Cited by 1,428HIV/AIDS Research and InterventionsMedication Adherence and ComplianceHIV/AIDS drug development and treatment

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Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence Instruments

Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., PATIENT CARE COMMITTEE & ADHERENCE·2000·AIDS Care

DOI 10.1080/09540120050042891

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Abstract

This paper describes the AACTG Adherence Instruments, which are comprised of two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antiretroviral therapy (ART), including at least one protease inhibitor. Eleven per cent of patients reported missing at least one dose the day before the interview, and 17% reported missing at least one dose during the two days prior. The most common reasons for missing medications included 'simply forgot' (66%) and a number of factors often associated with improved health, including being busy (53%), away from home (57%) and changes in routine (51%). Less adherent patients reported lower adherence self-efficacy (p = 0.006) and were less sure of the link between non-adherence and the development of drug resistance (p = 0.009). They were also more likely to consume alcohol, to be employed outside the home for pay and to have enrolled in clinical trials to gain access to drugs (all p < 0.05). Twenty-two per cent of patients taking drugs requiring special instructions were unaware of these instructions. Each questionnaire took approximately ten minutes to complete. Responses to the questionnaires were favourable. These questionnaires have been included in six AACTG clinical trials to date and have been widely disseminated to investigators both in the USA and abroad.

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van den Boogaard, J., Lyimo, R. A., Boeree, M. J., Kibiki, G. S., & Aarnoutse, R. E. (2011) · Bulletin of the World Health Organization · doi:10.2471/blt.11.086462 · Cited by 74
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“The Adult AIDS Clinical Trial Group Adherence to Combination Therapy Guide 31 (ACTG) assessed self-reported adherence.”
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“Principal component analysis on these items (using the non-orthogonal method of rotation, as recommended by Kline, 1994, and Cattell, 1995 ) yielded four categories of values, explaining 47% of the variance: “other people” (11 items: respect, tolerance, being understanding with others), “success” (11 items: have a goo…”
Method
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“Antiretroviral medication adherence was measured by patient self-report using a modified version of the Adult AIDS Clinical Trials Group Adherence Instrument.28 For the purposes of this analysis, patients were considered nonadherent if they reported missing any doses of their HIV medications during the previous 7 days…”
MethodInfluential
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“, 2006), they are nevertheless subject to social desirability and recall bias, and as such may under-estimate non-adherence compared with more objective measures such as pill counts and the use of electronic pill caps (Arnsten et al., 2001; Chesney et al., 2000; Liu et al., 2001; Reynolds, 2004; Wagner & Miller, 2004;…”
BackgroundMethodInfluential
Self-Reported Medication Adherence and Symptom Experience in Adults With HIV
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“measure adherence to antiretroviral medications (Chesney et al., 2000).”
Method
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“1,10,11 While these studies have examined the relationship between adherence and relatively milder forms of psychiatric illness, levels of antiretroviral adherence among patients with serious mental illness (e.g., schizophrenia, schizoaffective disorder, bipolar depression, major depression with…”
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A Social Media–Based Support Group for Youth Living With HIV in Nigeria (SMART Connections): Randomized Controlled Trial
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“Self-report using the AIDS Clinical Trials Group adherence questionnaire [52].”
Method
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“Follow-up visit procedures included evaluation of self-assessed HIV risk, self-reported PrEP adherence using 3-day recall [19] (a feasible-to-collect measure), rapid HIV antibody testing using country-standard serial testing algorithms, and PrEP refills.”
Method
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Self-citation
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“0 times (8 weekly from 1 to 48 weeks plus at week 72) and was dichotomized into those having missed or not having missed doses in the past 4 days.(47) Pill counts were made at each m-DOT visit between weeks 4 and 24 when used medication containers were returned (twice weekly).”
Method
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“20 They were also asked four standard questions pertaining to perceptions and practices around medication adherence from which the Morisky score was derived.”
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Method
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Background
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“Substance abuse has been associated with decreased adherence in several studies [29,30].”
