Processing efficiency of a verbal working memory system is modulated by amphetamine: an fMRI investigation
Abstract
Rationale Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possibility with human participants by varying amphetamine dosage and measuring the efficiency of cortical processing in brain regions associated with working memory. Objectives The modulation of cortical processing in a verbal working memory network by dextroamphetamine (D-amph) was examined using BOLD functional magnetic resonance imaging (fMRI) with healthy participants. The goal of the study was to test the hypothesis of an inverted U-shaped relationship between D-amph dose and processing efficiency of a verbal working memory system. Methods D-amph dosage was increased cumulatively every 2 h across four scanning sessions collected in a single day. The primary measure used for analyses in this study was the extent of activation in brain regions empirically defined as a working memory network. Results An inverted U-shaped relationship was observed between the amount of D-amph administered and working memory processing efficiency. This relationship was specific to brain areas functionally defined as working memory regions and to the encoding/maintenance phase (as opposed to the response phase) of the task. Conclusion The results are consistent with the hypothesis th…
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Psychostimulants (i.e., d-amphetamine) action on the DA system exerts bidirectional effects, improving or decreasing working memory performance depending on the dosage (inverted U-shaped curve).
“In fact, psychostimulants (i.e., d-amphetamine) action on the DA system exerts bidirectional effects, improving or decreasing working memory performance depending on the dosage (inverted U-shaped curve) (39, 40).”
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- Authors
- Tipper, C. M., Cairo, T. A., Woodward, T. S., Phillips, A. G., Liddle, P. F., & Ngan, E. T. C.
- Affiliations
- University of British Columbia (CA)
- Riverview Hospital (CA)
- Queen's Medical Centre (GB)
- Corresponding author
- Tipper, Christine M.
- Venue
- Psychopharmacology
- Published
- 2005-06-28
- Volume
- 180
- Issue
- 4
- Pages
- 634-643
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2120267169
- Cited by
- 34
- References
- 7
- Citations by year
- 2024: 1 · 2022: 1 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Michael Smith Health Research BC
- University of British Columbia
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- verbal working memory, amphetamine, d-amphetamine, dose-response relationship, inverted U-shaped relationship, working memory network, schizophrenia
- MeSH terms
- Adult, Amphetamine, Central Nervous System Stimulants, Analysis of Variance, Brain, Brain Mapping, Dose-Response Relationship, Drug, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Reaction Time, Verbal Learning, Single-Blind Method
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