Cited by 112Folate and B Vitamins ResearchTreatment of Major DepressionTryptophan and brain disorders

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Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis

Petridou, Eleni Th., Kousoulis, Antonis A., Michelakos, Theodoros, Papathoma, Paraskevi, Dessypris, Nick, Papadopoulos, Fotios C., Stefanadis, Christodoulos·2016·Aging & Mental Health

DOI 10.1080/13607863.2015.1049115

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Abstract

OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people. METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies. RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25). CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.

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Authors: Petridou, E. T., Kousoulis, A. A., Michelakos, T., Papathoma, P., Dessypris, N., Papadopoulos, F. C., & Stefanadis, C.
Affiliations: National and Kapodistrian University of Athens (GR)
Uppsala University (SE)
Corresponding author: Petridou, Eleni Th.
ORCID: Petridou, Eleni Th.
Kousoulis, Antonis A.
Michelakos, Theodoros
Papadopoulos, Fotios C.
Stefanadis, Christodoulos
Venue: Aging & Mental Health
Publisher: Informa UK Limited
Published: 2015-06-08
Volume: 20
Issue: 9
Pages: 965-973
ISSN: 1360-7863 (ISSN-L)
1364-6915
DOI: 10.1080/13607863.2015.1049115
OpenAlex: W2215638520
Cited by: 112
References: 57
Citations by year: 2025: 2 · 2024: 14 · 2023: 8 · 2022: 6 · 2021: 9 · 2020: 41 · 2019: 12 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 1
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Locations: Aging & Mental Health (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: folic acid, vitamin B12, serum folate, serum vitamin B12, depression, older adults, aging, sex differences, vitamin deficiency
MeSH terms: Aged, Aged, 80 and over, Depressive Disorder, Female, Folic Acid, Humans, Male

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Folate and B12 serum levels in association with depression in the aged: a systematic review and meta-analysis

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