Cited by 103Advanced Glycation End Products researchNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

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Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

Panigrahy, Suchitra Kumari, Bhatt, Renu, Kumar, Awanish·2017·Journal of Drug Targeting

DOI 10.1080/1061186x.2016.1207650

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Abstract

Oxidative stress has been considered as a central mediator in the progression of diabetic complication. The intracellular reactive oxygen species (ROS) leads to oxidative stress and it is raised from the mitochondria as well as by activation of five major pathways: increased polyol pathway flux, activation of protein kinase C (PKC) pathway, increased formation of advanced glycation end products (AGEs), over activity of hexosamine pathway and increased production of angiotensin II. The increased ROS through these pathways leads to β-cell dysfunction and insulin resistance, responsible for cell damage and death. This review not only highlights the sources of ROS production and their involvement in the progression of diabetes, but also emphasizes on pharmacological interventions and targeting of ROS in type 2 diabetes. This review summarizes the ROS as potential therapeutic targets, based on a putative mechanism in the progression of the diabetes. It also summarizes current knowledge of ROS activation in type 2 diabetes as well as ROS as a possible target for its treatment. Eventually, it would be a promising target for various strategies and drugs to modulate ROS levels in diabetes.

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“…receptor; GLP-1 - glucagon-like peptide-1; ROS – reactive oxygen species; PPAR-γ - peroxisome proliferator-activated receptor gamma; VLDL – very low-density lipoprotein; TC – total cholesterol; TG – triglycerides. be a strategy to reduce oxidative stress and cellular damage in pregnancy [128–130].”
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An insight into paper-based microfluidic devices for diabetes diagnosis: Fabrication, detection, and applications
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Self-citation
A fluorescence probe with targeted mitochondria for detecting hydrogen peroxide in vitro and in diabetic mice
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Preliminary studies on in vitro antioxidant and retardation of essential carbohydrate hydrolysing enzymes by some indigenous South African medicinal plants
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Glycemic management is inversely related to skeletal muscle microvascular endothelial function in patients with type 2 diabetes
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“, superoxide) (Panigrahy et al., 2017), or advanced glycation end products (Vlassara & Uribarri, 2014) attenuated NO bioavailability that promotes a pathologic milieu.”
Background
The susceptibility to autoxidation of erythrocytes in diabetic mice: Effects of melatonin and pentoxifylline
Şekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H., & Hakan, H. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21976 · Cited by 4
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Oxidative Stress and Antioxidant Interventions in Type 2 Diabetes
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The Positive Relationship Between the Low-Density Lipoprotein Cholesterol/Apoprotein B Ratio and Bone Turnover Markers in Patients With Type 2 Diabetes
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Effect of Ethanol Extract of Jamblang Aceh (Syzygium cumini) in Diabetic Mice (Mus musculus) and Its Potential As Anti-Diabetic Agent
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“Antioxidants have been proven to prevent the destruction of β-cells by inhibiting peroxidation chain reactions so that they can provide protection against the development of diabetes (Volpe et al., 2018; Panigrahy et al., 2017).”
Background
Antidiabetic, antihyperlipidemic and protective effects of Gladiolus psittacinus on hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats
Karigidi, K. O., Akintimehin, E. S., Karigidi, M. E., & Adetuyi, F. O. (2023) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2023-0018 · Cited by 3
l-norleucine on high glucose-induced insulin sensitivity and mitochondrial function in skeletal muscle cells
Ding, B., Fan, Y., Zhu, T., Bai, G., Liang, B., Tian, X., & Xie, X. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149742 · Cited by 3
Hierarchically Targeting and ROS-Responsive Platform for Diabetic Periodontitis Treatment through Mitochondrial Repair in M1 Macrophages
Xie, W., Wang, Y., Wu, J., Wang, X., Wu, J., Cheng, B., Feng, H., Huang, X., Cheng, X., Chen, J., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20136 · Cited by 2
Vascular actions of Ang 1–7 and Ang 1–8 through EDRFs and EDHFs in non-diabetes and diabetes mellitus
Mahmood, N. M. S., Mahmud, A. M. R., & Maulood, I. M. (2025) · Nitric Oxide · doi:10.1016/j.niox.2025.02.003 · Cited by 3
Cerebral ischemia in diabetics and oxidative stress
Cho, S., Fuchs, P., Sarmah, D., Kaur, H., Bhattacharya, P., & Dave, K. R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815776-3.00006-1 · Cited by 4
Dietary inclusion of coconut and date palm fruit blend attenuate hyperglycemia, insulin insensitivity and diabetes-induced complications in vivo
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Comparative efficacy of four potent bioactive molecules of fenugreek seed in holistic management of type 1 diabetes
Majumdar, J., Chatterjee, A., Chakraborty, S. B., Chakraborty, P., & Sarkar, S. (2024) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-024-00774-x · Cited by 1
“Both conditions trigger excessive reactive oxygen species (ROS) production leading to tissue damage in important organs (Takayanagi et al. 2010; Panigrahy et al. 2017) Glucagon-like peptide-1 (GLP-1) is an incretin hormone, secreted postprandially by intestinal enteroendocrine L-cells which…”
Recent Developments in Triazole Derivatives as α-Glucoside Inhibitors for the Treatment of Diabetes
Devi, P., Maity, S., Gupta, S., Singh, A., Verma, S. K., & Asati, V. (2025) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575371876250429175826 · Cited by 1
Unraveling the Antioxidant, Antihyperlipidemic, and Antidiabetic Potential of Jatropha integerrima in Streptozotocin-Induced Diabetic Rats
Bharati, D., Pualsa, D., Mayekar, S., Nadar, J., Mohite, P. B., Kumar, A. A. A. A., & Singh, S. K. (2026) · Life · doi:10.3390/life16020246 · Cited by 2
Self-citation
Predicting HbA1c Target Achievement in Type 2 Diabetes: A Retrospective Single-Centre Nomogram Derived From National MMC-Standardised Management
Lu, M., Zhou, H., Liu, Y., Song, J., Lü, X., & Liu, Y. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s535766 · Cited by 1
The Role of Galectin 3 in the Pathogenesis of Diabetes Mellitus: Focus on β-Cell Function and Survival
Marinković, M., & Petrović, I. (2022) · EABR. Experimental and Applied Biomedical Research · doi:10.2478/sjecr-2022-0008 · Cited by 1
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Shuilu Erxian Dan in Treating Diabetic Kidney DiseasePreprint
Wu, T., Yue, R., & He, M. (2020) · Research Square · doi:10.21203/rs.3.rs-54579/v1 · Cited by 1
Preliminary in Vitro Antioxidant and Retardation of Essential Carbohydrate Hydrolysing Enzymes by Some Indigenous South African Medicinal PlantPreprint
Ogbe, A. A., Gupta, S., Finnie, J. F., & van Staden, J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4188476 · Cited by 1
A demographic study on relation between uric acid and diabetes parameters in the Chhattisgarh State of India
Kumar, A., Thakur, P., Kumar, A., & Patra, P. K. (2017) · Advances in Human Biology · doi:10.4103/aihb.aihb_34_17
Self-citation
Evaluation of wound healing effects of ginsenoside Rg1 and red ginseng extract in STZ-induced diabetic wound model: an in vivo pilot studyPreprint
Lim, J. Y., Choi, Y. S., Lee, H. R., An, H. M., & Lee, Y. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.05.442721
Relationships among the Hexosamine Biosynthetic Pathway, Sleep Disturbance, and Cognition in Obstructive Sleep Apnea
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“ROS increase insulin resistance and decrease intracellular glucose levels, leading to reduction of HBP activation and O-GlcNAcylation [17].”
BackgroundInfluential
The current state of diabetes treatment
Danquah, M. K., & Jeevanandam, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85396-5.00007-5
Association of Thiol–disulfide Homeostasis with Retinal Layer Thickness in Patients with Diabetes MellitusPreprint
Bilginer, M. C., Tam, A. A., Ogmen, B. E., Güler, B. Y., Uğurlu, N., Yülek, F., Erel, Ö., Topaloğlu, O., Ersoy, R., & Çakır, B. (2021) · Research Square · doi:10.21203/rs.3.rs-791653/v1
Investigation Into the Antidiabetic Effects of a Developed Polyherbal Nanosuspension and Its Assessment
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ALDOSE REDUCTASE ENZYME'S CLINICAL AND THERMODYNAMIC CHARACTERISTICS IN THE SERUM OF IRAQI DIABETIC PATIENTS
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Age-related aspects of redox signaling cascades of wound healing
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Elucidating the Type 2 Diabetes Regulatory Network: Identification of EGFR as a Key Hub and Novel Drug CandidatesPreprint
Romero, R. C., & Rojas, C. A. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.602441
“Some studies have reported elevated EGFR levels in T2D patients, particularly in adipose tissue of obese individuals at high risk for T2D[38].”
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Study the role of GLP-1 receptor agonist (Liraglutide) on experimentally induced diabetic nephropathy in male albino rats
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Beyond traditional medicine: Erythrophyleum suaveolens (Guill. & Perr.) Brenan shows promising antidiabetic activity in experimentally induced type II diabetes
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Authors: Panigrahy, S. K., Bhatt, R., & Kumar, A.
Affiliations: Guru Ghasidas Vishwavidyalaya (IN)
National Institute of Technology Raipur (IN)
Corresponding author: Bhatt, Renu
Kumar, Awanish
ORCID: Bhatt, Renu
Kumar, Awanish
Venue: Journal of Drug Targeting
Publisher: Informa UK Limited
Published: 2016-07-19
Volume: 25
Issue: 2
Pages: 93-101
ISSN: 1026-7158 (ISSN-L)
1061-186X
1029-2330
DOI: 10.1080/1061186x.2016.1207650
OpenAlex: W2468238510
Cited by: 103
References: 142
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 1
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Locations: Journal of drug targeting (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, oxidative stress, type 2 diabetes, polyol pathway, protein kinase C, advanced glycation end products, hexosamine biosynthetic pathway, angiotensin II, beta-cell dysfunction, insulin resistance, diabetes complications, antioxidant therapy
MeSH terms: Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Reactive Oxygen Species

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Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

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