Cited by 74Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressGastrointestinal motility and disorders

Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat

Miyoshi, Mami, Kasahara, Emiko, Park, Ah-Mee, Hiramoto, Keiichi, Minamiyama, Yukiko, Takemura, Shigekazu, Sato, Eisuke F., Inoue, Masayasu·2003·Free Radical Research

Abstract

Dietary nitrate is reduced to nitrite by some oral bacteria and the resulting nitrite is converted to nitric oxide (NO) in acidic gastric juice. The aim of this study is to elucidate the pathophysiological role of dietary nitrate in the stomach. Intragastric administration of nitrate rapidly increased nitrate and NO in plasma and the gastric headspace, respectively. Water-immersion-restraint stress (WIRS) increased myeloperoxidase (MPO) activity in gastric mucosa and induced hemorrhagic erosions by a nitrate-inhibitable mechanism. In animals that had received either cardiac ligation or oral treatment with povidone-iodine, a potent bactericidal agent, administration of nitrate failed to increase gastric levels of NO and to inhibit WIRS-induced mucosal injury. WIRS decreased gastric mucosal blood flow by a mechanism which was inhibited by administration of nitrate. These data suggested that the enterosalivary cycle of nitrate and related metabolites consisted of gastrointestinal absorption and salivary secretion of nitrate, its conversion to nitrite by oral bacteria and then to NO in the stomach might play important roles in the protection of gastric mucosa from hazardous stress.

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Registry

Crossref · 10.1080/1071576021000086632

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24 of 24 references verified0 citation errors · 0 not checkable

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  • Oral ingestion of nitrite into the acidic environment of the stomach produces NO that augments mucus secretion, antibacterial effects of gastric fluids, and ulcer healing.

    “Moreover, oral ingestion of nitrite into the acidic environment of the stomach produces NO that augments mucus secretion, antibacterial effects of gastric fluids, and ulcer healing [93–97].”

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Authors
Miyoshi, M., Kasahara, E., Park, A.-M., Hiramoto, K., Minamiyama, Y., Takemura, S., Sato, E. F., & Inoue, M.
Affiliations
Osaka City University (JP)
Venue
Free Radical Research
Published
2003-01
Volume
37
Issue
1
Pages
85-90
ISSN
  • 1029-2470 (ISSN-L)
  • 1071-5762
OpenAlex
W2149637168
Cited by
74
References
24
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 3 · 2022: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
1.80
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
dietary nitrate, gastric mucosal injury, water immersion stress, nitric oxide, nitrite, oral bacteria, myeloperoxidase, gastric mucosal blood flow, stress-induced gastric damage, povidone-iodine
MeSH terms
Animals, Diet, Gastric Mucosa, Intestinal Absorption, Male, Neutrophils, Nitrates, Nitric Oxide, Nitrites, Regional Blood Flow, Saliva, Stress, Physiological, Rats, Wistar, Potassium Compounds, Rats

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