Predictors of Persistence and Remission of ADHD into Adolescence: Results from a Four-Year Prospective Follow-up Study
Abstract
Objective To evaluate the predictors of persistence and the timing of remission of attention-deficit hyperactivity disorder (ADHD). Method Subjects were 6- to 17-year old Caucasian, non-Hispanic boys with and without ADHD. DSM-III-R structured diagnostic interviews and blind raters were used to examine psychiatric diagnoses, cognitive achievement, social, school, and family functioning at a 4-year follow-up assessment. Results At the 4-year follow-up assessment, 85% of children with ADHD continued to have the disorder and 15% remitted. Of those who remitted, half did so in childhood and the other half in adolescence. Predictors of persistence were familiality of ADHD, psychosocial adversity, and comorbidity with conduct, mood, and anxiety disorders. Conclusions The findings prospectively confirm that the majority of children with ADHD will continue to express the disorder 4 years later. For a minority of children, ADHD was a transient disorder that remits early in development. In addition, we have shown that persistence of ADHD is predictable. Familiality, adversity, and psychiatric comorbidity may be clinically useful predictors of which children with ADHD are at risk for a persistent disorder.
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Most ADHD longitudinal studies simply define remission as failing to meet DSM criteria, with few attempts to identify or define distinct subtypes and patterns of remission.
“Most ADHD longitudinal studies simply define remission as “failing to meet DSM criteria,” with few attempts to identify/define distinct subtypes and patterns of remission.”
From Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD (2022) · cites this paper as [5]
Most longitudinal work on ADHD remission and persistence reports only a single-time snapshot of functioning.
“Most longitudinal work on ADHD remission and persistence reports only a single-time snapshot of functioning, even though ADHD is considered a life-course disorder.”
From Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD (2022) · cites this paper as [5]
ADHD is considered a life-course disorder.
“even though ADHD is considered a life-course disorder.”
From Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD (2022) · cites this paper as [5]
There is virtually no scientific information on the extent to which individuals sustain remission long-term, experience recurrence of ADHD post-remission, or fluctuate between full remission, partial remission, and ADHD persistence.
“There is virtually no scientific information on the extent to which individuals sustain remission long-term (i.e., recover from ADHD symptoms and impairments), experience recurrence of ADHD post-remission (i.e., remission is temporary), or fluctuate between full remission, partial remission, and ADHD persistence (whether ADHD might be a waxing and waning disorder).”
From Variable Patterns of Remission From ADHD in the Multimodal Treatment Study of ADHD (2022) · cites this paper as [5]
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- Authors
- BIEDERMAN, J., FARAONE, S., MILBERGER, S., CURTIS, S., CHEN, L., MARRS, A., OUELLETTE, C., MOORE, P., & SPENCER, T.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- BIEDERMAN, JOSEPH
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 35
- Issue
- 3
- Pages
- 343-351
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2093507141
- Cited by
- 510
- References
- 7
- Citations by year
- 2025: 8 · 2024: 4 · 2023: 7 · 2022: 7 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 11 · 2017: 15 · 2016: 24 · 2015: 23 · 2014: 22 · 2013: 34 · 2012: 31
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIMH (MH41314–08)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, ADHD persistence, predictors of remission, familiality, psychosocial adversity, psychiatric comorbidity, conduct disorder, mood disorders, anxiety disorders, children and adolescents, longitudinal follow-up
- MeSH terms
- Achievement, Adolescent, Psychology, Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Cognition, Follow-Up Studies, Humans, Longitudinal Studies, Male, Prospective Studies, Psychiatric Status Rating Scales, Remission Induction
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