Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds–a comprehensive review

Proceedings of the National Academy of Sciences of the United States of America

Dowling, J. E., & Wald, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1981.tb06752.x · Cited by 17,937

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895

The American Journal of Physiology

(1899) · The American Naturalist · doi:10.1086/277182 · Cited by 5,680

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882

Intestinal mucosal barrier function in health and disease

Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952

Emerging roles of caspase-3 in apoptosis

Porter, A. G., & Jänicke, R. U. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400476 · Cited by 3,921

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358

Neutrophils in the activation and regulation of innate and adaptive immunity

Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159

Discovery and resupply of pharmacologically active plant-derived natural products: A review

Atanasov, A. G., Waltenberger, B., Pferschy‐Wenzig, E., Linder, T., Wawrosch, C., Uhrín, P., Temml, V., Wang, L., Schwaiger, S., Heiß, E. H., et al. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.08.001 · Cited by 3,105

Natural products: A continuing source of novel drug leads

Cragg, G. M. L., & Newman, D. J. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.02.008 · Cited by 3,042

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889

Pharmacological Reviews

(2024) · Pharmacological Reviews · doi:10.1124/pr · Cited by 2,680

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100

Towards a systems understanding of MHC class I and MHC class II antigen presentation

Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology · doi:10.1038/nri3084 · Cited by 2,044

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

van der Flier, L. G., & Clevers, H. C. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,994

Mucins in cancer: protection and control of the cell surface

Hollingsworth, M. A., & Swanson, B. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1251 · Cited by 1,813

Intestinal barrier function: molecular regulation and disease pathogenesis

Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775

CURCUMIN: THE INDIAN SOLID GOLD

Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,740

The biological action of saponins in animal systems: a review

Francis, G., Kerem, Z., Makkar, H. P. S., & Becker, K. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002725 · Cited by 1,722

The Journal of Animal Science: 1988-1990

Owens, F. N. (1992) · Journal of Animal Science · doi:10.2527/1992.70123649x · Cited by 1,584

Use of phytogenic products as feed additives for swine and poultry1

Windisch, W. M., Schedle, K., Plitzner, C., & Kroismayr, A. (2007) · Journal of Animal Science · doi:10.2527/jas.2007-0459 · Cited by 1,565

Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress

Kim, Y. S., & Ho, S. B. (2010) · Current Gastroenterology Reports · doi:10.1007/s11894-010-0131-2 · Cited by 1,531

Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective

Wink, M. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00300-5 · Cited by 1,453

Regulation of intestinal epithelial permeability by tight junctions

Suzuki, T. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1070-x · Cited by 1,437

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

Fanning, A. S., Jameson, B. J., Jesaitis, L. A., & Anderson, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29745 · Cited by 1,432

History of the Use of Antibiotic as Growth Promoters in European Poultry Feeds

Castanon, J. I. R. (2007) · Poultry Science · doi:10.3382/ps.2007-00249 · Cited by 1,259

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151

Physiology and function of the tight junction

Anderson, J. M., & Van Itallie, C. M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002584 · Cited by 1,059

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

Plotnikov, A. N., Zehorai, E., Procaccia, S., & Seger, R. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.12.012 · Cited by 1,021

The complement system

Sarma, J. V., & Ward, P. A. (2010) · Cell and Tissue Research · doi:10.1007/s00441-010-1034-0 · Cited by 988

Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review

Gadde, U., Kim, W. H., Oh, S., & Lillehoj, H. S. (2017) · Animal Health Research Reviews · doi:10.1017/s1466252316000207 · Cited by 883

Exploitation of dietary tannins to improve rumen metabolism and ruminant nutrition

Patra, A. K., & Saxena, J. (2010) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4152 · Cited by 878

LPA Receptors: Subtypes and Biological Actions

Choi, J. W., Herr, D. R., Noguchi, K., Yung, Y. C., Lee, C., Mutoh, T., Lin, M., Teo, S. T., Park, K. E., Austin, A. M., et al. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105753 · Cited by 856

Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action

Joe, B., Vijaykumar, M. H., & Lokesh, B. R. (2004) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690490424702 · Cited by 815

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Amasheh, S., Meiri, N., Gitter, A. H., Schöneberg, T., Mankertz, J., Schulzke, J. D., & Fromm, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00165 · Cited by 812

Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee, S. H. (2015) · Intestinal Research · doi:10.5217/ir.2015.13.1.11 · Cited by 810

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., & Tsukita, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200510043 · Cited by 787

Cytokine regulation of tight junctions

Capaldo, C., & Nusrat, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.08.027 · Cited by 747