Result
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“Self-reported adherence was assessed over the previous 3 days to calculate percent adherence by dividing the number of pills taken by the total number of pills prescribed (38).”
MethodSelf-citation
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Background
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Method
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“The adherence measure developed to assess adherence in the AIDS Clinical Trials Group (ACTG) [16] solicits detailed information about self-reported adherence over the prior 3 days.”
Method
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Background
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Self-citation
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“Past studies have shown that approximately 12-50% of HIV-positive patients fail to achieve optimal adherence [22-27].”
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Method
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Method
Randomized controlled trial of a coordinated care intervention to improve risk factor control after stroke or transient ischemic attack in the safety net: Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED)
Towfighi, A., Cheng, E. M., Ayala-Rivera, M., McCreath, H. E., Sanossian, N., Dutta, T. M., Mehta, B. K., Bryg, R. J., Rao, N. M., Song, S. S., et al. (2017) · BMC Neurology · doi:10.1186/s12883-017-0792-7 · Cited by 71
Simplification Therapy with Once‐Daily Emtricitabine, Didanosine, and Efavirenz in HIV‐1–Infected Adults with Viral Suppression Receiving a Protease Inhibitor–Based Regimen: A Randomized Trial
Molina, J., Journot, V., Morand‐Joubert, L., Yéni, P., Rozenbaum, W., Rancinan, C., Fournier, S., Morlat, P., Palmer, P., Dupont, B., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/428091 · Cited by 68
“Adherence to study medication was assessed at baseline and every 4 weeks, by patient self-reporting by use of questionnaires about the number of pills not taken during the 4 days before each visit [23].”
Method
Drug resistance in patients experiencing early virological failure under a triple combination including indinavir
Gallego, O., de Mendoza, C., Pérez-Elı́as, M. J., Guardiola, J. M., Pedreira, J. D., Dalmau, D., González, J., Moreno, A. M., Arribas, J. R., Rubio, A., et al. (2001) · AIDS · doi:10.1097/00002030-200109070-00014 · Cited by 68
“Moreover, a questionnaire described elsewhere [18] was given to the patients at each visit.”
Method
Food Insufficiency is a Risk Factor for Suboptimal Antiretroviral Therapy Adherence among HIV-Infected Adults in Urban Peru
Franke, M. F., Murray, M. B., Muñoz, M., Hernández–Dı́az, S., Sebastián, J. L., Atwood, S. S., Caldas, A., Bayona, J. N., & Shin, S. S. (2010) · AIDS and Behavior · doi:10.1007/s10461-010-9789-6 · Cited by 67
“We measured ART adherence using a 30-day self-report tool that we adapted from the Adult AIDS Clinical Trials Groups (AACTG) self-report tool [29].”
Method
The impact of improved self-efficacy on HIV viral load and distress in culturally diverse women living with AIDS: the SMART/EST women's project
Ironson, G. H., Weiss, S. M., Lydston, D., Ishii, M., Jones, D. L., Asthana, D., Tobin, J. N., Lechner, S. C., LaPerriere, A. R., Schneiderman, N., et al. (2004) · AIDS Care · doi:10.1080/09540120512331326365 · Cited by 67
Medication adherence skills training for middle‐aged and elderly adults with bipolar disorder: development and pilot study
Depp, C. A., Lebowitz, B. D., Patterson, T. L., Lacro, J. P., & Jeste, D. V. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00397.x · Cited by 67
Quality of Sleep: Associations with Antiretroviral Nonadherence
Saberi, P., Neilands, T., & Johnson, M. O. (2011) · AIDS Patients Care and STDs · doi:10.1089/apc.2010.0375 · Cited by 60
How Treatment Partners Help: Social Analysis of an African Adherence Support Intervention
O’Laughlin, K. N., Wyatt, M. A., Kaaya, S., Bangsberg, D. R., & Ware, N. C. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-0038-4 · Cited by 68
The relationship between neuropsychological functioning and HAART adherence in HIV-positive adults: a systematic review
Lovejoy, T., & Suhr, J. (2009) · Journal of behavioral medicine · doi:10.1007/s10865-009-9212-9 · Cited by 72
“…between cognitive functioning and HAART adherence, early studies identified patient self-reports of memory impairment and problem solving/strategizing deficits as, at least partial, explanations for poor HIV medication adherence (Chesney et al. 2000; Nieuwkerk et al. 2001; Roberts 2000).”
