CoChat
Sign Up
Cited by 252Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersVirology and Viral Diseases

The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.

Autistic disorder and viral infections

Libbey, Jane, Sweeten, Thayne, McMahon, William, Fujinami, Robert·2005·Journal of NeuroVirology
DOI 10.1080/13550280590900553
Open this paper in CoChat — free account

Abstract

Autistic disorder (autism) is a behaviorally defined developmental disorder with a wide range of behaviors. Although the etiology of autism is unknown, data suggest that autism results from multiple etiologies with both genetic and environmental contributions, which may explain the spectrum of behaviors seen in this disorder. One proposed etiology for autism is viral infection very early in development. The mechanism, by which viral infection may lead to autism, be it through direct infection of the central nervous system (CNS), through infection elsewhere in the body acting as a trigger for disease in the CNS, through alteration of the immune response of the mother or offspring, or through a combination of these, is not yet known. Animal models in which early viral infection results in behavioral changes later in life include the influenza virus model in pregnant mice and the Borna disease virus model in newborn Lewis rats. Many studies over the years have presented evidence both for and against the association of autism with various viral infections. The best association to date has been made between congenital rubella and autism; however, members of the herpes virus family may also have a role in autism. Recently, controversy has arisen as to the involvement of measles virus and/or the measles, mumps, rubella (MMR) vaccine in the development of autism. Biological assays lend support to the association between measles virus or MMR and autism whereas epidemiologic studies show no association between MMR and autism. Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism.

Overview

Integrity signals

Registry

Crossref · 10.1080/13550280590900553

Cites

114 of 114 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

1 retracted

Research works printed but not linked: 2

  1. Tsunoda, I and Fujinami, R.(1999) Theiler's murine encephalomyelitis virus.. In Persistent viral infections.. ( pp. pp 517 - 536 ). Chichester : John Wiley & Sons.
  2. Desmond, M and Wilson, G and Verniaud, W and Melnick, J and Rawls, W. (1970) The early growth and development of infants with congenital rubella. Adv Teratol, 4, pp. 39 - 63.

Cited by

Sorted by citations

See all 252

Related

See all

Metadata

Authors
Libbey, J., Sweeten, T., McMahon, W., & Fujinami, R.
Affiliations
University of Utah (US)
Corresponding author
Fujinami, Robert
ORCID
Venue
Journal of NeuroVirology
Publisher
Springer Science and Business Media LLC
Published
2005-02-16
Volume
11
Issue
1
Pages
1-10
ISSN
1355-0284 (ISSN-L)
DOI
10.1080/13550280590900553
OpenAlex
W2119855769
Cited by
252
References
114
Citations by year
2026: 2 · 2025: 1 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 15 · 2019: 10 · 2018: 10 · 2017: 13 · 2016: 18 · 2015: 14 · 2014: 12 · 2013: 20 · 2012: 26
FWCI
0.99
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of NeuroVirology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U19 HD/DC25476)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords
autism spectrum disorder, autistic disorder, viral infection, autism etiology, congenital rubella syndrome, measles virus, MMR vaccine, herpesvirus, influenza virus, Borna disease virus, maternal immune response, animal models of autism, central nervous system infection
MeSH terms
Animals, Autistic Disorder, Humans, Virus Diseases, Measles-Mumps-Rubella Vaccine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review