Exploring the relationship of second-trimester corticotropin releasing hormone, chronic stress and preterm delivery
Abstract
OBJECTIVE: We examined the impact of chronic stress on the relationship between second-trimester serum corticotropin releasing hormone (CRH) concentrations and preterm delivery (PTD) in working women. METHODS: Birth records from mothers of 364 PTD and 730 controls in Southern California were linked to stored mid-pregnancy maternal serum analysed for CRH. Association of CRH with stressors reported in post-partum interviews was examined in cases and controls separately. Stratified multivariable logistic regression analyses examined moderating influence of seven chronic stressors on CRH in predicting PTD. RESULTS: Mean log CRH was lower among women with chronic stressors. Chronic stressors were not related to an increased risk of PTD, but did strengthen the association of CRH with PTD. Adjusted for confounders, the odds of PTD were 1.5-times higher per unit increase in log CRH in the overall study population, but were two-to-three times higher in subjects who reported unfulfilling jobs, little sleep or strong anger in the second trimester. CONCLUSION: The relation of CRH with PTD is moderated by exposure to chronic stressors during pregnancy.
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The study provides preliminary support for the accelerated placental clock theory, consistent with some but not all prior studies.
“We also provide preliminary support for the accelerated “placental clock” theory, which is consistent with some (Guendelman et al., 2008; Hobel et al., 1999; Hoffman et al., 2016; Mancuso et al., 2004; Moog et al., 2016), but not all (Himes and Simhan, 2011; Karakash et al., 2016; Kramer et al., 2009; Kramer et al., 2013; Noll et al., 2007; Owen et al., 2017), prior studies.”
From Childhood stress and birth timing among African American women: cortisol as biological mediator (2017) · cites this paper as Guendelman et al., 2008
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Corticotropin-Releasing Hormone
Creque, C., & Kolakowsky‐Hayner, S. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_1644-2
Corticotropin-Releasing Hormone
Creque, C., & Kolakowsky‐Hayner, S. A. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_1644
Corticotropin-Releasing Hormone
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- Authors
- Guendelman, S., Lang Kosa, J., Pearl, M., Graham, S., & Kharrazi, M.
- Affiliations
- University of California, Berkeley (US)
- California Department of Public Health (US)
- Corresponding author
- Guendelman, Sylvia
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2008-01
- Volume
- 21
- Issue
- 11
- Pages
- 788-795
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2018874767
- Cited by
- 34
- References
- 30
- Citations by year
- 2022: 4 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 2 · 2013: 3 · 2012: 3
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Wood Johnson Foundation
- National Institutes of Health
- National Institute of Mental Health (R21MH70950, R21MH070950)
- Maternal and Child Health Bureau
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- corticotropin-releasing factor, preterm birth, chronic stress, second trimester, maternal serum biomarkers, occupational stress, sleep, anger, women's employment
- MeSH terms
- Adolescent, Adult, Corticotropin-Releasing Hormone, Female, Humans, Pregnancy, Pregnancy Trimester, Second, Stress, Psychological, Case-Control Studies, Premature Birth, Term Birth, Young Adult
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