Consumption of Spinacia Oleracea (spinach) and aerobic exercise controls obesity in rats by an inhibitory action on pancreatic lipase
Abstract
Context: Spinaciaoleracea (spinach) is abundant in antioxidant phytoconstituents, termed as the natural antioxidant mixture (NAO).Objective: This study evaluates the anti-hyperlipidemicand anti-obesity effects of an antioxidant-rich extract of Spinaciaoleracea (NAOE) and aerobic exercise (AE) in rats fed with high fat diet (HFD).Methods: Rats received NAOE (200 and 400 mg/kg), the standard drug orlistat (10 mg/kg), AE and NAOEAE (NAOE 400 mg/kg + AE) daily with HFD for 21 d.Results: Orlistat, NAOE and NAOEAE treatments to HFD-fed rats significantly reduced the HFD-elevated food intake, weight gain, pancreatic lipase activity and lipid peroxidation, and successfully restored the HFD-skewed lipid profile and antioxidant levels.Conclusions: It may be concluded that NAOE exhibited a promising anti-hyperlipidemic effect by its inhibitory action on pancreatic lipase. The combination treatment NAOEAE produced the best results indicating the essential role of exercise along with consumption of antioxidant-rich foods in maintaining a normal lipid profile and controlling obesity.
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Spinach is associated with numerous health advantages, such as antioxidant characteristics, lipid-lowering effects, appetite regulation, tissue regeneration, and protection against oxidative stress-induced damage.
“These results show that spinach is associated with numerous health advantages, such as antioxidant characteristics, lipid-lowering effects, appetite regulation, tissue regeneration, and protection against oxidative stress-induced damage [156,162,164,165,166,167,168,169,170].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [164]
Panda et al. investigated whether spinach extract may reduce hyperlipidemia by reducing pancreatic lipase activity; this suggests the importance of consuming spinach in managing lipid levels and obesity.
“Panda et. al. investigated whether spinach extract may reduce hyperlipidemia by reducing pancreatic lipase activity. This suggests the importance of consuming spinach in managing lipid levels and obesity [164].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [164]
In a cited study, the antihyperlipidemic effects of spinach extract were evaluated using a model of aerobic exercise (swimming) in rats fed a high-fat diet, and the authors concluded that spinach extracts inhibit pancreatic lipase in vivo in rats, preventing intestinal absorption of food fat and thereby reducing weight gain-induced weight.
“However, this is most consistent with [13], where the antihyperlipidemic effects of spinach extract were evaluated using a model of aerobic exercise (swimming) in rats fed a high-fat diet. The authors concluded that spinach extracts inhibit pancreatic lipase in vivo in rats, preventing the intestinal absorption of food fat and thereby reducing weight gain-induced weight.”
From Adaptogenic Properties of a Phytoecdysteroid-Rich Extract from the Leaves of Spinacia oleracea L. (2021) · cites this paper as [13]
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Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
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- Authors
- Panda, V., Shinde, P., & Dande, P.
- Affiliations
- Department of Pharmacology & Toxicology, Prin. K. M. Kundnani College of Pharmacy, Mumbai, India;
- Narsee Monjee Institute of Management Studies (IN)
- Corresponding author
- Panda, Vandana
- Venue
- Archives of Physiology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2018-09-29
- Volume
- 126
- Issue
- 3
- Pages
- 187-195
- ISSN
- 0778-3124 (ISSN-L)
- 1381-3455
- 1744-4160
- OpenAlex
- W2894103703
- Cited by
- 10
- References
- 33
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 3 · 2019: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- spinach, obesity, aerobic exercise, pancreatic lipase inhibition, high-fat diet, orlistat, lipid peroxidation, lipid profile, dietary intake, weight gain, combination therapy
- MeSH terms
- Orlistat, Animals, Antioxidants, Dietary Fats, Female, Flavonoids, Glutathione, Intestinal Absorption, Lipase, Lipids, Obesity, Pancreas, Physical Conditioning, Animal, Plant Extracts, Lipid Peroxidation, Rats, Sprague-Dawley, Spinacia oleracea, Rats, Diet, High-Fat, Hydroxybenzoates
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