The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials
Abstract
Aims: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to determine the effect of quercetin administration on lipid profiles and inflammatory markers among patients with metabolic syndrome (MetS) and related disorders.Methods: We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until November 2018. Q-test and I2 statistics were applied to assess heterogeneity among included studies. Data were combined using fixed- or random-effects model and presented as standardized mean difference (SMD) with 95% confidence interval (CI).Results: Out of 591 citations, 16 RCTs were included in the meta-analysis. The pooled findings showed that quercetin consumption significantly decreased total-cholesterol (SMD = −0.98; 95% CI, −1.48, −0.49; p < 0.001; I2: 94.0), LDL-cholesterol (SMD = −0.88; 95% CI, −1.35, −0.41; p < 0.001; I2: 92.7) and C-reactive protein (CRP) levels (−0.64; 95% CI, −1.03, −0.25; p = 0.001; I2: 90.2). While, quercetin supplementation did not significantly affect triglycerides (TG) (SMD = −0.32; 95% CI, −0.68, 0.04; p = 0.08; I2: 84.8), HDL-cholesterol (SMD = 0.20; 95% CI, −0.20, 0.24; p = 0.84; I2: 70.6), interleukin 6 (IL-6) (SMD = −0.69; 95% CI, −1.69, 0.31; p = 0.17; I2: 94.5) and tumor necrosis factor-alpha (TNF-α) levels (SMD = −0.06; 95% CI, −0.25, 0.14; p = 0.58; I2: 35.6)Conclusions: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced total-cholesterol, LDL-cholesterol, and CRP levels, yet did not affect triglycerides, HDL-cholesterol, IL-6 and TNF-α among patients with MetS and related disorders.
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Others have found cardiometabolic improvement effects of anthocyanin, catechin, curcumin, flavanol, genistein, and quercetin.
“Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”
From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [39]
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Micronutrient Supplementation to Reduce Cardiovascular Risk
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- Authors
- Tabrizi, R., Tamtaji, O. R., Mirhosseini, N., Lankarani, K. B., Akbari, M., Heydari, S. T., Dadgostar, E., & Asemi, Z.
- Affiliations
- Shiraz University (IR)
- Kashan University of Medical Sciences (IR)
- University of Saskatchewan (CA)
- Shiraz University of Medical Sciences (IR)
- Halal Research Center of IRI, FDA, Tehran, Iran
- Corresponding author
- Heydari, Seyed Taghi
- Asemi, Zatollah
- ORCID
- Venue
- Critical Reviews in Food Science and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2019-04-24
- Volume
- 60
- Issue
- 11
- Pages
- 1855-1868
- ISSN
- 1040-8398 (ISSN-L)
- 1549-7852
- OpenAlex
- W2941748008
- Cited by
- 88
- References
- 49
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 11 · 2023: 22 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Food Science and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Elite Researcher Grant Committee (977483)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- quercetin, dietary supplementation, metabolic syndrome, lipid profile, inflammatory markers, total cholesterol, LDL cholesterol, C-reactive protein, interleukin-6, TNF-α, triglycerides, HDL cholesterol, cardiovascular risk, hypertriglyceridemia, dyslipidemia, obesity, type 2 diabetes, insulin resistance, hypertension
- MeSH terms
- Humans, Inflammation, Lipids, Quercetin, Randomized Controlled Trials as Topic, Dietary Supplements, Metabolic Syndrome
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