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Cited by 252Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersVirology and Viral Diseases

The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.

Autistic disorder and viral infections

Libbey, Jane, Sweeten, Thayne, McMahon, William, Fujinami, Robert·2005·Journal of NeuroVirology
DOI 10.1080/13550280590900553
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Abstract

Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide range of behaviors. Although the etiology of autism is unknown, data suggest that autism results from multiple etiologies with both genetic and environmental contributions, which may explain the spectrum of behaviors seen in this disorder. One proposed etiology for autism is viral infection very early in development. The mechanism, by which viral infection may lead to autism, be it through direct infection of the central nervous system (CNS), through infection elsewhere in the body acting as a trigger for disease in the CNS, through alteration of the immune response of the mother or offspring, or through a combination of these, is not yet known. Animal models in which early viral infection results in behavioral changes later in life include the influenza virus model in pregnant mice and the Borna disease virus model in newborn Lewis rats. Many studies over the years have presented evidence both for and against the association of autism with various viral infections. The best association to date has been made between congenital rubella and autism; however, members of the herpes virus family may also have a role in autism. Recently, controversy has arisen as to the involvement of measles virus and/or the measles, mumps, rubella (MMR) vaccine in the development of autism. Biological assays lend support to the association between measles virus or MMR and autism whereas epidemiologic studies show no association between MMR and autism. Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism.

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Crossref · 10.1080/13550280590900553

Cites

114 of 114 references verified0 citation errors · 0 not checkable

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Citations

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1 retracted

Show all 114 references

Research works printed but not linked: 2

  1. Tsunoda, I and Fujinami, R.(1999) Theiler's murine encephalomyelitis virus.. In Persistent viral infections.. ( pp. pp 517 - 536 ). Chichester : John Wiley & Sons.
  2. Desmond, M and Wilson, G and Verniaud, W and Melnick, J and Rawls, W. (1970) The early growth and development of infants with congenital rubella. Adv Teratol, 4, pp. 39 - 63.

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Metadata

Authors
Libbey, J., Sweeten, T., McMahon, W., & Fujinami, R.
Affiliations
University of Utah (US)
Corresponding author
Fujinami, Robert
ORCID
Venue
Journal of NeuroVirology
Publisher
Springer Science and Business Media LLC
Published
2005-02-16
Volume
11
Issue
1
Pages
1-10
ISSN
1355-0284 (ISSN-L)
DOI
10.1080/13550280590900553
OpenAlex
W2119855769
Cited by
252
References
114
Citations by year
2026: 2 · 2025: 1 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 18 · 2015: 14 · 2014: 12 · 2013: 20 · 2012: 26
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of NeuroVirology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U19 HD/DC25476)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
autism spectrum disorder, autistic disorder, viral infection, autism etiology, congenital rubella syndrome, measles virus, MMR vaccine, herpesvirus, influenza virus, Borna disease virus, maternal immune response, animal models of autism, central nervous system infection
MeSH terms
Animals, Autistic Disorder, Humans, Virus Diseases, Measles-Mumps-Rubella Vaccine

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