Cited by 106Stress Responses and CortisolAdrenal Hormones and DisordersEstrogen and related hormone effects

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Hypothalamic–pituitary–adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function: Review

Open access

Kolber, Benedict J., Wieczorek, Lindsay, Muglia, Louis J.·2008·Stress

DOI 10.1080/10253890701821081PMC PMC2744095

Open this paper in CoChat — free account Open PDF

Abstract

Corticosteroid receptors are critical for the maintenance of homeostasis after both psychological and physiological stress. To understand the different roles and interactions of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) during stress, it is necessary to dissect the role of corticosteroid signaling at both the system and sub-system level. A variety of GR transgenic mouse lines have recently been used to characterize the role of GR in the CNS as a whole and particularly in the forebrain. We will describe both the behavioral and cellular/molecular implications of disrupting GR function in these animal models and describe the implications of this data for our understanding of normal endocrine function and stress adaptation. MRs in tight epithelia have a long established role in sodium homeostasis. Recently however, evidence has suggested that MRs in the limbic brain also play an important role in psychological stress. Just as with GR, targeted mutations in MR induce a variety of behavioral changes associated with stress adaptation. In this review, we will discuss the implications of this work on MR. Finally, we will discuss the possible interaction between MR and GR and how future work using double mutants (through conventional means or virus based gene alteration) will be needed to more fully understand how signaling through these two steroid receptors provides the adaptive mechanisms to deal with a variety of stressors.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/10253890701821081

