The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
Abstract
Tomato juice containing rutin (quercetin-3-rutinoside) was ingested by healthy volunteers and ileostomists. Blood and urine collected over 24 h were analysed by HPLC with photodiode array (PDA) and tandem mass spectrometric detection. Low concentrations of isorhamnetin-3-glucuronide (Cmax = 4.3 +/- 1.5 nmoles/l) and quercetin-3-glucuronide (Cmax = 12 +/- 2 nmoles/l) were detected in plasma of healthy subjects. Metabolites appeared in blood after 4 h indicating absorption from the large intestine. Nine metabolites of rutin were detected in urine but with considerable variation in total amount (40 +/- 1-4981 +/- 115 nmoles over 24 h). No metabolites were detected in plasma or urine of ileostomists and 86 +/- 3% of the ingested rutin was recovered in ileal fluid. In subjects with an intact large intestine, but not ileostomists, rutin was catabolised with the appearance of 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in urine accounting for 22% of rutin intake.
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Citations
Cites
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175
Pharmacokinetics and bioavailability of quercetin glycosides in humans
Graefe, E. U., Wittig, J., Mueller, S., Riethling, A., Uehleke, B., Drewelow, B., Pforte, H., Jacobasch, G., Derendorf, H., & Veit, M. (2001) · The Journal of Clinical Pharmacology · doi:10.1177/00912700122010366 · Cited by 649 · cited 2×
“However, the low concentrations of quercetin metabolites detected in the plasma after ingestion of rutin could be due, in part, to the relatively low activity of a-L-rhamnosidase compared to that of b-glucosidase [13].”
BackgroundMethodChlorogenic Acid, Quercetin-3-Rutinoside and Black Tea Phenols Are Extensively Metabolized in Humans
Olthof, M. R., Hollman, P. C. H., Buijsman, M. N. C. P., van Amelsvoort, J. M. M., & Katan, M. B. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.6.1806 · Cited by 468 · cited 4×
“[9] who proposed that the urinary hydroxyphenylacetic acids originate in the colon through hydrolysis of rutin releasing quercetin which undergoes colonic bacterial mediated-fission of ring B producing 3,4-dihydroxyphenylacetic acid which is partially converted to 3-hydroxyphenylacetic acid.”
BackgroundInfluential
Cited by
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Self-citationFlavonoid Bioavailability and Attempts for Bioavailability Enhancement
Thilakarathna, S., & Rupasinghe, H. (2013) · Nutrients · doi:10.3390/nu5093367 · Cited by 787
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D'Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 721
RetractedKawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563
The role of polyphenols in modern nutrition
Williamson, G. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12278 · Cited by 551
Metadata
- Authors
- Jaganath, I. B., Jaganath, I. B., Mullen, W., Edwards, C. A., & Crozier, A.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 40
- Issue
- 10
- Pages
- 1035-1046
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2053310956
- Cited by
- 208
- References
- 3
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. https://app.cochat.ai/papers/10.1080/10715760600771400
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- Jaganath, I. B., Jaganath, I. B., Mullen, W., Edwards, C. A., & Crozier, A. (2006). The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Radical Research. https://doi.org/10.1080/10715760600771400
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