Role of neutrophils in ischemia-reperfusion-induced microvascular injury

Hernandez, L. A., Grisham, M. B., Twohig, B., Arfors, K. ‐., Harlan, J. M., & Granger, D. N. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.3.h699 · Cited by 699

Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression

Wang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692

The role of neutrophils during intestinal inflammation

Fournier, B., & Parkos, C. A. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.24 · Cited by 685

Mechanism of cytokine modulation of epithelial tight junction barrier

Al–Sadi, R. (2009) · Frontiers in bioscience · doi:10.2741/3413 · Cited by 649

Desmosome structure, composition and function

Garrod, D. R., & Chidgey, M. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.014 · Cited by 625

A new perspective on the use of plant secondary metabolites to inhibit methanogenesis in the rumen

Patra, A. K., & Saxena, J. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.05.010 · Cited by 623

IRF7: activation, regulation, modification and function

Ning, S., Pagano, J. S., & Barber, G. N. (2011) · Genes and Immunity · doi:10.1038/gene.2011.21 · Cited by 611

Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)—A Review

Ghanbari, R., Anwar, F., Alkharfy, K. M., Gilani, A. H., & Saari, N. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13033291 · Cited by 611

Occludin and claudins in tight-junction strands: leading or supporting players?

Tsukita, S., & Furuse, M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01578-0 · Cited by 592

CD19: a biomarker for B cell development, lymphoma diagnosis and therapy

Wang, K., Wei, G., & Liu, D. (2012) · Experimental Hematology and Oncology · doi:10.1186/2162-3619-1-36 · Cited by 579

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D. A., Awasthi, S., & Singhal, S. S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 576

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

Turner, J. R., Rill, B. K., Carlson, S. L., Carnes, D., Kerner, R., Mrsny, R. J., & Madara, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1378 · Cited by 553

Essential oil and aromatic plants as feed additives in non-ruminant nutrition: a review

Zeng, Z., Zhang, S., Wang, H., & Piao, X. (2015) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-015-0004-5 · Cited by 546

Structural basis for physiological regulation of paracellular pathways in intestinal epithelia

Madara, J., & Pappenheimer, J. R. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209147 · Cited by 522

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

Pichlmair, A., Lassnig, C., Eberle, C.-A., Górna, M. W., Baumann, C., Burkard, T. R., Bürckstümmer, T., Stefanovic, A., Krieger, S., Bennett, K. L., et al. (2011) · Nature Immunology · doi:10.1038/ni.2048 · Cited by 506

IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells

Nusrat, A., Turner, J. R., & Madara, J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g851 · Cited by 499

Role of mucus layers in gut infection and inflammation

Hansson, G. C. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.002 · Cited by 488

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

Bazzoni, G., Martínez-Estrada, O. M., Orsenigo, F., Cordenonsi, M., Citi, S., & Dejana, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m905251199 · Cited by 480

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467

Olive tree ( Olea europaea ) leaves: potential beneficial effects on human health

El, S. N., & Karakaya, S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2009.00248.x · Cited by 466

Transmembrane proteins of tight junctions

Chiba, H., Osanai, M., Murata, M., Kojima, T., & Sawada, N. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.017 · Cited by 464

Toll-like receptors: linking innate and adaptive immunity

Pasare, C., & Medzhitov, R. M. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.08.018 · Cited by 461

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis

Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455

Inhibition of the intestinal glucose transporter GLUT2 by flavonoids

Kwon, O., Eck, P., Chen, S., Corpe, C. P., Lee, J., Kruhlak, M. J., & Levine, M. N. (2006) · The FASEB Journal · doi:10.1096/fj.06-6620com · Cited by 450

Intestinal barrier function and absorption in pigs after weaning: a review

Wijtten, P. J. A., van der Meulen, J., & Verstegen, M. W. A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114510005660 · Cited by 443

Secretory Component

Phalipon, A., Cardona, A., Kraehenbuhl, J.-P., Edelman, L., Sansonetti, P. J., & Corthésy, B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00341-2 · Cited by 426

Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability

Al–Sadi, R., Ye, D., Dokładny, K., & Ma, T. Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.8.5653 · Cited by 419

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

Nusrat, A., Giry, M., Turner, J. R., Colgan, S. P., Parkos, C. A., Carnes, D. K., Lemichez, E., Boquet, P., & Madara, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10629 · Cited by 418

Effects of essential oils on methane production and fermentation by, and abundance and diversity of, rumen microbial populations

Patra, A. K., & Yu, Z. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.00309-12 · Cited by 416

