The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
Abstract
We evaluated the levels of (-)-epicatechin (EC) and its metabolites in plasma and urine after intake of chocolate or cocoa by male volunteers. EC metabolites were analyzed by HPLC and LC/MS after glucuronidase and/or sulfatase treatment. The maximum levels of total EC metabolites in plasma were reached 2 hours after either chocolate or cocoa intake. Sulfate, glucuronide, and sulfoglucuronide (mixture of sulfate and glucuronide) conjugates of nonmethylated EC were the main metabolites present in plasma rather than methylated forms. Urinary excretion of total EC metabolites within 24 hours after chocolate or cocoa intake was 29.8+/-5.3%'; and 25.3+/-8.1% of total EC intake. EC in chocolate and cocoa was partly absorbed and was found to be present as a component of various conjugates in plasma, and these were rapidly excreted in urine.
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Hertog, M. G. L. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430040053006 · Cited by 1,853
Hammerstone, J. F., Lazarus, S. A., Mitchell, A. E., Rucker, R., & Schmitz, H. H. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980760h · Cited by 455
Adamson, G. E., Lazarus, S. A., Mitchell, A. E., Prior, R. L., Cao, G., Jacobs, P. H., Kremers, B. G., Hammerstone, J. F., Rucker, R. B., Ritter, K. A., et al. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990317m · Cited by 404
Cited by
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711
Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563
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Metadata
- Authors
- Baba, S., Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Nakamura, T., & Terao, J.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2000-01
- Volume
- 33
- Issue
- 5
- Pages
- 635-641
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2108025709
- Cited by
- 240
- References
- 3
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baba, S., Osakabe, N., Yasuda, A., Natsume, M., Takizawa, T., Nakamura, T., & Terao, J. (2000). Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers. Free Radical Research. https://doi.org/10.1080/10715760000301151
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