The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.
Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds–a comprehensive review
Abstract
The use of antibiotics in diets has been restricted in several countries as a precautionary measure to avoid development of antibiotic resistance among pathogenic microorganisms. This regulation promoted the exploration of natural plant bioactive compounds (PBCs) as feed additives to improve productivity, welfare and health of livestock and poultry. Along with several beneficial attributes of PBCs, including antimicrobial, antioxidant and various pharmacological effects, they also improve barrier function and nutrient transport in the gastrointestinal (GI) tract. This comprehensive review discusses the effects of different PBCs on the integrity, nutrient transport and permeability of GI epithelia and their mechanism of actions. Dietary PBCs influence the maintenance and enhancement of GI integrity via a number of mechanisms including altered signaling pathways and expression of several tight junction proteins (claudins, occludin, and zonula occludens proteins), altered expression of various cytokines, chemokines, complement components and their transcription factors, goblet cell abundance and mucin gene expression, and the modulation of the cellular immune system. They also affect nutrient transporter gene expression and active absorption of nutrients, minerals and ammonia. One intriguing perspective is to select an effective dose at which a specific PBC could improve GI barrier function and nutrient absorption. The effective doses and clear-cut molecular mechanisms for PBCs are yet to be elucidated to understand discrepant observations among different studies and to improve the targeted biotechnological and pharmaceutical uses of PBCs in farm animals. The latter will also enable a more successful use of such PBCs in humans.
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“Plant secondary metabolites usually enhance the permeability and fluidity of the cellular membranes, further causing an efflux of metabolites and ions and ultimately leading to cell leakage and microbial death.”
From Phytogenic Additives Can Modulate Rumen Microbiome to Mediate Fermentation Kinetics and Methanogenesis Through Exploiting Diet–Microbe Interaction (2020) · cites this paper as [78]
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Cited by
Sorted by citations
Zheng, B., & McClements, D. J. (2020) · Molecules · doi:10.3390/molecules25122791 · Cited by 348
Symposium review: The importance of the ruminal epithelial barrier for a healthy and productive cow
Aschenbach, J. R., Zebeli, Q., Patra, A. K., Greco, G., Amasheh, S., & Penner, G. B. (2018) · Journal of Dairy Science · doi:10.3168/jds.2018-15243 · Cited by 173
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Patra, A. K., & Kar, I. (2021) · Journal of Animal Science and Technology · doi:10.5187/jast.2021.e48 · Cited by 150
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Metadata
- Authors
- Patra, A. K., Amasheh, S., & Aschenbach, J. R.
- Affiliations
- West Bengal University of Animal and Fishery Sciences (IN)
- Freie Universität Berlin (DE)
- Corresponding author
- Patra, Amlan Kumar
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2018-07-12
- Volume
- 59
- Issue
- 20
- Pages
- 3237-3266
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2808156997
- Cited by
- 130
- References
- 262
- Citations by year
- 2026: 18 · 2025: 19 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 17 · 2020: 16 · 2019: 9 · 2018: 5
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Ruminant Nutrition and Digestive Physiology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- phytochemicals, gastrointestinal barrier function, nutrient transport, tight junction proteins, claudins, occludin, intestinal permeability, goblet cells, mucin gene expression, feed additives, livestock, poultry, antibiotic alternatives, antioxidant activity, antimicrobial activity, cytokines, effective dose
- MeSH terms
- Nutrients, Animals, Immunity, Cellular, Intestinal Mucosa, Signal Transduction, Gastrointestinal Tract, Livestock, Tight Junction Proteins, Phytochemicals
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