Molecular Basis of the Core Structure of Tight JunctionsPreprint

Furuse, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002907 · Cited by 410

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

Itallie, C. M. V., Holmes, J. C., Bridges, A. S., Gookin, J. L., Coccaro, M. R., Proctor, W. R., Colegio, O. R., & Anderson, J. M. (2008) · Journal of Cell Science · doi:10.1242/jcs.021485 · Cited by 410

The Role of SGLT1 and GLUT2 in Intestinal Glucose Transport and Sensing

Röder, P. V., Geillinger, K. E., Zietek, T., Thorens, B., Koepsell, H., & Daniel, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089977 · Cited by 409

Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture

Colegio, O. R., Itallie, C. V., Rahner, C., & Anderson, J. M. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00547.2002 · Cited by 387

Green Tea Polyphenols Inhibit the Sodium-Dependent Glucose Transporter of Intestinal Epithelial Cells by a Competitive Mechanism

Kobayashi, Y., Suzuki, M. M., Satsu, H., Arai, S., Hara, Y., Suzuki, K., Miyamoto, Y., & Shimizu, M. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0006832 · Cited by 386

Recent advances in antigen processing and presentation

Jensen, P. E. (2007) · Nature Immunology · doi:10.1038/ni1516 · Cited by 379

Biological Properties of Olive Oil Phytochemicals

Visioli, F., & Galli, C. (2002) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690290825529 · Cited by 368

Dietary phytochemicals as rumen modifiers: a review of the effects on microbial populations

Patra, A. K., & Saxena, J. (2009) · Antonie van Leeuwenhoek · doi:10.1007/s10482-009-9364-1 · Cited by 352

Intestinal absorptive cell tight junctions are linked to cytoskeleton

Madara, J. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.1.c171 · Cited by 342

Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glycoprotein

Kindon, H., Pothoulakis, C., Thim, L., Lynch–Devaney, K., & Podolsky, D. K. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90340-2 · Cited by 337

The effect and mode of action of saponins on the microbial populations and fermentation in the rumen and ruminant production

Patra, A. K., & Saxena, J. (2009) · Nutrition Research Reviews · doi:10.1017/s0954422409990163 · Cited by 335

Influence of diet type on the inclusion of plant origin active substances on morphological and histochemical characteristics of the stomach and jejunum walls in chicken

Jamroz, D., Wertelecki, T., Houszka, M., & Kamel, C. (2006) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2005.00603.x · Cited by 330

Quercetin Decreases Oxidative Stress, NF-κB Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats

Dias, A. S., Porawski, M., Alonso-Chamorro, M., Marroni, N. P., Collado, P. S., & González‐Gallego, J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.10.2299 · Cited by 322

Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system

Netea, M. G., van der Graaf, C. A. A., van der Meer, J. W. M., & Kullberg, B. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103543 · Cited by 311

Catenins: Keeping Cells from Getting Their Signals Crossed

Pérez‐Moreno, M., & Fuchs, E. V. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.010 · Cited by 309

Dietary inclusion effects of phytochemicals as growth promoters in animal production

Valenzuela-Grijalva, N. V., Saavedra, A. P., Muhlia‐Almazán, A., Domínguez-Díaz, D., & González‐Ríos, H. (2017) · Journal of Animal Science and Technology · doi:10.1186/s40781-017-0133-9 · Cited by 297

Isolation and functional characterization of the actin‐binding region in the tight junction protein ZO‐1

Fanning, A. S., Ma, T. Y., & Anderson, J. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0121fje · Cited by 296

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

Wong, V. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1859 · Cited by 295

TNFR1‐induced activation of the classical NF‐κB pathway

Wajant, H., & Scheurich, P. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08015.x · Cited by 287

Junctional adhesion molecule (JAM) binds to PAR-3

Itoh, M., Sasaki, H., Furuse, M., Ozaki, H., Kita, T., & Tsukita, S. (2001) · Journal of Cell Biology · doi:10.1083/jcb.200103047 · Cited by 282

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria

Ríos, D., Wood, M. B., Li, J., Chassaing, B., Gewirtz, A. T., & Williams, I. R. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.121 · Cited by 266

Regulation of the intestinal epithelial barrier by the apical junctional complex

Laukoetter, M. G., Bruewer, M., & Nusrat, A. (2006) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000203864.48255.4f · Cited by 264

MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide

Basuroy, S., Seth, A., Elias, B. C., Naren, A. P., & Rao, R. (2005) · Biochemical Journal · doi:10.1042/bj20050959 · Cited by 257

