Cited by 136Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

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Vasopressinergic Regulation of the Hypothalamic Pituitary Adrenal Axis and Stress Adaptation

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Volpi, Simona, Rabadan-Diehl, Cristina, Aguilera, Greti·2004·Stress

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Abstract

Vasopressin (VP) stimulates pituitary ACTH secretion through interaction with receptors of the V1b subtype (V1bR, V3R), located in the plasma membrane of the pituitary corticotroph, mainly by potentiating the stimulatory effects of corticotropin releasing hormone (CRH). Chronic stress paradigms associated with corticotroph hyperresponsiveness lead to preferential expression of hypothalamic VP over CRH and upregulation of pituitary V1bR, suggesting an important role for VP during adaptation of the hypothalamic-pituitary-adrenal (HPA) axis to stress. Vasopressinergic regulation of ACTH secretion depends on the number of V1bRs as well as coupling of the receptor to phospholipase C (PLC) in the pituitary. Regulation of V1bR gene transcription may involve a number of regulatory elements in the promoter region, of which a GAGA box was shown to be essential. Although V1bR gene transcription is necessary to maintain V1bR mRNA levels, the lack of correlation between VP binding and V1bR mRNA suggests that regulation of mRNA translation is a major regulatory step of the number of V1bRs. V1bR translation appears to be under tonic inhibition by upstream minicistrons and positive regulation through protein kinase C (PKC) activation of an internal ribosome entry site (IRES) in the 5' untranslated region (5'UTR) of the mRNA. The data provide mechanisms by which regulation of hypothalamic VP and pituitary V1bR content contribute to controlling HPA axis activity during chronic stress.

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Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Morgan, J., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,689 · cited 3×
“…leading to the production of intermediate early genes or transcription factors capable to interact with glucocorticoid receptors and to modify their activity at the responsive element in the gene promoter (Diamond et al., 1990; Morgan and Curran, 1991; Webster and Cidlowski, 1999).”
Background
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · cited 1×
“Glucocorticoids are likely to act at multiple sites, inhibiting VP secretion by direct actions on the parvocellular neuron, and indirectly by modifying the activity of neural pathways to the parvocellular neuron such as GABAergic and glutamatergic afferents (Herman and Cullinan, 1997; Kiss, 1998).”
An analysis of vertebrate mRNA sequences: intimations of translational control.
Kozak, M. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.4.887 · Cited by 1,631 · cited 1×
“Upstream ORFs have been described in yeast and several eukaryotic mRNAs and are recognized to reduce the ability of ribosomes to linearly scan the V1b 50UTR mRNA according to conventional scanning models and therefore to slow translation (Kozak, 1991).”
Background
Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element
Diamond, M. I., Miner, J. N., Yoshinaga, S. K., & Yamamoto, K. R. (1990) · Science · doi:10.1126/science.2119054 · Cited by 1,274 · cited 2×
“…leading to the production of intermediate early genes or transcription factors capable to interact with glucocorticoid receptors and to modify their activity at the responsive element in the gene promoter (Diamond et al., 1990; Morgan and Curran, 1991; Webster and Cidlowski, 1999).”
Background
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Gillies, G. E., Linton, E. A., & Lowry, P. J. (1982) · Nature · doi:10.1038/299355a0 · Cited by 965 · cited 2×
“In humans and rodents, VP alone is a weak stimulus of ACTH secretion, but through its interaction with CRH it contributes to maintaining corticotroph responsiveness in spite of elevated glucocorticoid levels during chronic stress (Gilles et al., 1982; Antoni, 1993; Aguilera, 1994).”
Background
Nongenomic Glucocorticoid Inhibition via Endocannabinoid Release in the Hypothalamus: A Fast Feedback Mechanism
Di, S., Malcher‐Lopes, R., Halmos, K. C., & Tasker, J. G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04850.2003 · Cited by 820 · cited 1×
“Recent studies show that glucocorticoids induce the release of endogenous cannabinoids in the PVN, which can mediate rapid indirect, non-genomic glucocorticoid feedback in the parvocellular neuron (Di et al., 2003).”
Background
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · cited 3×
“Circulating glucocorticoids exert a negative feedback effect on the expression of CRH and VP in parvocellular PVN neurons (Dallman et al., 1987), but there is evidence of preferential inhibition of VP compared with CRH expression (Ma et al.”
Background
Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636 · cited 4×
“external zone of the median eminence (Antoni, 1993).”
BackgroundInfluential
Regulation of pituitary ACTH secretion during chronic stress
Aguilera, G. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1013 · Cited by 557 · cited 11×
“Also, VP markedly potentiates the stimulatory effects of corticotropin releasing hormone (CRH) on ACTH secretion (Gilles et al., 1982; DeGoeij et al., 1991; Aguilera, 1994).”
BackgroundInfluential
Hormonal regulation of peptide receptors and target cell responses
Catt, K. J., Harwood, J. P., Aguilera, G., & Dufau, M. L. (1979) · Nature · doi:10.1038/280109a0 · Cited by 531 · cited 1×
“In addition to receptor synthesis, the number of active VP receptors could be influenced by ligand binding, leading to receptor desensitization and internalization as occurs with other G-protein coupled receptors (Catt et al., 1979; Ferguson and Caron, 1998).”
Background

