The role of polyphenols in modern nutrition

Williamson, G.

doi:10.1111/nbu.12278

Cited by 551Phytochemicals and Antioxidant ActivitiesNutritional Studies and DietPomegranate: compositions and health benefits

The role of polyphenols in modern nutrition

Open access

Williamson, G.·2017·Nutrition Bulletin

DOI 10.1111/nbu.12278PMC PMC5601283

Open this paper in CoChat — free account Open PDF

Abstract

Abstract Polyphenols are found in plant‐based foods and beverages, notably apples, berries, citrus fruit, plums, broccoli, cocoa, tea and coffee and many others. There is substantial epidemiological evidence that a diet high in polyphenol‐rich fruit, vegetables, cocoa and beverages protects against developing cardiovascular disease and type 2 diabetes. The absorption and metabolism of these compounds have been well described and, for many, the gut microbiota play a critical role in absorption; taking into consideration the parent compound and the metabolites from colon bacteria catabolism, more than 80% of a dose can be absorbed and ultimately excreted in the urine. Common polyphenols in the diet are flavanols (cocoa, tea, apples, broad beans), flavanones (hesperidin in citrus fruit), hydroxycinnamates (coffee, many fruits), flavonols (quercetin in onions, apples and tea) and anthocyanins (berries). Many intervention studies, mechanistic in vitro data and epidemiological studies support a role for polyphenols against the development of chronic diseases. For example, flavanols decrease endothelial dysfunction, lower blood pressure and cholesterol, and modulate energy metabolism. Coffee and tea both reduce the risk of developing type 2 diabetes, through action of their constituent polyphenols. Despite extensive research, the exact mechanisms of action of polyphenols in the human body have not been decisively proven, but there is strong evidence that some targets such as nitric oxide metabolism, carbohydrate digestion and oxidative enzymes are important for health benefits. Consumption of polyphenols as healthy dietary components is consistent with the advice to eat five or more portions of fruit and vegetables per day, but it is currently difficult to recommend what ‘doses’ of specific polyphenols should be consumed to derive maximum benefit.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/nbu.12278

