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Cited by 47Trace Elements in HealthDermatology and Skin DiseasesContact Dermatitis and Allergies

Zinc in skin pathology and care

Bibi Nitzan, Yuval, Cohen, Aanon D.·2006·Journal of Dermatological Treatment
DOI 10.1080/09546630600791434
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Abstract

OBJECTIVES: To assess the significance of zinc in the etiology of various dermatological conditions and examine the role of zinc as a mode of treatment for a wide range of dermatoses. METHODS: Review of existing literature through searches using the PubMed site with zinc and the dermatosis in question as search words. RESULTS: Severe zinc deficiency states such as acrodermatitis enteropathica are associated with a variety of skin manifestations, such as perioral, acral and perineal dermatitis. These syndromes can be reversed with systemic zinc repletion. In addition to skin pathologies which are clearly zinc-dependent, many dermatological conditions (e.g. dandruff, acne and diaper rash) have been associated and treated with zinc. Success rates for treatment with zinc vary depending on the disease, mode of application and zinc salt used. Usually, alternative modes of treatment are superior to zinc. CONCLUSIONS: Generally, it seems that with the exception of systemic deficiency states, there is very little evidence to convincingly demonstrate the efficacy of zinc as a first-line treatment for any dermatological conditions. Further research is needed in order to establish the indications for zinc treatment in dermatology, optimal mode of delivery, type of compound and therapeutic indexes.

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Crossref · 10.1080/09546630600791434

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90 of 90 references verified0 citation errors · 0 not checkable

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  • Zinc plays an important role in preventing damage induced by UV radiation and influences collagen metabolism.

    “It plays an important role in preventing the damage induced by UV radiation, influences collagen metabolism, exhibits antiandrogen properties by modulating the activity of type 1 and 2 5α-reductase, and also promotes lipogenesis and glucose transport through insulin-like effects on 3T3-L1 fibroblasts and adipocytes [98,107,108].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [107]

  • Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens.

    “Zinc oxide, due to its ability to reflect and disperse UV rays, is used as a physical filter in sunscreens [97,98,99,107,110].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [107]

  • Zinc is used to treat numerous dermatological conditions, such as infections, inflammatory dermatoses and pigmentary disorders.

    “Zinc is used to treat numerous dermatological conditions, such as infections (e.g., warts), inflammatory dermatoses (acne vulgaris, rosacea, atopic dermatitis and alopecia areata) and pigmentary disorders (melasma) [97,98,99,107,110].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [107]

  • Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.

    “Zinc preparations in the form of pastes or ointments cleanse the skin of excess sebum, restore its natural pH, and have astringent, anti-inflammatory and anti-acne effects.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [107]

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Authors
Bibi Nitzan, Y., & Cohen, A. D.
Affiliations
  • Department of Medicine, University of Massachusetts, Worcester, Massachusetts, USA
  • Ben-Gurion University of the Negev (IL)
Venue
Journal of Dermatological Treatment
Publisher
Informa UK Limited
Published
2006-01-01
Volume
17
Issue
4
Pages
205-210
ISSN
  • 0954-6634 (ISSN-L)
  • 1471-1753
DOI
10.1080/09546630600791434
OpenAlex
W1974781335
Cited by
47
References
89
Citations by year
2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dermatological Treatment (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
Keywords
zinc, zinc deficiency, acrodermatitis enteropathica, zinc repletion, dandruff, acne, diaper dermatitis, zinc therapy, skin diseases, zinc salts
MeSH terms
Humans, Skin Diseases, Trace Elements, Zinc

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