Influence of Attention‐Deficit/Hyperactivity Disorder Symptoms on Methadone Treatment Outcome
Abstract
A review of 687 consecutive admissions to a Midwestern methadone maintenance program was undertaken to establish the prevalence of ADHD symptoms and their association with treatment outcome. Of the 687 admissions, 396 (58%) patients self‐reported experiencing one or more ADHD symptoms during the two weeks prior to admission, and 131 (19%) patients reported ADHD symptoms that significantly interfered with functioning in daily activities. At nine months post‐admission, the patients who reported significant symptoms of ADHD were able to reduce their drug use but were less likely to have achieved abstinence than those who did not report significant symptoms (p ≤ 0.001). The authors discuss the importance of screening for ADHD symptoms in methadone treatment programs and propose interventions believed helpful in improving management of ADHD symptoms and improving outcome.
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In SUD treatment outcomes, methadone maintenance patients in the USA with significant ADHD symptoms in the two weeks prior to admission were less likely to achieve abstinence.
“In SUD treatment outcomes, methadone maintenance patients in the USA with significant ADHD symptoms in the two weeks prior to admission were less likely to achieve abstinence [211].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [211]
Cites
Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment
Barkley, R. A., & Poillion, M. J. (1994) · Behavioral Disorders · doi:10.1177/019874299401900205 · Cited by 4,632 · see citing works
Attention Deficit Hyperactivity Disorder. A Handbook for Diagnosis and Treatment
Silver, L. B. (1991) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199107000-00040 · Cited by 1,395 · see citing works
ATTENTION-DEFICIT HYPERACTIVITY DISORDER IN ADULTS
Wender, P. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70039-3 · Cited by 728 · see citing works
BIEDERMAN, J., FARAONE, S., MILBERGER, S., CURTIS, S., CHEN, L., MARRS, A., OUELLETTE, C., MOORE, P., & SPENCER, T. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199603000-00016 · Cited by 510 · see citing works
Prevalence of attention-deficit/hyperactivity disorder and conduct disorder among substance abusers.
Schubiner, H., Tzelepis, A., Milberger, S., Lockhart, N. A., Kruger, M., Kelley, B. J., & Schoener, E. (2000) · Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0402 · Cited by 328 · see citing works
Shekim, W. O., Asarnow, R. F., Hess, E., Zaucha, K., & Wheeler, N. (1990) · Comprehensive Psychiatry · doi:10.1016/0010-440x(90)90026-o · Cited by 304 · see citing works
Carroll, K. M., & Rounsaville, B. (1993) · Comprehensive Psychiatry · doi:10.1016/0010-440x(93)90050-e · Cited by 276 · see citing works
Biederman, J., Faraone, S. V., Milberger, S., Jetton, J. G., Chen, L., Mick, E. O., Greene, R. W., & Russell, R. L. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199609000-00017 · Cited by 268 · see citing works
Attention deficit hyperactivity disorder in adults
Olagunju, A. E., & Ghoddusi, F. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.5.633 · Cited by 268 · see citing works
Levin, F., Evans, S., & Kleber, H. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00049-0 · Cited by 198 · see citing works
Attention Deficit Hyperactivity Disorder and Treatment Outcome in Opioid Abusers Entering Treatment
KING, V. L., BROONER, R. K., KIDORF, M. S., STOLLER, K. B., & MIRSKY, A. F. (1999) · The Journal of Nervous & Mental Disease · doi:10.1097/00005053-199908000-00005 · Cited by 111 · see citing works
Hyperactive Children Have Grown Up: What Have We Learned About What Happens to Them?
Cantwell, D. P. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330110013 · Cited by 82 · see citing works
History of Childhood Hyperactivity in a Clinic Population of Opiate Addicts
Eyre, S. L., Rounsaville, B. J., & Kleber, H. D. (1982) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198209000-00002 · Cited by 64 · see citing works
The DARP Research Program and Data System
Sells, S. B. (1975) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952997509002719 · Cited by 47 · see citing works
Davids, E., von Bünau, U., Specka, M., Fischer, B., Scherbaum, N., & Gastpar, M. (2005) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.014 · Cited by 40 · see citing works
Hyperactivity: diagnostic confusion.