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Polyphenols often act synergistically with other nutrients to influence glucose homeostasis and cellular processes.
“Often polyphenols act synergistically with other nutrients to influence glucose homeostasis and cellular processes”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [232]
It is uncertain whether isolated polyphenol supplements would have the maximum effect without eating a variety of whole foods, as in the MedDiet eating pattern.
“it is uncertain whether isolated supplements would have the maximum effect without eating a variety of whole foods, as in the MedDiet eating pattern [232]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [232]
Polyphenol-based synthetic supplements may have several drawbacks.
“However, despite representing a novel treatment paradigm for IR and IR-related diseases, polyphenol-based synthetic supplements may have several drawbacks [232].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [232]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dietary Intake and Bioavailability of Polyphenols
Scalbert, A., & Williamson, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.8.2073s · Cited by 3,658 · see citing works
Self-citation
Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Flavonoid Intake and Long-term Risk of Coronary Heart Disease and Cancer in the Seven Countries Study
Hertog, M. G. L. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430040053006 · Cited by 2,225 · see citing works
Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
Neveu, V., Pérez‐Jiménez, J., Vos, F., Crespy, V., Chaffaut, L. D., Mennen, L. I., Knox, C., Eisner, R., Cruz, J., Wishart, D. S., et al. (2010) · Database · doi:10.1093/database/bap024 · Cited by 1,442 · see citing works
Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., & Cassidy, A. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.1.38 · Cited by 1,097 · see citing works
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956 · see citing works
Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis
Ding, M., Bhupathiraju, S. N., Chen, M., van Dam, R. M., & Hu, F. B. (2014) · Diabetes Care · doi:10.2337/dc13-1203 · Cited by 511 · cited 1× · see citing works
“Data from systematic reviews and meta-analyses show that the reduction in risk is ~8% for each cup of coffee consumed per day and that this is independent of whether the coffee is decaffeinated or not (Bhupathiraju et al. 2013; Ding et al. 2014).”
Background
Dietary intake of 337 polyphenols in French adults
Pérez‐Jiménez, J., Fezeu, L., Touvier, M., Arnault, N., Manach, C., Herçberg, S., Galan, P., & Scalbert, A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007096 · Cited by 425 · see citing works
Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions
Mullen, W., Edwards, C. A., & Crozier, A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061809 · Cited by 421 · see citing works
Possible effects of dietary polyphenols on sugar absorption and digestion
Williamson, G. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200511 · Cited by 389 · see citing works
Mechanisms of body weight reduction and metabolic syndrome alleviation by tea
Yang, C. S., Zhang, J., Zhang, L., Huang, J., & Wang, Y. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500428 · Cited by 384 · see citing works
Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
Loke, W. M., Hodgson, J. M., Proudfoot, J. M., McKinley, A. J., Puddey, I. B., & Croft, K. D. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1018 · Cited by 372 · see citing works
Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., et al. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28548 · Cited by 364 · cited 2× · see citing works
“In studies of the latter design, coffee over 4 weeks, after a 4-week washout, attenuated DNA damage, reduced bodyweight and body fat (Bakuradze et al. 2011), and exerted beneficial effects on subclinical inflammation and HDL-cholesterol (Kempf et al. 2010).”
Background
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols
Williamson, G., & Clifford, M. N. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.03.012 · Cited by 346 · see citing works
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
Mastroiacovo, D., Kwik-Uribe, C. L., Grassi, D., Necozione, S., Raffaele, A., Pistacchio, L., Righetti, R., Bocale, R., Lechiara, M. C., Marini, C., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092189 · Cited by 344 · see citing works
Supplementation with Quercetin Markedly Increases Plasma Quercetin Concentration without Effect on Selected Risk Factors for Heart Disease in Healthy Subjects
Conquer, J. A., Maiani, G., Azzini, E., Raguzzini, A., & Holub, B. J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.3.593 · Cited by 332 · see citing works
Cocoa and health: a decade of research
Cooper, K., Donovan, J. L., Waterhouse, A. L., & Williamson, G. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507795296 · Cited by 302 · see citing works
Chocolate and Prevention of Cardiovascular Disease: A Systematic Review
Ding, E. L., Hutfless, S. M., Ding, X., & Girotra, S. R. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-2 · Cited by 267 · see citing works
THE CHOLESTEROL-RAISING FACTOR FROM COFFEE BEANS
Urgert, R., & Katan, M. B. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.305 · Cited by 260 · see citing works
Endogenous and exogenous mediators of quercetin bioavailability
Guo, Y., & Bruno, R. S. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.10.008 · Cited by 257 · see citing works
The metabolome of [2-14C](−)-epicatechin in humans: implications for the assessment of efficacy, safety and mechanisms of action of polyphenolic bioactives
Ottaviani, J. I., Borges, G., Momma, T. Y., Spencer, J. P. E., Keen, C. L., Crozier, A., & Schroeter, H. (2016) · Scientific Reports · doi:10.1038/srep29034 · Cited by 256 · see citing works
Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis
Buitrago-Lopez, A., Sanderson, J., Johnson, L., Warnakula, S., Wood, A., Di Angelantonio, E., & Franco, O. H. (2011) · BMJ · doi:10.1136/bmj.d4488 · Cited by 252 · see citing works
Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen‐stimulated platelet activation pathway in humans
Hubbard, G. P., Wolffram, S., Lovegrove, J. A., & Gibbins, J. M. (2004) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01067.x · Cited by 246 · see citing works
The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension
Watanabe, T., Arai, Y., Mitsui, Y., Kusaura, T., Okawa, W., Kajihara, Y., & Saito, I. (2006) · Clinical and Experimental Hypertension · doi:10.1080/10641960600798655 · Cited by 242 · see citing works
Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans
Olthof, M. R., Hollman, P. C., Zock, P. L., & Katan, M. B. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.532 · Cited by 222 · cited 2× · see citing works
“Coffee consumption over 1 week has been reported to increase (Olthof et al. 2001) or not affect (Esposito et al.”
Background
Caffeinated and caffeine-free beverages and risk of type 2 diabetes
Bhupathiraju, S. N., Pan, A., Malik, V. S., Manson, J. E., Willett, W. C., van Dam, R. M., & Hu, F. B. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.048603 · Cited by 222 · see citing works
ABSORPTION/METABOLISM OF SULFORAPHANE AND QUERCETIN, AND REGULATION OF PHASE II ENZYMES, IN HUMAN JEJUNUM IN VIVO
Petri, N., Tannergren, C., Holst, B., Mellon, F. A., Bao, Y., Plumb, G. W., Bacon, J., O’Leary, K. A., Kroon, P. A., Knutson, L., et al. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.6.805 · Cited by 220 · see citing works
Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial
Dower, J. I., Geleijnse, J. M., Gijsbers, L., Zock, P. L., Kromhout, D., & Hollman, P. C. H. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.098590 · Cited by 216 · see citing works
The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man
Jaganath, I. B., Jaganath, I. B., Mullen, W., Edwards, C. A., & Crozier, A. (2006) · Free Radical Research · doi:10.1080/10715760600771400 · Cited by 208 · see citing works
Serum Lipid and Blood Pressure Responses to Quercetin Vary in Overweight Patients by Apolipoprotein E Genotype
Egert, S., Boesch, C., Wolffram, S., Rimbach, G. H., & Müller, M. J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.117655 · Cited by 194 · see citing works
The Inhibition of α-Amylase by Tea Polyphenols
Hara, Y., & Honda, M. (1990) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1990.10870239 · Cited by 193 · see citing works
The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
Kay, C. D., Kroon, P. A., & Cassidy, A. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800461 · Cited by 192 · see citing works
Flavonoid Intake in European Adults (18 to 64 Years)
Vogiatzoglou, A., Mulligan, A. A., Lentjes, M. A. H., Luben, R., Spencer, J. P. E., Schroeter, H., Khaw, K., & Kuhnle, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128132 · Cited by 191 · see citing works
Coffee Consumption and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Dose-Response Meta-Analysis
Crippa, A., Discacciati, A., Larsson, S. C., Wolk, A., & Orsini, N. (2014) · American Journal of Epidemiology · doi:10.1093/aje/kwu194 · Cited by 191 · see citing works
Dietary reference intake (DRI) value for dietary polyphenols: are we heading in the right direction?
Williamson, G., & Holst, B. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508006867 · Cited by 185 · see citing works
Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial ,
Dower, J. I., Geleijnse, J. M., Gijsbers, L., Schalkwijk, C. G., Kromhout, D., & Hollman, P. C. H. (2015) · Journal of Nutrition · doi:10.3945/jn.115.211888 · Cited by 182 · see citing works
Usage of Plant Food Supplements across Six European Countries: Findings from the PlantLIBRA Consumer Survey
García-Álvarez, A., Egan, B., de Klein, S., Dima, L., Maggi, F. M., Isoniemi, M., Ribas‐Barba, L., Raats, M. M., Meissner, E. M., Badea, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092265 · Cited by 178 · see citing works
Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies
Martini, D., Bo’, C. D., Tassotti, M., Riso, P., Rio, D. D., Brighenti, F., & Porrini, M. (2016) · Molecules · doi:10.3390/molecules21080979 · Cited by 178 · see citing works
Estimated Daily Intake and Seasonal Food Sources of Quercetin in Japan
Nishimuro, H., Ohnishi, H., Sato, M., Ohnishi‐Kameyama, M., Matsunaga, I., Naito, S., Ippoushi, K., Oike, H., Nagata, T., Akasaka, H., et al. (2015) · Nutrients · doi:10.3390/nu7042345 · Cited by 177 · see citing works
Coffee consumption, obesity and type 2 diabetes: a mini-review
Santos, R. M. M., & Lima, D. R. A. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1206-0 · Cited by 169 · see citing works
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial
Shi, Y., & Williamson, G. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005310 · Cited by 157 · see citing works
The Bioavailability of Quercetin in Pigs Depends on the Glycoside Moiety and on Dietary Factors
Cermak, R., Landgraf, S., & Wolffram, S. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2802 · Cited by 154 · see citing works
Red wine, tea, and antioxidants
Serafini, M., Ghiselli, A., Ferro-Luzzi, A., & Melville, C. A. S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92017-6 · Cited by 152 · see citing works
Structurally related (−)-epicatechin metabolites in humans: Assessment using de novo chemically synthesized authentic standards
Ottaviani, J. I., Momma, T. Y., Kuhnle, G., Keen, C. L., & Schroeter, H. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.010 · Cited by 149 · see citing works
Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial
Heiß, C., Sansone, R., Karimi, H., Krabbe, M., Schuler, D., Rodriguez‐Mateos, A., Kræmer, T., Cortese-Krott, M. M., Kuhnle, G., Spencer, J. P. E., et al. (2015) · AGE · doi:10.1007/s11357-015-9794-9 · Cited by 142 · see citing works
Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis
Pang, J., Zhang, Z., Zheng, T., Bassig, B. A., Mao, C., Liu, X., Zhu, Y. L., Shi, K., Ge, J., Yang, Y., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.12.176 · Cited by 140 · see citing works
Elucidation of (−)-epicatechin metabolites after ingestion of chocolate by healthy humans
Actis‐Goretta, L., Lévèques, A., Giuffrida, F., Romanov‐Michailidis, F., Viton, F., Barron, D., Dueñas, M., González‐Manzano, S., Santos‐Buelga, C., Williamson, G., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.05.023 · Cited by 140 · see citing works
In Vivo Bioavailability, Absorption, Excretion, and Pharmacokinetics of [14C]Procyanidin B2 in Male Rats
Stoupi, S., Williamson, G., Viton, F., Barron, D., King, L. J., Brown, J. E., & Clifford, M. N. (2009) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.030304 · Cited by 137 · see citing works
Effect of a lipid-rich fraction from boiled coffee on serum cholesterol
Zock, P. L., Katan, M., Merkus, M. P., Dusseldorp, M., & Harryvan, J. L. (1990) · The Lancet · doi:10.1016/0140-6736(90)91302-q · Cited by 127 · see citing works
Phenolic sulfates as new and highly abundant metabolites in human plasma after ingestion of a mixed berry fruit purée
Pimpão, R. C., Ventura, M. R., Ferreira, R. B., Williamson, G., & Santos, C. N. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514003511 · Cited by 126 · see citing works
Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union
Vogiatzoglou, A., Mulligan, A. A., Luben, R., Lentjes, M. A. H., Heiß, C., Kelm, M., Merx, M. W., Spencer, J. P. E., Schroeter, H., & Kuhnle, G. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003930 · Cited by 122 · see citing works
Influence of Formulation and Processing on Absorption and Metabolism of Flavan-3-Ols from Tea and Cocoa
Neilson, A. P., & Ferruzzi, M. G. (2011) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022510-133725 · Cited by 121 · see citing works
Molecular mechanisms of the anti-obesity effect of bioactive compounds in tea and coffee
Pan, M., Tung, Y., Yang, G., Li, S., & Ho, C. (2016) · Food & Function · doi:10.1039/c6fo01168c · Cited by 120 · see citing works
Epidemiologic Evidence on Coffee and Cancer
Arab, L. (2010) · Nutrition and Cancer · doi:10.1080/01635580903407122 · Cited by 118 · see citing works
Quercetin Ingestion Does Not Alter Cytokine Changes in Athletes Competing in the Western States Endurance Run
Nieman, D. C., Henson, D. A., Davis, J. M., Dumke, C. L., Gross, S. J., Jenkins, D. P., Murphy, E. A., Carmichael, M. D., Quindry, J. C., McAnulty, S. R., et al. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0050 · Cited by 114 · see citing works
Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
McAnulty, S. R., McAnulty, L. S., Nieman, D. C., Quindry, J. C., Hosick, P. A., Hudson, M. H., Still, L., Henson, D. A., Milne, G. L., Morrow, J. D., et al. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-177 · Cited by 112 · see citing works
Acute Effects of Coffee on Endothelial Function in Healthy Subjects
Buscemi, S., Verga, S., Batsis, J. A., Donatelli, M., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., & Cerasola, G. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.9 · Cited by 110 · cited 2× · see citing works
“Unfavourable effects of coffee on endothelial function (Buscemi et al. 2010) were in contrast to favourable effects of decaffeinated coffee (Buscemi et al. 2009).”
Result
Interindividual variability in the human metabolism of ellagic acid: Contribution of Gordonibacter to urolithin production
Romo‐Vaquero, M., Garcı́a-Villalba, R., González‐Sarrías, A., Beltrán, D., Tomás-Barberán, F. A., Espı́n, J. C., & Selma, M. V. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.06.040 · Cited by 109 · see citing works
Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects
Esposito, F., Morisco, F., Verde, V., Ritieni, A., Alezio, A., Caporaso, N., & Fogliano, V. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01429.x · Cited by 105 · see citing works
Cocoa and Human Health
Sutulic, S., & Williamson, G. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150642 · Cited by 105 · see citing works
Antioxidant‐rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: Results from an intervention study
Bakuradze, T., Böhm, N., Janzowski, C., Lang, R., Hofmann, T. F., Stockis, J., Albert, F. W., Stiebitz, H., Bytof, G., Lantz, I., et al. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100093 · Cited by 104 · see citing works
Tea consumption and risk of type 2 diabetes: a dose–response meta-analysis of cohort studies
Yang, W.-S., Wang, W.-Y., Fan, W.-Y., Deng, Q., & Wang, X. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003887 · Cited by 103 · see citing works
Antidiabetic actions of cocoa flavanols
Martín, M. Á., Goya, L., & Ramos, S. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500961 · Cited by 101 · see citing works
Coffee Consumption and the Risk of Colorectal Cancer
Schmit, S. L., Rennert, H. S., Rennert, G., & Gruber, S. B. (2016) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-15-0924 · Cited by 94 · see citing works
The inhibition of .ALPHA.-amylase by tea polyphenols.
Hara, Y., & Honda, M. (1990) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.54.1939 · Cited by 94 · see citing works
Tea consumption and risk of type 2 diabetes mellitus: a systematic review and meta-analysis update
Yang, J., Mao, Q., Xu, H., Ma, X., & Zeng, C. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-005632 · Cited by 93 · see citing works
The cardiovascular benefits of dark chocolate
Kerimi, A., & Williamson, G. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.05.011 · Cited by 81 · see citing works
Gastrointestinal absorption and metabolism of hesperetin‐7‐O‐rutinoside and hesperetin‐7‐O‐glucoside in healthy humans
Actis‐Goretta, L., Dew, T. P., Lévèques, A., Pereira‐Caro, G., Rein, M. J., Teml, A., Schäfer, C., Hofmann, U., Schwab, M. G., Eichelbaum, M. F., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500202 · Cited by 79 · see citing works
Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones
Olthof, M. R., van Dijk, A. E., Deacon, C. F., Heine, R. J., & van Dam, R. M. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-10 · Cited by 77 · see citing works
Anthocyanin‐derived phenolic acids form glucuronides following simulated gastrointestinal digestion and microsomal glucuronidation
Woodward, G., Needs, P. W., & Kay, C. D. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000355 · Cited by 71 · see citing works
Worldwide (poly)phenol intake: assessment methods and identified gaps
Pinto, P., & dos Santos, C. N. (2017) · European Journal of Nutrition · doi:10.1007/s00394-016-1354-2 · Cited by 69 · see citing works
Epicatechin: Endothelial Function and Blood Pressure
Jiménez, R., Duarte, J., & Pérez‐Vizcaíno, F. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf205370q · Cited by 66 · see citing works
Apple and pear consumption and type 2 diabetes mellitus risk: a meta-analysis of prospective cohort studies
Guo, X., Yang, B., Tang, J., Jiang, J., & Li, D. (2017) · Food & Function · doi:10.1039/c6fo01378c · Cited by 65 · see citing works
Coffee and caffeine consumption and the risk of hypertension in postmenopausal women
Rhee, J. J., Qin, F., Hedlin, H., Chang, T. I., Bird, C. E., Zaslavsky, O., Manson, J. E., Stefanick, M. L., & Winkelmayer, W. C. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.120147 · Cited by 63 · see citing works
First synthesis, characterization, and evidence for the presence of hydroxycinnamic acid sulfate and glucuronide conjugates in human biological fluids as a result of coffee consumption
Fumeaux, R., Menozzi, C., Stalmach, A., Munari, C., Kraehenbuehl, K., Steiling, H., Crozier, A., Williamson, G., & Barron, D. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/c0ob00137f · Cited by 62 · see citing works
Scientific Opinion on the modification of the authorisation of a health claim related to cocoa flavanols and maintenance of normal endothelium‐dependent vasodilation pursuant to Article 13(5) of Regulation (EC) No 1924/2006 following a request in accordance with Article 19 of Regulation (EC) No 1924/2006
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3654 · Cited by 59 · see citing works
No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded, placebo-controlled crossover trial
Brüll, V., Burak, C., Stoffel‐Wagner, B., Wolffram, S., Nickenig, G., Müller, C., Langguth, P., Alteheld, B., Fimmers, R., Stehle, P., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1267-0 · Cited by 58 · see citing works
Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects
Buscemi, S., Verga, S., Batsis, J. A., Tranchina, M. R., Belmonte, S., Mattina, A., Re, A., Rizzo, R., & Cerasola, G. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.51 · Cited by 55 · see citing works
A comprehensive evaluation of the [2-14C](–)-epicatechin metabolome in rats
Borges, G., van der Hooft, J. J. J., & Crozier, A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.001 · Cited by 49 · see citing works
Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial
Brüll, V., Burak, C., Stoffel‐Wagner, B., Wolffram, S., Nickenig, G., Müller, C., Langguth, P., Alteheld, B., Fimmers, R., Stehle, P., et al. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1185-1 · Cited by 48 · see citing works
UPLC–MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices
Lévèques, A., Actis‐Goretta, L., Rein, M. J., Williamson, G., Dionisi, F., & Giuffrida, F. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.08.031 · Cited by 47 · see citing works
Coffee and oxidative stress: a human intervention study
Shaposhnikov, S. A., Hatzold, T., Yamani, N. E., Stavro, P. M., Lorenzo, Y., Dušinská, M., Reus, A. A., Pasman, W. J., & Collins, A. R. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1336-4 · Cited by 46 · see citing works
Plant food supplement (PFS) market structure in EC Member States, methods and techniques for the assessment of individual PFS intake
Vargas-Murga, L., García-Álvarez, A., Román‐Viñas, B., Ngo, J., Ribas‐Barba, L., van den Berg, S. J. P. L., Williamson, G., & Serra‐Majem, L. (2011) · Food & Function · doi:10.1039/c1fo10075k · Cited by 42 · see citing works
The Impact of Cocoa Flavanols on Cardiovascular Health
Vlachojannis, J., Erne, P., Zimmermann, B., & Chrubasik-Hausmann, S. (2016) · Phytotherapy Research · doi:10.1002/ptr.5665 · Cited by 40 · see citing works
Comparison of the urinary excretion of quercetin glycosides from red onion and aglycone from dietary supplements in healthy subjects: a randomized, single-blinded, cross-over study
Shi, Y., & Williamson, G. (2015) · Food & Function · doi:10.1039/c5fo00155b · Cited by 38 · see citing works
Cocoa Flavanol Cardiovascular Effects Beyond Blood Pressure Reduction
Jumar, A., & Schmieder, R. E. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12715 · Cited by 37 · see citing works
Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans
Cifuentes‐Gomez, T., Rodriguez‐Mateos, A., Gonzalez‐Salvador, I., Alañón, M. E., & Spencer, J. P. E. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00443 · Cited by 36 · see citing works
Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
Lee, A. H., Tan, L., Hiramatsu, N., Ishisaka, A., Alfonso, H. S., Tanaka, A., Uemura, N., Fujiwara, Y., & Takechi, R. (2016) · Nutrition and Diabetes · doi:10.1038/nutd.2016.19 · Cited by 36 · see citing works
The Effect of Onion Peel Extract on Inflammatory Mediators in Korean Overweight and Obese Women
Kim, K., & Yim, J. (2016) · Clinical Nutrition Research · doi:10.7762/cnr.2016.5.4.261 · Cited by 29 · see citing works
Dietary intake of 20 polyphenol subclasses in a cohort of UK women
Yahya, H. M., Day, A. J., Lawton, C. L., Myrissa, K., Croden, F., Dye, L., & Williamson, G. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1001-3 · Cited by 25 · see citing works
A Summary of a Cochrane Review: Green and Black Tea for the Primary Prevention of Cardiovascular Disease
Santesso, N. A., & Manheimer, E. W. (2014) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.003 · Cited by 16 · see citing works
Intake levels, sites of action and excretion routes of the cholesterol-elevating diterpenes from coffee beans in humans
Urgert, R., Kosmeijer‐Schuil, T. G., & Katan, M. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240800 · Cited by 15 · see citing works
Effect of cocoa products and flavanols on platelet aggregation in humans: a systematic review
Peluso, I., Palmery, M., & Serafini, M. (2015) · Food & Function · doi:10.1039/c5fo00113g · Cited by 15 · see citing works
No evidence for a thermic effect of the dietary flavonol quercetin: a pilot study in healthy normal-weight women
Egert, S., Rimbach, G. H., & Müller, M. J. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1674-5 · Cited by 12 · see citing works
Capillary integrity; a review and interim report after five year study of use of hesperidin-C.
Hl, D., Wr, E., Pj, W., & Horoschak, S. (1955) · PubMed · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

