Cited by 88Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietNatural Antidiabetic Agents Studies

The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Tabrizi, Reza, Tamtaji, Omid Reza, Mirhosseini, Naghmeh, Lankarani, Kamran B., Akbari, Maryam, Heydari, Seyed Taghi, Dadgostar, Ehsan, Asemi, Zatollah·2020·Critical Reviews in Food Science and Nutrition

Abstract

Aims: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to determine the effect of quercetin administration on lipid profiles and inflammatory markers among patients with metabolic syndrome (MetS) and related disorders.Methods: We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until November 2018. Q-test and I2 statistics were applied to assess heterogeneity among included studies. Data were combined using fixed- or random-effects model and presented as standardized mean difference (SMD) with 95% confidence interval (CI).Results: Out of 591 citations, 16 RCTs were included in the meta-analysis. The pooled findings showed that quercetin consumption significantly decreased total-cholesterol (SMD = −0.98; 95% CI, −1.48, −0.49; p < 0.001; I2: 94.0), LDL-cholesterol (SMD = −0.88; 95% CI, −1.35, −0.41; p < 0.001; I2: 92.7) and C-reactive protein (CRP) levels (−0.64; 95% CI, −1.03, −0.25; p = 0.001; I2: 90.2). While, quercetin supplementation did not significantly affect triglycerides (TG) (SMD = −0.32; 95% CI, −0.68, 0.04; p = 0.08; I2: 84.8), HDL-cholesterol (SMD = 0.20; 95% CI, −0.20, 0.24; p = 0.84; I2: 70.6), interleukin 6 (IL-6) (SMD = −0.69; 95% CI, −1.69, 0.31; p = 0.17; I2: 94.5) and tumor necrosis factor-alpha (TNF-α) levels (SMD = −0.06; 95% CI, −0.25, 0.14; p = 0.58; I2: 35.6)Conclusions: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced total-cholesterol, LDL-cholesterol, and CRP levels, yet did not affect triglycerides, HDL-cholesterol, IL-6 and TNF-α among patients with MetS and related disorders.

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Crossref · 10.1080/10408398.2019.1604491

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  • Others have found cardiometabolic improvement effects of anthocyanin, catechin, curcumin, flavanol, genistein, and quercetin.

    “Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”

    From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [39]

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Authors
Tabrizi, R., Tamtaji, O. R., Mirhosseini, N., Lankarani, K. B., Akbari, M., Heydari, S. T., Dadgostar, E., & Asemi, Z.
Affiliations
  • Shiraz University (IR)
  • Kashan University of Medical Sciences (IR)
  • University of Saskatchewan (CA)
  • Shiraz University of Medical Sciences (IR)
  • Halal Research Center of IRI, FDA, Tehran, Iran
Corresponding author
  • Heydari, Seyed Taghi
  • Asemi, Zatollah
Venue
Critical Reviews in Food Science and Nutrition
Published
2019-04-24
Volume
60
Issue
11
Pages
1855-1868
ISSN
  • 1040-8398 (ISSN-L)
  • 1549-7852
OpenAlex
W2941748008
Cited by
88
References
49
Citations by year
2026: 12 · 2025: 9 · 2024: 11 · 2023: 22 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 2
FWCI
0.80
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Reviews in Food Science and Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Elite Researcher Grant Committee (977483)
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
quercetin, dietary supplementation, metabolic syndrome, lipid profile, inflammatory markers, total cholesterol, LDL cholesterol, C-reactive protein, interleukin-6, TNF-α, triglycerides, HDL cholesterol, cardiovascular risk, hypertriglyceridemia, dyslipidemia, obesity, type 2 diabetes, insulin resistance, hypertension
MeSH terms
Humans, Inflammation, Lipids, Quercetin, Randomized Controlled Trials as Topic, Dietary Supplements, Metabolic Syndrome

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