Oxidative stress and Parkinson’s disease
Open accessAbstract
Parkinson disease (PD) is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in PD. Environmental factors, such as neurotoxins, pesticides, insecticides, dopamine (DA) itself, and genetic mutations in PD-associated proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation. In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process.
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Oxidative damage has been implicated in all major neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis.
“Oxidative damage has been implicated in all major neurodegenerative diseases including Alzheimer’s disease (AD) [108,109], Parkinson’s disease (PD) [110,111], Huntington’s disease (HD) [112,113], amyotrophic lateral sclerosis (ALS) [114], and multiple sclerosis (MS) [115].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [111]
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- Authors
- Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R.
- Affiliations
- Universidad San Pablo CEU (ES)
- Columbia University (US)
- Corresponding author
- Blesa, Javier
- ORCID
- Blesa, Javier
- Venue
- Frontiers in Neuroanatomy
- Publisher
- Frontiers Media SA
- Published
- 2015-07-08
- Volume
- 9
- Pages
- 91-91
- ISSN
- 1662-5129 (ISSN-L)
- PMC
- PMC4495335
- OpenAlex
- W1539334271
- Cited by
- 878
- References
- 146
- Citations by year
- 2026: 47 · 2025: 64 · 2024: 72 · 2023: 87 · 2022: 95 · 2021: 99 · 2020: 98 · 2019: 90 · 2018: 84 · 2017: 74 · 2016: 52 · 2015: 11 · 2014: 2 · 2013: 1
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroanatomy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Depósito Digital e-UCJC (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- Parkinson's disease, oxidative stress, dopaminergic neurotoxicity, substantia nigra pars compacta, mitochondrial dysfunction, complex I deficiency, reactive oxygen species, neurodegeneration, dopaminergic neurons, neurotoxins, pesticides, insecticides, dopamine, genetic mutations, neuroprotection
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