State of the Art of Anthocyanins: Antioxidant Activity, Sources, Bioavailability, and Therapeutic Effect in Human Health
Tena, N., Martı́n, J., & Asuero, A. G. (2020) · Antioxidants · doi:10.3390/antiox9050451 · Cited by 517 · see citing works
“However, the antioxidative activity of anthocyanins does not necessarily transfer to biological activity because any actions on the body depends both on bioavailability and cellular molecular targets [61].”
Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Yang, Q., Liang, Q., Balakrishnan, B., Belobrajdic, D. P., Feng, Q.-J., & Zhang, W. Y. (2020) · Nutrients · doi:10.3390/nu12020381 · Cited by 475 · see citing works
Phenolic Compounds
Vuolo, M. M., Lima, V. S., & Maróstica, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814774-0.00002-5 · Cited by 412 · see citing works
Composition and functionality of bee pollen: A review
Thakur, M., & Nanda, V. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.02.001 · Cited by 367 · see citing works
Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort
Bondonno, N. P., Dalgaard, F., Kyrø, C., Murray, K., Bondonno, C. P., Lewis, J. R., Croft, K. D., Gislason, G., Scalbert, A., Cassidy, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11622-x · Cited by 323 · see citing works
Food applications and potential health benefits of pomegranate and its derivatives
Kandylis, P., & Kokkinomagoulos, E. (2020) · Foods · doi:10.3390/foods9020122 · Cited by 324 · see citing works
A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities
Ulusoy, H. G., & Şanlıer, N. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1683810 · Cited by 319 · see citing works
Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks
Li, Y., Miao, Y., Yang, L., Zhao, Y., Wu, K., Lu, Z., Hu, Z., & Guo, J. (2022) · Advanced Science · doi:10.1002/advs.202202684 · Cited by 305 · see citing works
Revisiting the Oxidation of Flavonoids: Loss, Conservation or Enhancement of Their Antioxidant Properties
Speisky, H., Shahidi, F., de Camargo, A. C., & Fuentes, J. (2022) · Antioxidants · doi:10.3390/antiox11010133 · Cited by 288 · see citing works
Research trends in flavonoids and health
Pérez‐Vizcaíno, F., & Fraga, C. G. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.03.022 · Cited by 284 · see citing works
Liquid Chromatography Analysis of Common Nutritional Components, in Feed and Food
Cortés-Herrera, C., Artavia, G., Leiva, A., & Granados-Chinchilla, F. (2018) · Foods · doi:10.3390/foods8010001 · Cited by 275 · see citing works
“Data suggests that long-term consumption of such compounds can have beneficial effects [94] as it can improve an organism’s antioxidant capacity [93] which in turn relates, for example, to cognitive improvement [97] and reduction in adipogenesis and oxidative stress [98].”
Background
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“However, despite representing a novel treatment paradigm for IR and IR-related diseases, polyphenol-based synthetic supplements may have several drawbacks [232].”
BackgroundInfluential
Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application
Zhang, Z., Li, X., Sang, S., McClements, D. J., Chen, L., Long, J., Jiao, A., Jin, Z., & Qiu, C. (2022) · Foods · doi:10.3390/foods11152189 · Cited by 268 · see citing works
Bioactive Compounds of Edible Fruits with Their Anti-Aging Properties: A Comprehensive Review to Prolong Human Life
Dhalaria, R., Verma, R., Kumar, D., Puri, S., Tapwal, A., Kumar, V., Nepovimová, E., & Kuča, K. (2020) · Antioxidants · doi:10.3390/antiox9111123 · Cited by 262 · see citing works
Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials
Guo, X., Luo, W., Wu, L., Zhang, L., Chen, Y., Li, T., Li, H., Zhang, W., Liu, Y., Zheng, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202403388 · Cited by 250 · see citing works
Interactions between phenolic compounds, amylolytic enzymes and starch: an updated overview
Giuberti, G., Rocchetti, G., & Lucini, L. (2020) · Current Opinion in Food Science · doi:10.1016/j.cofs.2020.04.003 · Cited by 213 · see citing works
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2023) · Nutrients · doi:10.3390/nu15092150 · Cited by 213 · see citing works
Green extraction techniques from fruit and vegetable waste to obtain bioactive compounds—A review
García, S. L. R., & Raghavan, V. (2021) · Critical reviews in food science and nutrition · doi:10.1080/10408398.2021.1901651 · Cited by 164 · see citing works
Aronia melanocarpa Products and By-Products for Health and Nutrition: A Review
Jurendić, T., & Ščetar, M. (2021) · Antioxidants · doi:10.3390/antiox10071052 · Cited by 206 · see citing works
“During processing of fruits, the total quantity of anthocyanins can be significantly lower [32].”
Background
Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability
Mas‐Capdevila, A., Teichenne-Jané, J., Domenech-Coca, C., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Crescenti, A. (2020) · Nutrients · doi:10.3390/nu12051488 · Cited by 201 · see citing works
“After food intake, hesperidin is poorly absorbed in the small bowel [10,29].”
Background
Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota
Lippolis, T., Cofano, M., Caponio, G. R., Nunzio, V. D., & Notarnicola, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043813 · Cited by 192 · see citing works
Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability
Bié, J., Sepodes, B. M. N., Fernandes, P. C. D. B., & Ribeiro, M. H. L. (2023) · Compounds · doi:10.3390/compounds3010005 · Cited by 187 · see citing works
“Classification “Polyphenol” is used to refer to flavonoids, tannins, and phenolic acids and their various chemically modified or polymerized derivatives [65].”
Background
Anti-senescence compounds: A potential nutraceutical approach to healthy aging
Gurău, F., Baldoni, S., Prattichizzo, F., Espinosa, E., Amenta, F., Procopio, A. D., Albertini, M. C., Bonafè, M., & Olivieri, F. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.001 · Cited by 179 · see citing works
Glucose Metabolism and Glucose Transporters in Breast Cancer
Shin, E., & Koo, J. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728759 · Cited by 169 · see citing works
“Polyphenols, a huge family of natural compounds found in plants or food, is one category of the GLUT1 inhibitors (Williamson, 2017) that shows an antitumoral effect against various cancers including breast cancer.”
Background
Positive and negative effects of polyphenol incorporation in baked foods
Ou, J., Wang, M., Zheng, J., & Ou, S. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.096 · Cited by 165 · see citing works
Tea Compounds and the Gut Microbiome: Findings from Trials and Mechanistic Studies
Bond, T., & Derbyshire, E. J. (2019) · Nutrients · doi:10.3390/nu11102364 · Cited by 161 · see citing works
“The gut microbiota play a crucial role in the absorption of these compounds, with around 80% being absorbed and eventually excreted in urine [14].”
Background
Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson’s Disease
Kung, H., Lin, K.-J., Kung, C., & Lin, T. (2021) · Biomedicines · doi:10.3390/biomedicines9080918 · Cited by 160 · see citing works
Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies
Aatif, M. (2023) · Biomedicines · doi:10.3390/biomedicines11072078 · Cited by 152 · see citing works
“The European Food Safety Authority (EFSA) [60] acknowledges this effect of polyphenols thoroughly.”
Recent advances in extracting phenolic compounds from food and their use in disease prevention and as cosmetics
Dias, R., Oliveira, H., Fernandes, I., Simal‐Gándara, J., & Pérez-Gregório, R. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1754162 · Cited by 151 · see citing works
