The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Gestational diabetes: The forerunner for the development of maternal and childhood obesity and metabolic syndrome?
Abstract
OBJECTIVE: To examine the risk of obesity and metabolic syndrome in women with a history of gestational diabetes mellitus and in offspring born to mothers with gestational diabetes mellitus. METHODS: A review of studies examining the development of obesity, hypertension, metabolic abnormalities, metabolic syndrome, and type II diabetes in mothers with a history of gestational diabetes mellitus and control mothers, and offspring of mothers with a history of gestational diabetes and control mothers. RESULTS: Longitudinal studies demonstrate that women with a prior history of gestational diabetes mellitus and obesity are at significantly greater risk of developing metabolic syndrome than mothers with no history of gestational diabetes or obesity. The development of metabolic syndrome in children with increasing age is related to maternal gestational diabetes mellitus, maternal glycemia in the 3rd trimester, maternal obesity, neonatal macrosomia, and childhood obesity. CONCLUSIONS: The current prevalence of obesity in both adults and children and associated disorders of blood pressure and lipid metabolism, suggest a perpetuating cycle of increasing obesity, insulin resistance, and abnormal lipid metabolism, which has ominous consequences for future generations.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is also a longer-term risk of obesity, type 2 diabetes, and cardiovascular disease in the child.”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [67]
In the citing paper
“Children born to mothers with GDM have almost double the risk of developing childhood obesity when compared with nondiabetic mothers, even after adjusting for confounders such as maternal BMI [67,68]”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [67]
Citations
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
Prevalence and Trends in Overweight Among US Children and Adolescents, 1999-2000
Ogden, C. L. (2002) · JAMA · doi:10.1001/jama.288.14.1728 · Cited by 4,060
Berenson, G. S., Srinivasan, S. R., Bao, W., Newman, W. P., Tracy, R. E., & Wattigney, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806043382302 · Cited by 4,032
Obesity and the Metabolic Syndrome in Children and Adolescents
Weiss, R., Dziura, J., Burgert, T. S., Tamborlane, W. V., Taksali, S. E., Yeckel, C. W., Allen, K., Lopes, M., Savoye, M., Morrison, J. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031049 · Cited by 3,495
Freedman, D. S., Dietz, W. H., Srinivasan, S. R., & Berenson, G. S. (1999) · Pediatrics · doi:10.1542/peds.103.6.1175 · Cited by 2,456
Cook, S., Weitzman, M., Auinger, P., Nguyen, M., & Dietz, W. H. (2003) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.157.8.821 · Cited by 2,326
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
Self-citationCriteria for screening tests for gestational diabetes
Carpenter, M. W., & Coustan, D. R. (1982) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(82)90349-0 · Cited by 1,924
McKeigue, P. M., Shah, B., & Marmot, M. G. (1991) · The Lancet · doi:10.1016/0140-6736(91)91164-p · Cited by 1,618
Increased incidence of non-insulin-dependent diabetes mellitus among adolescents
Pinhas‐Hamiel, O., Dolan, L. M., Daniels, S. R., Standiford, D. A., Khoury, P. R., & Zeitler, P. S. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)80124-7 · Cited by 1,169
Identifying Risk for Obesity in Early Childhood
Nader, P. R., O’Brien, M., Houts, R., Bradley, R., Belsky, J., Crosnoe, R. L., Friedman, S. L., Mei, Z., & Susman, E. J. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2801 · Cited by 780
Claudio Napoli, A., Glass, C. K., Witztum, J. L., Deutsch, R., D’Armiento, F. P., & Palinski, W. (1999) · The Lancet · doi:10.1016/s0140-6736(99)02131-5 · Cited by 649
Increasing Pediatric Obesity in the United States
Gortmaker, S. L. (1987) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1987.04460050077035 · Cited by 562
Excessive Obesity in Offspring of Pima Indian Women with Diabetes during Pregnancy
Pettitt, D. J., Baird, H. R., Aleck, K. A., Bennett, P. H., & Knowler, W. C. (1983) · New England Journal of Medicine · doi:10.1056/nejm198302033080502 · Cited by 530
Insulin resistance is a characteristic feature of primary hypertension independent of obesity
Pollare, T., Lithell, H., & Berne, C. (1990) · Metabolism · doi:10.1016/0026-0495(90)90071-j · Cited by 530
Screening criteria for high-risk gestational diabetic patients
O'Sullivan, J. B., Mahan, C. M., Charles, D., & Dandrow, R. V. (1973) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)33833-9 · Cited by 478
Association of Body Fat Distribution and Cardiovascular Risk Factors in Children and Adolescents
Daniels, S. R., Morrison, J. A., Sprecher, D. L., Khoury, P. R., & Kimball, T. R. (1999) · Circulation · doi:10.1161/01.cir.99.4.541 · Cited by 444
Fetal origins of cardiovascular disease
Barker, D. J. P. (1999) · Annals of Medicine · doi:10.1080/07853890.1999.11904392 · Cited by 426
Obesity in the Pima Indians: its magnitude and relationship with diabetes
Knowler, W. C., Pettitt, D. J., Saad, M., Charles, M.-A. A., Nelson, R., Howard, B., Bogardus, C., & Bennett, P. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.6.1543s · Cited by 284
Friedman, J. E., Ishizuka, T., Shao, J., Huston, L., Highman, T., & Catalano, P. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1807 · Cited by 255 · cited 1×
“There is also evidence from studies in former GDM women that insulin resistance precedes the development of an abnormal glucose profile by several months to years post-delivery [19,20].”
BackgroundGestational Glucose Tolerance and Risk of Type 2 Diabetes in Young Pima Indian Offspring
Franks, P. W., Looker, H. C., Kobes, S., Touger, L., Tataranni, P. A., Hanson, R. L., & Knowler, W. C. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-0823 · Cited by 253
Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics
Haffner, S. M., Fong, D. S., Hazuda, H. P., Pugh, J. A., & Patterson, J. K. (1988) · Metabolism · doi:10.1016/0026-0495(88)90133-3 · Cited by 251
Birth Weight and Parental BMI Predict Overweight in Children From Mothers With Gestational Diabetes
Schaefer-Graf, U. M., Pawliczak, J., Passow, D., Hartmann, R., Rossi, R., Bührer, C., Harder, T., Plagemann, A., Vetter, K., & Kordonouri, O. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1745 · Cited by 219
The Insulin Resistance Syndrome: Impact on Lipoprotein Metabolism and Atherothrombosis
Ginsberg, H. N., & Huang, L.-S. (2000) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/204748730000700505 · Cited by 209
Increased Subclinical Atherosclerosis in Young Adults With Metabolic Syndrome
Tzou, W. S., Douglas, P. S., Srinivasan, S. R., Bond, M. G., Tang, R., Chen, W., Berenson, G. S., & Stein, J. H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.046 · Cited by 206
Obesity in offspring of diabetic Pima Indian women despite normal birth weight
Pettitt, D. J., Knowler, W. C., Bennett, P. H., Aleck, K. A., & Baird, H. R. (1987) · Diabetes Care · doi:10.2337/diacare.10.1.76 · Cited by 183
Childhood obesity in a population at high risk for type 2 diabetes
Young, T. K., Dean, H., Flett, B., & Wood-Steiman, P. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.103504 · Cited by 176
Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age
Vohr, B. R., McGarvey, S. T., & Tucker, R. (1999) · Diabetes Care · doi:10.2337/diacare.22.8.1284 · Cited by 166
Self-citationLanger, O., & Mazze, R. (1988) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(88)90578-9 · Cited by 158
Insulin Resistance Syndrome in Women with Prior History of Gestational Diabetes Mellitus
Verma, A., Boney, C. M., Tucker, R. J., & Vohr, B. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8684 · Cited by 158
Self-citationSecular trends of blood pressure and body size in a multi-ethnic adolescent population: 1986 to 1996
Luepker, R. V., Jacobs, D. R., Prineas, R. J., & Sinaiko, A. R. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70279-9 · Cited by 156
Bunt, J. C., Tataranni, P. A., & Salbe, A. D. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0007 · Cited by 140
Glucose, insulin concentrations and obesity in childhood and adolescence as predictors of NIDDM
McCance, D. R., Pettitt, D. J., Hanson, R. L., Jacobsson, L., Bennett, P. H., & Knowler, W. C. (1994) · Diabetologia · doi:10.1007/bf00403382 · Cited by 111
Lipid Levels in Former Gestational Diabetic Mothers
Meyers‐Seifer, C. H., & Vohr, B. R. (1996) · Diabetes Care · doi:10.2337/diacare.19.12.1351 · Cited by 105
Self-citationDiabetes and pregnancy: Blood sugar of newborn infants
Miller, H. C. (1953) · The Journal of Pediatrics · doi:10.1016/s0022-3476(53)80122-8 · Cited by 105
Morrison, J. A., James, F. W., Sprecher, D. L., Khoury, P. R., & Daniels, S. R. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.11.1708 · Cited by 95
Vohr, B. R., & McGarvey, S. T. (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1066 · Cited by 83
Self-citationSubclinical abnormalities of glucose metabolism in subjects with previous gestational diabetes
Catalano, P. M., Bernstein, I. M., Wolfe, R. R., Srikanta, S., Tyzbir, E. D., & Sims, E. A. H. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90155-9 · Cited by 82
Gautier, J., Mourier, A., de Kerviler, É., Tarentola, A., Bigard, X. A., Villette, J., Guézennec, C. Y., & Cathelineau, G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4713 · Cited by 76
Campaigne, B. N., Morrison, J. A., Schumann, B. C., Falkner, F., Lakatos, E., Sprecher, D. L., & Schreiber, G. B. (1994) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81354-x · Cited by 70
Chen, C., Lin, K., Tsai, S.-T., & Chou, P. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)00255-7 · Cited by 68
History of Gestational Diabetes, Insulin Resistance and Coronary Risk
Davis, C. L., Gutt, M., Llabre, M. M., Marks, J. B., O’Sullivan, M. J., Potter, J. E., Landel, J. L., Kumar, M., Schneiderman, N., Gellman, M. D., et al. (1999) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(99)00048-3 · Cited by 62
Effects of Maternal Gestational Diabetes and Adiposity on Neonatal Adiposity and Blood Pressure
Vohr, B. R., McGarvey, S. T., & Coll, C. G. (1995) · Diabetes Care · doi:10.2337/diacare.18.4.467 · Cited by 57
Self-citationGestational diabetes: current aspects on pathogenesis and treatment
Tamás, G., & Kerényi, Z. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-18598 · Cited by 49
Extreme Pediatric Obesity: Weighing the Health Dangers
Xanthakos, S. A., & Inge, T. H. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.11.040 · Cited by 48
Gynecologic anatomy with magnetic resonance imaging
MCCARTHY, S. M., & Vaquero, E. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90801-x · Cited by 13
Research works printed but not linked: 4
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP), 2001, JAMA, 285, 2486
- Gautier J F, 1998, J Clin Endocrinol Metab, 83, 1306
- Gortmaker S L, 1987, Am J Dis Child, 141, 535
- Green O C, 1987, Clin Res, 35, 657A
Cited by
Sorted by citations
The Pathophysiology of Gestational Diabetes Mellitus
Plows, J. F., Stanley, J. L., Baker, P. N., Reynolds, C. M., & Vickers, M. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113342 · Cited by 1,874
“A recent study reported a 63% increased risk of CVD amongst women with a history of GDM, which was partly, but not fully, explained by BMI [59].”
BackgroundInfluentialGestational diabetes: the need for a common ground
Reece, E. A., Leguizamón, G. F., & Wiznitzer, A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60515-8 · Cited by 599
Thompson, D. M., Berger, H. M., Feig, D. S., Gagnon, R. J., Kader, T., Keely, E., Kozak, S. E., Ryan, E. A., Sermer, M., & Vinokuroff, C. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.01.044 · Cited by 393
Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes
Alejandro, E. U., Mamerto, T. P., Chung, G., Villavieja, A., Gaus, N. L., Morgan, E., & Pineda-Cortel, M. R. B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145003 · Cited by 353
“The increased development of obesity observed in the offspring of mothers with GDM is also associated with an increased risk of metabolic disorders including cardiovascular diseases and insulin resistance [173].”
BackgroundThe fetal and maternal consequences of gestational diabetes mellitus
Reece, E. A. (2010) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050903550659 · Cited by 316
“Vohr and Boney [19], for example, reviewed the medical literature to examine the risk of obesity and metabolic syndrome in women with a history of GDM in their offspring.”
Influential
Metadata
- Authors
- Vohr, B. R., & Boney, C. M.
- Affiliations
- Brown University (US)
- Corresponding author
- Vohr, Betty R.
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 21
- Issue
- 3
- Pages
- 149-157
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2067953340
- Cited by
- 184
- References
- 50
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 6 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 14 · 2013: 9 · 2012: 16
- FWCI
- 18.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- gestational diabetes mellitus, maternal obesity, childhood obesity, metabolic syndrome, type 2 diabetes, hypertension, insulin resistance, neonatal macrosomia, maternal glycemia, offspring, intergenerational risk
- MeSH terms
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Longitudinal Studies, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Odds Ratio, Diabetes, Gestational, Metabolic Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