Schuckit, M. A., Petrich, J., & Chiles, J. A. (1978) · PubMed · Cited by 30 · see citing works
Schuckit, M. A., Petrich, J., & CHILES, J. (1978) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197802000-00001 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kooij, S. J., Bejerot, S., Blackwell, A., Caci, H., Casas-Brugué, M., Carpentier, P. J., Edvinsson, D., Fayyad, J., Foeken, K., Fitzgerald, M., et al. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-67 · Cited by 928 · see citing works
“methadone maintenance patients in the USA with significant ADHD symptoms in the two weeks prior to admission were less likely to achieve abstinence [211].”
Arias, A. J., Gelernter, J., Chan, G., Weiss, R. D., Brady, K. T., Farrer, L., & Kranzler, H. R. (2008) · Addictive Behaviors · doi:10.1016/j.addbeh.2008.05.003 · Cited by 211 · see citing works
Carpentier, P. J., van Gogh, M. T., Knapen, L. J. M., Buitelaar, J. K., & de Jong, C. A. J. (2010) · European Addiction Research · doi:10.1159/000321259 · Cited by 96 · see citing works
A Systematic Review of Global Publication Trends Regarding Long-Term Outcomes of ADHD
Hodgkins, P., Arnold, L. E., Shaw, M., Caci, H. M., Kahle, J. S., Woods, A. G., & Young, S. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00084 · Cited by 60 · see citing works
Prosser, J. M., London, E. D., & GALYNKER, I. I. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.022 · Cited by 54 · see citing works
When ADHD and substance use disorders intersect: Relationship and treatment implications
Wilens, T. E., & Fusillo, S. J. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0053-3 · Cited by 39 · see citing works
Alcohol and Substance Use History Among ADHD Adults
Huntley, Z., & Young, S. (2012) · Journal of Attention Disorders · doi:10.1177/1087054712446171 · Cited by 35 · see citing works
González, R. A., Vélez‐Pastrana, M. C., Varcárcel, J. J. R., LEVIN, F. R., & Albizu‐García, C. E. (2012) · Journal of Attention Disorders · doi:10.1177/1087054712461690 · Cited by 33 · see citing works
the ANRS Methaville study group, Nordmann, S., Lions, C., Vilotitch, A., Michel, L., Mora, M., Spire, B., Maradan, G., Morel, A., Roux, P., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4202-4 · Cited by 33 · see citing works
Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate
Crist, R. C., Li, J., Doyle, G. A. R., Gilbert, A. P. W., DeChairo, B. M., & Berrettini, W. H. (2018) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2017.1420795 · Cited by 32 · see citing works
Merrick, J., & Sher, L. (2013) · De Gruyter eBooks · doi:10.1515/9783110316612 · Cited by 29 · see citing works
Abel, K. F., Ravndal, E., Clausen, T., & Bramness, J. G. (2017) · European Addiction Research · doi:10.1159/000484240 · Cited by 27 · see citing works
Depression and severity of substance dependence among heroin dependent patients with ADHD symptoms
Liao, Y., Chen, C.-Y., Ng, M., Huang, K., Shao, W., Lin, T., Chen, V. C., & Gossop, M. (2016) · American Journal on Addictions · doi:10.1111/ajad.12487 · Cited by 26 · see citing works
Stimulant Medication for ADHD in Opioid Maintenance Treatment
Abel, K. F., Bramness, J. G., & Martinsen, E. W. (2013) · Journal of Dual Diagnosis · doi:10.1080/15504263.2013.867657 · Cited by 24 · see citing works
Peles, E., Schreiber, S., Sutzman, A., & Adelson, M. (2012) · Psychopathology · doi:10.1159/000336219 · Cited by 24 · see citing works
Ramos‐Quiroga, J. A., Díaz-Digón, L., Comín, M., Bosch, R., Gloria Palomar, A., Chalita, J. P., Roncero, C., Nogueira, M., Torrens, M., & Casas, M. (2012) · Journal of Attention Disorders · doi:10.1177/1087054712454191 · Cited by 22 · see citing works
Evren, C., Alnıak, İ., Karabulut, V., Cetin, T., Umut, G., Ağaçhanlı, R., & Evren, B. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.05.14.1 · Cited by 16 · see citing works
Hesse, M. (2009) · Addictive Behaviors · doi:10.1016/j.addbeh.2009.12.007 · Cited by 14 · see citing works