Background
Alcohol use and non‐adherence to antiretroviral therapy in HIV‐infected patients in West Africa
Jaquet, A., Ekouévi, D. K., Bashi, J., Aboubakrine, M., Messou, E., Maiga, M. Y., Traoré, H. A., Zannou, M. D., Guéhi, C., Ba-Gomis, O., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02978.x · Cited by 65
“Measurements The four-day recall on adherence to HAART was determined with the AIDS Clinical Trials Group (ACTG) follow-up questionnaire for adherence to antiretroviral medications (11).”
Method
Prevalence and Interactions of Patient-Related Risks for Nonadherence to Antiretroviral Therapy Among Perinatally Infected Youth in the United States
Rudy, B. J., Murphy, D. A., Harris, D. R., Muenz, L. R., & Ellen, J. M. (2010) · AIDS Patient Care and STDs · doi:10.1089/apc.2009.0198 · Cited by 66
Psychosocial Determinants of Adherence to Highly Active Antiretroviral Therapy among Injection Drug Users in Vancouver
Kerr, T. H., Palepu, A., Barnes, G. E., Walsh, J. C., Hogg, R. S., Montaner, J. S. G., TYNDALL, M. W., & Wood, E. (2004) · Antiviral Therapy · doi:10.1177/135965350400900314 · Cited by 66
“While forgetting has been documented as a risk factor previously [24,28,42], falling asleep has rarely been reported as frequently as it was in the present study [24,28].”
MethodResult
Stability of Adherence to Highly Active Antiretroviral Therapy Over Time Among Clients Enrolled in the Treatment Adherence Demonstration Project
Tesoriero, J. M., French, T., Weiss, L., Waters, M., Finkelstein, R., & Agins, B. (2003) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200308010-00009 · Cited by 66
Cognitive-behavioral therapy for HIV medication adherence and depression
Safren, S. A., Hendriksen, E., Mayer, K. H., Mimiaga, M. J., Pickard, R., & Otto, M. W. (2004) · Cognitive and Behavioral Practice · doi:10.1016/s1077-7229(04)80058-0 · Cited by 65
Are Psychological Consequences of Stigma Enduring or Transitory? A Longitudinal Study of HIV Stigma and Distress Among Asians and Pacific Islanders Living with HIV Illness
Kang, E., Rapkin, B. D., & DeAlmeida, C. (2006) · AIDS Patient Care and STDs · doi:10.1089/apc.2006.20.712 · Cited by 65
“An 11-item physical symptom distress scale was adapted from the Adult AIDS Clinical Trials Group (AACTG) 42 to measure participants’ physical health status (e.g., pain, gastrointestinal discomfort, high fever).”
A Smartphone-based Medication Self-management System with Real-time Medication Monitoring
Hayakawa, M., Uchimura, Y., Omae, K., Waki, K., Fujita, H., & Ohe, K. (2013) · Applied Clinical Informatics · doi:10.4338/aci-2012-10-ra-0045 · Cited by 67
“The rate of ‘simply for-got’ was 66% in HIV/AIDS clinical trials and 30% in other clinical trials [3, 7].”
Background
Central nervous system penetration effectiveness of antiretroviral drugs and neuropsychological impairment in the Ontario HIV Treatment Network Cohort Study
Carvalhal, A., Gill, M. J., Letendre, S. L., Rachlis, A., Bekele, T., Raboud, J., Burchell, A. N., & Rourke, S. B. (2015) · Journal of NeuroVirology · doi:10.1007/s13365-015-0404-5 · Cited by 64
“…counts, plasma viral load, a diagnosis of an AIDS defining condition , current cART regimen, and history of hepatitis C infection were extracted from individuals' charts. cART adherence in the past 4 days was estimated using the AIDS Clinical Trials Group adherence survey (Chesney et al. 2000).”
