Cited by 878Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingCoenzyme Q10 studies and effects

Oxidative stress and Parkinson’s disease

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Blesa, Javier, Trigo-Damas, Ines, Quiroga-Varela, Anna, Jackson-Lewis, Vernice R.·2015·Frontiers in Neuroanatomy

Abstract

Parkinson disease (PD) is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in PD. Environmental factors, such as neurotoxins, pesticides, insecticides, dopamine (DA) itself, and genetic mutations in PD-associated proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation. In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process.

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Crossref · 10.3389/fnana.2015.00091

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  • Oxidative damage has been implicated in all major neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.

    “Oxidative damage has been implicated in all major neurodegenerative diseases including Alzheimer’s disease (AD) [108,109], Parkinson’s disease (PD) [110,111], Huntington’s disease (HD) [112,113], amyotrophic lateral sclerosis (ALS) [114], and multiple sclerosis (MS) [115].”

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Authors
Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R.
Affiliations
  • Universidad San Pablo CEU (ES)
  • Columbia University (US)
Corresponding author
Blesa, Javier
Venue
Frontiers in Neuroanatomy
Published
2015-07-08
Volume
9
Pages
91-91
ISSN
1662-5129 (ISSN-L)
OpenAlex
W1539334271
Cited by
878
References
146
Citations by year
2026: 47 · 2025: 64 · 2024: 72 · 2023: 87 · 2022: 95 · 2021: 99 · 2020: 98 · 2019: 90 · 2018: 84 · 2017: 74 · 2016: 52 · 2015: 11 · 2014: 2 · 2013: 1
FWCI
9.70
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Neuroanatomy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Depósito Digital e-UCJC (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Keywords
Parkinson's disease, oxidative stress, dopaminergic neurotoxicity, substantia nigra pars compacta, mitochondrial dysfunction, complex I deficiency, reactive oxygen species, neurodegeneration, dopaminergic neurons, neurotoxins, pesticides, insecticides, dopamine, genetic mutations, neuroprotection

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