A review on therapeutic potentials of Trigonella foenum graecum (fenugreek) and its chemical constituents in neurological disorders: Complementary roles to its hypolipidemic, hypoglycemic, and antioxidant potential
Abstract
OBJECTIVES: The growing rate of neurological disorders is a major concern in today's scenario. Today's research is focusing on therapeutic interventions providing benefits in these disorders. Presently, drugs of natural origin have gained more interest for the treatment of central nervous system disorders for their efficacy and less/ no side effects. This review is emphasizing the cited roles of Trigonella foenum graecum (fenugreek) and its constituents in different neurological manifestations. METHOD: A review of the literature, relevant to the role of fenugreek and its major constituents including saponins and alkaloids in different neurological aspects and in delineating the health benefits, was conducted. RESULTS: The cited research acknowledged that fenugreek and its constituents exert positive influence on neurological health. Few studies have reported the beneficial role of fenugreek and its constituents like trigonelline in pathological symptoms of Alzheimer's disease. Similarly, other studies evidenced the neuroprotective, antidepressant, antianxiety as well as modulatory effect on cognitive functions and Parkinson's disease. DISCUSSION: Large populations are the sufferers of the neurological disorders, pointing the need for investigation of such therapeutic interventions which target and delay the underlying pathological hallmarks and exert positive influence on different neurological health problems. Hypolipidemic, hypoglycemic, antioxidant, and immunomodulatory effects of fenugreek and its constituents with their potential role in various neurological disorders were already reported. In future, it would be of even greater interest to further develop more effective dosage, supplementation period, and to evaluate the therapeutic potentials of fenugreek and its constituents in neurological disorders by exploring underlying cellular and molecular mechanisms.
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Fenugreek and its constituents have positive effects in several in vitro and in vivo Alzheimer's disease models.
“Zameer et al. (2018) have recently reviewed the positive effect of fenugreek and its constituents on several in vitro and in vivo AD models.”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Zameer et al., 2018
Trigonelline is an important chemotaxonomic marker of Trigonella species.
“Trigonelline is an important chemotaxonomic marker of Trigonella species (Mohammadi et al., 2020;Shailajan et al., 2011;Zameer et al., 2018) and was found to be the major compound in the sample analysed herein.”
From Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease (2022) · cites this paper as Zameer et al., 2018
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Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease
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- Authors
- Zameer, S., Najmi, A. K., Vohora, D., & Akhtar, M.
- Affiliations
- Jamia Hamdard (IN)
- Corresponding author
- Akhtar, Mohd
- Venue
- Nutritional Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2017-05-15
- Volume
- 21
- Issue
- 8
- Pages
- 539-545
- ISSN
- 1028-415X (ISSN-L)
- 1476-8305
- OpenAlex
- W2614471994
- Cited by
- 74
- References
- 49
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 17 · 2022: 10 · 2021: 12 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 1
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutritional Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- fenugreek, neurological disorders, neuroprotection, Alzheimer's disease, Parkinson's disease, trigonelline, saponins, alkaloids, hypolipidemic effect, hypoglycemic effect, antioxidant activity, antidepressant effects, anti-anxiety activity, cognitive function, natural products
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Hypolipidemic Agents, Antioxidants, Encephalitis, Humans, Hypoglycemic Agents, Nervous System Diseases, Plant Extracts, Seeds, Neuroprotective Agents, Nootropic Agents, Evidence-Based Medicine, Dietary Supplements, Neurodegenerative Diseases, Trigonella
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