Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential
Abstract
Type 2 diabetes mellitus (T2DM) has become one of the most prevalent diseases on earth and several treatments have been developed. However, the current intervention approaches have not been as effective as expected. One promising supplementary strategy is the use of probiotics through direct or indirect approaches. Probiotics are microbial food cultures conferring health-promoting properties. In this review, we summarized the current theories and mechanisms of T2DM intervention using probiotics and hypothesize that probiotics intervene T2DM during its onsetting, developing, and complicating. For the first time, we comprehensively analyzed T2DM intervention in animal models using both wide-type probiotics in different forms and using recombinant probiotics. Then, probiotic intervention in T2DM patients was reviewed and the main results were compared with that obtained from animal studies. Finally yet importantly, remaining questions that are important such as in which form and in which state, as well as the future potential of probiotic intervention in T2DM were discussed from a perspective of food microbiologists. In conclusion, probiotic intervention in T2DM is promising but there are still many important issues unsolved yet. Critical review of the advances, questions, and potential of probiotic intervention in T2DM promotes the development of this approach for further application in humans.
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Probiotics from Bifidobacteria and Lactobacilli taken orally showed encouraging antidiabetic effects.
“Probiotics from Bifidobacteria (including Bifidobacterium infantis, Bifidobacterium longum, and Bifidobacterium breve) and Lactobacilli (including Lactobacillus acidophilus, Lactiplantibacillus plantarum, Lactobacillus bulgaricus, and Lactobacillus delbrueckii subsp. that were taken orally showed encouraging antidiabetic effects.”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [106]
Probiotics diminish inflammatory, autoimmune, and oxidative stress responses.
“Furthermore, probiotics diminish the inflammatory, autoimmune, and OS responses.”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [106]
Probiotics may boost incretins, decrease endoplasmic reticulum stress, decrease systemic lipopolysaccharide levels, improve peripheral insulin sensitivity, and preserve the integrity of the gut.
“Probiotics may boost incretins, decrease endoplasmic reticulum stress, decrease systemic lipopolysaccharide levels, improve peripheral insulin sensitivity, and preserve the integrity of the gut.”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [106]
Lacticaseibacillus rhamnosus, when mixed with B. lactis and Lactobacillus gasseri, inhibits weight gain in humans, specifically fat tissue mass adiposity.
“Lacticaseibacillus rhamnosus, when mixed with B. lactis and Lactobacillus gasseri, has been demonstrated to inhibit weight gain in humans, specifically fat tissue mass adiposity, which strengthens the efficacy of probiotics in diabetes (105–107).”
From A critical review on diabetes mellitus type 1 and type 2 management approaches: from lifestyle modification to current and novel targets and therapeutic agents. (2024) · cites this paper as [106]
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“Although probiotic are generally regarded as safe (GRAS), careful consideration of side effects before application is still recommended, as adverse effects of probiotics, like sepsis, fungemia, and gastrointestinal ischemia are occasionally reported, especially in critically ill patients (Didari et al. 2014).”
BackgroundGut microbiota, probiotics and diabetes
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- Authors
- Sun, Z., Sun, X., Li, J., Li, Z., Hu, Q., Li, L., Hao, X., Song, M., & Li, C.
- Affiliations
- Zhengzhou University (CN)
- Zhoukou Normal University (CN)
- Zhoukou Maternal and Child Health Care Hospital, Zhoukou, China;
- College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China;
- Corresponding author
- Li, Chengwei
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2019-01-11
- Volume
- 60
- Issue
- 4
- Pages
- 670-683
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2909920335
- Cited by
- 117
- References
- 8
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 21 · 2023: 19 · 2022: 26 · 2021: 15 · 2020: 11 · 2019: 6
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Henan Province Science and Technology Agency (172102410055)
- the Education Department of Henan Province (17A180017)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- type 2 diabetes, probiotics, probiotic intervention, recombinant probiotics, animal models of diabetes, diabetes complications, gut microbiota, prebiotics, functional foods, diabetes prevention
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Probiotics
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