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Cited by 222Neuroendocrine regulation and behaviorMemory and Neural MechanismsNeuropeptides and Animal Physiology

The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy

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Young, W.S., Li, J., Wersinger, S.R., Palkovits, M.·2006·Neuroscience
DOI 10.1016/j.neuroscience.2006.08.040PMC PMC1748954
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Abstract

The vasopressin 1b receptor (Avpr1b) is one of two principal receptors mediating the behavioral effects of vasopressin (Avp) in the brain. Avpr1b has recently been shown to strongly influence social forms of aggression in mice and hamsters. This receptor appears to play a role in social recognition and motivation as well as in regulating the hypothalamic-pituitary-adrenal axis. Most of these studies have been performed in knockout mice, a species in which the localization of the Avpr1b has not been described, thus precluding correlations with the behaviors. We performed in situ hybridization histochemistry (ISHH) with specific probes and found especially prominent expression within the CA2 pyramidal neurons of the hippocampus, with much lower expression in the hypothalamic paraventricular nucleus and amygdala. Reverse transcriptase-polymerase chain reaction (RT-PCR) confirmed expression in those as well other areas in which the ISHH was not sensitive enough to detect labeled cells (e.g. piriform cortex, septum, caudate-putamen and lower brainstem areas). Mouse Avpr1b transcript levels were not altered in the CA2 field by restraint stress or adrenalectomy. Finally, ISHH and RT-PCR showed expression of the Avpr1b gene in the rat and human hippocampi as well. We suggest that the CA2 field may form or retrieve associations (memories) between olfactory cues and social encounters.

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  • V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala.

    “V1bRs appear to have a much more restricted distribution, although they are expressed prominently in the hippocampus and at lower levels in the hypothalamus and amygdala [23; 24].”

    From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [23]

  • Avpr1b mRNA is also expressed outside hippocampus, and its deletion results in changes in non-hippocampal dependent behaviors, including reduced aggression and decreased sociability.

    “However, Avpr1b mRNA is also expressed outside hippocampus21 and its deletion results in changes in non-hippocampal dependent behaviors, including reduced aggression and decreased sociability22,23”

    From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [21]

  • Avpr1b mRNA is strongly expressed in CA2.

    “Previous studies have shown that the mRNA for the vasopressin 1b receptor (Avpr1b) is strongly expressed in CA221”

    From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [21]

  • Mice lacking the vasopressin V1b receptor show a selective impairment in episodic memory of the temporal order of events.

    “Thus, mice lacking the vasopressin V1b receptor, which is highly expressed in CA2 neurons (Young et al., 2006), show a selective impairment in episodic memory of the temporal order of events (DeVito et al., 2009).”

    From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Young et al., 2006

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Authors
Young, W. S., Li, J., Wersinger, S. R., & Palkovits, M.
Affiliations
  • National Institutes of Health (US)
  • Semmelweis University (HU)
Corresponding author
Young, W.S.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2006-12
Volume
143
Issue
4
Pages
1031-1039
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.08.040
PMC
PMC1748954
OpenAlex
W1992729034
Cited by
222
References
8
Citations by year
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FWCI
11.22
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (Z01MH002498)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
AVPR1B, hippocampal CA2, pyramidal neurons, restraint stress, adrenalectomy, hypothalamic paraventricular nucleus, amygdala, social aggression, social recognition, olfactory cues, social memory, hypothalamic-pituitary-adrenal axis, gene expression, receptor localization
MeSH terms
Adrenal Cortex, Adrenal Cortex Hormones, Adrenalectomy, Adult, Animals, Brain, Disease Models, Animal, Female, Gene Expression Regulation, Hippocampus, Humans, Male, Mice, Inbred C57BL, Middle Aged, Pituitary Gland, Restraint, Physical, RNA, Messenger, Species Specificity, Stress, Psychological, Vasopressins, Receptors, Vasopressin, Mice, Knockout, Mice, Rats

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