Glucocorticoid Receptor Function In Vitro in Patients with Major Depression

Brain corticosteroid receptor balance in health and disease

de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977 · see citing works

Molecular Determinants of Glucocorticoid Receptor Function and Tissue Sensitivity to Glucocorticoids

Bamberger, C. M., Schulte, H. M., & Chrousos, G. P. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-245 · Cited by 892 · see citing works

The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions

McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837 · see citing works

Minireview: 11β-Hydroxysteroid Dehydrogenase Type 1— A Tissue-Specific Amplifier of Glucocorticoid Action1

Seckl, J. R., & Walker, B. R. (2001) · Endocrinology · doi:10.1210/endo.142.4.8114 · Cited by 714 · see citing works

Untitled work

(2000) · PubMed · Cited by 676 · see citing works

Untitled work

(1996) · PubMed · Cited by 547 · see citing works

Regulation of adult neurogenesis by antidepressant treatment

Duman, R. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00358-x · Cited by 463 · see citing works

Hypocortisolism and increased glucocorticoid sensitivity of pro-Inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder

Rohleder, N., Joksimovic, L., Wolf, J. M., & Kirschbaum, C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.018 · Cited by 393 · see citing works

Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition

van Rossum, E. F. C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.333 · Cited by 381 · see citing works

Ligand-independent Activation of the Glucocorticoid Receptor by β2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells

Eickelberg, O., Roth, M., Lörx, R., Bruce, V., Rüdiger, J., Johnson, M., & Block, L.-H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.1005 · Cited by 378 · see citing works

Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior

Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · see citing works

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice

Meijer, O. C., de Lange, E. C. M., Breimer, D. D., de Boer, A. G., Workel, J. O., & de Kloet, E. R. (1998) · Endocrinology · doi:10.1210/endo.139.4.5917 · Cited by 376 · see citing works

Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera.

Htun, H., Bársony, J., Renyi, I., Gould, D. L., & Hager, G. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4845 · Cited by 365 · see citing works

Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression

Zobel, A. W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F., & Ising, M. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00013-9 · Cited by 354 · see citing works

Hypothalamic-pituitary-adrenal axis function in patients with bipolar disorder

Watson, S., Gallagher, P., Ritchie, J. C., Ferrier, I. N., & Young, A. H. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.184.6.496 · Cited by 343 · see citing works

Depression in cancer: new developments regarding diagnosis and treatment

Raison, C. L., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00413-x · Cited by 333 · see citing works

The DST as a predictor of outcome in depression: a meta-analysis

Ribeiro, S. C. M., Tandon, R., Grunhaus, L. J., & Greden, J. F. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.11.1618 · Cited by 321 · see citing works

Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder

Young, A. H., Gallagher, P., Watson, S., Del-Estal, D., Owen, B. M., & Nicol Ferrier, I. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300471 · Cited by 318 · see citing works

24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*

Linkowski, P., Mendlewicz, J., Kerkhofs, M., Leclercq, R., GOLSTEIN, J., Brasseur, M., Copinschi, G., & Cauter, E. V. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-1-141 · Cited by 318 · see citing works

Mechanisms of glucocorticoid signalling

Schoneveld, O., Gaemers, I. C., & Lamers, W. H. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.09.004 · Cited by 305 · see citing works

Loss of Glucocorticoid Fast Feedback in Depression

Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299 · see citing works

Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands

Rupprecht, R., Reul, J. M. H. M., van Steensel, B., Spengler, D., Söder, M., Berning, B., Holsboer, F., & Damm, K. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90072-h · Cited by 297 · see citing works

Inhibition of P-Glycoprotein by Newer Antidepressants

Weiß, J., Dormann, S.-M. G., Martin‐Facklam, M., Kerpen, C. J., Ketabi‐Kiyanvash, N., & Haefeli, W. E. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046532 · Cited by 293 · see citing works

Rapid Reversal of Psychotic Depression Using Mifepristone

Belanoff, J. K., Flores, B. H., Kalezhan, M., Sund, B., & Schatzberg, A. F. (2001) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200110000-00009 · Cited by 282 · see citing works

Multidrug Resistance P-Glycoprotein Hampers the Access of Cortisol But Not of Corticosterone to Mouse and Human Brain

Karssen, A. M., Meijer, O. C., van der Sandt, I. C. J., Lucassen, P. J., de Lange, E. C. M., de Boer, A. G., & de Kloet, E. R. (2001) · Endocrinology · doi:10.1210/endo.142.6.8213 · Cited by 281 · see citing works

Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects

Heuser, I. J. E., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C.-H., Dettling, M., Yassouridis, A., & Holsboer, F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.1.93 · Cited by 275 · see citing works

Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders

Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90252-9 · Cited by 253 · see citing works

Depression, Stress and the Adrenal axis

(2003) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2003.01058.x · Cited by 242 · see citing works

Prediction of Medium-Term Outcome by Cortisol Response to the Combined Dexamethasone-CRH Test in Patients With Remitted Depression

Zobel, A. W., Yassouridis, A., Frieboes, R.-M., & Holsboer, F. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.949 · Cited by 228 · see citing works

Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders

Modell, S. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00144-9 · Cited by 207 · see citing works

Mineralocorticoid Receptor Function in Major Depression

Young, E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil, H. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.24 · Cited by 204 · see citing works

Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder

Yehuda, R., Golier, J. A., Yang, R.-K., & Tischler, L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.010 · Cited by 196 · see citing works

Do antidepressants regulate how cortisol affects the brain?

Pariante, C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.009 · Cited by 194 · see citing works

Pituitary volume in psychosis

Pariante, C. M., Vassilopoulou, K., Velakoulis, D., Phillips, L., Soulsby, B., Wood, S. J., Brewer, W., Smith, D., Dazzan, P., Yung, A. R., et al. (2004) · British Journal of Psychiatry · doi:10.1192/bjp.185.1.5 · Cited by 180 · see citing works

Plasma Steroid-Binding Proteins

Rosner, W. (1991) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30240-8 · Cited by 180 · see citing works

The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder

Yehuda, R., Halligan, S. L., Grossman, R., Golier, J. A., & Wong, C. M. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01357-4 · Cited by 172 · see citing works

Treatment with interferon-α in patients with chronic hepatitis and mood or anxiety disorders

Pariante, C. M., Orrù, M. G., Baita, A., Farci, M. G., & Carpiniello, B. (1999) · The Lancet · doi:10.1016/s0140-6736(98)04793-x · Cited by 165 · see citing works

A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37

Pratt, W. B., Silverstein, A. M., & Galigniana, M. D. (1999) · Cellular Signalling · doi:10.1016/s0898-6568(99)00064-9 · Cited by 164 · see citing works

Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness

Perlman, W. R., Webster, M. J., Kleinman, J. E., & Weickert, C. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.09.006 · Cited by 163 · see citing works

Modulation of glucocorticoid receptor function by protein kinase A.

Rangarajan, P. N., Umesono, K., & Evans, R. M. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.9.1435789 · Cited by 159 · see citing works

Antidepressants enhance glucocorticoid receptor function <i>in vitro</i> by modulating the membrane steroid transporters

Pariante, C. M., Makoff, A., Lovestone, S., Feroli, S., Heyden, A., Miller, A. H., & Kerwin, R. W. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704368 · Cited by 159 · see citing works

Corticosterone regulation of Type I and Type II adrenal steroid receptors in brain, pituitary, and immune tissue

Spencer, R. L., Miller, A. H., Stein, M., & McEwen, B. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)90463-6 · Cited by 156 · see citing works

Steroid-Independent Translocation of the Glucocorticoid Receptor by the Antidepressant Desipramine

Pariante, C. M., Pearce, B. D., Pisell, T. L., Owens, M. J., & Miller, A. H. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.4.571 · Cited by 156 · see citing works

Future therapeutic targets in mood disorders: the glucocorticoid receptor

McQuade, R., & Young, A. H. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.5.390 · Cited by 152 · see citing works

How does stress affect you? An overview of stress, immunity, depression and disease

Maddock, C., & Pariante, C. M. (2001) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00005285 · Cited by 140 · see citing works

Evidence that the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus

Czar, M. J., Lyons, R. H., Welsh, M. J., Renoir, J., & Pratt, W. B. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.11.8584032 · Cited by 137 · see citing works

Glucocorticoid receptors in depression: relationship to the dexamethasone suppression test

Gormley, G. J., Lowy, M. T., Reder, A. T., Hospelhorn, V. D., Antel, J. P., & Meltzer, H. Y. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.11.1278 · Cited by 133 · see citing works

Risk factors for suicide attempts among African American women

Kaslow, N., Thompson, M. P., Meadows, L. A., Chance, S., Puett, R., Hollins, L., Jessee, S., & Kellermann, A. (2000) · Depression and Anxiety · doi:10.1002/1520-6394(2000)12:1 · Cited by 129 · see citing works

Interleukin 1α (IL-1α) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function

Wang, X., Wu, H., & Miller, A. H. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001339 · Cited by 128 · see citing works

Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis

Bourgeois, S., Gruol, D. J., Newby, R. F., & Rajah, F. M. (1993) · Molecular Endocrinology · doi:10.1210/mend.7.7.8105374 · Cited by 113 · see citing works

Acute Antidepressant Effects of Intravenous Hydrocortisone and CRH in Depressed Patients: A Double-Blind, Placebo-Controlled Study

DeBattista, C., Posener, J. A., Kalehzan, B. M., & Schatzberg, A. F. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1334 · Cited by 113 · see citing works

Glucocorticoid resistance in depression: the dexamethasone suppression test and lymphocyte sensitivity to dexamethasone

Lowy, M. T., Reder, A. T., Antel, J. P., & Meltzer, H. Y. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1365 · Cited by 110 · see citing works

Glucocorticoid receptors and depression.

Whalley, L. J., Borthwick, N. M., Copolov, D., Dick, H., CHRISTIE, J. E., & Fink, G. (1986) · BMJ · doi:10.1136/bmj.292.6524.859 · Cited by 108 · see citing works

Dynamic Changes in Subcellular Localization of Mineralocorticoid Receptor in Living Cells: In Comparison with Glucocorticoid Receptor using Dual-Color Labeling with Green Fluorescent Protein Spectral Variants

Nishi, M., Ogawa, H., Ito, T., Matsuda, K., & Kawata, M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0659 · Cited by 108 · see citing works

Stress and the progression of the developmental hypothesis of schizophrenia

Cotter, D., & Pariante, C. M. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.5.363 · Cited by 98 · see citing works

Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment

Calfa, G. D., Kademian, S., Ceschin, D. G., Vega, G., Rabinovich, G. A., & Volosin, M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00051-3 · Cited by 97 · see citing works