Show all 60 references

Research works printed but not linked: 10

Carvallo P., 1989, Endocrinol, 3, 1935
Dallman M.F., 1987, Recent Prog. Horm. Res., 42, 113
DeGoeij D.C.E., 1991, Neuroendocrinology, 53, 150, 10.1159/000125712 · DOI · Paper page
Levin N., 1991, Front. Neuroendocrinol., 12, 1
McCann S.M., 1954, Proc. Natl Acad. Sci. USA, 87, 318
Mori Y., 1996, Role of upstream AUG triplets, Hypertension, 28, 810
Rabadan-Diehl C., 2002, Neuroscience, Orlando FL, abst
Rabadan-Diehl C., 2003, Endocrinol, 17, 1959
Seibold A., 1992, Am. J. Hum. Genet., 51, 1078
Sonnenberg, N. (1996) In: Hershey, J.W.B., Mathews, M.B. and Sonenberg, N., eds, Translational Control (Cold Spring Harbor Lab. Press, Plainview, NY), pp 245–269.

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Nakamura, K., Fujiwara, Y., Mizutani, R., Sanbe, A., Miyauchi, N., Hiroyama, M., Yamauchi, J., Yamashita, T., Nakamura, S., Mori, T., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1528 · Cited by 25
Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons
Brown, C. H., RUAN, M., Scott, V. M., Tobin, V. A., & LUDWIG, M. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00419-6 · Cited by 25
Distribution of the Vasotocin Subtype Four Receptor ( VT 4 R ) in the Anterior Pituitary Gland of the Chicken, G allus gallus, and its Possible Role in the Avian Stress Response
Selvam, R., Jurkevich, A., Kang, S. W., Mikhailova, M. V., Cornett, L. E., & Kuenzel, W. J. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02370.x · Cited by 25
Synthesis and evaluation of potent and selective human V1a receptor antagonists as potential ligands for PET or SPECT imaging
Fabio, K. M., Guillon, C., Lacey, C. J., Lu, S., Heindel, N. D., Ferris, C. F., Placzek, M. S., Jones, G. B., Brownstein, M., & Simon, N. G. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.12.013 · Cited by 24
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Zimmermann-Peruzatto, J. M., Lazzari, V. M., de Moura, A. C., Almeida, S., & Giovenardi, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00130 · Cited by 23
Introduction of the human AVPR1A gene significantly alters brain receptor expression patterns, and may enhance aspects of social behavior in transgenic mice
Charles, R., Sakurai, T., Takahashi, N., Elder, G. A., Sosa, M. A. G., Young, L. J., & Buxbaum, J. D. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.017053 · Cited by 25
“In addition, vasopressin has been shown to be elevated in individuals with major depression and has also been identified as a primary regulator of hypothalamic-pituitary-adrenal axis (HPA) function during chronic psychological stress (Simon et al., 2008; van Londen et al., 1997; Volpi et al., 2004).”
Background
Arcuate AgRP, but not POMC neurons, modulate paraventricular CRF synthesis and release in response to fasting
Fernandes, A. C. A., de Oliveira, F. P., Fernández, G., Vieira, L. D. G., Rosa, C. G., do Nascimento, T., França, S. D. C., Donato, J., Vella, K. R., Antunes‐Rodrigues, J., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00853-z · Cited by 22
Disorders of the Endocrine System
Reed, S. M., Bayly, W. M., & Sellon, D. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44329-6.00016-4 · Cited by 25
Immunohistochemical characterization of chicken pituitary cells containing the vasotocin VT2 receptor
Jurkevich, A., Berghman, L. R., Cornett, L. E., & Kuenzel, W. J. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0636-2 · Cited by 21
“The V1b receptor is expressed in corticotropes mediating the vasopressinergic regulation of ACTH release (Hernando et al. 2001; Volpi et al. 2004).”
Background
The prognostic value of copeptin for acute intracerebral hemorrhage patients
Zhang, A., Li, J., Li, X., Song, L., & Li, H. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.804 · Cited by 19
“Currently, it is considered that cerebral hemorrhage-related hematoma formation (4,5), increased bleeding and persistent hypertension are associated with early neurological degeneration and poor prognosis (6).”
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Yoshida, M. (2008) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s424 · Cited by 20
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Oxytocin, Vasopressin and Stress: A Hormetic Perspective
Nazarloo, H. P., Kingsbury, M. A., Lamont, H., Dale, C. V., Nazarloo, P., Davis, J. M., Porges, E. C., Cuffe, S. P., & Carter, C. S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080632 · Cited by 20
“VP, co-released with CRH from parvocellular neurons in the PVN, sustains and amplifies ACTH secretion through V1b receptor activation, particularly under chronic or repeated stressors, thereby contributing to HPA axis sensitization [83].”
Influential
Copeptin Predicts Mortality in Critically Ill Patients
Krychtiuk, K. A., Honeder, M. C., Lenz, M. W., Maurer, G., Wojta, J., Heinz, G., Huber, K., & Speidl, W. S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170436 · Cited by 18
Hyponatremia and activation of vasopressin secretion are both independently associated with 30‐day mortality: results of a multicenter, observational study
Eckart, A., Hausfater, P., Amin, D., Amin, A., Haubitz, S., Bernard, M., Baumgartner, A., Struja, T., Kutz, A., Christ‐Crain, M., et al. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12764 · Cited by 18
In Sickness and In Health: Interpersonal Risk and Resilience in Cardiovascular Disease
Ruiz, J. M., Hamann, H. A., Coyne, J. C., & Compare, A. (2006) · Springer eBooks · doi:10.1007/978-88-470-0378-1_14 · Cited by 16
Response of Interleukin‐1β in the Magnocellular System to Salt‐Loading
Summy‐Long, J. Y., Hu, S., Pruss, A., Chen, X., & Phillips, T. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01490.x · Cited by 17
A complex selection signature at the human AVPR1B gene
Cagliani, R., Fumagalli, M., Pozzoli, U., Riva, S., Cereda, M., Comi, G. P., Pattini, L., Bresolin, N., & Sironi, M. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-123 · Cited by 17
Heat-Stress Preconditioning Attenuates Behavioral Responses to Psychological Stress: The Role of HSP-70 in Modulating Stress Responses
Belity, T., Horowitz, M., Hoffman, J. R., Epstein, Y., Bruchim, Y., Todder, D., & Cohen, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084129 · Cited by 16
Characterization of CRH-Binding Protein (CRHBP) in Chickens: Molecular Cloning, Tissue Distribution and Investigation of Its Role as a Negative Feedback Regulator within the Hypothalamus–Pituitary–Adrenal Axis
Wan, Y., Zhang, Z., Lin, D., Wang, X., Huang, T., Su, J., Zhang, J., Li, J., & Wang, Y. (2022) · Genes · doi:10.3390/genes13101680 · Cited by 17
Arginine vasopressin in vasodilatory shock: effects on metabolism and beyond
Dünser, M. W., & Westphal, M. (2008) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e3282f4571a · Cited by 16
Effect of oestrogen-dependent vasopressin on HPA axis in the median eminence of female rats
Nishimura, K., Yoshino, K., Sanada, K., Beppu, H., Akiyama, Y., Nishimura, H., Tanaka, K., Sonoda, S., Ueno, H., Yoshimura, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41714-z · Cited by 15
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“Vasopressin (AVP) is a potent synergistic factor of corticotropin-releasing hormone as hypothalamic stimulator of the hypothalamo-pituitary-adrenal axis (Volpi et al. 2004).”
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“hypothalamic-pituitary-adrenal (HPA) axis through its involvement in the regulation of adrenocorticotropin (ACTH) release.(1,2) This function highlights the potential of hV1bR as a drug target for stress, anxiety and depression.”
Background
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Reduced cooperativeness and reward-dependence in depression with above-normal plasma vasopressin concentration
Jg, G., de Winter, R., Wolterbeek, R., Spinhoven, P., Zitman, F., & Wiegant, V. M. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108093584 · Cited by 13
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“Corticotrophinreleasing hormone (CRH) and arginine vasopressin (AVP), released from the hypothalamus, can activate the pituitary gland to release adrenocorticotropic hormone (ACTH), encephalin and endorphin (END), and the adrenal cortex to release ACTH-induced glucocorticoid (GC) (3,27).”
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“Other studies also support the prolongation of AVP secretion in male rats (Aguilera et al., 2008; Volpi et al., 2004), and a shift to more than half of CRH neurons coexpressing AVP (Aguilera, Kiss, Liu, & Kamitakahara, 2007; Aguilera et al., 2008; Chowdrey et al., 1995; de Goeij et al., 1991; Ma,…”
Influential
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Paraventricular Nucleus V1a Receptor Knockdown Blunts Neurocardiovascular Responses to Acute Stress in Male Rats after Chronic Mild Unpredictable Stress