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor
Arriza, J. L., Weinberger, C., Cerelli, G., Glaser, T. M., Handelin, B. L., Housman, D. E., & Evans, R. M. (1987) · Science · doi:10.1126/science.3037703 · Cited by 1,946
Primary structure and expression of a functional human glucocorticoid receptor cDNA
Hollenberg, S. M., Weinberger, C., Ong, E. S., Cerelli, G., Oro, A. E., Lebo, R. V., Thompson, E. B., Rosenfeld, M. G., & Evans, R. M. (1985) · Nature · doi:10.1038/318635a0 · Cited by 1,882
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety
Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841
Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated
Funder, J. W., Pearce, P. T., Smith, R., & Smith, A. I. (1988) · Science · doi:10.1126/science.2845584 · Cited by 1,628
Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction
Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
DNA binding of the glucocorticoid receptor is not essential for survival
Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068
Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
Cameron, H. A., & Gould, E. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90224-0 · Cited by 999
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
Cole, T. J., Blendy, J. A., Monaghan, A. P., Krieglstein, K., Schmid, W., Aguzzi, A., Fantuzzi, G., Hummler, E., Unsicker, K., & Schütz, G. (1995) · Genes & Development · doi:10.1101/gad.9.13.1608 · Cited by 946
Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load
McEwen, B. S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05830.x · Cited by 896
Functional interactions between Stat5 and the glucocorticoid receptor
Stöcklin, E., Wissler, M., Gouilleux, F., & Groner, B. (1996) · Nature · doi:10.1038/383726a0 · Cited by 675
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667
Animal models of social stress: Effects on behavior and brain neurochemical systems
Blanchard, R. J., McKittrick, C. R., & Blanchard, D. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00449-8 · Cited by 595
Feedback action and tonic influence of corticosteroids on brain function: A concept arising from the heterogeneity of brain receptor systems
de Kloet, E. R., & Reul, J. M. H. M. (1987) · Psychoneuroendocrinology · doi:10.1016/0306-4530(87)90040-0 · Cited by 595
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · cited 1×
“Compared with healthy individuals, depressed patients often have elevated levels of plasma cortisol (Carpenter and Bunney 1971; Brown et al. 2004), enlarged adrenal glands (Nemeroff et al. 1992), increased PVN CRH content (Raadsheer et al. 1994; Blanchard et al. 2001) and impaired feedback…”
Background
Untitled work
(2004) · PubMed · Cited by 567
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP‐1.
Heck, S., Kullmann, M. K., Gast, A., Ponta, H., Rahmsdorf, H. J., Herrlich, P. A., & Cato, A. C. B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06726.x · Cited by 516
On the Role of Brain Mineralocorticoid (Type I) and Glucocorticoid (Type II) Receptors in Neuroendocrine Regulation
Ratka, A., Sutanto, W., Bloemers, M., & de Kloet, E. R. (2008) · Neuroendocrinology · doi:10.1159/000125210 · Cited by 476
Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: an immunohistochemical and in situ hybridization study
Morimoto, M., Morita, N., Ozawa, H., Yokoyama, K., & Kawata, M. (1996) · Neuroscience Research · doi:10.1016/s0168-0102(96)01105-4 · Cited by 475
The stress cascade and schizophrenia: Etiology and onset
Corcoran, C., Walker, E., Huot, R., Mittal, V., Tessner, K., Kestler, L., & Malaspina, D. (2003) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a007038 · Cited by 439
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor
Reichardt, H. M., Tuckermann, J. P., Göttlicher, M., Vujic, M., Weih, F., Angel, P., Herrlich, P., & Schütz, G. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7168 · Cited by 429
Mineralocorticoid receptor knockout mice: Pathophysiology of Na + metabolism
Berger, S., Bleich, M., Schmid, W., Cole, T. J., Peters, J., Watanabe, H., Kriz, W., Warth, R., Greger, R. F., & Schütz, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9424 · Cited by 426
Rapid Glucocorticoid Signaling via Membrane-Associated Receptors
Tasker, J. G., Di, S., & Malcher‐Lopes, R. (2006) · Endocrinology · doi:10.1210/en.2006-0981 · Cited by 401
PREVENTION OF ECZEMA
Matthew, D. J., Norman, A., Taylor, B., Turnef, M. W., & Soothili, J. F. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91131-x · Cited by 390
Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions
Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M., Hörtnagl, H., Flor, H., Henn, F. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0736-05.2005 · Cited by 382
Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · cited 6×
“To more precisely define the role of GR in the CNS, some research groups have produced pan-neural GR knockout (GRNesCre; Tronche et al. 1999) and forebrain-specific GR knockout (FBGRKO; Boyle et al. 2005) lines.”
BackgroundMethodInfluential
Corticotropin-releasing hormone receptor subtypes and emotion
Steckler, T., & Holsboer, F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00170-5 · Cited by 323
Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior
Shepard, J. D., Barron, K. W., & Myers, D. A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02019-9 · Cited by 321
Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
