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Cited by 112Folate and B Vitamins ResearchTreatment of Major DepressionTryptophan and brain disorders

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis

Petridou, Eleni Th., Kousoulis, Antonis A., Michelakos, Theodoros, Papathoma, Paraskevi, Dessypris, Nick, Papadopoulos, Fotios C., Stefanadis, Christodoulos·2016·Aging & Mental Health
DOI 10.1080/13607863.2015.1049115
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Abstract

OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people. METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25). CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.

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Crossref · 10.1080/13607863.2015.1049115

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  1. 10.1001/archinte.157.4.449 · DOI · Paper page

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Metadata

Authors
Petridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C.
Affiliations
  • National and Kapodistrian University of Athens (GR)
  • Uppsala University (SE)
Corresponding author
Petridou, Eleni Th.
ORCID
Venue
Aging & Mental Health
Publisher
Informa UK Limited
Published
2015-06-08
Volume
20
Issue
9
Pages
965-973
ISSN
  • 1360-7863 (ISSN-L)
  • 1364-6915
DOI
10.1080/13607863.2015.1049115
OpenAlex
W2215638520
Cited by
112
References
57
Citations by year
2025: 2 · 2024: 14 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 41 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 1
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Aging & Mental Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
folic acid, vitamin B12, serum folate, serum vitamin B12, depression, older adults, aging, sex differences, vitamin deficiency
MeSH terms
Aged, Aged, 80 and over, Depressive Disorder, Female, Folic Acid, Humans, Male

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