The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis
Abstract
OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people. METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25). CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.
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“In terms of circulating vitamin status, analysis of the data from 10 cross-sectional studies and one prospective study demonstrated a relationship between low folate and vitamin B12 and depression [117], and analysis of data from 10 cross-sectional and three cohort studies showed that that folate, but not vitamin B12…”
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541
Köhler, C. A., Evangelou, E., Stubbs, B., Solmi, M., Veronese, N., Belbasis, L., Bortolato, B., Melo, M. C. A., Coelho, C. A., Fernandes, B. S., et al. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.05.020 · Cited by 302
“…of evidence* AMSTAR Dietary factors Petridou, 2016 Low B12 NA 8 OR 1.25 (0.97-1.59) 0.080 0.68-2.29 40 No/No NS 4 Petridou, 2016 Low folate NA 11 OR 1.21 (0.98-1.49) 0.079 0.71-2.05 37 No/No NS 4 Family factors Yan, 2011 Marital status (widowed, divorced, never…”
InfluentialEvidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
Carvalho, A. F., Solmi, M., Sanches, M., Machado, M. O., Stubbs, B., Ajnakina, O., Sherman, C., Sun, Y. R., Liu, C. S., Brunoni, A. R., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0835-5 · Cited by 204
Stress and the gut microbiota-brain axis
Molina‐Torres, G., Rodríguez-Arrastia, M. J., Román, P., Sánchez‐Labraca, N., & Cardona, D. (2019) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000478 · Cited by 189
“, 2016), HPA axis dysfunction, neuroactive substances and dietary deficiencies (Petridou et al., 2016).”
Metadata
- Authors
- Petridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Uppsala University (SE)
- Corresponding author
- Petridou, Eleni Th.
- ORCID
- Venue
- Aging & Mental Health
- Publisher
- Informa UK Limited
- Published
- 2015-06-08
- Volume
- 20
- Issue
- 9
- Pages
- 965-973
- ISSN
- 1360-7863 (ISSN-L)
- 1364-6915
- OpenAlex
- W2215638520
- Cited by
- 112
- References
- 57
- Citations by year
- 2025: 2 · 2024: 14 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 41 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Aging & Mental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- folic acid, vitamin B12, serum folate, serum vitamin B12, depression, older adults, aging, sex differences, vitamin deficiency
- MeSH terms
- Aged, Aged, 80 and over, Depressive Disorder, Female, Folic Acid, Humans, Male
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