Pépin, M.-C., Pothier, F., & Barden, N. (1992) · Nature · doi:10.1038/355725a0 · Cited by 319
Amygdaloid Nuclei Lesions Differentially Affect Glucocorticoid-Induced Memory Enhancement in an Inhibitory Avoidance Task
Roozendaal, B., & McGaugh, J. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0001 · Cited by 317
Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus
Eekelen, J. A. M. V., Jiang, W., de Kloet, E. R., & Bohn, M. C. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210113 · Cited by 316
Repeated dexamethasone suppression test during depressive illness
Holsboer, F., Liebl, R., & Hofschuster, E. (1982) · Journal of Affective Disorders · doi:10.1016/0165-0327(82)90039-8 · Cited by 301
Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory
Oitzl, M. S., Reichardt, H. M., Joëls, M., & de Kloet, E. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231313998 · Cited by 286
Adrenal Gland Enlargement in Major Depression: A Computed Tomographic Study
Nemeroff, C. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820050048008 · Cited by 283
Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity
Berger, S., Wolfer, D. P., Selbach, O., Alter, H., Erdmann, G., Reichardt, H. M., Chepkova, A. N., Welzl, H., Haas, H. L., Lipp, H.-P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503878102 · Cited by 272
Psychiatric Disorders Associated with Cushing??s Syndrome
Sonino, N., & Fava, G. A. (2001) · CNS Drugs · doi:10.2165/00023210-200115050-00003 · Cited by 267
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Q., Lu, X., Liu, L., Schafer, G. L., Shieh, K.-R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F., & Akil, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402208101 · Cited by 260
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
Revest, J., Blasi, F. D., Kitchener, P., Rougé‐Pont, F., Desmedt, A., Turiault, M., Tronche, F., & Piazza, P. V. (2005) · Nature Neuroscience · doi:10.1038/nn1441 · Cited by 243
11β-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action?
Seckl, J. R. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1996.0143 · Cited by 213
Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice
Rozeboom, A. M., Akil, H., & Seasholtz, A. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606067104 · Cited by 206
Stress in the brain
de Kloet, E. R. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00552-5 · Cited by 206
Mice with an Increased Glucocorticoid Receptor Gene Dosage Show Enhanced Resistance to Stress and Endotoxic Shock
Reichardt, H. M., Umland, T., Bauer, A., Kretz, O., & Schütz, G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.9009-9017.2000 · Cited by 206
The Pulsatile Characteristics of Hypothalamo-Pituitary-Adrenal Activity in Female Lewis and Fischer 344 Rats and Its Relationship to Differential Stress Responses*
Windle, R. J., Wood, S. A., Lightman, S. L., & Ingram, C. D. (1998) · Endocrinology · doi:10.1210/endo.139.10.6238 · Cited by 201 · cited 2×
“In addition, the circadian pattern exhibits smaller pulses during the circadian trough and higher pulses during the circadian peak (Carnes et al. 1989; Windle et al. 1998).”
Background
Exacerbation of Apoptosis in the Dentate Gyrus of the Aged Rat by Dexamethasone and the Protective Role of Corticosterone
Hassan, A. H., von Rosenstiel, P., Patchev, V. K., Holsboer, F., & Almeida, O. F. X. (1996) · Experimental Neurology · doi:10.1006/exnr.1996.0113 · Cited by 176
Long‐Term Antidepressant Treatment Reduces Behavioural Deficits in Transgenic Mice with Impaired Glucocorticoid Receptor Function
Montkowski, A., Barden, N., Wotjak, C. T., Stec, I. S. M., Ganster, J., Meaney, M. J., Engelmann, M., Reul, J. M. H. M., Landgraf, R., & Holsboer, F. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00724.x · Cited by 174
Forebrain Glucocorticoid Receptors Modulate Anxiety-Associated Locomotor Activation and Adrenal Responsiveness
Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2173-05.2006 · Cited by 172
Adrenal Cortical Activity in Depressive Illness
CARPENTER, W. T., & BUNNEY, W. E. (1971) · American Journal of Psychiatry · doi:10.1176/ajp.128.1.31 · Cited by 166
Facilitation of Feedback Inhibition Through Blockade of Glucocorticoid Receptors in the Hippocampus
van Haarst, A. D., Oitzl, M. S., & de Kloet, E. R. (1997) · Neurochemical Research · doi:10.1023/a:1022010904600 · Cited by 163
Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice
Gass, P., Kretz, O., Wolfer, D. P., Berger, S., Tronche, F., Reichardt, H. M., Kellendonk, C., Lipp, H., Schmid, W., & Schütz, G. (2000) · EMBO Reports · doi:10.1093/embo-reports/kvd088 · Cited by 159
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
Brewer, J. A., Khor, B., Vogt, S. K., Muglia, L. M., Fujiwara, H., Haegele, K. E., Sleckman, B. P., & Muglia, L. J. (2003) · Nature Medicine · doi:10.1038/nm895 · Cited by 149
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia
Lai, M., Horsburgh, K. J., Bae, S., Carter, R. N., Stenvers, D. J., Fowler, J. H., Yau, J. L. W., Gómez-Sánchez, C. E., Holmes, M. C., Kenyon, C. J., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05427.x · Cited by 147
Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor‐dependent behavioural response
Bilang‐Bleuel, A., Ulbricht, S., Chandramohan, Y., Carli, S. D., Droste, S. K., & Reul, J. M. H. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04358.x · Cited by 128
Spatial Learning Deficits in Mice with a Targeted Glucocorticoid Receptor Gene Disruption
