The DOI matches its Crossref record; 217 of the 217 references it cites were found in a registry or an index.
Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal
Abstract
The neurobiology of nicotine addiction is reviewed within the context of neurobiological and behavioral theories postulated for other drugs of abuse. The roles of various neurotransmitter systems, including acetylcholine, dopamine, serotonin, glutamate, gamma-aminobutyric acid, and opioid peptides in acute nicotine reinforcement and withdrawal from chronic administration are examined followed by a discussion of potential neuroadaptations within these neurochemical systems that may lead to the development of nicotine dependence. The link between nicotine administration, depression and schizophrenia are also discussed. Finally, a theoretical model of the neurobiological mechanisms underlying acute nicotine withdrawal and protracted abstinence involves alterations within dopaminergic, serotonergic, and stress systems that are hypothesized to contribute to the negative affective state associated with nicotine abstinence.
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“This phenomenon could also underlie the cyclical mood dysregulation experienced by smokers between smoking episodes, and could therefore perpetuate smoking behavior (Watkins et al., 2000).”
From Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states (2015) · cites this paper as Watkins et al., 2000
Citations
Cites
Items 201–217 of 217
Battaglia, G., Bruno, V., Ngomba, R. T., et al. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00551-2 · Cited by 50
Do Serotonin Uptake Inhibitors Decrease Smoking? Observations in a Group of Heavy Drinkers
Sellers, E. M., Naranjo, C. A., & Kadlec, K. E. (1987) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-198712000-00009 · Cited by 40
Behavioural pharmacology of nicotine: multiple mechanisms
Stolerman, I. P. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01803.x · Cited by 36
Nicotine abstinence syndrome precipitated by an analog of neuropeptide FF
Malin, D. H. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)02279-1 · Cited by 32
A Dopamine D1 Agonist Elevates Self-Stimulation Thresholds
Baldo, B. A., Jain, K., Veraldi, L., Koob, G. F., & Markou, A. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00206-8 · Cited by 30
Mosner, A., Kuhlman, G., Roehm, C., et al. (2008) · Pharmacology · doi:10.1159/000139486 · Cited by 29
Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons.
Rasmussen, K., & Czachura, J. F. (1995) · PubMed · Cited by 29
Effects of Chronic Nicotine Infusion on Kinetics of High‐Affinity Nicotine Binding
Bhat, R. V., Marks, M. J., & Collins, A. C. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62020574.x · Cited by 27
The CCK-B antagonist LY288513 blocks the effects of nicotine withdrawal on auditory startle
Rasmussen, K., Czachura, J. F., Kallman, M. J., & Helton, D. R. (1996) · Neuroreport · doi:10.1097/00001756-199604100-00019 · Cited by 26
Functional correlates of nicotine administration: similarity with drugs of abuse
Pontieri, F. E., Passarelli, F., Calò, L., & Caronti, B. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050208 · Cited by 26
Chapter 31 Opioid peptides, pain and stress
Terenius, L. Y. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61190-5 · Cited by 26
Novel antipsychotics and negative symptoms
Möller, H. (1998) · International Clinical Psychopharmacology · doi:10.1097/00004850-199803003-00008 · Cited by 24
The NMDA antagonist dizocilpine (M K801) attenuates tolerance to nicotine in rats
Shoaib, M. C., & Stolerman, I. P. (1996) · Journal of Psychopharmacology · doi:10.1177/026988119601000306 · Cited by 20
Role of Circulating Opioids in the Modulation of Pain a
Henry, J. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb14627.x · Cited by 13
Panagis, G., Hildebrand, B. E., Svensson, T. H., et al. (1998) · The Society for Neuroscience Abstracts · Cited by 1
Heavy Smokers, Smoking Cessation, and Clonidine: Results of a Double-blind, Randomized Trial
Glassman, A. H. (1988) · JAMA · doi:10.1001/jama.1988.03720190031026
Volkow (1999) · doi:10.1002/(sici)1098-2396(199901)31:1
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Leventhal, A. M., & Zvolensky, M. J. (2015) · Psychological Bulletin · doi:10.1037/bul0000003 · Cited by 524
Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
Changeux, J.-P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2849 · Cited by 453
Neurobiology of the nicotine withdrawal syndrome
Kenny, P. J., & Markou, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00651-7 · Cited by 310
Hughes, J. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188927 · Cited by 173
Picciotto, M. R., Lewis, A. S., van Schalkwyk, G. I., & Mineur, Y. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.028 · Cited by 157
Metadata
- Authors
- S. Watkins, G. F. K.
- Venue
- Nicotine & Tobacco Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-02-01
- Volume
- 2
- Issue
- 1
- Pages
- 19-37
- ISSN
- 1462-2203 (ISSN-L)
- 1469-994X
- OpenAlex
- W2158696674
- Cited by
- 424
- References
- 217
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 25 · 2021: 8 · 2020: 12 · 2019: 12 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 27 · 2014: 23 · 2013: 21 · 2012: 22
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nicotine & Tobacco Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5f31da005898-02)
- National Institute on Drug Abuse (DA04398, DA-08467, DA05898, R01DA004398, R01DA008467)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- nicotine dependence, nicotine withdrawal, nicotine reinforcement, neurotransmitter systems, acetylcholine, dopamine, serotonin, glutamate, GABA, opioid peptides, neural adaptation, depression, schizophrenia, negative affect, abstinence, stress system
- MeSH terms
- Animals, Mental Disorders, Humans, Models, Neurological, Neuropeptides, Reinforcement, Psychology, Substance Withdrawal Syndrome, Tobacco Use Disorder, Neurotransmitter Agents
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