Cited by 378Vitamin D Research StudiesNutrition and Health StudiesAntioxidant Activity and Oxidative Stress

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Vitamin D Bioavailability: State of the Art

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Borel, P., Caillaud, D., Cano, N. J.·2015·Critical Reviews in Food Science and Nutrition

DOI 10.1080/10408398.2012.688897

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Abstract

There has been renewed interest in vitamin D since numerous recent studies have suggested that besides its well-established roles in bone metabolism and immunity, vitamin D status is inversely associated with the incidence of several diseases, e.g., cancers, cardio-vascular diseases, and neurodegenerative diseases. Surprisingly, there is very little data on factors that affect absorption of this fat-soluble vitamin, although it is acknowledged that dietary vitamin D could help to fight against the subdeficient vitamin D status that is common in several populations. This review describes the state of the art concerning the fate of vitamin D in the human upper gastrointestinal tract and on the factors assumed to affect its absorption efficiency. The main conclusions are: (i) ergocalciferol (vitamin D2), the form mostly used in supplements and fortified foods, is apparently absorbed with similar efficiency to cholecalciferol (vitamin D3, the main dietary form), (ii) 25-hydroxyvitamin D (25OHD), the metabolite produced in the liver, and which can be found in foods, is better absorbed than the nonhydroxy vitamin D forms cholecalciferol and ergocalciferol, (iii) the amount of fat with which vitamin D is ingested does not seem to significantly modify the bioavailability of vitamin D3, (iv) the food matrix has apparently little effect on vitamin D bioavailability, (v) sucrose polyesters (Olestra) and tetrahydrolipstatin (orlistat) probably diminish vitamin D absorption, and (vi) there is apparently no effect of aging on vitamin D absorption efficiency. We also find that there is insufficient, or even no data on the following factors suspected of affecting vitamin D bioavailability: (i) effect of type and amount of dietary fiber, (ii) effect of vitamin D status, and (iii) effect of genetic variation in proteins involved in its intestinal absorption. In conclusion, further studies are needed to improve our knowledge of factors affecting vitamin D absorption efficiency. Clinical studies with labeled vitamin D, e.g., deuterated or (13)C, are needed to accurately and definitively assess the effect of various factors on its bioavailability.

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See all 378

Authors: Borel, P., Caillaud, D., & Cano, N. J.
Affiliations: Inserm (FR)
Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
Université Clermont Auvergne (FR)
Corresponding author: Borel, P.
ORCID: Borel, P.
Caillaud, D.
Cano, N. J.
Venue: Critical Reviews in Food Science and Nutrition
Publisher: Informa UK Limited
Published: 2013-10-02
Volume: 55
Issue: 9
Pages: 1193-1205
ISSN: 1040-8398 (ISSN-L)
1549-7852
DOI: 10.1080/10408398.2012.688897
OpenAlex: W2029625174
Cited by: 378
References: 104
Citations by year: 2026: 30 · 2025: 48 · 2024: 47 · 2023: 55 · 2022: 41 · 2021: 42 · 2020: 31 · 2019: 25 · 2018: 25 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 2
FWCI: 5.22
Type: journal article
Language: en
Open access: green
inserm.hal.science
Licence: other-oa
Locations: Critical Reviews in Food Science and Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: vitamin D bioavailability, vitamin D absorption, upper gastrointestinal tract, vitamin D3, vitamin D2, 25-hydroxyvitamin D, fat-soluble vitamins, dietary fat, food matrix, olestra, orlistat, aging, dietary fiber, intestinal absorption, vitamin D status
MeSH terms: Orlistat, Aging, Biological Availability, Cholecalciferol, Ergocalciferols, Fatty Acids, Food, Fortified, Humans, Intestinal Absorption, Lactones, Risk Factors, Sucrose, Vitamin D, Dietary Supplements

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