“In fact, the bioavailability of polyphenols was recently found to be higher when consumed as food ingredients than when used as supplements (Williamson 2017).”
Background
The gut microbiome and cardiovascular disease: current knowledge and clinical potential
Ahmad, A. F., Dwivedi, G., O’Gara, F., Caparros-Martin, J. A., & Ward, N. C. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2019 · Cited by 153 · see citing works
Specialized phenolic compounds in seeds: structures, functions, and regulations
Corso, M., Perreau, F., Mouille, G., & Lepiniec, L. (2020) · Plant Science · doi:10.1016/j.plantsci.2020.110471 · Cited by 149 · see citing works
Variation in Phenolic Compounds Content and Antioxidant Activity of Different Plant Organs from Rumex crispus L. and Rumex obtusifolius L. at Different Growth Stages
Feduraev, P., Николаевна, Ч. Г., Maslennikov, P., Tacenko, N., & Skrypnik, L. N. (2019) · Antioxidants · doi:10.3390/antiox8070237 · Cited by 148 · see citing works
Polyphenols: A first evidence in the synergism and bioactivities
Mitra, S., Tareq, A. M., Das, R. C., Emran, T. B., Nainu, F., Chakraborty, A. J., Ahmad, I., Tallei, T. E., Idris, A. M., & Simal‐Gándara, J. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2026376 · Cited by 144 · see citing works
Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as Food-Grade Nanovehicles for Hydrophobic Nutraceuticals or Bioactives
Tang, C., Chen, H.-L., & Dong, J.-R. (2023) · Applied Sciences · doi:10.3390/app13031726 · Cited by 145 · see citing works
Interactions between dietary flavonoids and the gut microbiome: a comprehensive review
Baky, M. H., Elshahed, M. S., Wessjohann, L. A., & Farag, M. A. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003627 · Cited by 145 · see citing works
Pharmacological values and therapeutic properties of black tea (Camellia sinensis): A comprehensive overview
Naveed, M., Bibi, J., Kamboh, A. A., Suheryani, I., Kakar, I., Fazlani, S. A., FangFang, X., Kalhoro, S. A., Liang, Y., Kakar, M. U., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.048 · Cited by 136 · see citing works
Targeting Glucose Transporters for Breast Cancer Therapy: The Effect of Natural and Synthetic Compounds
Barbosa, A. M., & Martel, F. (2020) · Cancers · doi:10.3390/cancers12010154 · Cited by 137 · see citing works
Biosynthesis Regulation of Folates and Phenols in Plants
Kołton, A., Długosz-Grochowska, O., Wojciechowska, R., & Czaja, M. A. (2021) · Scientia Horticulturae · doi:10.1016/j.scienta.2021.110561 · Cited by 135 · see citing works
“To date, there are no recommendations for daily allowances of phenolic compounds, and research is ongoing (Williamson, 2017).”
Background
Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats
Estruel‐Amades, S., Massot‐Cladera, M., Pérez-Cano, F. J., Franch, À., Castell, M., & Camps‐Bossacoma, M. (2019) · Nutrients · doi:10.3390/nu11020324 · Cited by 132 · see citing works
Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities
Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Martinez-Rozas, L., Rodríguez–Jiménez, R., Álvarez‐Mon, M., & Lahera, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01964-w · Cited by 129 · see citing works
“Diet is considered the greatest shaper of gut microbiota, as different dietary sources are needed for the biosynthesis of SCFAs and other microbial metabolites, determining the differential growth of certain bacterial populations [60, 276].”
Background
Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases
Renaud, J., & Martinoli, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081883 · Cited by 122 · see citing works
“Absorption and metabolism of polyphenols have extensively studied (see for review, References [61,62]).”
Background
Inhibition of the SARS-CoV-2 3CLpro main protease by plant polyphenols
Bahun, M., Jukič, M., Oblak, D., Kranjc, L., Bajc, G., Butala, M., Bozovičar, K., Bratkovič, T., Podlipnik, Č., & Ulrih, N. P. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131594 · Cited by 118 · see citing works
“Due to the abundance of polyphenols in edible plants, they constitute an important part of the human diet (Williamson, 2017).”
Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation
Jokioja, J., Yang, B., & Linderborg, K. M. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12836 · Cited by 120 · see citing works
A Review of Nutrients and Compounds, Which Promote or Inhibit Intestinal Iron Absorption: Making a Platform for Dietary Measures That Can Reduce Iron Uptake in Patients with Genetic Haemochromatosis
Milman, N. T. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/7373498 · Cited by 115 · see citing works
“Polyphenols are widely present in the human diet as components of fruits, berries, vegetables, spices, pulses, and whole grains, and they are especially high in tea, coffee, cocoa, red wine, and some herb teas [102, 103].”
Background
Polyphenols as Potent Epigenetics Agents for Cancer
Rajendran, P., Abdelsalam, S. A., Renu, K., Veeraraghavan, V., Ammar, R. B., & Ahmed, E. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911712 · Cited by 115 · see citing works
Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?
Iglesias‐Aguirre, C. E., Cortés‐Martín, A., Ávila‐Gálvez, M. Á., Giménez‐Bastida, J. A., Selma, M. V., González‐Sarrías, A., & Espı́n, J. C. (2021) · Food & Function · doi:10.1039/d1fo02033a · Cited by 117 · see citing works
Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral
Sandoval, V., Sanz‐Lamora, H., Arias, G., Marrero, P. F., Haro, D., & Relat, J. (2020) · Nutrients · doi:10.3390/nu12082393 · Cited by 111 · see citing works
Relationship between gut microbiota and host-metabolism: emphasis on hormones related to reproductive function
Hussain, T., Murtaza, G., Kalhoro, D. H., Kalhoro, M. S., Metwally, E., Chughtai, M. I., Mazhar, M. U., & Khan, S. A. (2021) · Animal Nutrition · doi:10.1016/j.aninu.2020.11.005 · Cited by 110 · see citing works
“Polyphenol compounds like flavonoids and others (Williamson, 2017) from different sources (Puupponen-Pimi€a et al., 2002) possess strong antioxidant, anti-inflammatory and cancer prevention properties (Han et al., 2007).”
Background
Recommendations for standardizing nomenclature for dietary (poly)phenol catabolites
Kay, C. D., Clifford, M. N., Mena, P. R., McDougall, G. J., Andrés‐Lacueva, C., Cassidy, A., Rio, D. D., Kuhnert, N., Manach, C., Pereira‐Caro, G., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa204 · Cited by 110 · see citing works
“One of the current goals of (poly)phenol research is to establish dietary guidance including a recommended intake or number of servings of (poly)phenol-rich foods to promote optimal health or reduce disease risk (4, 5).”
Background
Decrypting bacterial polyphenol metabolism in an anoxic wetland soil
McGivern, B. B., Tfaily, M., Borton, M., Kosina, S. M., Daly, R. A., Nicora, C., Purvine, S. O., Wong, A. R., Lipton, M. S. W., Hoyt, D. W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22765-1 · Cited by 111 · see citing works
“Consequently, the “enzyme latch”8,9 hypothesis states that polyphenols accumulate under anoxic soil conditions and further control soil microbial carbon cycling as these compounds (1) are toxic to microorganisms, (2) inactivate microbial extracellular enzymes, and/or (3) bind substrates, thus depriving microorganisms…”
Background
Unconventional food plants: Nutritional aspects and perspectives for industrial applications
Milião, G. L., de Oliveira, A. P. H., Soares, L. D. S., Arruda, T. R., Vieira, É. N. R., & Júnior, B. R. D. C. L. (2022) · Future Foods · doi:10.1016/j.fufo.2022.100124 · Cited by 109 · see citing works
Diet, Gut Microbiota and COVID-19
Rishi, P., Thakur, K., Vij, S., Rishi, L., Singh, A., Kaur, I. P., Patel, S. K. S., Lee, J.-K., & Kalia, V. C. (2020) · Indian Journal of Microbiology · doi:10.1007/s12088-020-00908-0 · Cited by 108 · see citing works