Das, S., Komnenov, D., Newhouse, L., Rishi, A. K., & Rossi, N. F. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113867 · Cited by 9
Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat
Baba, K., Kawasaki, M., Nishimura, H., Suzuki, H., Matsuura, T., Ikeda, N., Fujitani, T., Yamanaka, Y., Tsukamoto, M., Ohnishi, H., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17477-5 · Cited by 9
Evidence of vasopressinergic-noradrenergic mechanisms in depression with above-normal plasma vasopressin concentration with and without psychotic features
Goekoop, J. G., de Winter, R. F. P., Wolterbeek, R., Kempen, G. M. J. V., & Wiegant, V. M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109349839 · Cited by 9
“The second animal model has been induced by chronic stress, and has been found to induce increased expression of the pituitary vasopressin (V1b)-receptor (Volpi et al., 2004).”
Background
Influence of arginine vasopressin on the ultradian dynamics of Hypothalamic-Pituitary-Adrenal axis
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Hyponatremia is an independent predictor of emergency department revisits in acute exacerbation of COPD
Akyıl, F. T., Önür, S. T., Abalı, H., Sökücü, S. N., Özdemir, C., Boyracı, N., Kocaoğlu, A., & Altın, S. (2021) · The Clinical Respiratory Journal · doi:10.1111/crj.13409 · Cited by 8
“Eosinophil >%2 (n, %) 1123 (34) 978 (38) 145 (20) <0.”
Circuits underlying social function and dysfunction
Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9
Vasopressin-induced morphological changes in polarized rat hepatocyte multiplets: Dual calcium-dependent effects
Serrière-Lanneau, V., Tran, D., Stelly, N., Claret, M., Alonso, G., Tordjmann, T., & Guillon, G. (2007) · Cell Calcium · doi:10.1016/j.ceca.2007.04.008 · Cited by 7
Postpartum repeated separation from pups affects the behavior and neuroendocrine parameters of mandarin vole fathers
Kong, L., Wu, R., Wang, L., Feng, W., Cao, Y., & Tai, F. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.017 · Cited by 6
Establishment and Clinical Application in Stroke of a Serum Copeptin Time-Resolved Fluorescence Immunoassay
Zhou, Z., Sun, F., Jiang, J., Dou, Z., Lv, Y., Zhang, Z., Zhou, X., Zhao, X., Qin, Y., & Huang, B. (2023) · Journal of Fluorescence · doi:10.1007/s10895-023-03441-7 · Cited by 6
The clinical manifestation and treatment of Meniere's Disease from the viewpoint of the water homeostasis of the inner ear
Takeda, T., Takeda, S., & Kakigi, A. (2024) · Auris Nasus Larynx · doi:10.1016/j.anl.2024.08.002 · Cited by 7
Influence of nitric oxide synthase inhibition on vasopressin and corticosterone secretion during water deprivation in rats
Mornagui, B., Rezg, R., Grissa, A., Duvareille, M., Gharib, C., Kamoun, A., El‐Fazâa, S., & Gharbi, N. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0026-6 · Cited by 5
“Thus, in addition to the role of AVP on water conservation, it regulates pituitary ACTH secretion by potentiating the stimulatory effects of CRH and upregulating the pituitary AVP receptors, especially V1b subtype (V1bR, V3R), located in the plasma membrane of the pituitary corticotroph and coupled to calcium–phosphol…”

Authors: Volpi, S., Rabadan-Diehl, C., & Aguilera, G.
Affiliations: National Institutes of Health (US)
Corresponding author: Aguilera, Greti
ORCID: Volpi, Simona
Venue: Stress
Publisher: Informa UK Limited
Published: 2004-06
Volume: 7
Issue: 2
Pages: 75-83
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890410001733535
OpenAlex: W2094450224
Cited by: 136
References: 60
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 10 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 9 · 2012: 3
FWCI: 0.70
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
Locations: Stress (publishedVersion, public-domain)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: vasopressin, V1b receptor, hypothalamic-pituitary-adrenal axis, ACTH secretion, corticotropin-releasing factor, chronic stress, stress adaptation, phospholipase C signaling, mRNA translation regulation, protein kinase C, internal ribosome entry site, 5' untranslated region
MeSH terms: Adaptation, Physiological, Animals, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological, Vasopressins

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Vasopressinergic Regulation of the Hypothalamic Pituitary Adrenal Axis and Stress Adaptation

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