The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors

Beck, C. A., Estes, P. A., Bona, B. J., Muro‐Cacho, C., Nordeen, S. K., & Edwards, D. P. (1993) · Endocrinology · doi:10.1210/endo.133.2.8344212 · Cited by 93 · see citing works

Altered glucocorticoid immunoregulation in treatment resistant depression

Bauer, M. E., Papadopoulos, A. S., Poon, L., Perks, P., Lightman, S. L., Checkley, S. A., & Shanks, N. M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00009-4 · Cited by 91 · see citing works

Decreased expression of mineralocorticoid receptor mRNA in the prefrontal cortex in schizophrenia and bipolar disorder

Xing, G.-Q., Russell, S., Webster, M. J., & Post, R. M. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703004000 · Cited by 91 · see citing works

Antidepressant fluoxetine enhances glucocorticoid receptor function <i>in vitro</i> by modulating membrane steroid transporters

Pariante, C. M., Kim, R. B., Makoff, A., & Kerwin, R. W. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705357 · Cited by 89 · see citing works

ABCB1 (MDR1)-Type P-Glycoproteins at the Blood–Brain Barrier Modulate the Activity of the Hypothalamic–Pituitary–Adrenocortical System: Implications for Affective Disorder

Müller, M. B., Keck, M. E., Binder, E. B., Kresse, A. E., Hagemeyer, T. P., Landgraf, R., Holsboer, F., & Uhr, M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300257 · Cited by 86 · see citing works

Assessment of glucocorticoid receptor-heat shock protein 90 interactions in vivo during nucleocytoplasmic trafficking.

Yang, J., & DeFranco, D. B. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.1.8838140 · Cited by 86 · see citing works

Psychopharmacological Treatment of Depression, Anxiety, Irritability and Insomnia in Patients Receiving Interferon-α: a Prospective Case Series and a Discussion of Biological Mechanisms

Maddock, C., Baita, A., Orrù, M. G., Sitzia, R., Costa, A., Muntoni, E., Farci, M. G., Carpiniello, B., & Pariante, C. M. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104040230 · Cited by 85 · see citing works

Effects of glucocorticoids on declarative memory function in major depression

Bremner, J. D., Vythilingam, M., Vermetten, E. H. G. J. M., Anderson, G. M., Newcomer, J. W., & Charney, D. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.020 · Cited by 84 · see citing works

Dexamethasone augmentation in treatment‐resistant depression

Dinan, T. G., Lavelle, E., Cooney, J., Burnett, F., Scott, L. V., Dash, A. R., Thakore, J. H., & Berti, C. (1997) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1997.tb00374.x · Cited by 83 · see citing works

A novel prednisolone suppression test for the hypothalamic-pituitary-adrenal axis

Pariante, C. M., Papadopoulos, A. S., Poon, L., Checkley, S. A., English, J., Kerwin, R. W., & Lightman, S. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01314-2 · Cited by 74 · see citing works

Comparison of in vivo and in vitro glucocorticoid sensitivity in depression: Relationship to the dexamethasone suppression test

Lowy, M. T., Reder, A. T., Gormley, G. J., & Meltzer, H. Y. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90136-9 · Cited by 70 · see citing works

The Antidepressant Clomipramine Regulates Cortisol Intracellular Concentrations and Glucocorticoid Receptor Expression in Fibroblasts and Rat Primary Neurones

Pariante, C. M., Hye, A., Williamson, R., Makoff, A., Lovestone, S., & Kerwin, R. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300195 · Cited by 70 · see citing works

Squirrel Monkey Immunophilin FKBP51 Is a Potent Inhibitor of Glucocorticoid Receptor Binding¹

Denny, W. B., Valentine, D. L., Reynolds, P. D., Smith, D. F., & Scammell, J. G. (2000) · Endocrinology · doi:10.1210/en.141.11.4107 · Cited by 66 · see citing works

Potentiation of glucocorticoid receptor-mediated gene expression by heat and chemical shock.

Sánchez, E., Hu, J., Zhong, S., Shen, P., Greene, M. J., & Housley, P. R. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.4.8052262 · Cited by 66 · see citing works

Dexamethasone-induced effects on lymphocyte distribution and expression of adhesion molecules in treatment-resistant depression

Bauer, M. E., Papadopoulos, A., Poon, L., Perks, P., Lightman, S. L., Checkley, S., & Shanks, N. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00243-3 · Cited by 62 · see citing works

Involvement of multidrug resistance proteins (MDR) in the modulation of glucocorticoid response

Webster, J. I., & Carlstedt‐Duke, J. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00227-3 · Cited by 60 · see citing works

Interferon Alfa–Induced Adverse Effects in Patients with a Psychiatric Diagnosis

Pariante, C. M., Landau, S., & Carpiniello, B. (2002) · New England Journal of Medicine · doi:10.1056/nejm200207113470221 · Cited by 59 · see citing works

The Phosphodiesterase Type 4 Inhibitor, Rolipram, Enhances Glucocorticoid Receptor Function

Miller, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00381-0 · Cited by 57 · see citing works

Real‐time imaging of glucocorticoid receptor dynamics in living neurons and glial cells in comparison with non‐neural cells

Nishi, M., Takenaka, N., Morita, N., Ito, T., Ozawa, H., & Kawata, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00616.x · Cited by 56 · see citing works

Four days of citalopram increase suppression of cortisol secretion by prednisolone in healthy volunteers

