses on continuous testosterone data, results from the different assays were harmonized using a correction formula.
“For the analyses on continuous testosterone data, results from the different assays were harmonized using a correction formula (Daan et al., 2014).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Daan et al., 2014
Hyperandrogenic phenotypes are more associated with metabolic disturbances compared with nonhyperandrogenic ones.
“Moreover, hyperandrogenic phenotypes are also more associated with metabolic disturbances compared with the nonhyperandrogenic ones (Daan et al., 2014).”
From Improvements in PCOS characteristics and phenotype severity during a randomized controlled lifestyle intervention (2021) · cites this paper as Daan et al., 2014
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- Authors
- Daan, N. M. P., Louwers, Y. V., Koster, M. P. H., Eijkemans, M. J. C., de Rijke, Y. B., Lentjes, E. W. G., Fauser, B. C. J. M., & Laven, J. S. E.
- Affiliations
- University Medical Center Utrecht (NL)
- Erasmus MC (NL)
- Corresponding author
- Daan, Nadine M.P.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 102
- Issue
- 5
- Pages
- 1444-1451.e3
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2110503690
- Cited by
- 217
- References
- 50
- Citations by year
- 2026: 20 · 2025: 16 · 2024: 21 · 2023: 17 · 2022: 13 · 2021: 19 · 2020: 17 · 2019: 21 · 2018: 17 · 2017: 21 · 2016: 16 · 2015: 19
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, PCOS phenotypes, hyperandrogenism, cardiometabolic profile, cardiovascular risk factors, obesity, insulin resistance, metabolic syndrome, dyslipidemia, hypertension
- MeSH terms
- Adolescent, Adult, Cardiovascular Diseases, Cross-Sectional Studies, Female, Humans, Metabolic Diseases, Middle Aged, Netherlands, Obesity, Phenotype, Polycystic Ovary Syndrome, Risk Factors, Comorbidity, Incidence, Young Adult
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