Group Medication Management for Buprenorphine/Naloxone in Opioid-Dependent Veterans
Berger, R., Pulido, C., Lacro, J. P., Groban, S. E., & Robinson, S. K. (2014) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000071 · Cited by 14 · see citing works
Gupta, S., Bhatia, G., Sarkar, S., Chatterjee, B., Balhara, Y., & Dhawan, A. (2020) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_705_19 · Cited by 9 · see citing works
Ramey, O. L., Bonny, A. E., Almodóvar, A. S., & Nahata, M. C. (2022) · Annals of Pharmacotherapy · doi:10.1177/10600280221141065 · Cited by 10 · see citing works
Daigre, C., Terán, A., García-Vicent, V., & Roncero, C. (2013) · Adicciones · doi:10.20882/adicciones.65 · Cited by 10 · see citing works
Childhood Symptoms of ADHD and Impulsivity in Abstinent Heroin Users
Segalà, L., Vasilev, G. N., Raynov, I., González, R., & Vassileva, J. (2015) · Journal of Dual Diagnosis · doi:10.1080/15504263.2015.1104482 · Cited by 9 · see citing works
Maremmani, A. G. I., Rocco, P., Rocca, F. D., Perugi, G., Miccoli, M., & Maremmani, I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010997 · Cited by 5 · see citing works
Ramey, O. L., Bonny, A. E., Almodóvar, A. S., & Nahata, M. C. (2023) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2023.02.013 · Cited by 4 · see citing works
Konzeptualisierung der Psychotherapie bei ADHS und Sucht
Groß, S., & Philipsen, A. (2015) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911.a000387 · Cited by 3 · see citing works
Evren, C., Alnıak, İ., Karabulut, V., Cetin, T., Umut, G., Ağaçhanlı, R., & Evren, B. (2017) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2017.1395312 · Cited by 3 · see citing works
Substance misuse disguised as ADHD?
Berg, J. E. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.191.5.457 · Cited by 2 · see citing works
Sinclair, C. (2012) · Library and Archives Canada (Government of Canada) · Cited by 1 · see citing works
Co-occurring ADHD and Substance Abuse : Substance Use Patterns, Motives and Executive Functioning
Stanton, M. R. (2014) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Ornoy, A., & Yacobi, S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_71
Attention Deficit Hyperactivity Disorder, Substance Use Disorders, and Heroin Addiction
Salman, S., Idrees, J., Anees, M., & Idrees, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00096-1
TDAH CON TRASTORNOS POR CONSUMO DE SUSTANCIAS
Wilens, T. E. (2010) · Elsevier eBooks · doi:10.1016/b978-84-458-2021-6.00013-0
Jean, F. A. M., Galesne, C., Retuerto, N., Navarro, M. C., Azouz, Z., Tabyaoui, A., Macalli, M., Tzourio, C., & Galéra, C. (2025) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2025.100652
Addiction and the role of childhood externalising disorders
Carpentier, P. J. (2012) · Radboud Repository (Radboud University)
Jean, F. A. M. (2023) · theses.fr (ABES) · doi:10.70675/4f836fa7z0a4ez4eb1z9364z9a264cce0262
- Authors
- Kolpe, M., & Carlson, G. A.
- Affiliations
- Hennepin County Medical Center (US)
- Corresponding author
- Kolpe, Manasi
- Venue
- The American Journal on Addictions
- Publisher
- Wiley
- Published
- 2007-01-02
- Volume
- 16
- Issue
- 1
- Pages
- 46-48
- ISSN
- 1055-0496 (ISSN-L)
- 1521-0391
- OpenAlex
- W2145556774
- Cited by
- 36
- References
- 17
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 7
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal on Addictions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- attention deficit hyperactivity disorder, ADHD symptoms, methadone maintenance treatment, opioid use disorder, treatment outcomes, abstinence, drug use reduction, ADHD screening, comorbidities
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Female, Heroin Dependence, Hospitalization, Humans, Male, Mass Screening, Mental Health Services, Methadone, Severity of Illness Index, Incidence, Prevalence, Treatment Outcome
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