Pariante, C. M., Papadopoulos, A. S., Poon, L., Cleare, A. J., Checkley, S. A., English, J., Kerwin, R. W., & Lightman, S. L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1925-4 · Cited by 51 · see citing works

Reserpine-Induced Decrease in Type I and II Corticosteroid Receptors in Neuronal and Lymphoid Tissues of Adrenalectomized Rats

Lowy, M. T. (2008) · Neuroendocrinology · doi:10.1159/000125336 · Cited by 49 · see citing works

The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation

Lauer, C. J., Schreiber, W., Modell, S., Holsboer, F., & Krieg, J. C. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00026-0 · Cited by 45 · see citing works

Human fibroblasts as a relevant model to study signal transduction in affective disorders

Manier, D. H., Shelton, R. C., Ellis, T. C., Peterson, C. S., Eiring, A. M., & Sulser, F. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00190-1 · Cited by 45 · see citing works

Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine

Merry, S. P., Hamilton, T. G., Flanigan, P., Freshney, R. I., & Kaye, S. B. (1991) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(91)90054-h · Cited by 43 · see citing works

Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia

Schlechte, J., & Sherman, B. M. (1985) · Psychoneuroendocrinology · doi:10.1016/0306-4530(85)90086-1 · Cited by 41 · see citing works

Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression

Wodarz, N., Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., Braner, H. U., & Riederer, P. F. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90070-9 · Cited by 40 · see citing works

The Proinflammatory Cytokine, Interleukin-1α, Reduces Glucocorticoid Receptor Translocation and Function¹

Pariante, C. M., Pearce, B. D., Pisell, T. L., Sanchez, C. I., Po, C., Su, C., & Miller, A. H. (1999) · Endocrinology · doi:10.1210/en.140.9.4359 · Cited by 40 · see citing works

Plasma sialyltransferase levels in psychiatric disorders as a possible indicator of HPA axis function

Maguire, T. M., Thakore, J. H., Dinan, T. G., Hopwood, S., & Breen, K. C. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00223-5 · Cited by 38 · see citing works

Disturbed glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressives pretreated with metyrapone

Rupprecht, R., Kornhuber, J., Wodarz, N., Lugauer, J., Göbel, C., Haack, D., Beck, G., Müller, O. A., Riederer, P. F., & Beckmann, H. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90252-h · Cited by 37 · see citing works

Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder

Wodarz, N., Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., & Riederer, P. F. (1992) · Journal of Affective Disorders · doi:10.1016/0165-0327(92)90090-s · Cited by 30 · see citing works

Relationship between dexamethasone-inhibited lysozyme activity in peripheral mononuclear leukocytes and the cortisol and glucocorticoid receptor response to dexamethasone

Yehuda, R., Yang, R.-K., Guo, S. L., Makotkine, I., & Singh, B. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00073-6 · Cited by 29 · see citing works

Mononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression

Wassef, A. A. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90047-d · Cited by 23 · see citing works

Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD).

Sallee, F. R., Nesbitt, L., Dougherty, D. D., Hilal, R. E., Vrindavanam, N. S., & Sethuraman, G. (1995) · PubMed · Cited by 20 · see citing works

In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Rupprecht, R., Wodarz, N., Kornhuber, J., Wild, K., Schmitz, B., Braner, H. U., Müller, O. A., Riederer, P. F., & Beckmann, H. (1991) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02193752 · Cited by 16 · see citing works

Lymphocyte glucocorticoid receptor binding in depression: normal values following recovery

Hunter, R. (1988) · Journal of Affective Disorders · doi:10.1016/0165-0327(88)90058-4 · Cited by 16 · see citing works

Vasoconstrictor response to topical beclomethasone in major depression

Cotter, P. A., Mulligan, O. F., Landau, S., Papadopoulos, A. S., Lightman, S. L., & Checkley, S. A. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00065-8 · Cited by 15 · see citing works

Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery

Rupprecht, R., Kornhuber, J., Wodarz, N., Lugauer, J., Göbel, C., Riederer, P. F., & Beckmann, H. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90080-c · Cited by 14 · see citing works

Glucocorticoid receptor binding in three different cell types in major depressive disorder: Lack of evidence op receptor binding defect

Wassef, A. A., O'Boyle, M., Gardner, R., Rose, R. M., Brown, A., Harris, A., Nguyen, H. H., & Meyer, W. J. (1992) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(92)90009-4 · Cited by 12 · see citing works

Preservation of hypothalamic‐pituitary‐adrenal axis fast‐feedback responses in depression

Cooney, J. M., & Dinan, T. G. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09889.x · Cited by 8 · see citing works

Beclomethasone-induced vasoconstriction in women with major depressive disorder

Coupland, N. J., Hegadoren, K., & Myrholm, J. (2003) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0344 · Cited by 4 · see citing works

Salivary cortisol as a biomarker in stress research

Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925 · see citing works

The link between childhood trauma and depression: insights from HPA axis studies in humans

Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works

The human stress response

Russell, G., & Lightman, S. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0228-0 · Cited by 1,032 · see citing works

Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior

Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works

Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression

Pace, T. W. W., Hu, F., & Miller, A. H. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.08.009 · Cited by 621 · see citing works

The neuroprogressive nature of major depressive disorder: pathways to disease evolution and resistance, and therapeutic implications

Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.33 · Cited by 529 · see citing works

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030148 · Cited by 486 · see citing works

Neural control of chronic stress adaptation

Herman, J. P. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00061 · Cited by 384 · see citing works

Immune suppression and immune activation in depression

Blume, J., Douglas, S. D., & Evans, D. L. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.008 · Cited by 338 · see citing works

Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability

de Punder, K., & Pruimboom, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00223 · Cited by 321 · see citing works

Approaching the shared biology of obesity and depression: the stress axis as the locus of gene–environment interactions

Bornstein, S. R., Schuppenies, A., Wong, M., & Licinio, J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001873 · Cited by 267 · see citing works

Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies

Loftis, J. M., Huckans, M. S., & Morasco, B. J. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.015 · Cited by 252 · see citing works

Origin of ultradian pulsatility in the hypothalamic–pituitary–adrenal axis

Walker, J. J., Terry, J. R., & Lightman, S. L. (2010) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.2148 · Cited by 239 · see citing works

Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force.

Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian &amp; New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234 · see citing works

Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study

Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., & Brunello, N. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00005 · Cited by 229 · see citing works

A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks

Karin, O., Raz, M., Tendler, A., Bar, A., Korem Kohanim, Y., Milo, T., & Alon, U. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209510 · Cited by 200 · see citing works

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

Alboni, S., van Dijk, R. M., Poggini, S., Milior, G., Perrotta, M., Drenth, T., Brunello, N., Wolfer, D. P., Limatola, C., Amrein, I., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2015.142 · Cited by 207 · see citing works

The glucocorticoid receptor: part of the solution or part of the problem?

Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192 · see citing works

Risk Factors for Development of Depression and Psychosis

Pariante, C. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04978.x · Cited by 181 · see citing works

Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics

Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158 · see citing works

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 177 · see citing works

Different responses to dexamethasone and prednisolone in the same depressed patients

Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, C. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0555-4 · Cited by 147 · see citing works

Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder

Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.003 · Cited by 150 · see citing works

Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link?

Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.021 · Cited by 139 · see citing works

Acute and chronic stress induced changes in sensitivity of peripheral inflammatory pathways to the signals of multiple stress systems – 2011 Curt Richter Award Winner

Rohleder, N. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.015 · Cited by 136 · see citing works

The HPA Axis as Target for Depression

Menke, A. (2024) · Current Neuropharmacology · doi:10.2174/1570159x21666230811141557 · Cited by 131 · see citing works

The putative neurodegenerative links between depression and Alzheimer's disease

Wuwongse, S., Chang, R. C., & Law, A. C. K. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.005 · Cited by 124 · see citing works

Intranasal Immune Challenge Induces Sex-Dependent Depressive-Like Behavior and Cytokine Expression in the Brain

Tonelli, L. H., Holmes, A., & Postolache, T. T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301488 · Cited by 124 · see citing works

Successful Antidepressant Therapy Restores the Disturbed Interplay Between TNF-α System and HPA Axis

Himmerich, H., Binder, E. B., Kunzel, H. E., Schuld, A., Lucae, S., Uhr, M., Pollmächer, T., Holsboer, F., & Ising, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.075 · Cited by 120 · see citing works

Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder

de Kloet, C. S., Vermetten, E., Bikker, A., Meulman, E., Geuze, E., Kavelaars, A., Westenberg, H. G. M., & Heijnen, C. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001934 · Cited by 98 · see citing works

Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depression

Gold, S. M., Kruger, S., Ziegler, K. J., Krieger, T., Schulz, K., Otte, C., & Heesen, C. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.230029 · Cited by 98 · see citing works

The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors

Kumar, G., Couper, A., O'Brien, T. J., Salzberg, M. R., Jones, N. C., Rees, S. M., & Morris, M. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.05.011 · Cited by 95 · see citing works

Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring

Martinez, E. J., Kolb, B., Bell, A., Savage, D. D., & Allan, A. M. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.05.004 · Cited by 94 · see citing works

Depression and Alzheimer's Disease: Is Stress the Initiating Factor in a Common Neuropathological Cascade?

Aznar, S., & Knudsen, G. M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100390 · Cited by 93 · see citing works

Role of Inflammation in Depression: Implications for Phenomenology, Pathophysiology and Treatment

Raison, C. L., & Miller, A. H. (2013) · Modern Trends in Psychiatry · doi:10.1159/000343966 · Cited by 88 · see citing works

Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice

Alboni, S., Tascedda, F., Corsini, D., Benatti, C., Caggia, F., Capone, G., Barden, N., Blom, J. M. C., & Brunello, N. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.050 · Cited by 86 · see citing works

Glucocorticoid Receptor Polymorphisms in Major Depression

Claes, S. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05012.x · Cited by 83 · see citing works

Elevated Macrophage Migration Inhibitory Factor (MIF) is associated with depressive symptoms, blunted cortisol reactivity to acute stress, and lowered morning cortisol

Edwards, K. M., Bosch, J. A., Engeland, C. G., Cacioppo, J. T., & Marucha, P. T. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.03.011 · Cited by 76 · see citing works

In search of the HPA axis activity in unipolar depression patients with childhood trauma: combined cortisol awakening response and dexamethasone suppression test

Lu, S., Gao, W., Huang, M., Li, L., & Xu, Y. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.009 · Cited by 75 · see citing works

Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression

Carvalho, L. A., Juruena, M. F., Papadopoulos, A. S., Poon, L., Kerwin, R., Cleare, A. J., & Pariante, C. M. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.44 · Cited by 75 · see citing works

The neurobiology of suicide - A Review of post-mortem studies

Furczyk, K., Schutová, B., Michel, T. M., Thome, J., & Büttner, A. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-2 · Cited by 78 · see citing works

FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls

Hohne, N., Poidinger, M., Merz, F., Pfister, H., Bruckl, T., Zimmermann, P., Uhr, M., Holsboer, F., & Ising, M. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu087 · Cited by 74 · see citing works

Zebrafish models of major depressive disorders

Fonseka, T. M., Wen, X., Foster, J. A., & Kennedy, S. H. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23639 · Cited by 72 · see citing works

Glucocorticoid resistance syndrome: a diagnostic and therapeutic approach

van Rossum, E. F. C., & Lamberts, S. W. J. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.09.005 · Cited by 69 · see citing works

Hormones, Stress, and Cognition: The Effects of Glucocorticoids and Oxytocin on Memory

Wirth, M. M. (2014) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-014-0010-4 · Cited by 72 · see citing works

Nod-like receptors are critical for gut-brain axis signalling in mice

Pusceddu, M. M., Barboza, M., Keogh, C. E., Schneider, M., Stokes, P., Sladek, J. A., Kim, H. J. D., Torres‐Fuentes, C., Goldfild, L. R., Gillis, S. E., et al. (2019) · The Journal of Physiology · doi:10.1113/jp278640 · Cited by 69 · see citing works

How to measure glucocorticoid receptor’s sensitivity in patients with stress-related psychiatric disorders

Leistner, C., & Menke, A. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.023 · Cited by 69 · see citing works

Hypothalamic‐Pituitary‐Adrenal Axis Abnormalities in Response to Deletion of 11β‐HSD1 is Strain‐Dependent

Carter, R. N., Paterson, J. M., Tworowska, U., Stenvers, D. J., Mullins, J. J., Seckl, J. R., & Holmes, M. C. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01899.x · Cited by 68 · see citing works

In vitromodulation of the glucocorticoid receptor by antidepressants

de Carvalho, L. A., & Pariante, C. M. (2008) · Stress · doi:10.1080/10253890701850759 · Cited by 68 · see citing works

Are there meaningful biomarkers of treatment response for depression?

Breitenstein, B., Scheuer, S., & Holsboer, F. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.02.002 · Cited by 69 · see citing works

Altered functioning of the HPA axis in depressed postpartum women

de Rezende, M. G., Garcia-Leal, C., de Figueiredo, F. P., Cavalli, R. D. C., Schaufelberger, M. S., Barbieri, M. A., Bettiol, H., de Castro, M., & Del‐Ben, C. M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.065 · Cited by 65 · see citing works

Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy

Liu, X., Zhou, Y., Li, Z., Cui, J., Li, Z., Gao, X., Sun, H., Zhang, L., Du, G., & Qin, X. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01412.x · Cited by 62 · see citing works

The role of multi-drug resistance p-glycoprotein in glucocorticoid function: Studies in animals and relevance in humans

Pariante, C. M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.067 · Cited by 58 · see citing works

Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy

Katz, E. R., Stowe, Z. N., Newport, D. J., Kelley, M. E., Pace, T. W. W., Cubells, J. F., & Binder, E. B. (2011) · Psychological Medicine · doi:10.1017/s0033291711002121 · Cited by 58 · see citing works

Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice

Wu, J., Du, J., Xu, C., Le, J., Xu, Y., Liu, B., & Dong, J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.01.008 · Cited by 57 · see citing works

Antidepressants, but not antipsychotics, modulate GR function in human whole blood: An insight into molecular mechanisms

de Carvalho, L. A., Garner, B., Dew, T. K., Fazakerley, H., & Pariante, C. M. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.006 · Cited by 56 · see citing works

Receptor regulation in neuroendocrine–immune communication: Current knowledge and future perspectives

Heijnen, C. J. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.08.008 · Cited by 55 · see citing works

Protection of stress-induced impairment of hippocampal/prefrontal LTP through blockade of glucocorticoid receptors

Mailliet, F., Qi, H., Rocher, C., Spedding, M., Svenningsson, P., & Jay, T. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.02.030 · Cited by 55 · see citing works

Effect of the Glucocorticoid Receptor Antagonist Org 34850 on Basal and Stress‐Induced Corticosterone Secretion

Spiga, F., Harrison, L. R., Wood, S. A., Atkinson, H. C., MacSweeney, C. P., Thomson, F., Craighead, M., Grassie, M., & Lightman, S. L. (2007) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2007.01605.x · Cited by 53 · see citing works

ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clinical response to citalopram in a Turkish population

Özbey, G., Yucel, B., Taycan, S. E., Kan, D., Bodur, N. E., Arslan, T., Perçin, E. F., Yüksel, N., Güzey, C., & Uluoğlu, C. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2013.09.004 · Cited by 53 · see citing works

Neuroimmune endocrine effects of antidepressants

de Carvalho, L. A. (2012) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s16409 · Cited by 52 · see citing works

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance

Kumsta, R., Moser, D., Streit, F., Koper, J. W., Meyer, J., & Wüst, S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30837 · Cited by 52 · see citing works

Relevance of Rodent Models of Depression in Clinical Practice: Can We Overcome the Obstacles in Translational Neuropsychiatry?