Structural organization of gap junction channels

Sosinsky, G. E., & Nicholson, B. J. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.04.001 · Cited by 251

Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents

Riella, K. R., Marinho, R. R., Santos, J. S., Pereira‐Filho, R. N., Cardoso, J. C., Júnior, R. L. C. D. A., & Thomazzi, S. M. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.07.028 · Cited by 247

Effects of thymol and carvacrol supplementation on intestinal integrity and immune responses of broiler chickens challenged with Clostridium perfringens

Du, E., Wang, W., Gan, L., Li, Z., Guo, S., & Guo, Y. (2016) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-016-0079-7 · Cited by 245

Alternatives to antibiotics in poultry feed: molecular perspectives

Suresh, G., Das, R. K., Brar, S. K., Rouissi, T., Ramírez, A. A., Chorfi, Y., & Godbout, S. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1373062 · Cited by 241

Structural and functional diversity of cadherin at the adherens junction

Oda, H., & Takeichi, M. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008173 · Cited by 237

Role of flavonoids in intestinal tight junction regulation

Suzuki, T., & Hara, H. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.08.001 · Cited by 233

Resveratrol alleviates heat stress-induced impairment of intestinal morphology, microflora, and barrier integrity in broilers

Zhang, C., Zhao, X., Yang, L., Chen, X. Y., Jiang, R., Jin, S., & Geng, Z. (2017) · Poultry Science · doi:10.3382/ps/pex266 · Cited by 226

Regulation and roles for claudin‐family tight junction proteins

Findley, M. K., & Koval, M. H. (2009) · IUBMB Life · doi:10.1002/iub.175 · Cited by 224

Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine

Saunders, P. R., Kosecka, U., McKay, D. M., & Perdue, M. H. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.5.g794 · Cited by 215

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways

Qi, S., Xin, Y., Guo, Y., Diao, Y., Kou, X., Luo, L., & Yin, Z. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.12.001 · Cited by 215

Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia

Walsh, S. V., Hopkins, A. M., Chen, J. Z., Narumiya, S., Parkos, C. A., & Nusrat, A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27060 · Cited by 211

Strawberry Polyphenols Attenuate Ethanol-Induced Gastric Lesions in Rats by Activation of Antioxidant Enzymes and Attenuation of MDA Increase

Álvarez-Suárez, J. M., Dekanski, D., Ristić, S., Radonjić, N. V., Petronijević, N., Giampieri, F., Astolfi, P., Paramás, A. M. G., Santos‐Buelga, C., Tulipani, S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025878 · Cited by 210

Plants as sources of natural and recombinant anti-cancer agents

Buyel, J. F. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.02.002 · Cited by 210

Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase–dependent fashion

Scott, K. G. –., Meddings, J. B., Kirk, D. R., Lees‐Miller, S. P., & Buret, A. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.36002 · Cited by 207

The Gut Barrier

Scaldaferri, F., Pizzoferrato, M., Gerardi, V., Lopetuso, L. R., & Gasbarrini, A. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31826ae849 · Cited by 205

Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo

Clayburgh, D. R., Musch, M. W., Leitges, M., Fu, Y., & Turner, J. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29218 · Cited by 203

Effects of dietary supplementation with enzymatically treated Artemisia annua on growth performance, intestinal morphology, digestive enzyme activities, immunity, and antioxidant capacity of heat-stressed broilers

Song, Z., Cheng, K., Zheng, X., Ahmad, H., Zhang, L. L., & Wang, T. (2017) · Poultry Science · doi:10.3382/ps/pex312 · Cited by 201

Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum

Cermak, R., Landgraf, S., & Wolffram, S. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041128 · Cited by 194

Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis

Albanese, C., D’Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M. L., Somasundaram, K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34186 · Cited by 191

An Overview of Antimicrobial Properties of Different Classes of Phytochemicals

Patra, A. K. (2012) · Springer eBooks · doi:10.1007/978-94-007-3926-0_1 · Cited by 189

Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells3

Amasheh, M., Schlichter, S., Amasheh, S., Mankertz, J., Zeitz, M., Fromm, M., & Schulzke, J. D. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1067 · Cited by 181

Antimicrobial, Antioxidant, and Anti-Inflammatory Activities of Essential Oils from Five Selected Herbs

Mei-Lin, T. S. A. I., Lin, C., Lin, W., & Yang, C. (2011) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110377 · Cited by 180

Effects of dietary polyphenol-rich plant products from grape or hop on pro-inflammatory gene expression in the intestine, nutrient digestibility and faecal microbiota of weaned pigs