Health-related quality of life of HIV-infected adults receiving combination antiretroviral therapy in Addis Ababa
Mekuria, L. A., Sprangers, M. A. G., Prins, J. M., Worku, A., & Nieuwkerk, P. T. (2015) · AIDS Care · doi:10.1080/09540121.2015.1020748 · Cited by 64
“A single item was used to measure the patients’ satisfaction with social-support (Chesney et al., 2000).”
Method
HIV Medication Adherence and HIV Symptom Severity: The Roles of Sleep Quality and Memory
Babson, K. A., Heinz, A. J., & Bonn‐Miller, M. O. (2013) · AIDS Patient Care and STDs · doi:10.1089/apc.2013.0221 · Cited by 64
“The HSQ is a 43-item measure developed by the AIDS Clinical Trials Group to assess health status and outcomes for HIV and AIDS patients.(42) The HSQ assesses general health and energy, as well as social, physical, and cognitive functioning.”
Adherence to antiretroviral medications in HIV: Differences in data collected via self-report and electronic monitoring.
Levine, A. J., Hinkin, C. H., Marion, S., Keuning, A., Castellon, S. A., Lam, M. N., Robinet, M., Longshore, D. L., Newton, T. F., Myers, H. F., et al. (2006) · Health Psychology · doi:10.1037/0278-6133.25.3.329 · Cited by 64
A Randomized Study of Serial Telephone Call Support to Increase Adherence and Thereby Improve Virologic Outcome in Persons Initiating Antiretroviral Therapy
Collier, A. C., Ribaudo, H. J., Mukherjee, A., Feinberg, J., Fischl, M. A., & Chesney, M. A. (2005) · The Journal of Infectious Diseases · doi:10.1086/466526 · Cited by 64
Self-citation
The effect of Depressive Symptoms at ART Initiation on HIV Clinical Progression and Mortality: Implications in Clinical Practice
Villes, V., Spire, B., Lewden, C., Perronne, C., Besnier, J., Garre, M. A., Chêne, G., Leport, C., Carrieri, P., Moing, V. L., et al. (2007) · Antiviral Therapy · doi:10.1177/135965350701200705 · Cited by 64
High adherence to all-oral directly acting antiviral HCV therapy among an inner-city patient population in a phase 2a study
Petersen, T. L., Townsend, K., Gordon, L. A., Sidharthan, S., Silk, R., Nelson, A. K., Gross, C., Calderón, M., Proschan, M. A., Osinusi, A. O., et al. (2015) · Hepatology International · doi:10.1007/s12072-015-9680-7 · Cited by 63
Consistent ART Adherence Is Associated with Improved Quality of Life, CD4 Counts, and Reduced Hospital Costs in Central China
Wang, H., Zhou, J., He, G., Luo, Y., Li, X., Ai-yun, Y., Fennie, K., & Williams, A. B. (2009) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2008.0173 · Cited by 63
“30,31 Our ﬁnding suggests that people receiving ART need to integrate taking medication into their daily routine, have individualized medication plans, 32 and adopt strategies such as carrying a pillbox when going out and using medication reminders, thus reducing the chances of missing doses and…”
The association of benefit finding to psychosocial and health behavior adaptation among HIV+ men and women
Littlewood, R. A., Vanable, P. A., Carey, M. P., & Blair, D. C. (2007) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9142-3 · Cited by 64
“The four-item medication adherence questionnaire used in this study was adapted from previously validated measures (Catz et al. 2001; Chesney et al. 2000).”
Method
Racial Differences in Virologic Failure Associated With Adherence and Quality of Life on Efavirenz-Containing Regimens for Initial HIV Therapy
Schackman, B. R., Ribaudo, H. J., Krambrink, A., Hughes, V., Kuritzkes, D. R., & Gulick, R. M. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31815ac499 · Cited by 63
Promoting male involvement to improve PMTCT uptake and reduce antenatal HIV infection: a cluster randomized controlled trial protocol
Peltzer, K., Jones, D. L., Weiss, S. M., & Shikwane, M. E. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-778 · Cited by 63
“Adherence (Self reported ARV uptake - 4 days (ACTG 4-day Adherence Self Report measure) [56].”
Background
Improving AIDS Care After Trauma (ImpACT): Pilot Outcomes of a Coping intervention Among HIV-Infected Women with Sexual Trauma in South Africa
Sikkema, K. J., Mulawa, M. I., Robertson, C., Watt, M. H., Ciya, N., Stein, D. J., Cherenack, E. M., Choi, K. W., Kombora, M., & Joska, J. A. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-2013-1 · Cited by 63
“Any selfreported non-adherence was evaluated by asking the participant how many days she missed taking her medication within the past month [59].”
Background
Trauma, dissociation, and antiretroviral adherence among persons living with HIV/AIDS
Keuroghlian, A. S., Kamen, C. S., Neri, E., Lee, S. S., Liu, R., & Gore-Felton, C. E. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.05.003 · Cited by 62
Factors Associated with Suboptimal Antiretroviral Therapy Adherence to Dose, Schedule, and Dietary Instructions
Schönnesson, L. N., Williams, M. L., Ross, M. W., Bratt, G., & Keel, K. B. (2006) · AIDS and Behavior · doi:10.1007/s10461-006-9160-0 · Cited by 62
“Depressive symptoms (Catz et al., 2000; Chesney et al., 2000; Gordillo, del Amo, Soriano, & Gonzalez-Lahoz, 1999; Kleeberger et al., 2001; Murri et al., 2000; Paterson et al., 2000; Simoni, Frick, Lockhart, & Liebovitz, 2002), hopelessness (Sing et al., 1996), anxiety (Ingersoll, 2004; Molassiotis…”
Background
Psychiatric symptoms and antiretroviral nonadherence in US youth with perinatal HIV
Kacanek, D., Angelidou, K., Williams, P. L., Chernoff, M., Gadow, K. D., & Nachman, S. (2015) · AIDS · doi:10.1097/qad.0000000000000697 · Cited by 64
“We used the Pediatric AIDS Clinical Trials Group Adherence Module [23] to measure 3-day recall nonadherence, defined as taking less than 95% of the prescribed ART doses in the past 3 days.”
Method
Perceived Stress Mediates the Effects of Coping on the Quality of Life of HIV-Positive Women on Highly Active Antiretroviral Therapy
Weaver, K. E., Antoni, M. H., Lechner, S. C., Durán, R. E., Penedo, F. J., Fernandez, M. I., Ironson, G. H., & Schneiderman, N. (2004) · AIDS and Behavior · doi:10.1023/b:aibe.0000030248.52063.11 · Cited by 61
“Alpha reliability for the ACTG symptom measure in the sample was excellent (α = .85).”
Feasibility of Interactive Text message Response (ITR) as a Novel, Real-Time Measure of Adherence to Antiretroviral Therapy for HIV+ Youth
Dowshen, N., Kuhns, L. M., Gray, C., Lee, S., & Garofalo, R. (2013) · AIDS and Behavior · doi:10.1007/s10461-013-0464-6 · Cited by 61
Adherence to Early Antiretroviral Therapy
Safren, S. A., Mayer, K. H., Ou, S., McCauley, M., Grinsztejn, B. G. J., Hosseinipour, M. C., Kumarasamy, N., Gamble, T., Hoffman, I., Celentano, D. D., et al. (2015) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000593 · Cited by 61
“This involved a checklist for “never,” “rarely,” “sometimes,” and “often” and had 24 potential reasons for nonadherence, such as “forgot,” “side effects,” “transportation problems getting to the clinic,” and “lost pills,” which were generated from the study sites and using items from previous AIDS Clinical Trials Grou…”
Stimulant Use is Associated with Immune Activation and Depleted Tryptophan Among HIV-Positive Persons on Anti-Retroviral Therapy
Carrico, A., Johnson, M. O., Morin, S., Remien, R., Riley, E., Hecht, F., & Fuchs, D. (2008) · Brain, behavior, and immunity · doi:10.1016/j.bbi.2008.07.010 · Cited by 63
Family Experiences with Pediatric Antiretroviral Therapy: Responsibilities, Barriers, and Strategies for Remembering Medications
Marhefka, S. L., Koenig, L. J., Allison, S. M., Bachanas, P. J., Bulterys, M., Bettica, L., Tepper, V. J., & Abrams, E. J. (2008) · AIDS Patient Care and STDs · doi:10.1089/apc.2007.0110 · Cited by 61
Four Measures of Antiretroviral Medication Adherence and Virologic Response in AIDS Clinical Trials Group Study 359
Fletcher, C. V., Testa, M. A., Brundage, R. C., Chesney, M. A., Haubrich, R., Acosta, E. P., Martinez, A. L. S., Jiang, H., & Gulick, R. M. (2005) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000180078.53321.6a · Cited by 61
Self-citation
First-line antiretroviral therapy and dyslipidemia in people living with HIV-1 in Cameroon: a cross-sectional study
Yone, E. W. P., Betyoumin, A. F., Kengne, A. P., Folefack, F. J. K., & Ngogang, J. Y. (2011) · AIDS Research and Therapy · doi:10.1186/1742-6405-8-33 · Cited by 61
“The 95% rate of adherence is referable to 4-day recall data [13].”
Background
The HIV Medication Taking Self‐efficacy Scale: psychometric evaluation
Erlen, J. A., Cha, E., Kim, K. H., Caruthers, D., & Sereika, S. M. (2010) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2010.05400.x · Cited by 60
Taking Control: The Efficacy and Durability of a Peer-Led Uncertainty Management Intervention for People Recently Diagnosed With HIV
Brashers, D. E., Basinger, E. D., Rintamaki, L. S., Caughlin, J. P., & Para, M. F. (2016) · Health Communication · doi:10.1080/10410236.2015.1089469 · Cited by 61
“Treatment adherence is vital not only to proper management of HIV, but also to the prevention of treatment-resistant strains of the virus (Chesney et al., 2000).”
Background
A computer-based assessment detects regimen misunderstandings and nonadherence for patients on HIV antiretroviral therapy
Bangsberg, D. R., Bronstone, A. B., & Hofmann, R. H. (2002) · AIDS Care · doi:10.1080/09540120220097892 · Cited by 61
Supportive Relationships and Medication Adherence in HIV-Infected, Low-Income Latinos
van Servellen, G. M., & Lombardi, E. L. (2005) · Western Journal of Nursing Research · doi:10.1177/0193945905279446 · Cited by 61
“The presence or absence of social support has been identified as a strong and consistent predictor of successful adherence management in those with HIV/AIDS (Berg et al., 2004; Catz, Heckman, Kochman, & DiMarco, 2001; Catz, Kelly, Bogart, Benotsch, & McAuliffe, 2000; Chesney et al., 2000; Garcia & Cote, 2003; Johnson…”
BackgroundMethodInfluential
Matching Social Support to Individual Needs: A Community-Based Intervention to Improve HIV Treatment Adherence in a Resource-Poor Setting
Muñoz, M., Bayona, J. N., Sánchez, E., Arévalo, J., Sebastian, J. L., Arteaga, F., Guerra, D., Zeladita-Huamán, J. A., Espiritu, B., Wong, M., et al. (2010) · AIDS and Behavior · doi:10.1007/s10461-010-9697-9 · Cited by 60
“Adherence was defined as having taken at least 95% of prescribed days of HAART within the last month of observation, based on a modified AIDS Clinical Trials Group instrument that included 30-day recall [29, 30].”
Method
Efavirenz versus Boosted Atazanavir or Zidovudine and Abacavir in Antiretroviral Treatment–Naive, HIV‐Infected Subjects: Week 48 Data from the Altair Study
Puls, R. L., Srasuebkul, P., Petoumenos, K., Boesecke, C., Duncombe, C. J., Belloso, W. H., Molina, J., Li, L., Avihingsanon, A., Gazzard, B., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/656363 · Cited by 60
“Seven-day adherence to therapy was assessed at weeks 4 and 48 by the Community Programs for Clinical Research on AIDS Antiretroviral Medication Self-Report Form [30].”
Method
Comparing dedicated and designated models of integrating mental health into chronic disease care: study protocol for a cluster randomized controlled trial
MYERS, B. J., Lund, C., Lombard, C. J., Joska, J. A., Levitt, N. S., Butler, C., Cleary, S., Naledi, T., Milligan, P. D., Stein, D. J., et al. (2018) · Trials · doi:10.1186/s13063-018-2568-9 · Cited by 67
A low-cost, sustainable intervention for drinking reduction in the HIV primary care setting
Aharonovich, E., Hatzenbuehler, M. L., Johnston, B. E., O’Leary, A., Morgenstern, J., Wainberg, M. L., Yao, P., Helzer, J. E., & Hasin, D. S. (2006) · AIDS Care · doi:10.1080/09540120500264134 · Cited by 59
“Heavy drinking is also associated with both increased sexual transmission risk behaviour (Marks et al., 1998; Robins et al., 1997; Lauchli et al., 1996; McKirnan et al., 2001) and poor adherence to ARV (Chesney et al., 2000; Palepu et al., 2004; Samet et al., 2004), which may in turn lead to higher viral load and incr…”
Background
Adherence to antiretroviral therapy (ART) during the early months of treatment in rural Zambia: influence of demographic characteristics and social surroundings of patients
Sasaki, Y., Kakimoto, K., Dube, C., Sikazwe, I. T., Moyo, C., Syakantu, G., Komada, K., Miyano, S., Ishikawa, N., Kita, K., et al. (2012) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-11-34 · Cited by 59
“Structured questionnaires for both baseline and followup interviews were developed, following the generic tools developed by World Health Organization (WHO) [21] and the AIDS clinical trial group (ACTG) adherence follow-up questionnaires [22].”
Method

Authors: Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., & PATIENT CARE COMMITTEE & ADHERENCE
Affiliations: University of California, San Francisco (US)
Yale University (US)
University of California San Diego (US)
The Ohio State University (US)
Indiana University Indianapolis (US)
Johns Hopkins University (US)
ORCID: Chesney, M. A.
Ickovics, J. R.
Gifford, A. L.
Wu, A. W.
Venue: AIDS Care
Publisher: Informa UK Limited
Published: 2000-06
Volume: 12
Issue: 3
Pages: 255-266
ISSN: 0954-0121 (ISSN-L)
1360-0451
DOI: 10.1080/09540120050042891
OpenAlex: W2088423598
Cited by: 1,428
References: 12
Citations by year: 2026: 14 · 2025: 28 · 2024: 29 · 2023: 29 · 2022: 40 · 2021: 53 · 2020: 51 · 2019: 55 · 2018: 61 · 2017: 66 · 2016: 67 · 2015: 76 · 2014: 81 · 2013: 84 · 2012: 74
FWCI: 27.22
Type: journal article
Language: en
Open access: closed
Locations: AIDS Care (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (P50-MH42459, P30MH059037, P50MH042459, P30-MH 59037)
National Institute of Allergy and Infectious Diseases (U01AI-38858, U01AI038858)
Topics: Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords: antiretroviral therapy adherence, HIV, self-report questionnaire, medication non-adherence, adherence self-efficacy, alcohol consumption, protease inhibitors, clinical trial participants, questionnaire development
MeSH terms: Adult, Alcohol Drinking, Clinical Trials as Topic, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Patient Compliance, Pilot Projects, Surveys and Questionnaires, Risk Factors, Socioeconomic Factors, HIV Infections, Anti-HIV Agents, Substance-Related Disorders

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Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: The AACTG Adherence Instruments

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