Söderlund, J., & Lindskog, M. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy037 · Cited by 50 · see citing works

Pro-inflammatory Monocyte Phenotype and Cell-Specific Steroid Signaling Alterations in Unmedicated Patients With Major Depressive Disorder

Hasselmann, H., Gamradt, S., Taenzer, A., Nowacki, J., Zain, R., Patas, K., Ramien, C., Paul, F., Wingenfeld, K., Piber, D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02693 · Cited by 50 · see citing works

Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic‐pituitary‐adrenal axis and immune system

Duffy, A. C., Lewitzka, U., Doucette, S., Andreazza, A. C., & Grof, P. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00323.x · Cited by 47 · see citing works

Mifepristone (RU-486) treatment for depression and psychosis: a review of the therapeutic implications

Gallagher, P., & Young, A. H. (2006) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a811 · Cited by 47 · see citing works

The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice

Yau, J. L. W., Noble, J., Thomas, S., Kerwin, R., Morgan, P. E., Lightman, S., Seckl, J. R., & Pariante, C. M. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301389 · Cited by 46 · see citing works

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

Mellon, S. H., Wolkowitz, O. M., Schonemann, M. D., Epel, E. S., Rosser, R., Burke, H. B., Mahan, L., Reus, V. I., Stamatiou, D., Liew, C. C., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.79 · Cited by 45 · see citing works

Abnormalities of the HPA axis in affective disorders: clinical subtypes and potential treatments

Porter, R., & Gallagher, P. (2006) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2006.00152.x · Cited by 45 · see citing works

Insulin Resistance and Depressive Symptoms in Young Adult Males: Findings From Finnish Military Conscripts

Timonen, M., Salmenkaita, I., Jokelainen, J. J., Laakso, M., Härkönen, P. K., Koskela, P. U., Meyer‐Rochow, V. B., Peitso, A., & Keinanen-Kiukaanniemi, S. M. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318157ad2e · Cited by 45 · see citing works

Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT5 activation in mouse HT22 cells

Hu, F., Pace, T. W. W., & Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.01.001 · Cited by 42 · see citing works

Mood and metabolic consequences of sleep deprivation as a potential endophenotype’ in bipolar disorder

Aydin, A., Selvi, Y., Besiroglu, L., Boysan, M., Atli, A., Ozdemir, O., Kilic, S., & Balaharoglu, R. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.04.007 · Cited by 40 · see citing works

Mechanistic insights into corticosteroids in multiple sclerosis: War horse or chameleon?☆

Krieger, S. C., Sorrells, S. F., Nickerson, M., & Pace, T. W. W. (2014) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2013.12.021 · Cited by 40 · see citing works

Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes

Kumsta, R., Entringer, S., Koper, J. W., van Rossum, E. F. C., Hellhammer, D. H., & Wüst, S. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.04.007 · Cited by 40 · see citing works

Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour

Hageman, I., Nielsen, M., Wörtwein, G., Diemer, N. H., & Jørgensen, M. B. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.07.037 · Cited by 39 · see citing works

Changes in the Hypothalamic-Pituitary-Adrenal Axis and Leptin Levels during Antidepressant Treatment

Himmerich, H., Zimmermann, P., Ising, M., Kloiber, S. M., Lucae, S., Kunzel, H. E., Binder, E. B., Holsboer, F., & Uhr, M. (2007) · Neuropsychobiology · doi:10.1159/000103573 · Cited by 39 · see citing works

Phosphorylation status of glucocorticoid receptor, heat shock protein 70, cytochrome c and Bax in lymphocytes of euthymic, depressed and manic bipolar patients

Bei, E., Salpeas, V., Pappa, D., Anagnostara, C., Alevizos, V., & Moutsatsou, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.002 · Cited by 35 · see citing works

Chronic blockade of glucocorticoid receptors by RU486 enhances lipopolysaccharide-induced depressive-like behaviour and cytokine production in rats

Wang, D., Lin, W., Pan, Y., KUANG, X.-Y., Qi, X., & Sun, H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.01.011 · Cited by 33 · see citing works

Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder

Spíndola, L., Pan, P. M., Moretti, P. N. S., Ota, V., Santoro, M. L., Cogo‐Moreira, H., Gadelha, A., Salum, G. A., Manfro, G. G., Mari, J. D. J., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.015 · Cited by 31 · see citing works

Early-Life Adversity Interacts with FKBP5 Genotypes: Altered Working Memory and Cardiac Stress Reactivity in the Oklahoma Family Health Patterns Project

Lovallo, W. R., Enoch, M., Acheson, A., Cohoon, A. J., Sorocco, K. H., Hodgkinson, C. A., Vincent, A. S., & Goldman, D. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.347 · Cited by 31 · see citing works

Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients

Watanuki, T., Funato, H., Uchida, S., Matsubara, T., Kobayashi, A., Wakabayashi, Y., Otsuki, K., Nishida, A., & Watanabe, Y. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.01.003 · Cited by 31 · see citing works

IFN-γ Reduction by Tricyclic Antidepressants

Himmerich, H., Fulda, S., Sheldrick, A. J., Plümäkers, B., & Rink, L. (2010) · The International Journal of Psychiatry in Medicine · doi:10.2190/pm.40.4.e · Cited by 29 · see citing works

Resveratrol and quercetin attenuate depressive-like behavior and restore impaired contractility of vas deferens in chronic stress-exposed rats: involvement of oxidative stress and inflammation

ŞAHİN, T. D., Göçmez, S. S., Duruksu, G., Yazır, Y., & Utkan, T. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01781-5 · Cited by 27 · see citing works

An integrated approach to infer causal associations among gene expression, genotype variation, and disease

Lee, E., Cho, S., Kim, K., & Park, T. (2009) · Genomics · doi:10.1016/j.ygeno.2009.06.002 · Cited by 26 · see citing works

Pedicularis resupinata Extract Prevents Depressive-like Behavior in Repeated Corticosterone-Induced Depression in Mice: A Preliminary Study

Lim, D. W., Han, D., & Lee, C.-H. (2022) · Molecules · doi:10.3390/molecules27113434 · Cited by 26 · see citing works

Ex vivo stimulation of whole blood as a means to determine glucocorticoid sensitivity

Marketon, J. I. W., Burnsides, Corry, J., -, A., Bálint, Cosmar, & Philips (2012) · Journal of Inflammation Research · doi:10.2147/jir.s33569 · Cited by 26 · see citing works

Correlations between changes in the hypothalamic-pituitary-adrenal axis and neurochemistry of the anterior cingulate gyrus in postpartum depression

de Rezende, M. G., Rosa, C. E., Garcia-Leal, C., de Figueiredo, F. P., Cavalli, R. D. C., Bettiol, H., Salmón, C. E. G., Barbieri, M. A., de Castro, M., dos Santos, A. C., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.028 · Cited by 25 · see citing works

Corticotropin‐releasing hormone neurons in hypertensive patients are activated in the hypothalamus but not in the brainstem

Goncharuk, V. D., Buijs, R. M., & Swaab, D. F. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21387 · Cited by 23 · see citing works

Gender differences of acute and chronic administration of dehydroepiandrosterone in rats submitted to the forced swimming test

Andrade, S., Silveira, S. L., Gomez, R., Barros, H. M. T., & Ribeiro, M. F. M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.006 · Cited by 23 · see citing works

Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding

Spiga, F., Knight, D. M., Droste, S. K., Conway-Campbell, B. L., Kershaw, Y. M., MacSweeney, C. P., THOMSON, F. J., Craighead, M. W., Peeters, B. W. M. M., & Lightman, S. L. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109348175 · Cited by 23 · see citing works

Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells

Bernal-Sore, I., Navarro-Márquez, M., Osorio‐Fuentealba, C., Díaz‐Castro, F., del Campo, A., Donoso-Barraza, C., Porras, O. H., Lavandero, S., & Troncoso, R. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.028 · Cited by 23 · see citing works

Cognitive and locomotor/exploratory behavior after chronic exercise in the olfactory bulbectomy animal model of depression

Hoomissen, J. D. V., Kunrath, J., Dentlinger, R. B., Lafrenz, A. J., Krause, M. A., & Azar, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.017 · Cited by 21 · see citing works

Differential Effects of Inflammatory and Psychosocial Stress on Mood, Hypothalamic-Pituitary-Adrenal Axis, and Inflammation in Remitted Depression

Niemegeers, P., Boer, P. D., Dumont, G., Eede, F. V. D., Fransén, E., Claes, S. J., Morrens, M., & Sabbe, B. (2016) · Neuropsychobiology · doi:10.1159/000466698 · Cited by 21 · see citing works

Phenytoin: an anti-bipolar anticonvulsant?

Bersudsky, Y. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705006140 · Cited by 21 · see citing works

Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients

Akiyoshi, J., Tanaka, Y., Ishitobi, Y., Maruyama, Y., Kawano, A., Ando, T., Inoue, A., Imanaga, J., Okamoto, S., Kanehisa, M., et al. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s48722 · Cited by 21 · see citing works

Antiglucocorticoids, Neurogenesis and Depression

Fitzsimons, C. P., van Hooijdonk, L. W. A., Morrow, J. A., Peeters, B. W. M. M., Hamilton, N. M., Craighead, M. W., & Vreugdenhil, E. (2009) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955709787316001 · Cited by 19 · see citing works

Clinical Pharmacology and Therapeutics of Antidepressants

Ciraulo, D. A., Tsirulnik-Barts, L., Shader, R. I., & Greenblatt, D. J. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-792-5_2 · Cited by 20 · see citing works

Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen

Bekhbat, M., Ulukaya, G. B., Bhasin, M., Felger, J. C., & Miller, A. H. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100462 · Cited by 21 · see citing works

Saliva Estriol Levels in Women with and Without Prenatal Antidepressant Treatment

Suri, R., Hellemann, G., Cohen, L. S., Aquino, A., & Altshuler, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.015 · Cited by 19 · see citing works

Estradiol stimulates an anti-translocation expression pattern of glucocorticoid co-regulators in a hippocampal cell model

Malviya, S. A., Kelly, S. D., Greenlee, M. M., Eaton, D. C., Duke, B. J., Bourke, C. H., & Neigh, G. N. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.03.018 · Cited by 17 · see citing works

In vitromodulation of the glucocorticoid receptor by antidepressants

de Carvalho, L. A., & Pariante, C. M. (2008) · Stress · doi:10.1080/10253890701850759 · Cited by 68 · see citing works

The glucocorticoid receptor: part of the solution or part of the problem?

Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192 · see citing works

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works

The hypothalamic pituitary adrenal axis, glucocorticoid receptor function and relevance to depression. [Portuguese]

Juruena, M. F., Cleare, A. J., & Pariante, C. M. (2004) · Research Portal (King's College London)

Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders

Juruena, M. F., Cleare, A. J., Bauer, M. E., & Pariante, C. M. (2003) · Acta Neuropsychiatrica · doi:10.1046/j.1601-5215.2003.00051.x · Cited by 59 · see citing works