Modern vision of the Mediterranean diet
Kiani, A. K., Medori, M. C., Bonetti, G., Aquilanti, B., Velluti, V., Matera, G., Iaconelli, A., Stuppia, L., Connelly, S., Herbst, K. L., et al. (2022) · Journal of preventive medicine and hygiene · doi:10.15167/2421-4248/jpmh2022.63.2s3.2745 · Cited by 107 · see citing works
“The main components of pulses and beans are flavanols, a type of polyphenols with a ketone group in their chemical formula, which reduce endothelial dysfunction, decrease cholesterol and blood pressure, and regulate energy metabolism [21].”
Background
Health Effects of Coffee: Mechanism Unraveled?
Kolb, H., Kempf, K., & Martin, S. (2020) · Nutrients · doi:10.3390/nu12061842 · Cited by 105 · see citing works
In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity
Fang, J., Lin, C.-H., Huang, T., & Chuang, S.-Y. (2019) · Nutrients · doi:10.3390/nu11030530 · Cited by 109 · see citing works
Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers
Bakuradze, T., Tausend, A., Galan, J., Groh, I. A. M., Berry, D., Tur, J. A., Marko, D., & Richling, E. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1618851 · Cited by 105 · see citing works
Milk-Derived Exosomes as Nanocarriers to Deliver Curcumin and Resveratrol in Breast Tissue and Enhance Their Anticancer Activity
González‐Sarrías, A., Iglesias‐Aguirre, C. E., Cortés‐Martín, A., Vallejo, F., Cattivelli, A., del Pozo‐Acebo, L., del Saz‐Lara, A., Hazas, M. L. D. L., Dávalos, A., & Espı́n, J. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052860 · Cited by 105 · see citing works
Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
Health Benefits of Apple Juice Consumption: A Review of Interventional Trials on Humans
Marcotte, B. V., Verheyde, M., Pomerleau, S., Doyen, A., & Couillard, C. (2022) · Nutrients · doi:10.3390/nu14040821 · Cited by 102 · see citing works
Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer
AL-Ishaq, R. K., Líšková, A., Kubatka, P., & Büsselberg, D. (2021) · Cancers · doi:10.3390/cancers13163934 · Cited by 100 · see citing works
“Hesperidin is considered a potential anticancer, antioxidant, anti-depressive and immunomodulatory agent [49].”
Background
Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview
Meccariello, R., & D’Angelo, S. (2021) · Antioxidants · doi:10.3390/antiox10040507 · Cited by 110 · see citing works
Digestive fate of polyphenols: updated view of the influence of chemical structure and the presence of cell wall material
Nagar, E. E., Okun, Z., & Shpigelman, A. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.10.009 · Cited by 99 · see citing works
Screening of Phenolic Compounds in Australian Grown Berries by LC-ESI-QTOF-MS/MS and Determination of Their Antioxidant Potential
Subbiah, V., Zhong, B., Nawaz, M. A., Barrow, C. J., Dunshea, F. R., & Suleria, H. A. R. (2020) · Antioxidants · doi:10.3390/antiox10010026 · Cited by 93 · see citing works
Integration of environment and nutrition in life cycle assessment of food Items: opportunities and challenges
McLaren, S. J., Berardy, A., Henderson, A. D., Holden, N. M., Huppertz, T., Jolliet, O., De Camillis, C., Renouf, M. A., Rugani, B., Saarinen, M., et al. (2021) · FAO eBooks · doi:10.4060/cb8054en · Cited by 98 · see citing works
Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines
Qiu, C., Zhang, J. Z., Wu, B., Xu, C. C., Pang, H. H., Tu, Q., Lu, Y. Q., Guo, Q. Y., Xia, F., & Wang, J. G. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02165-x · Cited by 98 · see citing works
“Furthermore, polyphenols exhibit remarkable structural diversity, ranging from simple phenolic acids to complex flavonoids, stilbenes, and lignans, and are pre-sent in a variety of dietary sources, including fruits, vegetables, nuts, and beverages such as tea, coffee, and wine [39–41].”
Background
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health: A Narrative Review
Abrignani, V., Salvo, A., Pacinella, G., & Tuttolomondo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094942 · Cited by 90 · see citing works
“These ﬂavanols are associated with the reduction in endothelial dysfunction, the lowering of cholesterol and blood pressure, and the regulation of energy metabolism [28].”
Background
Diet Regulation of Long-Chain PUFA Synthesis: Role of Macronutrients, Micronutrients, and Polyphenols on Δ-5/Δ-6 Desaturases and Elongases 2/5
Gonzalez‐Soto, M., & Mutch, D. M. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa142 · Cited by 88 · see citing works
From Fighting Critters to Saving Lives: Polyphenols in Plant Defense and Human Health
Stiller, A., Garrison, K., Gurdyumov, K., Kenner, J., Yasmin, F., Yates, P., & Song, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168995 · Cited by 91 · see citing works
Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review
Ansari, P., Khan, J. T., Chowdhury, S., Reberio, A. D., Kumar, S., Seidel, V., Abdel‐Wahab, Y. H. A., & Flatt, P. R. (2024) · Nutrients · doi:10.3390/nu16213709 · Cited by 106 · see citing works
Polyphenols in fermented apple juice: Beneficial effects on human health
Zhang, S., Hu, C. Y., Guo, Y., Wang, X., & Meng, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104294 · Cited by 87 · see citing works
The beneficial health effects of flavonoids on the cardiovascular system: Focus on K+ channels
Fusi, F., Trezza, A., Tramaglino, M., Sgaragli, G., Saponara, S., & Spiga, O. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2019.104625 · Cited by 86 · see citing works
Prebiotics – an added benefit of some fibre types
Lockyer, S., & Stanner, S. A. (2019) · Nutrition Bulletin · doi:10.1111/nbu.12366 · Cited by 84 · see citing works
“As well as fibre, carbohydrate-containing foods also provide other nutrients such as vitamins, minerals and plant bioactives (e.g. polyphenols), some of which can nourish gut microbes (Conlon & Bird 2014) and may confer other health benefits (Williamson 2017).”
Background
Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability– a comprehensive review
Saad, A. M., Mohammed, D. M., Alkafaas, S. S., Ghosh, S. B., Negm, S. H., Salem, H. M., Fahmy, M. A., Semary, H. E., Ibrahim, E. H., AbuQamar, S. F., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1653378 · Cited by 97 · see citing works
Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1
Hamilton, K. E., Rekman, J. F., Gunnink, L. K., Busscher, B. M., Scott, J. L., Tidball, A. M., Stehouwer, N. R., Johnecheck, G. N., Looyenga, B. D., & Louters, L. L. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.012 · Cited by 84 · see citing works
Cynara cardunculus L.: Outgoing and potential trends of phytochemical, industrial, nutritive and medicinal merits
Zayed, A., Serag, A., & Farag, M. A. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103937 · Cited by 82 · see citing works
The Influence of Dietary Interventions on Arterial Stiffness in Overweight and Obese Subjects
Stanek, A., Grygiel‐Górniak, B., Brożyna-Tkaczyk, K., Myśliński, W., Cholewka, A., & Zolghadri, S. (2023) · Nutrients · doi:10.3390/nu15061440 · Cited by 77 · see citing works
Anti- and pro-oxidant properties of polyphenols and their role in modulating glutathione synthesis, activity and cellular redox potential: Potential synergies for disease management
Dzah, C. S., Zhang, H., Gobe, V. A. D., Asante-Donyinah, D., & Duan, Y. (2024) · Advances in Redox Research · doi:10.1016/j.arres.2024.100099 · Cited by 81 · see citing works
Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation
Rabbani, N., Xue, M., Weickert, M. O., & Thornalley, P. J. (2021) · Nutrients · doi:10.3390/nu13072374 · Cited by 74 · see citing works
“Treatment with tRES-HESP alleviates these UPR-mediated responses [9,10]; tRES-HESP may also decrease expression of TXNIP directly via Nrf2 and ARE-linked suppression [68]. tRES-HESP may thereby be a potent inducer of reversal of insulin resistance with applications for both prevention and treatment of T2DM.”
BackgroundInfluential
Absorption Coefficients of Phenolic Structures in Different Solvents Routinely Used for Experiments
Kaeswurm, J., Scharinger, A., Teipel, J., & Buchweitz, M. (2021) · Molecules · doi:10.3390/molecules26154656 · Cited by 73 · see citing works
Anti-breast cancer effects of phytochemicals: primary, secondary, and tertiary care
Mazuráková, A., Koklesová, L., Samec, M., Kúdela, E., Kajo, K., Skuciova, V., Csizmár, S. H., Mešťanová, V., Péč, M. J., Adamkov, M., et al. (2022) · The EPMA Journal · doi:10.1007/s13167-022-00277-2 · Cited by 73 · see citing works
Effect of wheat species (Triticum aestivum vs T. spelta), farming system (organic vs conventional) and flour type (wholegrain vs white) on composition of wheat flour – Results of a retail survey in the UK and Germany – 2. Antioxidant activity, and phenolic and mineral content
Wang, J., Chatzidimitriou, E., Wood, L., Hasanaliyeva, G., Markellou, E., Iversen, P. O., Seal, C. J., Barański, M., Vigar, V., Ernst, L., et al. (2020) · Food Chemistry X · doi:10.1016/j.fochx.2020.100091 · Cited by 71 · see citing works
The role of bread in the UK diet: An update
Lockyer, S., & Spiro, A. (2020) · Nutrition Bulletin · doi:10.1111/nbu.12435 · Cited by 71 · see citing works
Vegan diet: nutritional components, implementation, and effects on adults’ health
Łuszczki, E., Boakye, F., Zielińska, M., Dereń, K., Bartosiewicz, A., Oleksy, Ł., & Stolarczyk, A. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1294497 · Cited by 81 · see citing works
“The results suggest that elevated F&V intake may enhance HDL’s antioxidant properties through an increase in carotenoid content (35).”
Biological Role of Nutrients, Food and Dietary Patterns in the Prevention and Clinical Management of Major Depressive Disorder
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Álvarez-Mon, M. Á., Lahera, G., Monserrat, J., Llavero-Valero, M., Gutiérrez-Rojas, L., Molina, R., Rodríguez–Jiménez, R., et al. (2022) · Nutrients · doi:10.3390/nu14153099 · Cited by 69 · see citing works
Revisiting the bioavailability of flavan-3-ols in humans: A systematic review and comprehensive data analysis
Pede, G. D., Mena, P. R., Bresciani, L., Achour, M., Lamuela-Raventós, R. M., Estruch, R., Landberg, R., Kulling, S. E., Wishart, D. S., Rodriguez‐Mateos, A., et al. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101146 · Cited by 69 · see citing works
Mediterranean Diet as a Shield against Male Infertility and Cancer Risk Induced by Environmental Pollutants: A Focus on Flavonoids
Montano, L., Maugeri, A., Volpe, M. G., Micali, S., Mirone, V. G., Mantovani, A., Navarra, M., & Piscopo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031568 · Cited by 67 · see citing works
Recent understanding of the mechanisms of the biological activities of hesperidin and hesperetin and their therapeutic effects on diseases
Ji, Z., Deng, W., Chen, D., Liu, Z., Shen, Y., Dai, J., Zhou, H., Zhang, M., Xu, H., & Dai, B. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26862 · Cited by 66 · see citing works
“Mice were administered Hsd at dosages ≤ 5 percent to validate its safety and even after long-term administration, Hsd caused no mutation, toxicity, or carcinogenesis [6].”
Method
Total Polyphenol Content and Antioxidant Capacity of Tea Bags: Comparison of Black, Green, Red Rooibos, Chamomile and Peppermint over Different Steep Times
Cleverdon, R. E. G., Elhalaby, Y., McAlpine, M. D., Gittings, W., & Ward, W. E. (2018) · Beverages · doi:10.3390/beverages4010015 · Cited by 64 · see citing works
Polyphenols, the Healthy Brand of Olive Oil: Insights and Perspectives
Finicelli, M., Squillaro, T., Galderisi, U., & Peluso, G. (2021) · Nutrients · doi:10.3390/nu13113831 · Cited by 63 · see citing works
“Without these understandings, the real power of foods will remain unknown to scientists, and nutrition will be a black box with no scope for improvement [2,3].”
Background
Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Santé French Cohort
Adriouch, S., Lampuré, A., Nechba, A., Baudry, J., Assmann, K. E., Kesse‐Guyot, E., Herçberg, S., Scalbert, A., Touvier, M., & Fezeu, L. (2018) · Nutrients · doi:10.3390/nu10111587 · Cited by 64 · see citing works
“Cardiovascular protection by polyphenol intakes may encompass various mechanisms [6–8], including anti-inﬂammatory properties [9], an increase in antioxidant capacity [10], and an inhibition of platelet aggregation and antithrombotic properties [11].”
Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome
Dong, W., Jia, C., Li, J., Zhou, Y., Luo, Y., Liu, J., Zhao, Z., Zhang, J., Lin, S., & Chen, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.783706 · Cited by 62 · see citing works
Daily Consumption of an Anthocyanin-Rich Extract Made From New Zealand Blackcurrants for 5 Weeks Supports Exercise Recovery Through the Management of Oxidative Stress and Inflammation: A Randomized Placebo Controlled Pilot Study
Hurst, R. D., Lyall, K. A., Wells, R. W., Sawyer, G. M., Lomiwes, D. D., Ngametua, N., & Hurst, S. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00016 · Cited by 63 · see citing works
Profile and Content of Betalains in Plasma and Urine of Volunteers after Long-Term Exposure to Fermented Red Beet Juice
Sawicki, T., Topolska, J., Romaszko, E., & Wiczkowski, W. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00925 · Cited by 61 · see citing works
Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer
Bhattacharya, T., Dutta, S., Akter, R., Rahman, M. H., Karthika, C., Nagaswarupa, H. P., Murthy, H. C. A., Frățilă, O., Brata, R. D., & BUNGAU, S. G. (2021) · Biomolecules · doi:10.3390/biom11081176 · Cited by 59 · see citing works
Host–Microbe Interplay in the Cardiometabolic Benefits of Dietary Polyphenols
Anhê, F. F., Choi, B. S.-Y., Dyck, J. R. B., Schertzer, J. D., & Marette, A. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.04.002 · Cited by 58 · see citing works
Protocatechuic Acid, a Simple Plant Secondary Metabolite, Induced Apoptosis by Promoting Oxidative Stress through HO-1 Downregulation and p21 Upregulation in Colon Cancer Cells
Acquaviva, R., Tomasello, B., Giacomo, C. D., Santangelo, R., Mantia, A. L., Николаевна, Н. И., Sarpietro, M. G., Castelli, F., & Malfa, G. A. (2021) · Biomolecules · doi:10.3390/biom11101485 · Cited by 59 · see citing works
“They play a key role in several processes of plant metabolism and are strictly involved in defense mechanisms against biotic and abiotic factors [23].”
Background
Influence of Cooking Methods on Onion Phenolic Compounds Bioaccessibility
Cattivelli, A., Conte, A., Martini, S., & Tagliazucchi, D. (2021) · Foods · doi:10.3390/foods10051023 · Cited by 58 · see citing works
Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism
Keating, E., & Martel, F. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00025 · Cited by 58 · see citing works
Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression in a High-Fat Diet Mouse Model
Torres, L., Cogliati, B., & Otton, R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4168380 · Cited by 57 · see citing works
“Among the main biological effects attributed to GT polyphenols, we can highlight the antioxidant, anti-inflammatory, antitumor, antidiabetic, antiobesity, and hepatoprotective activities [8, 9].”
Background
Alternative Methods of Bioactive Compounds and Oils Extraction from Berry Fruit By-Products—A Review
Piasecka, I., Wiktor, A., & Górska, A. (2022) · Applied Sciences · doi:10.3390/app12031734 · Cited by 55 · see citing works

Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works
Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota
Rodriguez‐Mateos, A., Sayec, M. L., & Cheok, A. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124000156 · Cited by 27 · see citing works
The effects of polyphenols and other bioactives on human health
Fraga, C. G., Croft, K. D., Kennedy, D. O., & Tomás-Barberán, F. A. (2019) · Food & Function · doi:10.1039/c8fo01997e · Cited by 1,150 · see citing works
Intestinal absorption and bioavailability of coffee phenolics and green tea polyphenols: a study in healthy and ileostomy volunteers
Stalmach, A. (2009) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.1241
Importance of polyphenols: Consumption and human health
Voss, G. B., Oliveira, A. L. S., Alexandre, E. M. D. C., & Pintado, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85273-9.00008-9 · Cited by 1 · see citing works

Authors: Williamson, G.
Affiliations: University of Leeds (GB)
Corresponding author: Williamson, G.
ORCID: Williamson, G.
Venue: Nutrition Bulletin
Publisher: Wiley
Published: 2017-08-15
Volume: 42
Issue: 3
Pages: 226-235
ISSN: 1467-3010 (ISSN-L)
1471-9827
DOI: 10.1111/nbu.12278
PMC: PMC5601283
OpenAlex: W2749105166
Cited by: 551
References: 95
Citations by year: 2026: 62 · 2025: 55 · 2024: 54 · 2023: 61 · 2022: 79 · 2021: 71 · 2020: 71 · 2019: 62 · 2018: 32 · 2017: 3
FWCI: 5.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Nutrition Bulletin (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Funders: European Research Council (POLYTRUE? 322467)
Biotechnology and Biological Sciences Research Council (DRINC BB/M027406/1)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
Keywords: polyphenols, dietary polyphenols, cardiovascular disease, type 2 diabetes, gut microbiota, flavan-3-ols, flavonoids, hydroxycinnamic acids, anthocyanins, Theobroma cacao, tea, coffee, fruit and vegetable intake, endothelial dysfunction, nitric oxide, oxidative enzymes, chronic disease prevention

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of polyphenols in modern nutrition

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks