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Changes of intestinal microbiota in early life
Open accessAbstract
There is an increasing evidence that the intestinal microbiota plays a pivotal role in the maturation of the immune system and in the prevention of diseases occurring during the neonatal period, childhood, and adulthood. A number of nonphysiological conditions during the perinatal period (i.e. caesarean section, prolonged hospitalization, formula feeding, low gestational age) may negatively affect the normal development of the microbiota, leading to decreased amounts of lactobacilli and bifidobacteria and increased amounts of Clostridia. In addition, perinatal antibiotics can cause intestinal dysbiosis that has been associated with short- and long-term diseases. For example, prolonged early empiric antibiotics increase the risk of necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in preterm neonates, whereas the administration of intrapartum antibiotic prophylaxis (IAP) has been associated with inflammatory bowel diseases, obesity, and atopic conditions, such as eczema and wheezing. Promoting breastfeeding, reducing the length of hospital stay, and reducing unnecessary antibiotic therapies are useful strategies to counterbalance unintended effects of these conditions.
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“Dysbiosis and other determinants of intestinal microbiota formation in childhood, such as birth via cesarean section or formula feeding, are associated with a higher risk of developing obesity, both in child and adulthood (3, 68).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [68]
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Cited by
Kefir and Intestinal Microbiota Modulation: Implications in Human Health
Peluzio, M. D. C. G., Dias, M. D. M. E., Martinez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638740 · Cited by 92
Metadata
- Authors
- Ficara, M., Pietrella, E., Spada, C., Della Casa Muttini, E., Lucaccioni, L., Iughetti, L., & Berardi, A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, Modena, Italy;
- Corresponding author
- Berardi, Alberto
- Venue
- The Journal of Maternal-Fetal & Neonatal Medicine
- Publisher
- Informa UK Limited
- Published
- 2018-09-10
- Volume
- 33
- Issue
- 6
- Pages
- 1036-1043
- ISSN
- 1476-4954 (ISSN-L)
- 1476-7058
- OpenAlex
- W2885836988
- Cited by
- 106
- References
- 5
- Citations by year
- 2026: 9 · 2025: 6 · 2024: 12 · 2023: 25 · 2022: 17 · 2021: 12 · 2020: 10 · 2019: 14 · 2018: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by
- Locations
- The Journal of Maternal-Fetal & Neonatal Medicine (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- Pfizer
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, early life, perinatal period, cesarean section, prolonged hospital stay, bottle feeding, low gestational age, lactobacilli, Bifidobacterium, Clostridia, gut dysbiosis, necrotizing enterocolitis, late-onset sepsis, preterm infants, intrapartum antibiotic prophylaxis, breastfeeding, immune system maturation
- MeSH terms
- Child Health, Infant Health, Gastrointestinal Microbiome, Anti-Bacterial Agents, Breast Feeding, Cesarean Section, Child, Child, Preschool, Dermatitis, Atopic, Gestational Age, Health Promotion, Hospitalization, Humans, Infant, Infant, Newborn, Obesity, Risk Factors, Inflammatory Bowel Diseases, Sepsis, Enterocolitis, Necrotizing, Protective Factors
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
