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Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice
Open accessAbstract
CONTEXT: Alcoholic liver fibrosis (ALF) is treatable and reversible consequence of liver disease. Intestinal microflora plays an important role in the progression of liver disease. Garlic (Allium sativum L. [Amaryllidaceae]) has been consumed as a traditional medicine to treat liver injury. OBJECTIVE: To investigate the effects of garlic polysaccharide (GP) on ALF and intestinal microflora in mice. MATERIALS AND METHODS: KM mice were orally administered with alcohol (56%, 6 mL/kg) for 30 d to establish ALF model, and divided into four groups together with control group (water only). Hugan tablet (60 mg/kg) or GP (250 and 150 mg/kg) were given 5 h after each dose of alcohol. Biochemical markers in serum and liver homogenate were determined with kits. Alteration of intestinal microflora, and protein expressions of TGF-β1, TNF-α and decorin were detected. RESULTS: In GP-H group, ALT and AST decreased to 18.85 ± 4.71 U/L and 40.84 ± 7.89 U/L. MDA, TC, TG and LDL-C decreased to 2.32 ± 0.86 mmol/mg, 0.21 ± 0.12 mmol/L, 0.96 ± 0.31 mmol/L and 0.084 ± 0.027 mmol/L. SOD, GSH-Px and GSH increased to 118.32 ± 16.32 U/mg, 523.72 ± 64.20 U/mg and 0.56 ± 0.05 mg/g. Ratios of TGF-β1 and TNF-α decreased to 0.608 ± 0.170 and 1.057 ± 0.058, decorin increased to 2.182 ± 0.129. Lachnospiraceae and Lactobacillus increased, Facklamia and Firmicutes decreased with GP pretreatment. DISCUSSION AND CONCLUSIONS: Intestinal microflora provides novel insight into the mechanisms of GP that may be used to treat ALF and intestinal microflora dysbiosis.
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“Fructan from garlic has been reported to increase the abundance of f_ Lachnospiraceae [54,55].”
From Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis (2019) · cites this paper as [55]
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Metadata
- Authors
- Wang, Y., Guan, M., Zhao, X., & Li, X.
- Affiliations
- Dalian Medical University (CN)
- Corresponding author
- Li, Xinli
- Venue
- Pharmaceutical Biology
- Publisher
- Informa UK Limited
- Published
- 2018-01-01
- Volume
- 56
- Issue
- 1
- Pages
- 325-332
- ISSN
- 0925-1618 (ISSN-L)
- 1388-0209
- 1744-5116
- PMC
- PMC6130653
- OpenAlex
- W2810636402
- Cited by
- 110
- References
- 35
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 22 · 2023: 12 · 2022: 24 · 2021: 17 · 2020: 9 · 2019: 10
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutical Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Foundation of Liaoning Educational Committee of China (L2016004)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- garlic polysaccharide, alcoholic liver fibrosis, gut microbiota, gut dysbiosis, alcohol-induced liver injury, TGF-β1, TNF-α, decorin, antioxidant enzymes, Lachnospiraceae, Lactobacillus, Firmicutes, garlic
- MeSH terms
- Gastrointestinal Microbiome, Animals, Garlic, Liver Diseases, Alcoholic, Male, Plant Extracts, Polysaccharides, Treatment Outcome, Mice
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