Oitzl, M. S., de Kloet, E. R., Joëls, M., Schmid, W., & Cole, T. J. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01646.x · Cited by 122
Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?
Gass, P., Reichardt, H. M., Strekalova, T. V., Henn, F. A., & Tronche, F. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00518-2 · Cited by 121
Novelty stress induces phospho‐acetylation of histone H3 in rat dentate gyrus granule neurons through coincident signalling via the N‐methyl‐d‐aspartate receptor and the glucocorticoid receptor: relevance for c‐fos induction
Chandramohan, Y., Droste, S. K., & Reul, J. M. H. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04396.x · Cited by 117
Homodimerization of the Glucocorticoid Receptor Is Not Essential for Response Element Binding: Activation of the Phenylethanolamine N-Methyltransferase Gene by Dimerization-Defective Mutants
Adams, M., Meijer, O. C., Wang, J., Bhargava, A., & Pearce, D. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0305 · Cited by 113
Contrasting Roles of Corticosteroid Receptors in Hippocampal Plasticity
Avital, A., Segal, M., & Richter‐Levin, G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1628-06.2006 · Cited by 109
GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant.
Cole, T. J., Myles, K., Purton, J. F., Brereton, P., Solomon, N., Godfrey, D., & Funder, J. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00407-x · Cited by 105
Rescue of the mineralocorticoid receptor knock-out mouse
Bleich, M., Warth, R., Schmidt‐Hieber, M., Schulz‐Baldes, A., Hasselblatt, P., Fisch, D., Berger, S., Kunzelmann, K., Kriz, W., Schütz, G., et al. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050906 · Cited by 104
Endocrine Profile and Neuroendocrine Challenge Tests in Transgenic Mice Expressing Antisense RNA against the Glucocorticoid Receptor
Barden, N., Stec, I. S. M., Montkowski, A., Holsboer, F., & Reul, J. M. H. M. (2008) · Neuroendocrinology · doi:10.1159/000127240 · Cited by 94
Expression of Cre recombinase in dopaminoceptive neurons
Lemberger, T., Parlato, R., Dassesse, D., Westphal, M., Casanova, E., Turiault, M., Tronche, F., Schiffmann, S. N., & Schütz, G. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-4 · Cited by 86
Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain
Kitayama, I. T., Janson, A. M., Cintra, A., Fuxé, K., Agnati, L. F., Ögren, S. O., H�rfstrand, A., Eneroth, P. H. E., & Gustafsson, J.-Α. (1988) · Journal of Neural Transmission · doi:10.1007/bf01250136 · Cited by 77
Plasma Adrenocorticotropic Hormone in the Rat Demonstrates Three Different Rhythms within 24 h
Carnes, M. L., Lent, S. J., Feyzi, J. M., & Hazel, D. K. (2008) · Neuroendocrinology · doi:10.1159/000125197 · Cited by 72
Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function
Dijkstra, I., Tilders, F. J. H., Aguilera, G., Kiss, A., Rabadan‐Diehl, C., Barden, N., Karanth, S., Holsboer, F., & Reul, J. M. H. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03909.1998 · Cited by 69
Corticotropin-releasing hormone expression is the major target for glucocorticoid feedback-control at the hypothalamic level
Kretz, O., Reichardt, H. M., Schütz, G., & Bock, R. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01277-3 · Cited by 66
Feedback Control of Glucocorticoid Production is Established during Fetal Development
Reichardt, H. M., & Schütz, G. (1996) · Molecular Medicine · doi:10.1007/bf03401657 · Cited by 61
Behavioral reactivity to aversive stimuli in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: effects of diazepam and FG-7142
Rochford, J. M., Beaulieu, S., Rousse, I., Glowa, J. R., & Barden, N. (1997) · Psychopharmacology · doi:10.1007/s002130050330 · Cited by 57
Hippocampal Cell Responses in Mice with a Targeted Glucocorticoid Receptor Gene Disruption
Hesen, W., Karst, H., Meijer, O. C., Cole, T. J., Schmid, W., de Kloet, E. R., Schütz, G., & Joëls, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06766.1996 · Cited by 48
Spatial memory in transgenic mice with impaired glucocorticoid receptor function
Rousse, I., Beaulieu, S., Rowe, W. B., Meaney, M. J., Barden, N., & Rochford, J. M. (1997) · Neuroreport · doi:10.1097/00001756-199703030-00007 · Cited by 46
NEUROENDOCRINE DISTURBANCES AND THE DIAGNOSIS AND qTIOLOGY OF ENDOGENOUS DEPRESSION
Carroll, B. J. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90826-0 · Cited by 40
The mineralocorticoid receptor expression in the mouse CNS is conserved during development
Kretz, O., Schmid, W., Berger, S., & Gass, P. (2001) · Neuroreport · doi:10.1097/00001756-200105080-00017 · Cited by 39
Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice
Steckler, T., Rammes, G., Sauvage, M. M., van Gaalen, M. M., Weis, C., Zieglgänsberger, W., & Holsboer, F. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00040-6 · Cited by 36
Enhanced conditioned approach responses in transgenic mice with impaired glucocorticoid receptor function
Steckler, T., & Holsboer, F. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00003-0 · Cited by 31
Behavioral and Endocrine Impact of Impaired Type II Glucocorticoid Receptor Function in a Transgenic Mouse Modela
Beaulieu, S., Rousse, I., Gratton, A. P., Barden, N., & Rochford, J. M. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb39263.x · Cited by 22
Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption
Oitzl, Meijer, O. C., Joëls, M., Cole, T. J., Schmid, W., & de Kloet, E. R. (1997) · Journal of Molecular Medicine · Cited by 20

