Cited by 103Advanced Glycation End Products researchNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

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Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

Panigrahy, Suchitra Kumari, Bhatt, Renu, Kumar, Awanish·2017·Journal of Drug Targeting

DOI 10.1080/1061186x.2016.1207650

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Abstract

Oxidative stress has been considered as a central mediator in the progression of diabetic complication. The intracellular reactive oxygen species (ROS) leads to oxidative stress and it is raised from the mitochondria as well as by activation of five major pathways: increased polyol pathway flux, activation of protein kinase C (PKC) pathway, increased formation of advanced glycation end products (AGEs), over activity of hexosamine pathway and increased production of angiotensin II. The increased ROS through these pathways leads to β-cell dysfunction and insulin resistance, responsible for cell damage and death. This review not only highlights the sources of ROS production and their involvement in the progression of diabetes, but also emphasizes on pharmacological interventions and targeting of ROS in type 2 diabetes. This review summarizes the ROS as potential therapeutic targets, based on a putative mechanism in the progression of the diabetes. It also summarizes current knowledge of ROS activation in type 2 diabetes as well as ROS as a possible target for its treatment. Eventually, it would be a promising target for various strategies and drugs to modulate ROS levels in diabetes.

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Authors: Panigrahy, S. K., Bhatt, R., & Kumar, A.
Affiliations: Guru Ghasidas Vishwavidyalaya (IN)
National Institute of Technology Raipur (IN)
Corresponding author: Bhatt, Renu
Kumar, Awanish
ORCID: Bhatt, Renu
Kumar, Awanish
Venue: Journal of Drug Targeting
Publisher: Informa UK Limited
Published: 2016-07-19
Volume: 25
Issue: 2
Pages: 93-101
ISSN: 1026-7158 (ISSN-L)
1061-186X
1029-2330
DOI: 10.1080/1061186x.2016.1207650
OpenAlex: W2468238510
Cited by: 103
References: 142
Citations by year: 2026: 3 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 20 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 1
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Locations: Journal of drug targeting (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, oxidative stress, type 2 diabetes, polyol pathway, protein kinase C, advanced glycation end products, hexosamine biosynthetic pathway, angiotensin II, beta-cell dysfunction, insulin resistance, diabetes complications, antioxidant therapy
MeSH terms: Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Reactive Oxygen Species

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Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes

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