Fiesel, A., Geßner, D. K., Most, E., & Eder, K. (2014) · BMC Veterinary Research · doi:10.1186/s12917-014-0196-5 · Cited by 179

Effects of butyrate, avilamycin, and a plant extract combination on the intestinal equilibrium of early-weaned pigs1

Manzanilla, E. G., Nofrarías, M., Anguita, M., Castillo, M., Pérez, J. F., Martín-Orúe, S. M., Kamel, C., & Gasa, J. (2006) · Journal of Animal Science · doi:10.2527/jas.2005-509 · Cited by 178

Carvacrol attenuates mechanical hypernociception and inflammatory response

Guimarães, A. G., Xavier, M. A., de Santana, M. T., Camargo, E. A., dos Santos, C. A., Brito, F. A., Barreto, E., Cavalcanti, S. C. H., Antoniolli, Â. R., Oliveira, R. C. M., et al. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0715-x · Cited by 172

Interferon-γ selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores

Watson, C. J. E., Hoare, C. J., Garrod, D. R., Carlson, G., & Warhurst, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02630 · Cited by 171

Amelioration of IFN-γ and TNF-α-Induced Intestinal Epithelial Barrier Dysfunction by Berberine via Suppression of MLCK-MLC Phosphorylation Signaling Pathway

Cao, M., Wang, P., Sun, C., He, W., & Wang, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061944 · Cited by 168

Essential oils—their antimicrobial activity against Escherichia coli and effect on intestinal cell viability

Fabián, D., Marián, S., Katarína, D., & Bujňáková, D. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.06.012 · Cited by 167

Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia

Gu, L., Li, N., Gong, J., Li, Q., Zhu, W., & Li, J. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir147 · Cited by 167

The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?

Forbes-Hernández, T. Y., Gasparrini, M., Afrin, S., Bompadre, S., Mezzetti, B., Quiles, J. L., Giampieri, F., & Battino, M. A. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1051919 · Cited by 166

Different essential oils in diets of broiler chickens: 2. Gut microbes and morphology, immune response, and some blood profile and antioxidant enzymes

Chowdhury, S., Mandal, G. P., Patra, A. K., Kumar, P., Samanta, I., Pradhan, S., & Samanta, A. K. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.12.003 · Cited by 166

Structural Change in Microbiota by a Probiotic Cocktail Enhances the Gut Barrier and Reduces Cancer via TLR2 Signaling in a Rat Model of Colon Cancer

Kuugbee, E. D., Shang, X., Gamallat, Y., Bamba, D., Awadasseid, A., Suliman, M. A., Zang, S., Ma, Y., Chiwala, G., Xin, Y., et al. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4238-7 · Cited by 165

Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli1

Liu, Y., Song, M., Che, T. M., Almeida, J. A. S., Lee, J. J., Bravo, D., Maddox, C. W., & Pettigrew, J. E. (2013) · Journal of Animal Science · doi:10.2527/jas.2012-6194 · Cited by 157

Transmembrane proteins of tight junctions

Balda, M. S., & Matter, K. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0177 · Cited by 154

A carvacrol–thymol blend decreased intestinal oxidative stress and influenced selected microbes without changing the messenger RNA levels of tight junction proteins in jejunal mucosa of weaning piglets

Wei, H., Xue, H., Zhou, Z., & Peng, J. (2016) · animal · doi:10.1017/s1751731116001397 · Cited by 154

Kaempferol Enhances Intestinal Barrier Function through the Cytoskeletal Association and Expression of Tight Junction Proteins in Caco-2 Cells

Suzuki, T., Tanabe, S., & Hara, H. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125633 · Cited by 146

Effect of thyme essential oil and selenium on intestine integrity and antioxidant status of broilers

Plachá, I., Takacova, J., Ryzner, M., Čobanová, K., Lauková, A., Strompfová, V., Venglovská, K., & Faix, S. (2014) · British Poultry Science · doi:10.1080/00071668.2013.873772 · Cited by 140

Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model

Zou, Y., Xiang, Q., Wang, J., Peng, J., & Wei, H. (2016) · BioMed Research International · doi:10.1155/2016/5436738 · Cited by 138

Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation

Ling, K. H., Wan, M. L. Y., El-Nezami, H. S., & Wang, M. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00001 · Cited by 135

Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats

Fukudome, I., Kobayashi, M., Dabanaka, K., Maeda, H., Okamoto, K., Okabayashi, T., Baba, R., Kumagai, N., Oba, K., Fujita, M., et al. (2013) · Medical Molecular Morphology · doi:10.1007/s00795-013-0055-7 · Cited by 133

Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

Yang, G., Bibi, S., Du, ‬., Suzuki, T., & Zhu, M. J. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1152230 · Cited by 132

Dietary grape seed proanthocyanidins (GSPs) improve weaned intestinal microbiota and mucosal barrier using a piglet model

Han, M., Song, P., Huang, C., Rezaei, A., Farrar, S., Brown, M. A., & Ma, X. (2016) · Oncotarget · doi:10.18632/oncotarget.13450 · Cited by 132

Dietary supplementation of young broiler chickens with Capsicum and turmeric oleoresins increases resistance to necrotic enteritis

Lee, S. H., Lillehoj, H. S., Jang, S. I., Lillehoj, E. P., Min, W., & Bravo, D. M. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512006083 · Cited by 131

Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs

Geßner, D. K., Fiesel, A., Most, E., Dinges, J., Wen, G., Ringseis, R., & Eder, K. (2013) · Acta veterinaria Scandinavica · doi:10.1186/1751-0147-55-18 · Cited by 131

Resveratrol modulates intestinal morphology and HSP70/90, NF-κB and EGF expression in the jejunal mucosa of black-boned chickens on exposure to circular heat stress

Liu, L., Fu, C., Yan, M., Xie, H.-B., Li, S., Yu, Q., He, S., & He, J. (2016) · Food & Function · doi:10.1039/c5fo01338k · Cited by 129

Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites

Kim, D., Lillehoj, H. S., Lee, S. H., Lillehoj, E. P., & Bravo, D. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512000530 · Cited by 128

Dimerization of the Scaffolding Protein ZO-1 through the Second PDZ Domain

Utepbergenov, D., Fanning, A. S., & Anderson, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512820200 · Cited by 127

Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice

Bukovská, A., Cikoš, Š., Juhás, Š., Il’ková, G., Rehák, P., & Koppel, J. (2007) · Mediators of Inflammation · doi:10.1155/2007/23296 · Cited by 125

Quantitative analyses of genes associated with mucin synthesis of broiler chickens with induced necrotic enteritis

Forder, R. E. A., Nattrass, G. S., Geier, M. S., Hughes, R., & Hynd, P. (2012) · Poultry Science · doi:10.3382/ps.2011-02062 · Cited by 123

Effects of vanillin, quillaja saponin, and essential oils on in vitro fermentation and protein-degrading microorganisms of the rumen

Patra, A. K., & Yu, Z. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4930-x · Cited by 120

Organosulfur compounds and cardiovascular disease

Prieto, M. A. V., & Miatello, R. M. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.009 · Cited by 120

Essential oils and their use in animal feeds for monogastric animals - Effects on feed quality, gut microbiota, growth performance and food safety: a review

Bento, M. H. L., Ouwehand, A. C., Tiihonen, K., Lahtinen, S. J., Nurminen, P. H., Saarinen, M., Schulze, H., Mygind, T., & Fischer, J. (2013) · Veterinární Medicína · doi:10.17221/7029-vetmed · Cited by 118

Anethole and Its Role in Chronic Diseases

Aprotosoaie, A. C., Costache, I. I., & Miron, A. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41342-6_11 · Cited by 115

Dietary Curcuma longa enhances resistance against Eimeria maxima and Eimeria tenella infections in chickens

Kim, D., Lillehoj, H. S., Lee, S. H., Jang, S. I., Lillehoj, E. P., & Bravo, D. (2013) · Poultry Science · doi:10.3382/ps.2013-03095 · Cited by 114

Mechanisms regulating chemokine receptor activity

Bennett, L. D., Fox, J. M., & Signoret, N. Y. M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03485.x · Cited by 112

Is the origin of type 1 diabetes in the gut?

Vaarala, O. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2011.115 · Cited by 111

Effect of diet composition on postweaning colibacillosis in piglets123

Montagné, L., Cavaney, F. S., Hampson, D. J., Lallès, J. P., & Pluske, J. R. (2004) · Journal of Animal Science · doi:10.2527/2004.8282364x · Cited by 111

Effects of curcumin on growth performance, jejunal mucosal membrane integrity, morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli

Xun, W., Shi, L., Zhou, H., Hou, G., Cao, T., & Zhao, C. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.04.038 · Cited by 108

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

Stevenson, B. R., Anderson, J. M., Braun, I. D., & Mooseker, M. S. (1989) · Biochemical Journal · doi:10.1042/bj2630597 · Cited by 106

Gingerol and Its Role in Chronic Diseases

Yusof, Y. A. M. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41342-6_8 · Cited by 105

Natural products from resurrection plants: Potential for medical applications

Gechev, T., Hille, J., Woerdenbag, H. J., Benina, M., Mehterov, N. H., Toneva, V., Fernie, A. R., & Mueller‐Roeber, B. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.03.005 · Cited by 104

Molecular basis of epithelial Ca 2+ and Mg 2+ transport: insights from the TRP channel family

Dimke, H., Hoenderop, J. G. J., & Bindels, R. J. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.199869 · Cited by 104

Interaction of quercetin glucosides with the intestinal sodium/glucose co-transporter (SGLT-1)

Ader, P., Blöck, M., Pietzsch, S., & Wolffram, S. (2001) · Cancer Letters · doi:10.1016/s0304-3835(00)00645-5 · Cited by 104

Regulation of human jejunal transmucosal resistance and MLC phosphorylation by Na+-glucose cotransport

Berglund, J. J., Riegler, M. F., Zolotarevsky, Y., Wenzl, E., & Turner, J. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.6.g1487 · Cited by 102

Dietary supplementation of enzymatically treated Artemisia annua could alleviate the intestinal inflammatory response in heat-stressed broilers

Song, Z., Cheng, K., Zhang, L., & Wang, T. (2017) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2017.07.015 · Cited by 102

Essential oils affect populations of some rumen bacteria in vitro as revealed by microarray (RumenBactArray) analysis

Patra, A. K., & Yu, Z. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00297 · Cited by 101

Cucurmin, anticancer, & antitumor perspectives: A comprehensive review

Imran, M., Ullah, A., Saeed, F., Nadeem, M., Arshad, M. U., & Suleria, H. A. R. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1252711 · Cited by 101

Iranian Journal of Veterinary Medicine

(2023) · Iranian Journal of Veterinary Medicine · doi:10.32598/ijvm · Cited by 98

Xylanase supplementation to a wheat-based diet alleviated the intestinal mucosal barrier impairment of broiler chickens challenged byClostridium perfringens

Liu, D., Guo, S., & Guo, Y. (2012) · Avian Pathology · doi:10.1080/03079457.2012.684089 · Cited by 94

Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK‐dependent mechanism

Benoit, Y. D., Lussier, C. R., Ducharme, P., Sivret, S., Schnapp, L. M., Basora, N., & Beaulieu, J. (2009) · Biology of the Cell · doi:10.1042/bc20090060 · Cited by 92

Reduced lesions in chickens with Clostridium perfringens-induced necrotic enteritis by Lactobacillus fermentum 1.2029 ,

Cao, L., Yang, X., Li, Z., Sun, F., Wu, X. H., & Yao, J. (2012) · Poultry Science · doi:10.3382/ps.2012-02548 · Cited by 92

Effect of Dietary Curcuma, Capsicum, and Lentinus, on Enhancing Local Immunity against Eimeria acervulina Infection

Lee, S. H., Lillehoj, H. S., Jang, S. I., Kim, D., Ionescu, C., & Bravo, D. (2010) · The Journal of Poultry Science · doi:10.2141/jpsa.009025 · Cited by 91

Bicarbonate transport proteins

Sterling, D., & Casey, J. R. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-152 · Cited by 89

Naringenin enhances intestinal barrier function through the expression and cytoskeletal association of tight junction proteins in Caco-2 cells

Noda, S., Tanabe, S., & Suzuki, T. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300045 · Cited by 88

Dietary Astragalus polysaccharide alleviated immunological stress in broilers exposed to lipopolysaccharide

Liu, L., Shen, J., Zhao, C., Wang, X., Yao, J., Gong, Y.-S., & Yang, X. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.08.057 · Cited by 88

Dietary calcium, phosphorus, and phytase effects on bird performance, intestinal morphology, mineral digestibility, and bone ash during a natural necrotic enteritis episode

Paiva, D. M., Walk, C. L., & Mcelroy, A. P. (2014) · Poultry Science · doi:10.3382/ps.2014-04148 · Cited by 87

Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms

Song, J. C., Hanson, C. M., Tsai, V., Farokhzad, O. C., Lotz, M. M., & Matthews, J. B. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.2.c649 · Cited by 85

Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-κB Activation

Song, W.-B., Wang, Y. Y., Meng, F.-S., Zhang, Q., Zeng, J., Xiao, L., Yu, X., Peng, D.-D., Su, L., Xiao, B., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012969 · Cited by 85

Functions of Claudin Tight Junction Proteins and Their Complex Interactions in Various Physiological Systems

Elkouby-Naor, L., & Ben‐Yosef, T. (2010) · International review of cytology · doi:10.1016/s1937-6448(10)79001-8 · Cited by 83

The Role of Protein Kinase C Isoforms in Modulating Injury and Repair of the Intestinal Barrier

Farhadi, A., Keshavarzian, A., Ranjbaran, Z. S., Fields, J. Z., & Banan, A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085449 · Cited by 82

Protection of Intestinal Occludin Tight Junction Protein by Dietary Gangliosides in Lipopolysaccharide‐induced Acute Inflammation

Park, E. J., Thomson, A. B., & Clandinin, M. T. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181ae2ba0 · Cited by 81

Flavanol-Enriched Cocoa Powder Alters the Intestinal Microbiota, Tissue and Fluid Metabolite Profiles, and Intestinal Gene Expression in Pigs

Jang, S., Sun, J., Chen, P. C., Lakshman, S., Molokin, A., Harnly, J. M., Vinyard, B. T., Urban, J. F., Davis, C. D., & Solano-Aguilar, G. I. (2016) · Journal of Nutrition · doi:10.3945/jn.115.222968 · Cited by 81

Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes

Harmon, A. W., & Patel, Y. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00720-4 · Cited by 80

Effect of black cumin seeds on growth performance, nutrient utilization, immunity, gut health and nitrogen excretion in broiler chickens

Kumar, P., Patra, A. K., Mandal, G. P., Samanta, I., & Pradhan, S. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8237 · Cited by 79

Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection1

Liu, Y.-D., Song, M., Che, T. M., Lee, J. J., Bravo, D., Maddox, C. W., & Pettigrew, J. E. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-6422 · Cited by 78

Green tea polyphenol epigallocatechin‐3‐gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD‐1 and pBD‐2 in monolayers of porcine intestinal epithelial IPEC‐J2 cells

Wan, M. L. Y., Ling, K. H., Wang, M., & El-Nezami, H. S. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500992 · Cited by 77

Protective effect of quercetin on pig intestinal integrity after transport stress is associated with regulation oxidative status and inflammation

Zou, Y., Wei, H.-K., Xiang, Q., Wang, J., Zhou, Y.-F., & Peng, J. (2016) · Journal of Veterinary Medical Science · doi:10.1292/jvms.16-0090 · Cited by 77

Magnesium homeostasis in cattle: absorption and excretion

Märtens, H., Leonhard-Marek, S., Röntgen, M., & Stumpff, F. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422417000257 · Cited by 74

Tumor-targeting delivery of herb-based drugs with cell-penetrating/tumor-targeting peptide-modified nanocarriers

Kebebe, D., Liu, Y., Wu, Y., Vilakhamxay, M., Liu, Z., & Li, J. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s156616 · Cited by 73

Influence of supplemental magnesium, tryptophan, vitamin C, vitamin E, and herbs on stress responses and pork quality1

Peeters, E., Driessen, B., & Geers, R. (2006) · Journal of Animal Science · doi:10.2527/jas.2005-600 · Cited by 72

Modulation of tight junction integrity by food components

Kosińska, A., & Andlauer, W. (2012) · Food Research International · doi:10.1016/j.foodres.2012.12.038 · Cited by 70

Effects of Coriander Essential Oil on the Performance, Blood Characteristics, Intestinal Microbiota and Histological of Broilers

Ghazanfari, S., Mohammadi, Z., & Moradi, M. A. (2015) · Brazilian Journal of Poultry Science · doi:10.1590/1516-635x1704419-426 · Cited by 69

The Survivin-mediated radioresistant phenotype of glioblastomas is regulated by RhoA and inhibited by the green tea polyphenol (−)-epigallocatechin-3-gallate

McLaughlin, N., Annabi, B., Bouzeghrane, M., Temme, A., Bahary, J.-P., Moumdjian, R. A., & Béliveau, R. (2006) · Brain Research · doi:10.1016/j.brainres.2005.10.009 · Cited by 66

Extract of Oregano, Coffee, Thyme, Clove, and Walnuts Inhibits NF-κB in Monocytes and in Transgenic Reporter Mice

Paur, I., Balstad, T. R., Kolberg, M., Pedersen, M. K., Austenaa, L. M. I., Jacobs, D. R., & Blomhoff, R. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0089 · Cited by 64

Effects of dietary essential oil and enzyme supplementation on growth performance and gut health of broilers challenged by Clostridium perfringens

Sun, Q., Liu, D., Guo, S., Chen, Y., & Guo, Y. (2015) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2015.06.021 · Cited by 63

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