Research works printed but not linked: 3

Chandramohan Y, 2007, J Neurochem
De Kloet ER, 1998, Endocr Rev, 19, 269
Nemeroff CB, 2004, J Clin Psychiatry, 65, 18

Sorted by citations

The HPA â€“ Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain
Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases
Beck, I. M. E., Vanden Berghe, W., Vermeulen, L., Yamamoto, K. R., Haegeman, G., & De Bosscher, K. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0013 · Cited by 298
Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity
Suri, D., & Vaidya, V. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.065 · Cited by 269
An affective disorder in zebrafish with mutation of the glucocorticoid receptor
Ziv, L., Muto, A., Schoonheim, P. J., Meijsing, S. H., Strasser, D., Ingraham, H. A., Schaaf, M. J. M., Yamamoto, K. R., & Baier, H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.64 · Cited by 242
Epigenetic effects of stress and corticosteroids in the brain
Hunter, R. G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00018 · Cited by 150

See all 106

Authors: Kolber, B. J., Wieczorek, L., & Muglia, L. J.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Muglia, Louis J.
ORCID: Kolber, Benedict J.
Muglia, Louis J.
Venue: Stress
Publisher: Informa UK Limited
Published: 2008-01
Volume: 11
Issue: 5
Pages: 321-338
ISSN: 1025-3890 (ISSN-L)
1607-8888
DOI: 10.1080/10253890701821081
PMC: PMC2744095
OpenAlex: W2135772988
Cited by: 106
References: 79
Citations by year: 2026: 3 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 13 · 2019: 7 · 2018: 6 · 2017: 11 · 2016: 4 · 2015: 3 · 2014: 10 · 2013: 5 · 2012: 12
FWCI: 2.23
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stress (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG018876)
National Institute of Mental Health (F31MH075250, F31MH084391)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: hypothalamic-pituitary-adrenal axis, glucocorticoid receptor, mineralocorticoid receptor, corticosteroid signaling, stress adaptation, mouse mutants, limbic system, sodium homeostasis, forebrain, endocrine function
MeSH terms: Animals, Anxiety, Behavior, Animal, Circadian Rhythm, Hypothalamo-Hypophyseal System, Learning Disabilities, Memory Disorders, Mice, Mutant Strains, Mice, Transgenic, Pituitary-Adrenal System, Receptors, Glucocorticoid, Stress, Psychological, Prosencephalon, Receptors, Mineralocorticoid, Mice, Knockout, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypothalamic–pituitary–adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function: Review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks