Gabapentin for the treatment of alcohol use disorder
Open accessAbstract
INTRODUCTION: Alcohol misuse is the fifth leading risk factor for premature death and disability worldwide. Fewer than 10% of afflicted Americans receive pharmacological treatment for alcohol use disorder. Gabapentin is a calcium channel GABAergic modulator that is widely used for pain. Studies showing reduced drinking and decreased craving and alcohol-related disturbances in sleep and affect in the months following alcohol cessation suggest therapeutic potential for alcohol use disorder. Areas covered: Human laboratory and clinical studies assessing gabapentin for alcohol use disorder are reviewed. Data were obtained by searching for English peer-reviewed articles on PubMed, reference lists of identified articles, and trials registered on clinicaltrials.gov. Additionally, the mechanism of action of gabapentin specific to alcohol use disorder, and studies of gabapentin for alcohol withdrawal and non-alcohol substance use disorders are summarized. Expert opinion: Alcohol use disorder represents a challenge and large, unmet medical need. Evidence from single-site studies lend support to the safety and efficacy of gabapentin as a novel treatment for alcohol use disorder, with unique benefits for alcohol-related insomnia and negative affect, relative to available treatments. Proprietary gabapentin delivery systems may open a path to pivotal trials and registration of gabapentin as a novel treatment for alcohol use disorder.
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Gabapentin binds to calcium channels, inhibits calcium influx, and reduces the release of excitatory neurotransmitters.
“Gabapentin, a structural analog of GABA, functions by binding to calcium channels. This binding action inhibits calcium influx, leading to a reduction in the release of excitatory neurotransmitters [28].”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [28]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Lim, S. S., Vos, T., Flaxman, A. D., Danaei, G., Shibuya, K., Adair-Rohani, H., AlMazroa, M. A., Amann, M., Anderson, H. R., Andrews, K. G., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61766-8 · Cited by 11,805 · see citing works
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069 · see citing works
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
SULLIVAN, J. T., SYKORA, K., SCHNEIDERMAN, J., NARANJO, C. A., & SELLERS, E. M. (1989) · British Journal of Addiction · doi:10.1111/j.1360-0443.1989.tb00737.x · Cited by 1,988 · see citing works
A Role for Brain Stress Systems in Addiction
Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056 · see citing works
Jonas, D. E., Amick, H. R., Feltner, C., Bobashev, G., Thomas, K., Wines, R., Kim, M. M., Shanahan, E., Gass, C. E., Rowe, C. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.3628 · Cited by 923 · see citing works
Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893 · see citing works
A summary of mechanistic hypotheses of gabapentin pharmacology
Taylor, C. P., GEE, N. S., Su, T., Kocsis, J. D., Welty, D. F., Brown, J. P., Dooley, D. J., Boden, P., & Singh, L. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(97)00084-3 · Cited by 773 · see citing works
The mechanisms of action of gabapentin and pregabalin
Sills, G. J. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.11.003 · Cited by 672 · see citing works
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.256.11.1449 · Cited by 541 · see citing works
Activation of Corticotropin-Releasing Factor in the Limbic System During Cannabinoid Withdrawal
Rodrı́guez de Fonseca, F., Carrera, M. R. A., Navarro, M., Koob, G. F., & Weiss, F. (1997) · Science · doi:10.1126/science.276.5321.2050 · Cited by 499 · see citing works
Maisel, N. C., Blodgett, J. C., Wilbourne, P. L., Humphreys, K., & Finney, J. W. (2013) · Addiction · doi:10.1111/j.1360-0443.2012.04054.x · Cited by 470 · see citing works
Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.1986.03380110055026 · Cited by 431 · cited 2× · see citing works
“Problems with patient non-compliance have been noted with oral naltrexone [16,18], thus the development of a long-acting (30 days) injectable formulation.”
Naltrexone and Alcohol Dependence
Volpicelli, J. R. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830200071010 · Cited by 411 · see citing works
Gabapentin misuse, abuse and diversion: A systematic review
Smith, R. V., Havens, J. R., & Walsh, S. L. (2016) · Addiction · doi:10.1111/add.13324 · Cited by 378 · see citing works
Jørgensen, C. H., Pedersen, B., & Tønnesen, H. (2011) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01523.x · Cited by 366 · see citing works
Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis
Skinner, M. D., Lahmek, P., Pham, H., & Aubin, H.-J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087366 · Cited by 347 · cited 1× · see citing works
“may comprise the primary mechanism of disulfiram’s deterrent effect, as opposed to the drug’s pharmacodynamic (PD) properties [15].”
Gabapentin Treatment for Alcohol Dependence: A Randomized Clinical Trial
Mason, B. J., Quello, S., Goodell, V., Shadan, F., Kyle, M., & Begovic, A. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.11950 · Cited by 340 · see citing works
Self-citationRoberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.007 · Cited by 336 · see citing works
Stewart, B. H., Kugler, A. R., Thompson, P. R., et al. (1993) · Pharmaceutical Research · doi:10.1023/a:1018951214146 · Cited by 312 · see citing works
Alcohol and opioid dependence medications: Prescription trends, overall and by physician specialty
Mark, T. L., Kassed, C. A., Vandivort-Warren, R., Levit, K. R., & Kranzler, H. R. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.07.018 · Cited by 246 · see citing works
Mason, B. J., Crean, R., Goodell, V., Light, J. M., Quello, S., Shadan, F., Buffkins, K., Kyle, M., Adusumalli, M., Begovic, A., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.14 · Cited by 242 · see citing works
Self-citationPolysomnographic and subjective sleep predictors of alcoholic relapse
Brower, K. J., Aldrich, M. S., & Hall, J. M. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03995.x · Cited by 223 · see citing works
A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal
Myrick, H., Malcolm, R., Randall, P. K., Boyle, E., Anton, R. F., Becker, H. C., & Randall, C. L. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00986.x · Cited by 201 · see citing works
Chiappini, S., & Schifano, F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0359-y · Cited by 189 · see citing works
Brower, K. J., Kim, H. M., Strobbe, S., Karam‐Hage, M., Consens, F. B., & Zucker, R. A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00706.x · Cited by 180 · see citing works
Xiao, W. H., Boroujerdi, A., Bennett, G. J., & Luo, Z. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.044 · Cited by 177 · see citing works
Gillin, J. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030025003 · Cited by 175 · see citing works
Fink, K., Meder, W. P., Dooley, D. J., & Göthert, M. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703380 · Cited by 169 · see citing works
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
Fuller, R. K., Branchey, L., Brightwell, D. R., Derman, R., Emrick, C. D., Iber, F. L., James, K. E., Lacoursiere, R. B., Lee, K. K., & Lowenstam, I. (1986) · PubMed · Cited by 166 · see citing works
Gabapentin Combined With Naltrexone for the Treatment of Alcohol Dependence
Anton, R. F., Myrick, H., Wright, T. M., Latham, P. K., Baros, A. M., Waid, L. R., & Randall, P. K. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10101436 · Cited by 157 · see citing works
Lowman, C., Allen, J., & Stout, R. L. (1996) · Addiction · doi:10.1111/j.1360-0443.1996.tb02327.x · Cited by 155 · see citing works
Impaired Sleep in Alcohol Misusers and Dependent Alcoholics and the Impact Upon Outcome
Foster, J., & Peters, T. J. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04223.x · Cited by 153 · see citing works
Furieri, F. A., & Nakamura-Palacios, E. M. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1108 · Cited by 144 · see citing works
Gabapentin in PTSD: A Retrospective, Clinical Series of Adjunctive Therapy1
Hamner, M. B., Brodrick, P. S., & Labbate, L. A. (2001) · Annals of Clinical Psychiatry · doi:10.1023/a:1012281424057 · Cited by 144 · see citing works
Acamprosate Produces Its Anti-Relapse Effects Via Calcium
Spanagel, R., Vengeliene, V., Jandeleit, B., Fischer, W.-N., Grindstaff, K. K., Zhang, X., Gallop, M. A., Krstew, E., Lawrence, A. J., & Kiefer, F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.264 · Cited by 141 · see citing works
Profiles of pregabalin and gabapentin abuse by postmortem toxicology
Häkkinen, M., Vuori, E., Kalso, E. A., Gergov, M., & Ojanperä, I. A. (2014) · Forensic Science International · doi:10.1016/j.forsciint.2014.04.028 · Cited by 139 · see citing works
Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro
Cunningham, M. O., Woodhall, G. L., Thompson, S. E., Dooley, D. J., & Jones, R. S. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03625.x · Cited by 135 · see citing works
Cellular and behavioral interactions of gabapentin with alcohol dependence
Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., & Koob, G. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-08.2008 · Cited by 126 · see citing works
Cundy, K. C., Annamalai, T., Bu, L., et al. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067959 · Cited by 121 · see citing works
Effect of anticonvulsants on nocturnal sleep in epilepsy.
Placidi, F., Diomedi, M., Scalise, A., Marciani, M. G., Romigi, A., & Gigli, G. L. (2000) · PubMed · Cited by 120 · see citing works
Leggio, L., Kenna, G. A., & Swift, R. M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.09.021 · Cited by 120 · see citing works
Effects of topiramate and gabapentin on cognitive abilities in healthy volunteers
Salinsky, M., Storzbach, D. M., Spencer, D. C., Oken, B., Landry, T., & Dodrill, C. B. (2005) · Neurology · doi:10.1212/01.wnl.0000152877.08088.87 · Cited by 116 · see citing works
Mason, B. J., Light, J. M., Williams, L. D., & Drobes, D. J. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00133.x · Cited by 115 · see citing works
Self-citationTranscriptome organization for chronic alcohol abuse in human brain
Farris, S. P., Arasappan, D., Hunicke-Smith, S., Harris, R. A., & Mayfield, R. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.159 · Cited by 111 · see citing works
Treatment Effects of Gabapentin for Primary Insomnia
Lo, H.-S., Yang, C., Lo, H. G., Lee, C., Ting, H., & Tzang, B. (2010) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181cda242 · Cited by 110 · see citing works
Collins, F. S. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3461 · Cited by 108 · see citing works
The Anticonvulsant Gabapentin (Neurontin) Does Not Act through γ-Aminobutyric Acid-B Receptors
Jensen, A. A., Mosbacher, J., Elg, S., Lingenhoehl, K., Lohmann, T., Johansen, T. N., Abrahamsen, B., Mattsson, J. P., Lehmann, A., Bettler, B., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.6.1377 · Cited by 108 · see citing works
Gabapentin in PTSD: A Retrospective, Clinical Series of Adjunctive Therapy1
Hamner, M. B., Brodrick, P. S., & Labbate, L. A. (2001) · Annals of Clinical Psychiatry · doi:10.3109/10401230109148960 · Cited by 106 · see citing works
Acamprosate: A Prototypic Neuromodulator in the Treatment of Alcohol Dependence
Mason, B. J., & Heyser, C. J. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710790966641 · Cited by 104 · see citing works
Self-citationClark, C. P., Gillin, J. C., Golshan, S., DeModena, A., Smith, T. L., Danowski, S., Irwin, M. R., & Schuckit, M. A. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00457-5 · Cited by 104 · see citing works
The Role of Gabapentin in the Management of Alcohol Withdrawal and Dependence
Leung, J. G., Hall‐Flavin, D. K., Nelson, S. E., Schmidt, K. A., & Schak, K. M. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015585849 · Cited by 97 · see citing works
Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients
Karam‐Hage, M., & Brower, K. J. (2003) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.2003.01161.x · Cited by 96 · see citing works
Gabapentin in the Treatment of Cocaine Dependence
Myrick, H., Henderson, S., Brady, K. T., & Malcolm, R. J. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0105 · Cited by 95 · see citing works
Bertrand, S. S., Ng, G., Purisai, M. G., Wolfe, S. E., Severidt, M. W., Nouel, D., Robitaille, R., Low, M. J., O’Neill, G. P., Metters, K. M., et al. (2001) · PubMed · Cited by 92 · see citing works
Gonzalez, G. M., Desai, R. A., Sofuoglu, M., Poling, J., Oliveto, A. H., Gonsai, K., & Kosten, T. R. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.07.003 · Cited by 90 · see citing works
A randomized placebo-controlled trial of gabapentin for cocaine dependence
Bisaga, A. M., Aharonovich, E., Garawi, F., LEVIN, F. R., Rubin, E., Raby, W. N., & Nunes, E. V. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.07.009 · Cited by 88 · see citing works
Gabapentin Treatment for Insomnia Associated With Alcohol Dependence
Karam‐Hage, M., & Brower, K. J. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.151 · Cited by 86 · see citing works
Pregabalin versus naltrexone in alcohol dependence: a randomised, double-blind, comparison trial
Martinotti, G., Nicola, M. D., Tedeschi, D., Andreoli, S., Reina, D., Pomponi, M., Mazza, M., Romanelli, R., Moroni, N., de Filippis, R., et al. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109102623 · Cited by 82 · see citing works
Abuse of Gabapentin is Associated with Opioid Addiction
Bastiaens, L., Galus, J., & Mazur, C. (2016) · Psychiatric Quarterly · doi:10.1007/s11126-016-9421-7 · Cited by 82 · see citing works
Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum.
Götz, E., Tj, F., Lais, A., & Dk, M. (1993) · PubMed · Cited by 81 · see citing works
Martinotti, G., Nicola, M. D., Frustaci, A., Romanelli, R., Tedeschi, D., Guglielmo, R., Guerriero, L., Bruschi, A., de Filippis, R., Pozzi, G., et al. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02792.x · Cited by 80 · see citing works
Prescription medication misuse among opioid dependent patients seeking inpatient detoxification
Wilens, T. E., Zulauf-McCurdy, C. A., Ryland, D., Carrellas, N. W., & Catalina‐Wellington, I. (2015) · American Journal on Addictions · doi:10.1111/ajad.12159 · Cited by 79 · see citing works
Anticonvulsants for the Treatment of Alcohol Withdrawal Syndrome and Alcohol Use Disorders
Hammond, C. J., Niciu, M. J., Drew, S., & Arias, A. J. (2015) · CNS Drugs · doi:10.1007/s40263-015-0240-4 · Cited by 77 · see citing works
Efficacy of a Combination of Flumazenil and Gabapentin in the Treatment of Alcohol Dependence
Anton, R. F., Myrick, H., Baros, A. M., Latham, P. K., Randall, P. K., Wright, T. M., Stewart, S., Waid, R., & Malcolm, R. J. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181aba6a4 · Cited by 75 · see citing works
Myrick, H., Anton, R. F., Voronin, K. E., Wang, W., & Henderson, S. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00299.x · Cited by 73 · see citing works
Importance of Gabapentin Dose in Treatment of Opioid Withdrawal
Salehi, M., Kheirabadi, G. R., Maracy, M. R., et al. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31822bb378 · Cited by 69 · see citing works
A Beneficial Effect on Mood in Partial Epilepsy Patients Treated with Gabapentin
Harden, C. L., Lazar, L. M., Pick, L. H., Nikolov, B. G., Goldstein, M. A., Carson, D., Ravdin, L., Kocsis, J. H., & Labar, D. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00830.x · Cited by 68 · see citing works
Acamprosate in Alcohol Dependence: Implications of a Unique Mechanism of Action
Littleton, J. M. (2007) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318156c26f · Cited by 68 · see citing works
Gabapentin augmentation therapy in bipolar depression
Wang, P. W., Santosa, C. M., Schumacher, M. R., Winsberg, M. E., Strong, C. M., & Ketter, T. A. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01211.x · Cited by 63 · see citing works
Acute modulation of calcium currents and synaptic transmission by gabapentinoids
Uchitel, O. D., Guilmi, M. N. D., Urbano, F. J., & Inchauspe, C. G. (2010) · Channels · doi:10.4161/chan.4.6.12864 · Cited by 62 · see citing works
Perugi, G., Toni, C., Frare, F., Ruffolo, G., Moretti, L., Torti, C., & Akiskal, H. S. (2002) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200212000-00008 · Cited by 61 · see citing works
Schjerning, O., Pottegård, A., Damkier, P., et al. (2016) · Pharmacopsychiatry · doi:10.1055/s-0042-101868 · Cited by 61 · see citing works
Add-on gabapentin in the treatment of opiate withdrawal
Martı́nez-Raga, J., Sabater, A., Gálvez, B. P., Castellano, M., & Cervera, G. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.11.020 · Cited by 59 · see citing works
Efficacy and safety of pregabalin in alcohol dependence
Martinotti, G., Nicola, M. D., Tedeschi, D., Mazza, M., Janiri, L., & Bria, P. (2008) · Advances in Therapy · doi:10.1007/s12325-008-0066-2 · Cited by 56 · see citing works
Pregabalin for the Treatment of Drug and Alcohol Withdrawal Symptoms: A Comprehensive Review
Freynhagen, R., Bačkonja, M., Schug, S. A., Lyndon, G. J., Parsons, B., WATT, S. J., & Behar, R. (2016) · CNS Drugs · doi:10.1007/s40263-016-0390-z · Cited by 55 · see citing works
Nicola, M. D., Martinotti, G., Tedeschi, D., Frustaci, A., Mazza, M., Sarchiapone, M., Pozzi, G., Bria, P., & Janiri, L. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1098 · Cited by 52 · see citing works
Yurcheshen, M. E., Guttuso, T. J., McDermott, M., Holloway, R. G., & Perlis, M. L. (2009) · Journal of Women s Health · doi:10.1089/jwh.2008.1257 · Cited by 52 · see citing works
The acute effects of gabapentin in combination with alcohol in heavy drinkers
Bisaga, A. M., & Evans, S. M. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.10.008 · Cited by 50 · see citing works
Lavigne, J., Heckler, C., Mathews, J., Palesh, O., Kirshner, J., Lord, R. S., Jacobs, A., Amos, E., Morrow, G., & Mustian, K. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2251-x · Cited by 49 · see citing works
Gabapentin Improves Sleep in the Presence of Alcohol
Bazil, C. W., Battista, J., & Basner, R. C. (2005) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26345 · Cited by 47 · see citing works
Bıyık, Z., Solak, Y., Atalay, H., Gaipov, A., Güney, F., & Türk, S. (2012) · International Urology and Nephrology · doi:10.1007/s11255-012-0193-1 · Cited by 47 · see citing works
Bertrand, S. S., Ng, G., Purisai, M. G., Wolfe, S. E., Severidt, M. W., Nouel, D., Robitaille, R., Low, M. J., O’Neill, G. P., Metters, K. M., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29346-0 · Cited by 46 · see citing works
Furey, S., Hull, S. G., Leibowitz, M., Jayawardena, S., & Roth, T. (2014) · Journal of Clinical Sleep Medicine (JCSM) · doi:10.5664/jcsm.4110 · Cited by 42 · see citing works
Mancino, M. J., McGaugh, J., Chopra, M. P., Guise, J. B., Cargile, C. S., Williams, D. K., Thostenson, J., Kosten, T. R., Sanders, N., & Oliveto, A. H. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000062 · Cited by 39 · see citing works
Gabapentin Reduces Cocaine Use Among Addicts From a Community Clinic Sample
Raby, W. N., & Coomaraswamy, S. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0114 · Cited by 37 · see citing works
Effect of add‐on gabapentin on opioid withdrawal symptoms in opium‐dependent patients
Kheirabadi, G. R., Ranjkesh, M., Maracy, M. R., et al. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02248.x · Cited by 37 · see citing works
Adjunctive gabapentin in treatment-resistant depression: a retrospective chart review
Yasmin, S., Carpenter, L. L., Leon, Z., Siniscalchi, J. M., & Price, L. H. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00187-7 · Cited by 36 · see citing works
Rosenberg, R., Hull, S. G., Lankford, D., Mayleben, D., Seiden, D., Furey, S., Jayawardena, S., & Roth, T. (2014) · Journal of Clinical Sleep Medicine (JCSM) · doi:10.5664/jcsm.4108 · Cited by 35 · see citing works
Double‐blind placebo‐controlled evaluation of the PROMETA™ protocol for methamphetamine dependence
Ling, W. W., SHOPTAW, S. J., Hillhouse, M. P., Bholat, M. A., Charuvastra, C., Heinzerling, K. G., Chim, D., Annon, J. J., Dowling, P. T., & Doraimani, G. (2011) · Addiction · doi:10.1111/j.1360-0443.2011.03619.x · Cited by 35 · see citing works
PREGABALIN IS EFFECTIVE AGAINST BEHAVIORAL AND ELECTROGRAPHIC SEIZURES DURING ALCOHOL WITHDRAWAL
Becker, H. C., Myrick, H., & Veatch, L. M. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl029 · Cited by 33 · see citing works
Trevisan, L. A., Ralevski, E., Keegan, K. A., et al. (2008) · Addictive Disorders & Their Treatment · doi:10.1097/adt.0b013e31812e6a3c · Cited by 30 · see citing works
Importance of sleep restoration in co-morbid disease: effect of anticonvulsants.
Ehrenberg, B. L. (2000) · PubMed · Cited by 29 · see citing works
Hart, C. L., Haney, M., Vosburg, S. K., Rubin, E., & Foltin, R. W. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328014139d · Cited by 27 · see citing works
Katsura, M., Shibasaki, M., Hayashida, S., et al. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0060781 · Cited by 27 · see citing works
Urschel, H. C., Hanselka, L. L., & Baron, M. I. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109349837 · Cited by 23 · see citing works
Urschel, H. C., Hanselka, L. L., Gromov, I., White, L., & Baron, M. I. (2007) · Mayo Clinic Proceedings · doi:10.4065/82.10.1170 · Cited by 20 · see citing works
Bogan, R., Lee, D. O., Buchfuhrer, M. J., et al. (2015) · Annals of Medicine · doi:10.3109/07853890.2015.1025825 · Cited by 20 · see citing works
Mann, K. F., Hoffmann, S., & Pawlak, C. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.175 · Cited by 19 · see citing works
Mehta, N. D., Bucior, I., Bujanover, S., Shah, R., & Gulati, A. (2016) · Health and Quality of Life Outcomes · doi:10.1186/s12955-016-0456-0 · Cited by 19 · see citing works
Trial of Tramadol Plus Gabapentin for Opioid Detoxification
Ziaaddini, H., Ziaaddini, A., Asghari, N., Nakhaee, N., & Shahrbabaki, M. E. (2014) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.18202 · Cited by 17 · see citing works
Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent.
Kumar, P. J., & Jain, M. K. (2003) · PubMed · Cited by 13 · see citing works
Mowla, A., Ahmadzadeh, L., Jahromi, L. R., et al. (2015) · Clinical Drug Investigation · doi:10.1007/s40261-015-0304-8 · Cited by 12 · see citing works
Canafax, D. M., Bhanegaonkar, A. J., Bharmal, M. F., & Calloway, M. O. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-48 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [15]American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 4 Washington, DC American Psychiatric Press 2000
Cited by
Sorted by citations
Falk, D. E., Ryan, M. L., Fertig, J. B., Devine, E. G., Cruz, R., Brown, E. S., Burns, H., Salloum, I. M., Newport, D. J., Mendelson, J., et al. (2019) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13917 · Cited by 89 · see citing works
Self-citationOff-label and investigational drugs in the treatment of alcohol use disorder: A critical review
Fischler, P. V., Soyka, M., Seifritz, E., & Mutschler, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927703 · Cited by 34 · see citing works
A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder
Celik, M., Gold, M. S., & Fuehrlein, B. (2024) · Brain Sciences · doi:10.3390/brainsci14030294 · Cited by 25 · see citing works
Mattle, A. G., McGrath, P., Sanu, A., Kunadharaju, R., Kersten, B., Zammit, K., & Mammen, M. J. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109671 · Cited by 21 · see citing works
- Authors
- Mason, B. J., Quello, S., & Shadan, F.
- Affiliations
- Scripps Research Institute (US)
- Scripps Green Hospital (US)
- Corresponding author
- Mason, Barbara J.
- Venue
- Expert Opinion on Investigational Drugs
- Publisher
- Informa UK Limited
- Published
- 2017-12-23
- Volume
- 27
- Issue
- 1
- Pages
- 113-124
- ISSN
- 1354-3784 (ISSN-L)
- 1744-7658
- PMC
- PMC5957503
- OpenAlex
- W2774483423
- Cited by
- 104
- References
- 105
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 17 · 2023: 12 · 2022: 17 · 2021: 7 · 2020: 17 · 2019: 13 · 2018: 11
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Expert Opinion on Investigational Drugs (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA023152, P60AA006420, U01AA025476)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- gabapentin, alcoholism, alcohol craving, alcohol withdrawal, negative affect, calcium channel blockers, pharmacological treatment of alcoholism
- MeSH terms
- Gabapentin, Alcohol Drinking, Alcoholism, Amines, Animals, Calcium Channel Blockers, Cyclohexanecarboxylic Acids, gamma-Aminobutyric Acid, Humans, Sleep Initiation and Maintenance Disorders, Substance Withdrawal Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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